Aliases for POLR3G Gene

Aliases for POLR3G Gene

  • RNA Polymerase III Subunit G 2 3 5
  • RPC32 2 3 4
  • Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) 2 3
  • DNA-Directed RNA Polymerase III Subunit RPC7 3 4
  • DNA-Directed RNA Polymerase III Subunit G 3 4
  • RNA Polymerase III 32 KDa Apha Subunit 3 4
  • RNA Polymerase III 32 KDa Subunit 3 4
  • RNA Polymerase III Subunit C7 3 4
  • RPC32-Alpha 3 4
  • RPC7 2 3
  • C31 2 3
  • DNA-Directed RNA Polymerase III 32 KDa Polypeptide 3
  • Polymerase (RNA) III Subunit G 3
  • POLR3G 5

External Ids for POLR3G Gene

Previous GeneCards Identifiers for POLR3G Gene

  • GC05P089854
  • GC05P089807
  • GC05P084981

Summaries for POLR3G Gene

GeneCards Summary for POLR3G Gene

POLR3G (RNA Polymerase III Subunit G) is a Protein Coding gene. Diseases associated with POLR3G include Adiaspiromycosis. Among its related pathways are Transcription of tRNA and RNA Polymerase III Transcription Initiation. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase III activity.

UniProtKB/Swiss-Prot Summary for POLR3G Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLR3G Gene

Genomics for POLR3G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POLR3G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J090527 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11 +57.5 57483 3.7 BCLAF1 SP1 NCOR1 MYC ZNF654 IKZF1 ZNF600 JUND ZNF580 ZNF592 LYSMD3 ADGRV1 HSALNG0043415 POLR3G MBLAC2
GH05J090558 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.1 +87.7 87653 4 EZH2 IKZF1 ZNF600 JUND ZNF223 ZNF10 POLR2A ZIC2 NONO SMAD5 ADGRV1 POLR3G LYSMD3 MK280144-562 ARRDC3
GH05J090472 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 7.2 +3.5 3479 6.1 BCLAF1 SP1 MYC ZNF600 ZNF580 ZNF592 KLF9 POLR2A ZNF223 ZNF10 MBLAC2 POLR3G HSALNG0043414 ADGRV1
GH05J090518 Enhancer 0.6 Ensembl 22.3 +47.1 47099 1.3 NFIC BHLHE40 SP7 ZNF366 ZNF629 MAFK RAD51 RUNX3 USF1 SCRT2 POLR3G MBLAC2 HSALNG0043415 LYSMD3 ADGRV1
GH05J090439 Promoter/Enhancer 1.1 ENCODE CraniofacialAtlas 11.6 -31.8 -31754 0.9 ZNF654 IKZF1 REST TRIM22 HES1 CTCF NFATC3 RAD21 SMC3 ZFP91 ADGRV1 LYSMD3 POLR3G MBLAC2 LOC731157 CETN3 piR-49406-012 piR-37750-003 lnc-POLR3G-9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR3G on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLR3G

Top Transcription factor binding sites by QIAGEN in the POLR3G gene promoter:
  • aMEF-2
  • AML1a
  • Arnt
  • c-Myc
  • Egr-3
  • HNF-1
  • HNF-1A
  • LCR-F1
  • Max1
  • MEF-2A

Genomic Locations for POLR3G Gene

Latest Assembly
chr5:90,471,748-90,514,557
(GRCh38/hg38)
Size:
42,810 bases
Orientation:
Plus strand

Previous Assembly
chr5:89,769,746-89,810,374
(GRCh37/hg19 by Entrez Gene)
Size:
40,629 bases
Orientation:
Plus strand

chr5:89,767,565-89,810,370
(GRCh37/hg19 by Ensembl)
Size:
42,806 bases
Orientation:
Plus strand

Genomic View for POLR3G Gene

Genes around POLR3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3G Gene

Proteins for POLR3G Gene

  • Protein details for POLR3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15318-RPC7_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC7
    Protein Accession:
    O15318
    Secondary Accessions:
    • A8MTH0

    Protein attributes for POLR3G Gene

    Size:
    223 amino acids
    Molecular mass:
    25914 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Directly interacts with POLR3C/RPC62 (PubMed:21358628, PubMed:24107381, PubMed:26394183). Also found a trimeric complex with POLR3C and POLR3GL (PubMed:24107381).
    SequenceCaution:
    • Sequence=AAB63676.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for POLR3G Gene

Post-translational modifications for POLR3G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

No data available for DME Specific Peptides for POLR3G Gene

Domains & Families for POLR3G Gene

Gene Families for POLR3G Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POLR3G Gene

InterPro:

Suggested Antigen Peptide Sequences for POLR3G Gene

GenScript: Design optimal peptide antigens:
  • RNA polymerase III 32 kDa subunit (RPC7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15318

UniProtKB/Swiss-Prot:

RPC7_HUMAN :
  • Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3G: view

Function for POLR3G Gene

Molecular function for POLR3G Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370).
UniProtKB/Swiss-Prot Induction:
Induced by NANOG and POU5F1/OCT4 (PubMed:21898682). Negatively regulated by the interaction of microRNA MIR1305 with 3 miRNA responsive elements (miREs) in its 3'-UTR (PubMed:27339422).

Phenotypes From GWAS Catalog for POLR3G Gene

Gene Ontology (GO) - Molecular Function for POLR3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 24107381
GO:0003899 DNA-directed 5'-3' RNA polymerase activity TAS,IEA --
GO:0005515 protein binding IPI 20154270
genes like me logo Genes that share ontologies with POLR3G: view
genes like me logo Genes that share phenotypes with POLR3G: view

Animal Models for POLR3G Gene

MGI Knock Outs for POLR3G:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR3G

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLR3G Gene

Localization for POLR3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3G Gene

Nucleus. Cytoplasm. Note=Excluded from nucleoli (PubMed:21898682). In zygotes and the 2-cell stage embryos, mainly in the cytoplasm. Starts to localize to the nucleus in the 8-16 cell stage embryo and early blastocysts (By similarity). {ECO:0000250 UniProtKB:Q6NXY9, ECO:0000269 PubMed:21898682}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3G gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POLR3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IEA,IDA 20154270
GO:0005654 nucleoplasm IDA,TAS --
GO:0005666 RNA polymerase III complex TAS,IDA 24107381
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with POLR3G: view

Pathways & Interactions for POLR3G Gene

genes like me logo Genes that share pathways with POLR3G: view

Pathways by source for POLR3G Gene

1 GeneGo (Thomson Reuters) pathway for POLR3G Gene
  • ATP/ITP metabolism
2 Qiagen pathways for POLR3G Gene
  • Assembly of RNA Polymerase-III Initiation Complex
  • Transcription of tRNA

Gene Ontology (GO) - Biological Process for POLR3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006359 regulation of transcription by RNA polymerase III TAS 9171375
GO:0006383 transcription by RNA polymerase III IEA,IDA 20154270
GO:0008283 cell proliferation IBA,IEP 24107381
GO:0032481 positive regulation of type I interferon production TAS --
genes like me logo Genes that share ontologies with POLR3G: view

No data available for SIGNOR curated interactions for POLR3G Gene

Drugs & Compounds for POLR3G Gene

(5) Drugs for POLR3G Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nevirapine Approved Pharma 233
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for POLR3G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with POLR3G: view

Transcripts for POLR3G Gene

mRNA/cDNA for POLR3G Gene

5 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR3G

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3G Gene

No ASD Table

Relevant External Links for POLR3G Gene

GeneLoc Exon Structure for
POLR3G

Expression for POLR3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR3G Gene

Protein differential expression in normal tissues from HIPED for POLR3G Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR3G Gene



Protein tissue co-expression partners for POLR3G Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLR3G

SOURCE GeneReport for Unigene cluster for POLR3G Gene:

Hs.282387

mRNA Expression by UniProt/SwissProt for POLR3G Gene:

O15318-RPC7_HUMAN
Tissue specificity: Barely detectable in differentiated tissues. Expressed in embryonic stem cells and in other dividing cells, such as some tumor cell lines.

Evidence on tissue expression from TISSUES for POLR3G Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with POLR3G: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3G Gene

Orthologs for POLR3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for POLR3G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POLR3G 29 30
  • 99.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia POLR3G 29 30
  • 92.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia POLR3G 29 30
  • 90.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Polr3g 29
  • 83.78 (n)
Mouse
(Mus musculus)
Mammalia Polr3g 29 16 30
  • 83.63 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia POLR3G 30
  • 69 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia POLR3G 30
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves POLR3G 29 30
  • 75.27 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia polr3g 29
  • 66.51 (n)
Zebrafish
(Danio rerio)
Actinopterygii polr3g 29 30
  • 63.96 (n)
OneToOne
Species where no ortholog for POLR3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for POLR3G Gene

ENSEMBL:
Gene Tree for POLR3G (if available)
TreeFam:
Gene Tree for POLR3G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR3G: view image
Alliance of Genome Resources:
Additional Orthologs for POLR3G

Paralogs for POLR3G Gene

(1) SIMAP similar genes for POLR3G Gene using alignment to 7 proteins:

  • RPC7_HUMAN
  • D6R921_HUMAN
  • D6R9U7_HUMAN
  • D6REQ0_HUMAN
  • D6RIT0_HUMAN
  • D6RJH6_HUMAN
  • L8E8B4_HUMAN

Pseudogenes.org Pseudogenes for POLR3G Gene

genes like me logo Genes that share paralogs with POLR3G: view

No data available for Paralogs for POLR3G Gene

Variants for POLR3G Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for POLR3G Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for POLR3G Gene

Variant ID Type Subtype PubMed ID
esv2666589 CNV deletion 23128226
esv3441535 CNV insertion 20981092
esv3605765 CNV loss 21293372
nsv518131 CNV loss 19592680
nsv823125 CNV loss 20364138
nsv968218 CNV duplication 23825009

Variation tolerance for POLR3G Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3G
Leiden Open Variation Database (LOVD)
POLR3G

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLR3G Gene

Disorders for POLR3G Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR3G Gene - From: COP

Disorder Aliases PubMed IDs
adiaspiromycosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for POLR3G

genes like me logo Genes that share disorders with POLR3G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3G Gene

Publications for POLR3G Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P … Hernandez N (Molecular and cellular biology 2002) 2 3 4
  2. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. (PMID: 9171375) Wang Z … Roeder RG (Genes & development 1997) 2 3 4
  3. RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. (PMID: 28494942) Lund RJ … Lahesmaa R (Stem cell reports 2017) 3 4
  4. Gene duplication and neofunctionalization: POLR3G and POLR3GL. (PMID: 24107381) Renaud M … Hernandez N (Genome research 2014) 3 4
  5. Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. (PMID: 21358628) Lefèvre S … Fribourg S (Nature structural & molecular biology 2011) 3 4

Products for POLR3G Gene

Sources for POLR3G Gene