The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protei... See more...

Aliases for POLR3F Gene

Aliases for POLR3F Gene

  • RNA Polymerase III Subunit F 2 3 5
  • RPC39 2 3 4
  • DNA-Directed RNA Polymerase III Subunit RPC6 3 4
  • RNA Polymerase III C39 Subunit 2 3
  • RNA Polymerase III Subunit C6 3 4
  • RPC6 2 3
  • C34 2 3
  • Polymerase (RNA) III (DNA Directed) Polypeptide F (39 KDa) 2
  • Polymerase (RNA) III (DNA Directed) Polypeptide F, 39 KDa 3
  • DNA-Directed RNA Polymerase III Subunit F 4
  • RNA Polymerase III 39 KDa Subunit 4
  • Polymerase (RNA) III Subunit F 3
  • POLR3F 5

External Ids for POLR3F Gene

Previous GeneCards Identifiers for POLR3F Gene

  • GC20P018435
  • GC20P018396
  • GC20P018443
  • GC20P018395
  • GC20P018449
  • GC20P018410
  • GC20P018454
  • GC20P018455
  • GC20P018456
  • GC20P018457
  • GC20P018458
  • GC20P018459
  • GC20P018460

Summaries for POLR3F Gene

Entrez Gene Summary for POLR3F Gene

  • The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for POLR3F Gene

POLR3F (RNA Polymerase III Subunit F) is a Protein Coding gene. Diseases associated with POLR3F include Corneal Dystrophy, Posterior Polymorphous, 1. Among its related pathways are Transcription of tRNA and RNA Polymerase III Transcription Initiation. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase III activity.

UniProtKB/Swiss-Prot Summary for POLR3F Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628).

Gene Wiki entry for POLR3F Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLR3F Gene

Genomics for POLR3F Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POLR3F Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR3F on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLR3F

Top Transcription factor binding sites by QIAGEN in the POLR3F gene promoter:
  • Nkx6-1
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A

Genomic Locations for POLR3F Gene

Latest Assembly
chr20:18,467,389-18,484,646
(GRCh38/hg38)
Size:
17,258 bases
Orientation:
Plus strand

Previous Assembly
chr20:18,448,034-18,465,290
(GRCh37/hg19 by Entrez Gene)
Size:
17,257 bases
Orientation:
Plus strand

chr20:18,447,771-18,465,287
(GRCh37/hg19 by Ensembl)
Size:
17,517 bases
Orientation:
Plus strand

Genomic View for POLR3F Gene

Genes around POLR3F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3F Gene

Proteins for POLR3F Gene

  • Protein details for POLR3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1D9-RPC6_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC6
    Protein Accession:
    Q9H1D9
    Secondary Accessions:
    • A8K4C7
    • O15319

    Protein attributes for POLR3F Gene

    Size:
    316 amino acids
    Molecular mass:
    35684 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex (By similarity). Directly interacts with POLR3C (PubMed:21358628). Interacts with TBP and TFIIIB90 and GTF3C4 (By similarity) (PubMed:10523658). Interacts with MAF1 (PubMed:18377933).

    Three dimensional structures from OCA and Proteopedia for POLR3F Gene

neXtProt entry for POLR3F Gene

Post-translational modifications for POLR3F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR3F Gene

No data available for DME Specific Peptides for POLR3F Gene

Domains & Families for POLR3F Gene

Gene Families for POLR3F Gene

Protein Domains for POLR3F Gene

InterPro:
Blocks:
  • RNA polymerase Rpc34 subunit

Suggested Antigen Peptide Sequences for POLR3F Gene

GenScript: Design optimal peptide antigens:
  • Polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa, isoform CRA_c (Q05DB8_HUMAN)
  • RNA polymerase III 39 kDa subunit (RPC6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H1D9

UniProtKB/Swiss-Prot:

RPC6_HUMAN :
  • Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3F: view

Function for POLR3F Gene

Molecular function for POLR3F Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628).

Phenotypes From GWAS Catalog for POLR3F Gene

Gene Ontology (GO) - Molecular Function for POLR3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IDA 21358628
GO:0003899 DNA-directed 5'-3' RNA polymerase activity NAS 9171375
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with POLR3F: view
genes like me logo Genes that share phenotypes with POLR3F: view

Animal Models for POLR3F Gene

MGI Knock Outs for POLR3F:
  • Polr3f Polr3f<tm1a(EUCOMM)Wtsi>

miRNA for POLR3F Gene

miRTarBase miRNAs that target POLR3F

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR3F

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLR3F Gene

Localization for POLR3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3F Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3F gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLR3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005666 RNA polymerase III complex IDA,NAS 10623476
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3F: view

Pathways & Interactions for POLR3F Gene

genes like me logo Genes that share pathways with POLR3F: view

Pathways by source for POLR3F Gene

1 GeneGo (Thomson Reuters) pathway for POLR3F Gene
  • ATP/ITP metabolism
3 Qiagen pathways for POLR3F Gene
  • Assembly of RNA Polymerase-III Initiation Complex
  • DNA Repair Mechanisms
  • Transcription of tRNA

Gene Ontology (GO) - Biological Process for POLR3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006359 regulation of transcription by RNA polymerase III NAS 9171375
GO:0006383 transcription by RNA polymerase III IEA --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0032728 positive regulation of interferon-beta production IMP 19631370
genes like me logo Genes that share ontologies with POLR3F: view

No data available for SIGNOR curated interactions for POLR3F Gene

Drugs & Compounds for POLR3F Gene

(4) Drugs for POLR3F Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for POLR3F Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with POLR3F: view

Transcripts for POLR3F Gene

mRNA/cDNA for POLR3F Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR3F

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3F Gene

No ASD Table

Relevant External Links for POLR3F Gene

GeneLoc Exon Structure for
POLR3F

Expression for POLR3F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR3F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR3F Gene

This gene is overexpressed in Retina (11.2), Testis (9.2), Placenta (8.4), and Blymphocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR3F Gene



Protein tissue co-expression partners for POLR3F Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLR3F

SOURCE GeneReport for Unigene cluster for POLR3F Gene:

Hs.472227

Evidence on tissue expression from TISSUES for POLR3F Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with POLR3F: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3F Gene

Orthologs for POLR3F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR3F Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POLR3F 29 30
  • 99.68 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia POLR3F 30
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia POLR3F 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia POLR3F 29 30
  • 94.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia POLR3F 29 30
  • 93.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Polr3f 29
  • 91.56 (n)
Mouse
(Mus musculus)
Mammalia Polr3f 29 16 30
  • 90.72 (n)
OneToOne
Chicken
(Gallus gallus)
Aves POLR3F 29 30
  • 81.32 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia POLR3F 30
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia polr3f 29
  • 77.07 (n)
MGC76106 29
Zebrafish
(Danio rerio)
Actinopterygii polr3f 29 30
  • 77.18 (n)
OneToOne
zgc56299 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9235 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG5380 29 30 31
  • 55.13 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011973 29
  • 53.29 (n)
Worm
(Caenorhabditis elegans)
Secernentea W09C3.4 29 30 31
  • 45.95 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04532g 29
  • 45.4 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER191W 29
  • 41.96 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC34 29 30 32
  • 41.47 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 60 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpc34 29
  • 46.16 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.9623 29
Species where no ortholog for POLR3F was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for POLR3F Gene

ENSEMBL:
Gene Tree for POLR3F (if available)
TreeFam:
Gene Tree for POLR3F (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR3F: view image
Alliance of Genome Resources:
Additional Orthologs for POLR3F

Paralogs for POLR3F Gene

Pseudogenes.org Pseudogenes for POLR3F Gene

genes like me logo Genes that share paralogs with POLR3F: view

No data available for Paralogs for POLR3F Gene

Variants for POLR3F Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for POLR3F Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for POLR3F Gene

Variant ID Type Subtype PubMed ID
dgv4283n100 CNV loss 25217958
esv3645437 CNV gain 21293372
esv3645439 CNV loss 21293372
nsv1062244 CNV gain 25217958
nsv965861 CNV duplication 23825009

Variation tolerance for POLR3F Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR3F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3F
Leiden Open Variation Database (LOVD)
POLR3F

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLR3F Gene

Disorders for POLR3F Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR3F Gene - From: COP

Disorder Aliases PubMed IDs
corneal dystrophy, posterior polymorphous, 1
  • ppcd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for POLR3F

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with POLR3F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3F Gene

Publications for POLR3F Gene

  1. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. (PMID: 9171375) Wang Z … Roeder RG (Genes & development 1997) 2 3 4
  2. Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. (PMID: 21358628) Lefèvre S … Fribourg S (Nature structural & molecular biology 2011) 3 4
  3. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PMID: 19631370) Chiu YH … Chen ZJ (Cell 2009) 3 4
  4. Regulation of RNA polymerase III transcription by Maf1 in mammalian cells. (PMID: 18377933) Goodfellow SJ … White RJ (Journal of molecular biology 2008) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for POLR3F Gene

Sources for POLR3F Gene