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Aliases for POLR3E Gene

Aliases for POLR3E Gene

  • RNA Polymerase III Subunit E 2 3 5
  • Polymerase (RNA) III (DNA Directed) Polypeptide E (80kD) 2 3
  • DNA-Directed RNA Polymerase III 80 KDa Polypeptide 3 4
  • RNA Polymerase III Subunit C5 3 4
  • DNA-Directed RNA Polymerase III Subunit RPC5 3
  • RNA Polymerase III 80 KDa Subunit RPC5 3
  • Polymerase (RNA) III Subunit E 3
  • KIAA1452 4
  • RPC5 3
  • SIN 3

External Ids for POLR3E Gene

Previous GeneCards Identifiers for POLR3E Gene

  • GC16P022276
  • GC16P022216
  • GC16P022308
  • GC16P020553

Summaries for POLR3E Gene

GeneCards Summary for POLR3E Gene

POLR3E (RNA Polymerase III Subunit E) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase III activity.

UniProtKB/Swiss-Prot for POLR3E Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Gene Wiki entry for POLR3E Gene

Additional gene information for POLR3E Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3E Gene

Genomics for POLR3E Gene

GeneHancer (GH) Regulatory Elements for POLR3E Gene

Promoters and enhancers for POLR3E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J022296 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 679.8 +0.4 416 3.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 POLR3E TRL-AAG2-4 NPIPB4 SMG1P3 NPIPB3 NPIPB5 SMG1P1 MOSMO RRN3P1 SMG1P4
GH16J021819 Promoter/Enhancer 1.5 Ensembl ENCODE 74.4 -477.1 -477065 1.8 HDGF SMAD1 ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF207 ZNF143 RRN3P1 NPIPB4 NPIPB5 NPIPB3 SMG1P3 ENSG00000260635 SMG1P4 SMG1P1 ENSG00000260905 POLR3E
GH16J022204 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 21.3 -90.7 -90746 3.8 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 EEF2K NPIPB4 NPIPB3 NPIPB5 SMG1P1 SMG1P3 POLR3E MFSD13B ENSG00000260306 ENSG00000260635
GH16J022194 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 29.2 -101.7 -101666 2.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B IRF4 GC16M022196 TRL-TAG3-1 SMG1P3 SMG1P1 NPIPB3 SMG1P4 NPIPB4 NPIPB5 ENSG00000260635 POLR3E
GH16J022187 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.8 -106.5 -106496 6.5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 GC16P022190 POLR3E PDZD9 ENSG00000260306 UQCRC2 NPIPB5 ENSG00000260973 NPIPB3 MFSD13B NPIPB4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR3E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLR3E gene promoter:
  • IRF-7A
  • LCR-F1
  • AP-1
  • POU2F1a
  • POU2F1
  • Arnt
  • SRF
  • SRF (504 AA)
  • ISGF-3
  • GR-beta

Genomic Locations for POLR3E Gene

Genomic Locations for POLR3E Gene
chr16:22,297,366-22,335,103
(GRCh38/hg38)
Size:
37,738 bases
Orientation:
Plus strand
chr16:22,308,730-22,346,424
(GRCh37/hg19)
Size:
37,695 bases
Orientation:
Plus strand

Genomic View for POLR3E Gene

Genes around POLR3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3E Gene

Proteins for POLR3E Gene

  • Protein details for POLR3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVU0-RPC5_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC5
    Protein Accession:
    Q9NVU0
    Secondary Accessions:
    • B4DL24
    • B4DUP6
    • H3BT11
    • Q9BWF7
    • Q9H8W8
    • Q9H907
    • Q9P276

    Protein attributes for POLR3E Gene

    Size:
    708 amino acids
    Molecular mass:
    79898 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with POLR3D/RPC4.
    SequenceCaution:
    • Sequence=BAA95976.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14481.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for POLR3E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR3E Gene

Post-translational modifications for POLR3E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POLR3E Gene

Domains & Families for POLR3E Gene

Gene Families for POLR3E Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POLR3E Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with POLR3E: view

No data available for UniProtKB/Swiss-Prot for POLR3E Gene

Function for POLR3E Gene

Molecular function for POLR3E Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Phenotypes From GWAS Catalog for POLR3E Gene

Gene Ontology (GO) - Molecular Function for POLR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR3E: view
genes like me logo Genes that share phenotypes with POLR3E: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR3E Gene

Localization for POLR3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3E gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005666 DNA-directed RNA polymerase III complex IDA 24107381
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3E: view

Pathways & Interactions for POLR3E Gene

genes like me logo Genes that share pathways with POLR3E: view

Gene Ontology (GO) - Biological Process for POLR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006383 transcription by RNA polymerase III IEA --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with POLR3E: view

No data available for SIGNOR curated interactions for POLR3E Gene

Drugs & Compounds for POLR3E Gene

(4) Drugs for POLR3E Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for POLR3E Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with POLR3E: view

Transcripts for POLR3E Gene

Unigene Clusters for POLR3E Gene

Polymerase (RNA) III (DNA directed) polypeptide E (80kD):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3E Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a ·
SP1: - - - - -
SP2:
SP3: -
SP4: -
SP5:
SP6:

ExUns: 20b ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for POLR3E Gene

GeneLoc Exon Structure for
POLR3E
ECgene alternative splicing isoforms for
POLR3E

Expression for POLR3E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR3E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR3E Gene

This gene is overexpressed in Platelet (51.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR3E Gene



Protein tissue co-expression partners for POLR3E Gene

NURSA nuclear receptor signaling pathways regulating expression of POLR3E Gene:

POLR3E

SOURCE GeneReport for Unigene cluster for POLR3E Gene:

Hs.460298

Evidence on tissue expression from TISSUES for POLR3E Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with POLR3E: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3E Gene

Orthologs for POLR3E Gene

This gene was present in the common ancestor of animals.

Orthologs for POLR3E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3E 34 33
  • 95.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia POLR3E 34 33
  • 91.58 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3E 34
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR3E 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr3e 16 34 33
  • 87.76 (n)
rat
(Rattus norvegicus)
Mammalia Polr3e 33
  • 87.49 (n)
dog
(Canis familiaris)
Mammalia POLR3E 34 33
  • 86.96 (n)
OneToOne
chicken
(Gallus gallus)
Aves POLR3E 34 33
  • 73.08 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR3E 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3e 33
  • 67.82 (n)
Str.681 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3880 33
zebrafish
(Danio rerio)
Actinopterygii polr3e 34 33
  • 67.2 (n)
OneToOne
wufb12d10 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005922 33
  • 51 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sin 34 33
  • 49.28 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W06E11.1 34
  • 22 (a)
OneToOne
Species where no ortholog for POLR3E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3E Gene

ENSEMBL:
Gene Tree for POLR3E (if available)
TreeFam:
Gene Tree for POLR3E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR3E: view image

Paralogs for POLR3E Gene

No data available for Paralogs for POLR3E Gene

Variants for POLR3E Gene

Sequence variations from dbSNP and Humsavar for POLR3E Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000142062 -- 22,307,694(+) T/G intron_variant
rs1000154348 -- 22,328,631(+) T/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000235706 -- 22,331,038(+) TCTGTC/TC genic_downstream_transcript_variant, intron_variant
rs1000261634 -- 22,304,683(+) T/C intron_variant
rs1000281826 -- 22,318,025(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3E Gene

Variant ID Type Subtype PubMed ID
dgv2812n100 CNV loss 25217958
dgv3n1 OTHER inversion 15895083
dgv47n16 OTHER inversion 17901297
esv2758637 CNV gain+loss 17122850
esv3368991 OTHER inversion 20981092
esv3638204 CNV gain 21293372
esv998989 OTHER inversion 20482838
nsv1077770 OTHER inversion 25765185
nsv1140248 OTHER inversion 24896259
nsv499139 OTHER inversion 21111241
nsv7280 OTHER inversion 18451855
nsv952951 CNV deletion 24416366

Variation tolerance for POLR3E Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR3E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3E Gene

Disorders for POLR3E Gene

Additional Disease Information for POLR3E

No disorders were found for POLR3E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR3E Gene

Publications for POLR3E Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P … Hernandez N (Molecular and cellular biology 2002) 3 4 58
  5. SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal. (PMID: 10521666) Dong Z … Bell LR (Gene 1999) 2 3 58

Products for POLR3E Gene

Sources for POLR3E Gene

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