Aliases for POLR3E Gene
External Ids for POLR3E Gene
Previous GeneCards Identifiers for POLR3E Gene
GeneCards Summary for POLR3E Gene
POLR3E (RNA Polymerase III Subunit E) is a Protein Coding gene. Diseases associated with POLR3E include Cataract 31, Multiple Types and Acute Retrobulbar Neuritis. Among its related pathways are Transcription of tRNA and RNA Polymerase III Transcription Initiation. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase III activity.
UniProtKB/Swiss-Prot Summary for POLR3E Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).