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This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
POLR3D (RNA Polymerase III Subunit D) is a Protein Coding gene. Diseases associated with POLR3D include Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Transcription of tRNA. Gene Ontology (GO) annotations related to this gene include chromatin binding and RNA polymerase III activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IEA | -- |
GO:0003899 | DNA-directed 5'-3' RNA polymerase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | colocalizes_with nuclear chromatin | IEA,IDA | 24107381 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005666 | RNA polymerase III complex | IEA,IDA | 24107381 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RNA Polymerase III Transcription Initiation |
.46
|
|
2 | Cytosolic sensors of pathogen-associated DNA | ||
3 | Transcription of tRNA |
Assembly of RNA Polymerase-III Initiation Complex
.01
|
Transcription of tRNA
-
|
4 | Innate Immune System |
.61
|
|
5 | Chks in Checkpoint Regulation |
DNA Repair Mechanisms
.31
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0006383 | transcription by RNA polymerase III | IEA | -- |
GO:0032481 | positive regulation of type I interferon production | TAS | -- |
GO:0032728 | positive regulation of interferon-beta production | IDA | 19631370 |
GO:0045087 | innate immune response | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phosphoric acid | Approved | Pharma | 0 | |||
Cytidine triphosphate | Experimental | Pharma | 0 | |||
Guanosine triphosphate | Experimental | Pharma | 0 | |||
Uridine triphosphate | Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | POLR3D 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | POLR3D 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | POLR3D 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Polr3d 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Polr3d 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | POLR3D 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | POLR3D 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | POLR3D 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | polr3d 30 |
|
||
Str.12617 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.31157 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | polr3d 30 31 |
|
OneToOne | |
zgc56407 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5147 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism |
|
|