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This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008] See more...
Aliases for POLR3D Gene
Aliases for POLR3D Gene
- RNA Polymerase III Subunit D 2 3 5
- Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa 2 3
- BN51 (BHK21) Temperature Sensitivity Complementing 2 3
- DNA-Directed RNA Polymerase III Subunit RPC4 3 4
- DNA-Directed RNA Polymerase III Subunit D 3 4
- RNA Polymerase III 47 KDa Subunit 3 4
- RNA Polymerase III Subunit C4 3 4
- RPC53 Homolog 3 4
- TSBN51 2 3
External Ids for POLR3D Gene
- HGNC: 1080
- Entrez Gene: 661
- Ensembl: ENSG00000168495
- OMIM: 187280
- UniProtKB: P05423
Previous HGNC Symbols for POLR3D Gene
- BN51T
Previous GeneCards Identifiers for POLR3D Gene
- GC08P022455
- GC08P021923
- GC08P022124
- GC08P022158
- GC08P022102
- GC08P020644
- GC08P022248
- GC08P022249
- GC08P022260
- GC08P022261
- GC08P022259
- GC08P022258
- GC08P022250
- GC08P022251
- GC08P022252
- GC08P022254
- GC08P022255
- GC08P022257
Summaries for POLR3D Gene
-
This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
GeneCards Summary for POLR3D Gene
POLR3D (RNA Polymerase III Subunit D) is a Protein Coding gene. Diseases associated with POLR3D include Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Transcription of tRNA. Gene Ontology (GO) annotations related to this gene include chromatin binding and RNA polymerase III activity.
UniProtKB/Swiss-Prot Summary for POLR3D Gene
-
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Additional gene information for POLR3D Gene
- HGNC(1080)
- Entrez Gene(661)
- Ensembl(ENSG00000168495)
- OMIM(187280)
- UniProtKB(P05423)
- Open Targets Platform(ENSG00000168495)
- Search for POLR3D at DataMed
- Search for POLR3D at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLR3D Gene
Genomics for POLR3D Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for POLR3D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around POLR3D on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLR3D
- Top Transcription factor binding sites by QIAGEN in the POLR3D gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Egr-2
- NRSF form 1
- NRSF form 2
- ZIC2
Genomic Locations for POLR3D Gene
Genomic Locations for POLR3D Gene
- chr8:22,245,104-22,254,601
- (GRCh38/hg38)
- Size:
- 9,498 bases
- Orientation:
- Plus strand
- chr8:22,102,617-22,112,113
- (GRCh37/hg19)
- Size:
- 9,497 bases
- Orientation:
- Plus strand
Genomic View for POLR3D Gene
Genes around POLR3D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by HGNC
- 8p21.3 by Entrez Gene
- 8p21.3 by Ensembl
POLR3D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POLR3D Gene
Proteins for POLR3D Gene
-
Protein details for POLR3D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05423-RPC4_HUMAN
- Recommended name:
- DNA-directed RNA polymerase III subunit RPC4
- Protein Accession:
- P05423
- Q6FI28
- Q9BPV7
- Q9BPZ1
- Q9BXB3
Protein attributes for POLR3D Gene
- Size:
- 398 amino acids
- Molecular mass:
- 44396 Da
- Quaternary structure:
-
- Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with POLR3E/RPC5.
- SequenceCaution:
-
- Sequence=BC000516; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BC003039; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for POLR3D Gene
Post-translational modifications for POLR3D Gene
Other Protein References for POLR3D Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RPC4 Antibody
- Creative Biolabs Recombinant Anti-Human POLR3D Antibody
- Creative Diagnostics Anti-POLR3D (aa 175-225) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for POLR3D
- Novus Biologicals Antibodies for POLR3D
-
Abcam antibodies for POLR3D
- Invitrogen Antibodies for POLR3D (AFLGC-Polr3d)
Protein Products
- Creative Biomart Recombinant Human POLR3D
- Search Origene for MassSpec and Protein Over-expression Lysates for POLR3D
- Origene Custom Protein Services for POLR3D
- antibodies-online: Show 8 available POLR3D Proteins ranked by validation data
- Compare Top POLR3D Proteins
-
Quality Products:
-
Abcam proteins for POLR3D
No data available for DME Specific Peptides for POLR3D Gene
Domains & Families for POLR3D Gene
Gene Families for POLR3D Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for POLR3D Gene
- GenScript: Design optimal peptide antigens:
-
- Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa, isoform CRA_a (D3DSR2_HUMAN)
- RPC53 homolog (RPC4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P05423UniProtKB/Swiss-Prot:
RPC4_HUMAN :- Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.
- Family:
-
- Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.
Function for POLR3D Gene
Molecular function for POLR3D Gene
- UniProtKB/Swiss-Prot Function:
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Phenotypes From GWAS Catalog for POLR3D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003899 | DNA-directed 5'-3' RNA polymerase activity | IEA | -- |
Phenotypes for POLR3D Gene
Animal Model Products
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CRISPR Products
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for POLR3D
miRNA for POLR3D Gene
- miRTarBase miRNAs that target POLR3D
-
- hsa-miR-320a (MIRT001964)
- hsa-miR-149-5p (MIRT045444)
- hsa-let-7e-5p (MIRT051623)
- hsa-let-7a-5p (MIRT123972)
- hsa-let-7b-5p (MIRT123973)
- hsa-let-7c-5p (MIRT123974)
- hsa-let-7d-5p (MIRT123975)
- hsa-let-7f-5p (MIRT123976)
- hsa-miR-24-3p (MIRT123977)
- hsa-miR-98-5p (MIRT123978)
- hsa-let-7g-5p (MIRT123980)
- hsa-let-7i-5p (MIRT123981)
- hsa-miR-4458 (MIRT123990)
- hsa-miR-4500 (MIRT123991)
- hsa-miR-4446-5p (MIRT654920)
- hsa-miR-4753-3p (MIRT654921)
- hsa-miR-4279 (MIRT654922)
- hsa-miR-7111-3p (MIRT654923)
- hsa-miR-3156-3p (MIRT654924)
- hsa-miR-1260b (MIRT654925)
- hsa-miR-1260a (MIRT654926)
- hsa-miR-188-3p (MIRT654927)
- hsa-miR-8071 (MIRT654928)
- hsa-miR-627-3p (MIRT654929)
- hsa-miR-130b-5p (MIRT654930)
- hsa-miR-6769b-3p (MIRT654931)
- hsa-miR-4723-3p (MIRT654932)
- hsa-miR-3183 (MIRT654933)
- hsa-miR-665 (MIRT674362)
- hsa-miR-887-5p (MIRT674363)
- hsa-miR-6780a-5p (MIRT674364)
- hsa-miR-6779-5p (MIRT674365)
- hsa-miR-3689c (MIRT674366)
- hsa-miR-3689b-3p (MIRT674367)
- hsa-miR-3689a-3p (MIRT674368)
- hsa-miR-30b-3p (MIRT674369)
- hsa-miR-1273h-5p (MIRT674370)
- hsa-miR-6788-5p (MIRT674371)
- hsa-miR-30c-2-3p (MIRT674372)
- hsa-miR-30c-1-3p (MIRT674373)
- hsa-miR-7977 (MIRT674374)
- hsa-miR-6799-5p (MIRT674375)
- hsa-miR-6883-5p (MIRT674376)
- hsa-miR-6785-5p (MIRT674377)
- hsa-miR-4728-5p (MIRT674378)
- hsa-miR-149-3p (MIRT674379)
- hsa-miR-7106-5p (MIRT674380)
- hsa-miR-4284 (MIRT674381)
- hsa-miR-5693 (MIRT674382)
- hsa-miR-383-3p (MIRT674383)
- hsa-miR-3614-5p (MIRT674384)
- hsa-miR-6851-5p (MIRT700685)
- hsa-miR-3689d (MIRT700686)
- hsa-miR-4641 (MIRT700687)
- hsa-miR-5189-3p (MIRT700688)
- hsa-miR-4254 (MIRT700689)
- hsa-miR-4308 (MIRT700690)
- hsa-miR-6729-3p (MIRT700691)
- hsa-miR-136-3p (MIRT700692)
- hsa-miR-3651 (MIRT700693)
- hsa-miR-4678 (MIRT700694)
- hsa-miR-504-5p (MIRT700695)
- hsa-miR-6732-3p (MIRT700696)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for POLR3D - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for POLR3D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POLR3D
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR3D Gene
Localization for POLR3D Gene
Subcellular locations from UniProtKB/Swiss-Prot for POLR3D Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | colocalizes_with nuclear chromatin | IEA,IDA | 24107381 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005666 | RNA polymerase III complex | IEA,IDA | 24107381 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for POLR3D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RNA Polymerase III Transcription Initiation |
.46
|
|
| 2 | Cytosolic sensors of pathogen-associated DNA | ||
| 3 | Transcription of tRNA |
Assembly of RNA Polymerase-III Initiation Complex
.01
|
Transcription of tRNA
-
|
| 4 | Innate Immune System |
.61
|
|
| 5 | Chks in Checkpoint Regulation |
DNA Repair Mechanisms
.31
|
|
Pathways by source for POLR3D Gene
2 BioSystems pathways for POLR3D Gene
13 Reactome pathways for POLR3D Gene
2 KEGG pathways for POLR3D Gene
1 GeneGo (Thomson Reuters) pathway for POLR3D Gene
- ATP/ITP metabolism
3 Qiagen pathways for POLR3D Gene
- Assembly of RNA Polymerase-III Initiation Complex
- DNA Repair Mechanisms
- Transcription of tRNA
Interacting Proteins for POLR3D Gene
Selected Interacting proteins:
P05423-RPC4_HUMAN
ENSP00000380904
for POLR3D Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for POLR3D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0006383 | transcription by RNA polymerase III | IEA | -- |
| GO:0032481 | positive regulation of type I interferon production | TAS | -- |
| GO:0032728 | positive regulation of interferon-beta production | IDA | 19631370 |
| GO:0045087 | innate immune response | IEA | -- |
No data available for SIGNOR curated interactions for POLR3D Gene
Drugs & Compounds for POLR3D Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phosphoric acid | Approved | Pharma | 0 | |||
| Cytidine triphosphate | Experimental | Pharma | 0 | |||
| Guanosine triphosphate | Experimental | Pharma | 0 | |||
| Uridine triphosphate | Experimental, Investigational | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Drug Products
- Creative Biomart Recombinant Human POLR3D
Transcripts for POLR3D Gene
mRNA/cDNA for POLR3D Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000306433 5336 nts (view in UCSC)
- ENST00000397802 5494 nts (view in UCSC)
- ENST00000517789 841 nts (view in UCSC)
- ENST00000518039 1202 nts (view in UCSC)
- ENST00000519237 683 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for POLR3D - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for POLR3D
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POLR3D
-
Santa Cruz Biotechnology (SCBT) CRISPR for POLR3D
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for POLR3D - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for POLR3D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POLR3D
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: |
Relevant External Links for POLR3D Gene
- GeneLoc Exon Structure for
- POLR3D
Expression for POLR3D Gene
This gene is overexpressed in Adipocyte (12.3), Retina (8.8), Testis (7.3), and Gallbladder (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR3D Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLR3D
SOURCE GeneReport for Unigene cluster for POLR3D Gene:
Hs.148342Evidence on tissue expression from TISSUES for POLR3D Gene
- Lung(4.1)
- Nervous system(2.9)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for POLR3D
-
OriGene qPCR primer pairs and template standards for POLR3D
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3D Gene
Orthologs for POLR3D Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | POLR3D 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | POLR3D 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | POLR3D 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Polr3d 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Polr3d 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | POLR3D 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | POLR3D 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | POLR3D 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | polr3d 30 |
|
||
| Str.12617 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.31157 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | polr3d 30 31 |
|
OneToOne | |
| zgc56407 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG5147 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for POLR3D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for POLR3D Gene
- ENSEMBL:
- Gene Tree for POLR3D (if available)
- TreeFam:
- Gene Tree for POLR3D (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for POLR3D: view image
Paralogs for POLR3D Gene
Pseudogenes.org Pseudogenes for POLR3D Gene
No data available for Paralogs for POLR3D Gene
Variants for POLR3D Gene
Residual Variation Intolerance Score:
35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.21;
39.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for POLR3D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- POLR3D
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLR3D Gene
Disorders for POLR3D Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism |
|
|
Search POLR3D in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for POLR3D
No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3D Gene
Publications for POLR3D Gene
- Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P … Hernandez N (Molecular and cellular biology 2002) 2 3 4
- Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex. (PMID: 11279001) Chong SS … Hernandez N (The Journal of biological chemistry 2001) 2 3 4
- RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PMID: 19631370) Chiu YH … Chen ZJ (Cell 2009) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing. (PMID: 7799973) Jackson AJ … Pugh BF (Molecular and cellular biology 1995) 3 23
ExternalLinks
Products for POLR3D Gene
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for POLR3D
- Novus Biologicals proteins and lysates for POLR3D
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for POLR3D
- Abcam proteins for POLR3D
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for POLR3D (AFLGC-Polr3d)
- VectorBuilder Custom and pre-made DNA vectors for POLR3D (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for POLR3D (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for POLR3D (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for POLR3D CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for POLR3D
- antibodies-online: Show 19 available POLR3D Antibodies ranked by validation data
- Compare Top POLR3D Antibodies
- antibodies-online: Search results for available POLR3D related products ranked by validation data
- antibodies-online: Show 8 available POLR3D Proteins ranked by validation data
- Compare Top POLR3D Proteins
- Quality Products:
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POLR3D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POLR3D
- Search GeneCopoeia for miRNA 3'UTR Target clone products for POLR3D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR3D
Sources for POLR3D Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB