Aliases for POLR3C Gene
External Ids for POLR3C Gene
Previous GeneCards Identifiers for POLR3C Gene
GeneCards Summary for POLR3C Gene
POLR3C (RNA Polymerase III Subunit C) is a Protein Coding gene. Diseases associated with POLR3C include Thrombocytopenia-Absent Radius Syndrome and Chickenpox. Among its related pathways are RNA Polymerase III Transcription Initiation and Transcription of tRNA. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase III activity.
UniProtKB/Swiss-Prot Summary for POLR3C Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628).