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Aliases for POLR3C Gene

Aliases for POLR3C Gene

  • RNA Polymerase III Subunit C 2 3 5
  • Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) 2 3
  • DNA-Directed RNA Polymerase III Subunit C 3 4
  • RNA Polymerase III 62 KDa Subunit 3 4
  • RNA Polymerase III Subunit C3 3 4
  • RPC62 3 4
  • DNA-Directed RNA Polymerase III Subunit RPC3 3
  • DNA-Directed III 62 KDa Polypeptide 3
  • Polymerase (RNA) III Subunit C 3
  • RPC3 3

External Ids for POLR3C Gene

Previous GeneCards Identifiers for POLR3C Gene

  • GC01M143342
  • GC01M143081
  • GC01M144303
  • GC01M145592
  • GC01M119556

Summaries for POLR3C Gene

GeneCards Summary for POLR3C Gene

POLR3C (RNA Polymerase III Subunit C) is a Protein Coding gene. Diseases associated with POLR3C include Chickenpox. Among its related pathways are RNA Polymerase III Transcription Initiation and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase III activity.

UniProtKB/Swiss-Prot for POLR3C Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628).

Gene Wiki entry for POLR3C Gene

Additional gene information for POLR3C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR3C Gene

Genomics for POLR3C Gene

GeneHancer (GH) Regulatory Elements for POLR3C Gene

Promoters and enhancers for POLR3C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J145822 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 679.2 -0.2 -165 2.6 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 POLR3C RNF115 NBPF20 GPR89A NUDT17 PIAS3 PIR40983
GH01J146034 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 141 +213.5 213482 5.6 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 HJV GC01P146046 TRE-CTC1-1 PIR58458 TRG-TCC2-1 TRH-GTG1-1 TRK-CTT2-1 POLR3C PIAS3 NBPF20
GH01J146050 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 120.8 +227.6 227639 2.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 LINC01719 RNVU1-6 POLR3C NBPF20 PIAS3 GPR89A ENSG00000213240 ANKRD35 LIX1L-AS1 GC01M146050
GH01J145990 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 89.6 +171.3 171273 10.5 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 NFYC MEF2D TXNIP PIR35110 POLR3C NBPF20 LIX1L-AS1 PIAS3 GPR89A ENSG00000213240 HJV RBM8A
GH01J145925 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 52.6 +103.6 103556 3.3 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 RBM8A LIX1L-AS1 ENSG00000280778 POLR3C NBPF20 PIAS3 GPR89A ANKRD35 ENSG00000213240 PDZK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around POLR3C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLR3C gene promoter:
  • Pax-2a
  • Pax-2
  • S8
  • Sox5
  • CREB
  • deltaCREB
  • AML1a
  • Msx-1
  • N-Myc
  • ER-alpha

Genomic Locations for POLR3C Gene

Genomic Locations for POLR3C Gene
chr1:145,824,069-145,844,402
(GRCh38/hg38)
Size:
20,334 bases
Orientation:
Plus strand
chr1:145,592,605-145,611,025
(GRCh37/hg19)
Size:
18,421 bases
Orientation:
Minus strand

Genomic View for POLR3C Gene

Genes around POLR3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3C Gene

Proteins for POLR3C Gene

  • Protein details for POLR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUI4-RPC3_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC3
    Protein Accession:
    Q9BUI4
    Secondary Accessions:
    • O15317
    • Q9Y3R6

    Protein attributes for POLR3C Gene

    Size:
    534 amino acids
    Molecular mass:
    60612 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex (PubMed:9171375, PubMed:12391170). Directly interacts with POLR3G and POLR3GL (PubMed:24107381, PubMed:21358628, PubMed:26394183). Directly interacts with POLR3F/RPC39 (PubMed:26394183). Interacts with GTF3C4 (PubMed:10523658).
    Miscellaneous:
    • Antibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc).

    Three dimensional structures from OCA and Proteopedia for POLR3C Gene

neXtProt entry for POLR3C Gene

Post-translational modifications for POLR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR3C Gene

No data available for DME Specific Peptides for POLR3C Gene

Domains & Families for POLR3C Gene

Gene Families for POLR3C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POLR3C Gene

Suggested Antigen Peptide Sequences for POLR3C Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUI4

UniProtKB/Swiss-Prot:

RPC3_HUMAN :
  • Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR3C: view

Function for POLR3C Gene

Molecular function for POLR3C Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628).

Phenotypes From GWAS Catalog for POLR3C Gene

Gene Ontology (GO) - Molecular Function for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IDA 21358628
GO:0003899 DNA-directed 5-3 RNA polymerase activity TAS 9171375
GO:0005515 protein binding IPI 20154270
genes like me logo Genes that share ontologies with POLR3C: view
genes like me logo Genes that share phenotypes with POLR3C: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for POLR3C Gene

Localization for POLR3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3C gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IDA,TAS 24107381
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3C: view

Pathways & Interactions for POLR3C Gene

genes like me logo Genes that share pathways with POLR3C: view

Gene Ontology (GO) - Biological Process for POLR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006359 regulation of transcription by RNA polymerase III TAS 9171375
GO:0006383 transcription by RNA polymerase III IEA --
GO:0032481 positive regulation of type I interferon production TAS --
genes like me logo Genes that share ontologies with POLR3C: view

No data available for SIGNOR curated interactions for POLR3C Gene

Drugs & Compounds for POLR3C Gene

(4) Drugs for POLR3C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for POLR3C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with POLR3C: view

Transcripts for POLR3C Gene

Unigene Clusters for POLR3C Gene

Polymerase (RNA) III (DNA directed) polypeptide C (62kD):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: -
SP7:
SP8: - - -
SP9:

ExUns: 18c ^ 19
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for POLR3C Gene

GeneLoc Exon Structure for
POLR3C
ECgene alternative splicing isoforms for
POLR3C

Expression for POLR3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR3C Gene

Protein differential expression in normal tissues from HIPED for POLR3C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.2), Testis (11.0), and CD8 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR3C Gene



Protein tissue co-expression partners for POLR3C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR3C Gene:

POLR3C

SOURCE GeneReport for Unigene cluster for POLR3C Gene:

Hs.591457
genes like me logo Genes that share expression patterns with POLR3C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3C Gene

Orthologs for POLR3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR3C 34 33
  • 99.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia POLR3C 34 33
  • 92.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia POLR3C 34 33
  • 92.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr3c 33
  • 87.93 (n)
mouse
(Mus musculus)
Mammalia Polr3c 16 34 33
  • 87.18 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 87 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia POLR3C 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr3c 33
  • 72.34 (n)
Str.5213 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.26628 33
zebrafish
(Danio rerio)
Actinopterygii polr3c 34 33
  • 64.71 (n)
OneToOne
zgc56348 33
fruit fly
(Drosophila melanogaster)
Insecta CG12267 34 33
  • 46.94 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002394 33
  • 44.97 (n)
worm
(Caenorhabditis elegans)
Secernentea C48E7.2 34 33
  • 42.72 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC82 36 34
  • 16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49000 33
  • 41.82 (n)
rice
(Oryza sativa)
Liliopsida Os01g0679000 33
  • 38.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Cin.11029 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11029 33
Species where no ortholog for POLR3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR3C Gene

ENSEMBL:
Gene Tree for POLR3C (if available)
TreeFam:
Gene Tree for POLR3C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR3C: view image

Paralogs for POLR3C Gene

No data available for Paralogs for POLR3C Gene

Variants for POLR3C Gene

Sequence variations from dbSNP and Humsavar for POLR3C Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000073992 -- 145,823,949(+) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000137256 -- 145,831,000(+) G/A intron_variant
rs1000431646 -- 145,829,965(+) G/A intron_variant
rs1000777793 -- 145,842,081(+) C/T genic_downstream_transcript_variant, intron_variant
rs1001204013 -- 145,841,523(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for POLR3C Gene

Variant ID Type Subtype PubMed ID
nsv831381 CNV gain 17160897
nsv1015025 CNV gain 25217958
nsv1005055 CNV loss 25217958
esv3894089 CNV loss 25118596
esv3587420 CNV gain 21293372
esv3572008 CNV gain 25503493
dgv531n54 CNV loss 21841781
dgv33n27 CNV loss 19166990
dgv331n100 CNV gain 25217958

Variation tolerance for POLR3C Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR3C Gene

Human Gene Mutation Database (HGMD)
POLR3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3C Gene

Disorders for POLR3C Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR3C Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chickenpox
  • varicella
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for POLR3C

genes like me logo Genes that share disorders with POLR3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR3C Gene

Publications for POLR3C Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P … Hernandez N (Molecular and cellular biology 2002) 2 3 4 58
  2. Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. (PMID: 9171375) Wang Z … Roeder RG (Genes & development 1997) 2 3 4 58
  3. Gene duplication and neofunctionalization: POLR3G and POLR3GL. (PMID: 24107381) Renaud M … Hernandez N (Genome research 2014) 3 4 58
  4. Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. (PMID: 21358628) Lefèvre S … Fribourg S (Nature structural & molecular biology 2011) 3 4 58
  5. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. (PMID: 19609254) Ablasser A … Hornung V (Nature immunology 2009) 3 4 58

Products for POLR3C Gene

Sources for POLR3C Gene