This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multi... See more...

Aliases for POLR3B Gene

Aliases for POLR3B Gene

  • RNA Polymerase III Subunit B 2 3 5
  • C128 2 3 4
  • DNA-Directed RNA Polymerase III 127.6 KDa Polypeptide 3 4
  • Polymerase (RNA) III (DNA Directed) Polypeptide B 2 3
  • DNA-Directed RNA Polymerase III Subunit RPC2 3 4
  • DNA-Directed RNA Polymerase III Subunit B 3 4
  • RNA Polymerase III Subunit C2 3 4
  • EC 2.7.7.6 4 51
  • RPC2 2 3
  • Interphase Nucleus And Mitotic Apparatus Associated Protein 3
  • Polymerase (RNA) III Subunit B 3
  • FLJ10388 2
  • POLR3B 5
  • INMAP 3
  • HLD8 3

External Ids for POLR3B Gene

Previous GeneCards Identifiers for POLR3B Gene

  • GC12P105254
  • GC12P105255
  • GC12P106751
  • GC12P103811

Summaries for POLR3B Gene

Entrez Gene Summary for POLR3B Gene

  • This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for POLR3B Gene

POLR3B (RNA Polymerase III Subunit B) is a Protein Coding gene. Diseases associated with POLR3B include Leukodystrophy, Hypomyelinating, 8, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism and Cerebellar Hypoplasia With Endosteal Sclerosis. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and ribonucleoside binding. An important paralog of this gene is POLR2B.

UniProtKB/Swiss-Prot Summary for POLR3B Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLR3B Gene

Genomics for POLR3B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POLR3B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR3B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLR3B

Top Transcription factor binding sites by QIAGEN in the POLR3B gene promoter:
  • AML1a
  • AP-1
  • AREB6
  • C/EBPbeta
  • FOXO3b
  • HOXA5
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for POLR3B Gene

Genomic Locations for POLR3B Gene
chr12:106,357,712-106,510,198
(GRCh38/hg38)
Size:
152,487 bases
Orientation:
Plus strand
chr12:106,751,436-106,903,976
(GRCh37/hg19)
Size:
152,541 bases
Orientation:
Plus strand

Genomic View for POLR3B Gene

Genes around POLR3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR3B Gene

Proteins for POLR3B Gene

  • Protein details for POLR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW08-RPC2_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC2
    Protein Accession:
    Q9NW08
    Secondary Accessions:
    • A8K6H0
    • B3KV73
    • F5H1E6
    • Q9NW59

    Protein attributes for POLR3B Gene

    Size:
    1133 amino acids
    Molecular mass:
    127785 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
    SequenceCaution:
    • Sequence=BAA91527.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91581.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for POLR3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR3B Gene

Selected DME Specific Peptides for POLR3B Gene

Q9NW08:
  • AMGKQAMG
  • LTRQPTEGR
  • EGRSRDGGLR
  • DGGRLCRP
  • LNECPLDPGGYF
  • SQFEKTRKV
  • NPHGFPSRMT
  • EQLSKNRII
  • YQKLKHMV
  • GDKFSSR
  • KLLFQEL
  • PHECRLRD
  • SRHGQKGV
  • GPRSLQPSQWGMLCPSDTPEGEAC
  • GEMERDC
  • HNQSPRNTYQ
  • ERLMISSDAFEVDVC

Post-translational modifications for POLR3B Gene

  • Ubiquitination at Lys157, Lys324, Lys691, and Lys950
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR3B Gene

Antibody Products

  • Abcam antibodies for POLR3B
  • Santa Cruz Biotechnology (SCBT) Antibodies for POLR3B

Domains & Families for POLR3B Gene

Gene Families for POLR3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for POLR3B Gene

GenScript: Design optimal peptide antigens:
  • DNA-directed RNA polymerase (F5H1E6_HUMAN)
  • DNA-directed RNA polymerase III subunit B (RPC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NW08

UniProtKB/Swiss-Prot:

RPC2_HUMAN :
  • Belongs to the RNA polymerase beta chain family.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR3B: view

Function for POLR3B Gene

Molecular function for POLR3B Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA-COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:83400; EC=2.7.7.6;.

Enzyme Numbers (IUBMB) for POLR3B Gene

Phenotypes From GWAS Catalog for POLR3B Gene

Gene Ontology (GO) - Molecular Function for POLR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003899 contributes_to DNA-directed 5'-3' RNA polymerase activity IEA,IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
GO:0032549 ribonucleoside binding IEA --
genes like me logo Genes that share ontologies with POLR3B: view
genes like me logo Genes that share phenotypes with POLR3B: view

Human Phenotype Ontology for POLR3B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR3B

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for POLR3B Gene

Localization for POLR3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR3B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR3B gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POLR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005666 RNA polymerase III complex IDA 24107381
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with POLR3B: view

Pathways & Interactions for POLR3B Gene

genes like me logo Genes that share pathways with POLR3B: view

Pathways by source for POLR3B Gene

2 KEGG pathways for POLR3B Gene
1 GeneGo (Thomson Reuters) pathway for POLR3B Gene
  • ATP/ITP metabolism

Gene Ontology (GO) - Biological Process for POLR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0032728 positive regulation of interferon-beta production IMP 19609254
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with POLR3B: view

No data available for SIGNOR curated interactions for POLR3B Gene

Drugs & Compounds for POLR3B Gene

(5) Drugs for POLR3B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Thymidine 5'-triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for POLR3B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with POLR3B: view

Transcripts for POLR3B Gene

mRNA/cDNA for POLR3B Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR3B

Alternative Splicing Database (ASD) splice patterns (SP) for POLR3B Gene

No ASD Table

Relevant External Links for POLR3B Gene

GeneLoc Exon Structure for
POLR3B

Expression for POLR3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for POLR3B Gene

This gene is overexpressed in Neutrophil (55.1) and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR3B Gene



Protein tissue co-expression partners for POLR3B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLR3B

SOURCE GeneReport for Unigene cluster for POLR3B Gene:

Hs.62696

Evidence on tissue expression from TISSUES for POLR3B Gene

  • Muscle(4.4)
  • Nervous system(3.5)
  • Skin(2.2)
  • Kidney(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR3B Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • pharynx
  • pituitary gland
  • salivary gland
  • skull
  • tooth
Thorax:
  • breast
  • esophagus
Abdomen:
  • stomach
Pelvis:
  • fallopian tube
  • ovary
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • foot
  • lower limb
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with POLR3B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR3B Gene

Orthologs for POLR3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR3B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POLR3B 30 31
  • 99.79 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia POLR3B 31
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia POLR3B 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia POLR3B 30 31
  • 92.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia POLR3B 30 31
  • 92.41 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Polr3b 30 17 31
  • 89.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Polr3b 30
  • 89.09 (n)
Chicken
(Gallus gallus)
Aves POLR3B 30 31
  • 83.63 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia POLR3B 31
  • 96 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia polr3b 30
  • 79.58 (n)
Str.3762 30
Zebrafish
(Danio rerio)
Actinopterygii polr3b 30 31
  • 77.58 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9197 30
Fruit Fly
(Drosophila melanogaster)
Insecta RpIII128 30 31
  • 63.73 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008151 30
  • 62.14 (n)
Worm
(Caenorhabditis elegans)
Secernentea rpc-2 31
  • 62 (a)
OneToOne
F09F7.3 30
  • 61.33 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADL275C 30
  • 62.26 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RET1 30 33
  • 61.42 (n)
RPB2 31
  • 34 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01078g 30
  • 60.57 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons NRPC2 30
  • 58.53 (n)
Soybean
(Glycine max)
eudicotyledons Gma.5065 30
Rice
(Oryza sativa)
Liliopsida Os03g0403100 30
  • 57.7 (n)
Os.23203 30
Wheat
(Triticum aestivum)
Liliopsida Ta.6722 30
Corn
(Zea mays)
Liliopsida Zm.3221 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 70 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpc2 30
  • 60.3 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01772 30
  • 56.94 (n)
Species where no ortholog for POLR3B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR3B Gene

ENSEMBL:
Gene Tree for POLR3B (if available)
TreeFam:
Gene Tree for POLR3B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR3B: view image

Paralogs for POLR3B Gene

Paralogs for POLR3B Gene

(2) SIMAP similar genes for POLR3B Gene using alignment to 2 proteins:

  • RPC2_HUMAN
  • F8VRU2_HUMAN
genes like me logo Genes that share paralogs with POLR3B: view

Variants for POLR3B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLR3B Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
718768 Likely Benign: not provided 106,427,204(+) C/T MISSENSE_VARIANT
720126 Likely Benign: not provided 106,380,037(+) C/T SYNONYMOUS_VARIANT
722004 Likely Benign: not provided 106,433,842(+) A/G MISSENSE_VARIANT
722734 Likely Benign: not provided 106,357,893(+) C/T MISSENSE_VARIANT
729182 Benign: not provided 106,433,710(+) T/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for POLR3B Gene

Structural Variations from Database of Genomic Variants (DGV) for POLR3B Gene

Variant ID Type Subtype PubMed ID
esv3373508 CNV insertion 20981092
esv3580456 CNV loss 25503493
esv3580457 CNV loss 25503493
nsv476893 CNV novel sequence insertion 20440878
nsv507670 OTHER sequence alteration 20534489
nsv832510 CNV loss 17160897

Variation tolerance for POLR3B Gene

Residual Variation Intolerance Score: 3.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR3B Gene

Human Gene Mutation Database (HGMD)
POLR3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR3B Gene

Disorders for POLR3B Gene

MalaCards: The human disease database

(23) MalaCards diseases for POLR3B Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RPC2_HUMAN
  • Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism (HLD8) [MIM:614381]: An autosomal recessive neurodegenerative disorder characterized by early childhood onset of cerebellar ataxia and mild intellectual disabilities associated with diffuse hypomyelination apparent on brain MRI. Variable features include oligodontia and/or hypogonadotropic hypogonadism. {ECO:0000269 PubMed:22036171, ECO:0000269 PubMed:22036172, ECO:0000269 PubMed:23355746}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for POLR3B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with POLR3B: view

No data available for Genatlas for POLR3B Gene

Publications for POLR3B Gene

  1. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PMID: 12391170) Hu P … Hernandez N (Molecular and cellular biology 2002) 2 3 4
  2. Mutations in POLR3A and POLR3B are a major cause of hypomyelinating leukodystrophies with or without dental abnormalities and/or hypogonadotropic hypogonadism. (PMID: 23355746) Daoud H … Bernard G (Journal of medical genetics 2013) 3 4
  3. Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy. (PMID: 22036172) Tétreault M … Bernard G (American journal of human genetics 2011) 3 4
  4. Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy. (PMID: 22036171) Saitsu H … Matsumoto N (American journal of human genetics 2011) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

Products for POLR3B Gene

Sources for POLR3B Gene