This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008] See more...

Aliases for POLR2L Gene

Aliases for POLR2L Gene

  • RNA Polymerase II, I And III Subunit L 2 3
  • RNA Polymerase II Subunit L 2 3 5
  • RPB7.6 2 3 4
  • DNA-Directed RNA Polymerases I, II, And III Subunit RPABC5 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide L, 7.6kDa 2 3
  • RNA Polymerases I, II, And III Subunit ABC5 3 4
  • DNA-Directed RNA Polymerase III Subunit L 3 4
  • RNA Polymerase II 7.6 KDa Subunit 3 4
  • RPB10 Homolog 3 4
  • RPB10beta 2 3
  • HRPB7.6 2 3
  • RPABC5 2 3
  • RBP10 2 3
  • Polymerase (RNA) II Subunit L 3
  • EC 2.7.7.6 51
  • HsRPB10b 2
  • POLR2L 5
  • RPB10 3

External Ids for POLR2L Gene

Previous GeneCards Identifiers for POLR2L Gene

  • GC11U990108
  • GC11P000668
  • GC11P000355
  • GC11M000831
  • GC11M000655

Summaries for POLR2L Gene

Entrez Gene Summary for POLR2L Gene

  • This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2L Gene

POLR2L (RNA Polymerase II, I And III Subunit L) is a Protein Coding gene. Diseases associated with POLR2L include Cockayne Syndrome and Cockayne Syndrome B. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase I activity. An important paralog of this gene is RPL32.

UniProtKB/Swiss-Prot Summary for POLR2L Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).

Gene Wiki entry for POLR2L Gene

Additional gene information for POLR2L Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLR2L Gene

Genomics for POLR2L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POLR2L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR2L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLR2L

Top Transcription factor binding sites by QIAGEN in the POLR2L gene promoter:
  • AP-2gamma
  • C/EBPalpha
  • CHOP-10
  • E2F
  • Egr-4
  • HEN1
  • MyoD
  • POU2F1
  • POU2F1a

Genomic Locations for POLR2L Gene

Genomic Locations for POLR2L Gene
chr11:837,356-842,529
(GRCh38/hg38)
Size:
5,174 bases
Orientation:
Minus strand
chr11:837,356-842,545
(GRCh37/hg19)
Size:
5,190 bases
Orientation:
Minus strand

Genomic View for POLR2L Gene

Genes around POLR2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2L Gene

Proteins for POLR2L Gene

  • Protein details for POLR2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62875-RPAB5_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC5
    Protein Accession:
    P62875
    Secondary Accessions:
    • P52436
    • Q6FHX3

    Protein attributes for POLR2L Gene

    Size:
    67 amino acids
    Molecular mass:
    7645 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

    Three dimensional structures from OCA and Proteopedia for POLR2L Gene

neXtProt entry for POLR2L Gene

Selected DME Specific Peptides for POLR2L Gene

P62875:
  • RYCCRRM
  • PVRCFTCG

Post-translational modifications for POLR2L Gene

  • Ubiquitination at Lys17 and Lys41
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for POLR2L Gene

Gene Families for POLR2L Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for POLR2L Gene

InterPro:
Blocks:
  • RNA polymerases N/8 Kd subunits
ProtoNet:

Suggested Antigen Peptide Sequences for POLR2L Gene

GenScript: Design optimal peptide antigens:
  • RPB10 homolog (RPAB5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62875

UniProtKB/Swiss-Prot:

RPAB5_HUMAN :
  • Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2L: view

Function for POLR2L Gene

Molecular function for POLR2L Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).
GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) small polypeptide L (7,6kDa),yeast RPB11 homolog

Enzyme Numbers (IUBMB) for POLR2L Gene

Phenotypes From GWAS Catalog for POLR2L Gene

Gene Ontology (GO) - Molecular Function for POLR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003899 contributes_to DNA-directed 5'-3' RNA polymerase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with POLR2L: view
genes like me logo Genes that share phenotypes with POLR2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2L

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2L Gene

Localization for POLR2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2L gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for POLR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 RNA polymerase II, core complex IDA 9852112
GO:0005666 RNA polymerase III complex IBA 21873635
GO:0005736 RNA polymerase I complex IBA 21873635
genes like me logo Genes that share ontologies with POLR2L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for POLR2L Gene

Pathways & Interactions for POLR2L Gene

PathCards logo

SuperPathways for POLR2L Gene

SuperPathway Contained pathways
1 HIV Transcription Elongation
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 RNA Polymerase III Transcription Initiation
4 RNA Polymerase II Transcription Initiation And Promoter Clearance
.91
.91
.33
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with POLR2L: view

Pathways by source for POLR2L Gene

3 GeneGo (Thomson Reuters) pathways for POLR2L Gene
  • ATP/ITP metabolism
  • DNA damage_Role of Brca1 and Brca2 in DNA repair
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
2 Qiagen pathways for POLR2L Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Transcription of mRNA

Gene Ontology (GO) - Biological Process for POLR2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006356 regulation of transcription by RNA polymerase I TAS 8786124
GO:0006360 transcription by RNA polymerase I IBA 21873635
genes like me logo Genes that share ontologies with POLR2L: view

No data available for SIGNOR curated interactions for POLR2L Gene

Drugs & Compounds for POLR2L Gene

(43) Drugs for POLR2L Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
Actinomycin D Pharma RNA polymerase inhibitor 0

(36) Additional Compounds for POLR2L Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8

(1) ApexBio Compounds for POLR2L Gene

Compound Action Cas Number
Actinomycin D RNA polymerase inhibitor 50-76-0
genes like me logo Genes that share compounds with POLR2L: view

Drug Products

Transcripts for POLR2L Gene

mRNA/cDNA for POLR2L Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2L

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2L Gene

No ASD Table

Relevant External Links for POLR2L Gene

GeneLoc Exon Structure for
POLR2L

Expression for POLR2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2L Gene

This gene is overexpressed in Pancreas (17.2) and Tlymphocyte (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR2L Gene



Protein tissue co-expression partners for POLR2L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLR2L

SOURCE GeneReport for Unigene cluster for POLR2L Gene:

Hs.441072

Evidence on tissue expression from TISSUES for POLR2L Gene

  • Kidney(4.4)
  • Nervous system(4.4)
  • Bone marrow(4.3)
  • Skin(2.4)
  • Lung(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with POLR2L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2L Gene

Orthologs for POLR2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POLR2L 30 31
  • 100 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm10774 31
  • 99 (a)
OneToMany
Polr2l 30 17 31
  • 89.55 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia POLR2L 30 31
  • 94.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100911840 30
  • 88.06 (n)
Chicken
(Gallus gallus)
Aves POLR2L 30 31
  • 82.59 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia POLR2L 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia polr2l.1 30
  • 78.61 (n)
Str.6602 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8250 30
Zebrafish
(Danio rerio)
Actinopterygii polr2l 30 31
  • 80.1 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011761 30
  • 81.09 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Rpb10 30 31 32
  • 79.6 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y37E3.3 32
  • 85 (a)
rpb-10 30 31
  • 73.63 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR163W 30
  • 68.66 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06699g 30
  • 58.71 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB10 30 31 33
  • 58.21 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons NRPB10 30
  • 70.65 (n)
Rice
(Oryza sativa)
Liliopsida Os11g0194800 30
  • 77.61 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.6936 30
Corn
(Zea mays)
Liliopsida Zm.7018 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4791 31
  • 90 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU02605 30
  • 73.96 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb10 30
  • 65.67 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3728 30
Species where no ortholog for POLR2L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2L Gene

ENSEMBL:
Gene Tree for POLR2L (if available)
TreeFam:
Gene Tree for POLR2L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR2L: view image

Paralogs for POLR2L Gene

Paralogs for POLR2L Gene

genes like me logo Genes that share paralogs with POLR2L: view

Variants for POLR2L Gene

Additional dbSNP identifiers (rs#s) for POLR2L Gene

Structural Variations from Database of Genomic Variants (DGV) for POLR2L Gene

Variant ID Type Subtype PubMed ID
dgv1013n100 CNV gain 25217958
dgv1526n54 CNV gain 21841781
dgv1527n54 CNV loss 21841781
dgv182e199 CNV deletion 23128226
esv2759794 CNV loss 17122850
nsv1040044 CNV gain+loss 25217958
nsv1048774 CNV gain 25217958
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv552871 CNV loss 21841781
nsv552874 CNV gain 21841781
nsv552879 CNV loss 21841781
nsv552882 CNV loss 21841781
nsv552887 CNV loss 21841781
nsv552888 CNV loss 21841781
nsv832044 CNV loss 17160897
nsv8760 CNV loss 18304495
nsv951272 CNV deletion 24416366

Variation tolerance for POLR2L Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLR2L Gene

Disorders for POLR2L Gene

MalaCards: The human disease database

(5) MalaCards diseases for POLR2L Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with POLR2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2L Gene

Publications for POLR2L Gene

  1. The HIV-1 Tat team gets bigger. (PMID: 20227660) Rice AP (Cell host & microbe 2010) 3 23
  2. Will diverse Tat interactions lead to novel antiretroviral drug targets? (PMID: 17168834) Harrich D … Meredith L (Current drug targets 2006) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. (PMID: 12887902) Kaehlcke K … Ott M (Molecular cell 2003) 3 23
  5. Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences. (PMID: 11809800) Bourgeois CF … Karn J (Molecular and cellular biology 2002) 3 23

Products for POLR2L Gene

Sources for POLR2L Gene