This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008] See more...

Aliases for POLR2K Gene

Aliases for POLR2K Gene

  • RNA Polymerase II, I And III Subunit K 2 3
  • RNA Polymerase II Subunit K 2 3 5
  • RPB10alpha 2 3 4
  • DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa 2 3
  • RNA Polymerases I, II, And III Subunit ABC4 3 4
  • DNA-Directed RNA Polymerase II Subunit K 3 4
  • RNA Polymerase II 7.0 KDa Subunit 3 4
  • ABC10-Alpha 3 4
  • RPB7.0 3 4
  • RPB12 2 3
  • DNA Directed RNA Polymerases I, II, And III 7.0 Kda Polypeptide 3
  • Polymerase (RNA) II Subunit K 3
  • HsRPB10a 3
  • HRPB7.0 3
  • RPABC4 3
  • POLR2K 5

External Ids for POLR2K Gene

Previous GeneCards Identifiers for POLR2K Gene

  • GC08P100168
  • GC08P101232
  • GC08P100831
  • GC08P101119
  • GC08P096365
  • GC08P101162

Summaries for POLR2K Gene

Entrez Gene Summary for POLR2K Gene

  • This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2K Gene

POLR2K (RNA Polymerase II, I And III Subunit K) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase I activity.

UniProtKB/Swiss-Prot Summary for POLR2K Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Gene Wiki entry for POLR2K Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLR2K Gene

Genomics for POLR2K Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POLR2K Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR2K on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLR2K

Top Transcription factor binding sites by QIAGEN in the POLR2K gene promoter:
  • C/EBPbeta
  • Chx10
  • CUTL1
  • GATA-1
  • GATA-2
  • GATA-3
  • Nkx2-2
  • POU2F1
  • SRY

Genomic Locations for POLR2K Gene

Genomic Locations for POLR2K Gene
chr8:100,150,623-100,154,003
(GRCh38/hg38)
Size:
3,381 bases
Orientation:
Plus strand
chr8:101,162,812-101,166,230
(GRCh37/hg19)
Size:
3,419 bases
Orientation:
Plus strand

Genomic View for POLR2K Gene

Genes around POLR2K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2K Gene

Proteins for POLR2K Gene

  • Protein details for POLR2K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53803-RPAB4_HUMAN
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC4
    Protein Accession:
    P53803
    Secondary Accessions:
    • Q6IBD4

    Protein attributes for POLR2K Gene

    Size:
    58 amino acids
    Molecular mass:
    7004 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

    Three dimensional structures from OCA and Proteopedia for POLR2K Gene

neXtProt entry for POLR2K Gene

Post-translational modifications for POLR2K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POLR2K Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2K Gene

Domains & Families for POLR2K Gene

Gene Families for POLR2K Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POLR2K Gene

InterPro:
Blocks:
  • RNA polymerase Rbp10
ProtoNet:

Suggested Antigen Peptide Sequences for POLR2K Gene

GenScript: Design optimal peptide antigens:
  • RPB10alpha (RPAB4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53803

UniProtKB/Swiss-Prot:

RPAB4_HUMAN :
  • Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2K: view

Function for POLR2K Gene

Molecular function for POLR2K Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Phenotypes From GWAS Catalog for POLR2K Gene

Gene Ontology (GO) - Molecular Function for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed 5'-3' RNA polymerase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with POLR2K: view
genes like me logo Genes that share phenotypes with POLR2K: view

Animal Model Products

CRISPR Products

miRNA for POLR2K Gene

miRTarBase miRNAs that target POLR2K

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2K

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2K Gene

Localization for POLR2K Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2K Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2K gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 RNA polymerase II, core complex IDA 9852112
GO:0005666 RNA polymerase III complex IBA 21873635
GO:0005736 RNA polymerase I complex IBA 21873635
genes like me logo Genes that share ontologies with POLR2K: view

Pathways & Interactions for POLR2K Gene

PathCards logo

SuperPathways for POLR2K Gene

SuperPathway Contained pathways
1 HIV Transcription Elongation
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 RNA Polymerase II Transcription Initiation And Promoter Clearance
.91
.91
.33
4 RNA Polymerase III Transcription Initiation
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with POLR2K: view

Pathways by source for POLR2K Gene

3 GeneGo (Thomson Reuters) pathways for POLR2K Gene
  • ATP/ITP metabolism
  • DNA damage_Role of Brca1 and Brca2 in DNA repair
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
2 Qiagen pathways for POLR2K Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Transcription of mRNA

Gene Ontology (GO) - Biological Process for POLR2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated IEA,TAS --
GO:0006356 regulation of transcription by RNA polymerase I TAS 7651387
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with POLR2K: view

No data available for SIGNOR curated interactions for POLR2K Gene

Drugs & Compounds for POLR2K Gene

(4) Drugs for POLR2K Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for POLR2K Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with POLR2K: view

Transcripts for POLR2K Gene

mRNA/cDNA for POLR2K Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2K

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2K Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for POLR2K Gene

GeneLoc Exon Structure for
POLR2K

Expression for POLR2K Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR2K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2K Gene

This gene is overexpressed in Breast (16.7), Fetal Brain (8.5), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR2K Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLR2K

SOURCE GeneReport for Unigene cluster for POLR2K Gene:

Hs.351475

Evidence on tissue expression from TISSUES for POLR2K Gene

  • Nervous system(3.9)
  • Liver(2.4)
  • Kidney(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with POLR2K: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2K Gene

Orthologs for POLR2K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR2K Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POLR2K 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia POLR2K 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia POLR2K 30 31
  • 95.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia POLR2K 30 31
  • 95.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Polr2k 30
  • 94.83 (n)
Mouse
(Mus musculus)
Mammalia Polr2k 30 17 31
  • 92.53 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia POLR2K 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves POLR2K 31
  • 97 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia POLR2K 31
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia polr2k 30
  • 85.63 (n)
Str.6978 30
Zebrafish
(Danio rerio)
Actinopterygii polr2k 30 31
  • 81.03 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Rpb12 31
  • 68 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea rpb-12 31
  • 58 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPC10 33
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2976 31
  • 56 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.13296 30
Species where no ortholog for POLR2K was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for POLR2K Gene

ENSEMBL:
Gene Tree for POLR2K (if available)
TreeFam:
Gene Tree for POLR2K (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR2K: view image

Paralogs for POLR2K Gene

Pseudogenes.org Pseudogenes for POLR2K Gene

genes like me logo Genes that share paralogs with POLR2K: view

No data available for Paralogs for POLR2K Gene

Variants for POLR2K Gene

Additional dbSNP identifiers (rs#s) for POLR2K Gene

Structural Variations from Database of Genomic Variants (DGV) for POLR2K Gene

Variant ID Type Subtype PubMed ID
nsv611814 CNV loss 21841781

Variation tolerance for POLR2K Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR2K Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLR2K Gene

Disorders for POLR2K Gene

Additional Disease Information for POLR2K

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for POLR2K Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2K Gene

Publications for POLR2K Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 41
  2. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S … Benhamou S (Carcinogenesis 2009) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. (PMID: 7651387) Shpakovski GV … Vigneron M (Molecular and cellular biology 1995) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for POLR2K Gene

  • Signalway Proteins for POLR2K

Sources for POLR2K Gene