Aliases for POLR2I Gene
External Ids for POLR2I Gene
Previous GeneCards Identifiers for POLR2I Gene
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for POLR2I Gene
POLR2I (RNA Polymerase II Subunit I) is a Protein Coding gene. Diseases associated with POLR2I include Polyomavirus-Associated Nephropathy. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-directed 5'-3' RNA polymerase activity. An important paralog of this gene is POLR3K.
UniProtKB/Swiss-Prot Summary for POLR2I Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).