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Aliases for POLR2G Gene

Aliases for POLR2G Gene

  • RNA Polymerase II Subunit G 2 3 5
  • Polymerase (RNA) II (DNA Directed) Polypeptide G 2 3
  • DNA-Directed RNA Polymerase II Subunit G 3 4
  • RNA Polymerase II 19 KDa Subunit 3 4
  • RNA Polymerase II Subunit B7 3 4
  • RPB19 3 4
  • RPB7 3 4
  • DNA Directed RNA Polymerase II 19 Kda Polypeptide 3
  • DNA-Directed RNA Polymerase II 19 KDa Polypeptide 3
  • DNA-Directed RNA Polymerase II Subunit RPB7 3
  • RNA Polymerase II Seventh Subunit 3
  • Polymerase (RNA) II Subunit G 3
  • HRPB19 3
  • HsRPB7 3

External Ids for POLR2G Gene

Previous GeneCards Identifiers for POLR2G Gene

  • GC11P065041
  • GC11P064104
  • GC11P062779
  • GC11P062304
  • GC11P062285
  • GC11P062529
  • GC11P058857

Summaries for POLR2G Gene

Entrez Gene Summary for POLR2G Gene

  • This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]

GeneCards Summary for POLR2G Gene

POLR2G (RNA Polymerase II Subunit G) is a Protein Coding gene. Diseases associated with POLR2G include Myasthenic Syndrome, Congenital, 5 and Congenital Myasthenic Syndrome. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and single-stranded RNA binding.

UniProtKB/Swiss-Prot for POLR2G Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.

Gene Wiki entry for POLR2G Gene

Additional gene information for POLR2G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2G Gene

Genomics for POLR2G Gene

GeneHancer (GH) Regulatory Elements for POLR2G Gene

Promoters and enhancers for POLR2G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062760 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.3 329 1.9 ATF1 ARNT ARID4B SIN3A YY1 ZNF121 POLR2B ELK1 ZNF143 ATF7 POLR2G B3GAT3 TAF6L
GH11J062712 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 11.5 -47.6 -47613 3.5 FOXA2 MAX RAD21 YY1 FOSL1 ZNF316 HNF4G CBFA2T2 ZNF600 NFE2 PIR38618 HNRNPUL2 TTC9C UBXN1 LBHD1 LRRN4CL POLR2G GANAB B3GAT3 UQCC3
GH11J061826 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 -929.2 -929170 12.6 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 POLR2B ZNF766 ZNF213 ZNF143 FADS2 FADS1 CPSF7 MTA2 STX5 NXF1 TMEM138 EML3 TTC9C CSKMT
GH11J062694 Enhancer 0.7 ENCODE 10.7 -66.7 -66674 1.1 MEIS2 CTCF RB1 BACH1 SIN3A RAD21 CC2D1A POLR2A EGR1 ARID2 BSCL2 TTC9C LBHD1 SNORA57 CSKMT ENSG00000255432 INTS5 GANAB UQCC3 EML3
GH11J061841 Enhancer 1.2 ENCODE dbSUPER 4.9 -919.2 -919231 1.6 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 NCOA1 FADS2 FADS3 FADS1 POLR2G EML3 MIR6746
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR2G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLR2G gene promoter:
  • p53
  • ER-alpha
  • FOXD1
  • MyoD
  • ZIC2
  • XBP-1
  • E2F-1
  • E2F
  • c-Myc
  • E2F-2

Genomic Locations for POLR2G Gene

Genomic Locations for POLR2G Gene
chr11:62,761,539-62,766,715
(GRCh38/hg38)
Size:
5,177 bases
Orientation:
Plus strand
chr11:62,529,011-62,534,187
(GRCh37/hg19)
Size:
5,177 bases
Orientation:
Plus strand

Genomic View for POLR2G Gene

Genes around POLR2G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2G Gene

Proteins for POLR2G Gene

  • Protein details for POLR2G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62487-RPB7_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB7
    Protein Accession:
    P62487
    Secondary Accessions:
    • B2R5C0
    • P52433
    • Q2M1Z4

    Protein attributes for POLR2G Gene

    Size:
    172 amino acids
    Molecular mass:
    19294 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.

    Three dimensional structures from OCA and Proteopedia for POLR2G Gene

neXtProt entry for POLR2G Gene

Post-translational modifications for POLR2G Gene

  • Ubiquitination at posLast=8181, Lys71, and posLast=2727
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2G Gene

No data available for DME Specific Peptides for POLR2G Gene

Domains & Families for POLR2G Gene

Gene Families for POLR2G Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POLR2G Gene

Suggested Antigen Peptide Sequences for POLR2G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62487

UniProtKB/Swiss-Prot:

RPB7_HUMAN :
  • Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2G: view

Function for POLR2G Gene

Molecular function for POLR2G Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.
GENATLAS Biochemistry:
polymerase II,RNA (DNA dependent,polypeptide G,expressed in retina,brain,kidney,closely linked to D11S1765)

Phenotypes From GWAS Catalog for POLR2G Gene

Gene Ontology (GO) - Molecular Function for POLR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003697 single-stranded DNA binding IBA --
GO:0003723 RNA binding IEA --
GO:0003727 single-stranded RNA binding IBA --
GO:0003899 contributes_to DNA-directed 5-3 RNA polymerase activity IEA,IBA --
genes like me logo Genes that share ontologies with POLR2G: view
genes like me logo Genes that share phenotypes with POLR2G: view

Animal Model Products

CRISPR Products

miRNA for POLR2G Gene

miRTarBase miRNAs that target POLR2G

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2G

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2G Gene

Localization for POLR2G Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2G gene
Compartment Confidence
nucleus 5
cytoskeleton 3
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000428 DNA-directed RNA polymerase complex IBA --
GO:0000932 P-body IBA --
GO:0005634 nucleus IDA,IEA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
genes like me logo Genes that share ontologies with POLR2G: view

Pathways & Interactions for POLR2G Gene

SuperPathways for POLR2G Gene

SuperPathway Contained pathways
1 Formation of HIV-1 elongation complex containing HIV-1 Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 HIV Life Cycle
.45
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Signaling by FGFR2 in disease
genes like me logo Genes that share pathways with POLR2G: view

Gene Ontology (GO) - Biological Process for POLR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic IBA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS,IEA --
GO:0006366 transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with POLR2G: view

No data available for SIGNOR curated interactions for POLR2G Gene

Drugs & Compounds for POLR2G Gene

(4) Drugs for POLR2G Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for POLR2G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with POLR2G: view

Transcripts for POLR2G Gene

mRNA/cDNA for POLR2G Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(280) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POLR2G Gene

Polymerase (RNA) II (DNA directed) polypeptide G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2G

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2G Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: -

Relevant External Links for POLR2G Gene

GeneLoc Exon Structure for
POLR2G
ECgene alternative splicing isoforms for
POLR2G

Expression for POLR2G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2G Gene

This gene is overexpressed in Tlymphocyte (24.9) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR2G Gene



Protein tissue co-expression partners for POLR2G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2G Gene:

POLR2G

SOURCE GeneReport for Unigene cluster for POLR2G Gene:

Hs.14839

Evidence on tissue expression from TISSUES for POLR2G Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with POLR2G: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2G Gene

Orthologs for POLR2G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2G 34 33
  • 100 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2G 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2G 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2G 34 33
  • 94.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia POLR2G 34 33
  • 93.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Polr2g 33
  • 90.89 (n)
mouse
(Mus musculus)
Mammalia Polr2g 16 34 33
  • 90.31 (n)
lizard
(Anolis carolinensis)
Reptilia POLR2G 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2g 33
  • 80.62 (n)
zebrafish
(Danio rerio)
Actinopterygii polr2gl 34 33
  • 80.81 (n)
OneToOne
wufc18d05 33
fruit fly
(Drosophila melanogaster)
Insecta Rpb7 34 33
  • 70.74 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002121 33
  • 70.54 (n)
worm
(Caenorhabditis elegans)
Secernentea Y54E10BR.6 35
  • 77 (a)
rpb-7 34 33
  • 69.19 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR402C 33
  • 52.66 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06787g 33
  • 50.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB7 36 34 33
  • 49.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB7 33
  • 58.67 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4671 33
rice
(Oryza sativa)
Liliopsida Os05g0400700 33
  • 61.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7943 34
  • 88 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb7 33
  • 57.68 (n)
Species where no ortholog for POLR2G was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLR2G Gene

ENSEMBL:
Gene Tree for POLR2G (if available)
TreeFam:
Gene Tree for POLR2G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR2G: view image

Paralogs for POLR2G Gene

No data available for Paralogs for POLR2G Gene

Variants for POLR2G Gene

Sequence variations from dbSNP and Humsavar for POLR2G Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000087984 -- 62,767,077(+) C/G/T downstream_transcript_variant
rs1000149207 -- 62,761,857(+) G/A coding_sequence_variant, synonymous_variant
rs1000840438 -- 62,764,132(+) A/G intron_variant
rs1001294084 -- 62,763,814(+) C/T intron_variant
rs1001722549 -- 62,764,894(+) C/G intron_variant

Variation tolerance for POLR2G Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR2G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for POLR2G Gene

Disorders for POLR2G Gene

MalaCards: The human disease database

(2) MalaCards diseases for POLR2G Gene - From: DISEASES

Disorder Aliases PubMed IDs
myasthenic syndrome, congenital, 5
  • cms5
congenital myasthenic syndrome
  • familial limb-girdle myasthenia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for POLR2G

genes like me logo Genes that share disorders with POLR2G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2G Gene

Publications for POLR2G Gene

  1. Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology. (PMID: 7579693) Khazak V … Golemis EA (Molecular biology of the cell 1995) 2 3 4 22 58
  2. Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization. (PMID: 9256063) Schoen TJ … Rodriguez IR (Biochimica et biophysica acta 1997) 2 3 4 58
  3. Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II. (PMID: 16282592) Meka H … Brick P (Nucleic acids research 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PMID: 9852112) Kershnar E … Chiang CM (The Journal of biological chemistry 1998) 3 4 58

Products for POLR2G Gene

Sources for POLR2G Gene

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