Aliases for POLR2E Gene
- RNA Polymerase II Subunit E 2 3 5
- DNA-Directed RNA Polymerases I, II, And III Subunit RPABC1 3 4
- DNA Directed RNA Polymerase II 23 Kda Polypeptide 2 3
- DNA-Directed RNA Polymerase II 23 KDa Polypeptide 3 4
- RNA Polymerases I, II, And III Subunit ABC1 3 4
- DNA-Directed RNA Polymerase II Subunit E 3 4
- RPB5 Homolog 3 4
- XAP4 3 4
External Ids for POLR2E Gene
Previous GeneCards Identifiers for POLR2E Gene
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
GeneCards Summary for POLR2E Gene
POLR2E (RNA Polymerase II Subunit E) is a Protein Coding gene. Diseases associated with POLR2E include Esophageal Cancer and Retinitis Pigmentosa 20. Among its related pathways are RNA Polymerase III Transcription Initiation and Formation of HIV-1 elongation complex containing HIV-1 Tat. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase I activity.
UniProtKB/Swiss-Prot Summary for POLR2E Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).