Aliases for POLR2D Gene
External Ids for POLR2D Gene
Previous GeneCards Identifiers for POLR2D Gene
This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for POLR2D Gene
POLR2D (RNA Polymerase II Subunit D) is a Protein Coding gene. Diseases associated with POLR2D include Nemaline Myopathy 7 and Leukodystrophy, Hypomyelinating, 10. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include nucleotide binding and single-stranded RNA binding.
UniProtKB/Swiss-Prot Summary for POLR2D Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).