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Aliases for POLR2C Gene

Aliases for POLR2C Gene

  • RNA Polymerase II Subunit C 2 3 5
  • RNA Polymerase II Subunit 3 2 3 4
  • DNA-Directed RNA Polymerase II 33 KDa Polypeptide 3 4
  • DNA-Directed RNA Polymerase II Subunit C 3 4
  • RNA Polymerase II Subunit B3 3 4
  • RPB31 3 4
  • RPB33 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide C (33kD) 2
  • Polymerase (RNA) II (DNA Directed) Polypeptide C, 33kDa 3
  • DNA-Directed RNA Polymerase II Subunit RPB3 3
  • Polymerase (RNA) II Subunit C 3
  • HRPB33 3
  • HsRPB3 3
  • RPB3 3

External Ids for POLR2C Gene

Previous GeneCards Identifiers for POLR2C Gene

  • GC16P047891
  • GC16P057556
  • GC16P057230
  • GC16P057271
  • GC16P056054
  • GC16P057496
  • GC16P043364

Summaries for POLR2C Gene

Entrez Gene Summary for POLR2C Gene

  • This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2C Gene

POLR2C (RNA Polymerase II Subunit C) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and RNA polymerase II activity.

UniProtKB/Swiss-Prot for POLR2C Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).

Gene Wiki entry for POLR2C Gene

Additional gene information for POLR2C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2C Gene

Genomics for POLR2C Gene

GeneHancer (GH) Regulatory Elements for POLR2C Gene

Promoters and enhancers for POLR2C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I057462 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.6 606 1.8 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 ENSG00000260345 POLR2C RSPRY1 CIAPIN1 CSNK2A2 NLRC5 DOK4 CCDC102A PIR63065
GH16I057626 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 48.1 +166.5 166498 4.8 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 ZNF766 ZNF302 ZNF416 ZNF207 ADGRG1 RSPRY1 LOC101927556 POLR2C NUP93 LOC105371286 SETD6 ADGRG3 CSNK2A2 CCDC102A
GH16I056604 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.1 -852.1 -852131 10.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 MT2A ENSG00000260823 GC16P056608 GC16P056609 RSPRY1 POLR2C BBS2 MT1A MT1F MT1G
GH16I058125 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.1 +665.7 665680 4.6 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC LOC101927556 CFAP20 RSPRY1 CNOT1 POLR2C CSNK2A2 CCL17 ENSG00000260545 GC16M058096
GH16I056930 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.2 -526.8 -526768 10.1 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 HERPUD1 RSPRY1 NUDT21 NUP93 POLR2C CETP SLC12A3 LOC105371286 ENSG00000261270 NLRC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around POLR2C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLR2C gene promoter:

Genomic Locations for POLR2C Gene

Genomic Locations for POLR2C Gene
chr16:57,462,287-57,472,010
(GRCh38/hg38)
Size:
9,724 bases
Orientation:
Plus strand
chr16:57,496,299-57,505,922
(GRCh37/hg19)

Genomic View for POLR2C Gene

Genes around POLR2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2C Gene

Proteins for POLR2C Gene

  • Protein details for POLR2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19387-RPB3_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB3
    Protein Accession:
    P19387
    Secondary Accessions:
    • O15161

    Protein attributes for POLR2C Gene

    Size:
    275 amino acids
    Molecular mass:
    31441 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB11/POLR2J and RPB3/POLR2C subunits interact with each other.

    Three dimensional structures from OCA and Proteopedia for POLR2C Gene

neXtProt entry for POLR2C Gene

Post-translational modifications for POLR2C Gene

  • Ubiquitination at Lys20, Lys81, Lys175, Lys225, and isoforms=255
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2C Gene

Domains & Families for POLR2C Gene

Gene Families for POLR2C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P19387

UniProtKB/Swiss-Prot:

RPB3_HUMAN :
  • Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2C: view

Function for POLR2C Gene

Molecular function for POLR2C Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) small polypeptide C (33kDa)
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).

Phenotypes From GWAS Catalog for POLR2C Gene

Gene Ontology (GO) - Molecular Function for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IEA --
GO:0005515 protein binding IPI 12860379
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with POLR2C: view
genes like me logo Genes that share phenotypes with POLR2C: view

Animal Model Products

CRISPR Products

miRNA for POLR2C Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2C Gene

Localization for POLR2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2C gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubules (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with POLR2C: view

Pathways & Interactions for POLR2C Gene

SuperPathways for POLR2C Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 mRNA Capping
4 HIV Life Cycle
.45
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2C: view

Gene Ontology (GO) - Biological Process for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS,IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with POLR2C: view

No data available for SIGNOR curated interactions for POLR2C Gene

Drugs & Compounds for POLR2C Gene

(4) Drugs for POLR2C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for POLR2C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with POLR2C: view

Transcripts for POLR2C Gene

Unigene Clusters for POLR2C Gene

Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2C Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for POLR2C Gene

GeneLoc Exon Structure for
POLR2C
ECgene alternative splicing isoforms for
POLR2C

Expression for POLR2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2C Gene

Protein differential expression in normal tissues from HIPED for POLR2C Gene

This gene is overexpressed in Pancreas (13.3) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for POLR2C Gene



Protein tissue co-expression partners for POLR2C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2C Gene:

POLR2C

SOURCE GeneReport for Unigene cluster for POLR2C Gene:

Hs.79402

Evidence on tissue expression from TISSUES for POLR2C Gene

  • Nervous system(4.8)
  • Muscle(4.4)
  • Kidney(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with POLR2C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2C Gene

Orthologs for POLR2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR2C 33 34
  • 99.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2C 34
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2C 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2C 33 34
  • 92.85 (n)
cow
(Bos Taurus)
Mammalia POLR2C 33 34
  • 92.24 (n)
rat
(Rattus norvegicus)
Mammalia Polr2c 33
  • 91.76 (n)
mouse
(Mus musculus)
Mammalia Polr2c 33 16 34
  • 91.03 (n)
chicken
(Gallus gallus)
Aves POLR2C 33 34
  • 84 (n)
lizard
(Anolis carolinensis)
Reptilia POLR2C 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2c 33
  • 79.64 (n)
MGC76329 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16883 33
zebrafish
(Danio rerio)
Actinopterygii polr2c 33 34
  • 78.42 (n)
wufk48d01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5536 33
fruit fly
(Drosophila melanogaster)
Insecta RpII33 35 33 34
  • 68.73 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010321 33
  • 64.46 (n)
worm
(Caenorhabditis elegans)
Secernentea rpb-3 33 34
  • 57.74 (n)
C36B1.3 35
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL120C 33
  • 55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16170g 33
  • 53.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB3 33 34 36
  • 51.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB3 33
  • 50.6 (n)
soybean
(Glycine max)
eudicotyledons Gma.10273 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1797 33
rice
(Oryza sativa)
Liliopsida Os09g0110400 33
  • 56.7 (n)
Os.5510 33
barley
(Hordeum vulgare)
Liliopsida Hv.9186 33
wheat
(Triticum aestivum)
Liliopsida Ta.10459 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4193 34
  • 68 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01515 33
  • 56.08 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb3 33
  • 51.67 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5647 33
Species where no ortholog for POLR2C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2C Gene

ENSEMBL:
Gene Tree for POLR2C (if available)
TreeFam:
Gene Tree for POLR2C (if available)

Paralogs for POLR2C Gene

Pseudogenes.org Pseudogenes for POLR2C Gene

genes like me logo Genes that share paralogs with POLR2C: view

No data available for Paralogs for POLR2C Gene

Variants for POLR2C Gene

Sequence variations from dbSNP and Humsavar for POLR2C Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs223869 likely-benign, Coenzyme Q10 deficiency, primary 57,461,080(+) C/A upstream_transcript_variant
rs223870 benign, Coenzyme Q10 deficiency, primary 57,461,114(+) T/C upstream_transcript_variant
rs373048666 uncertain-significance, Coenzyme Q10 deficiency, primary 57,460,724(+) C/T upstream_transcript_variant
rs534696904 uncertain-significance, Coenzyme Q10 deficiency, primary 57,461,246(+) A/G upstream_transcript_variant
rs550304608 uncertain-significance, Coenzyme Q10 deficiency, primary 57,461,116(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2C Gene

Variant ID Type Subtype PubMed ID
esv2676266 CNV deletion 23128226
nsv833245 CNV loss 17160897

Variation tolerance for POLR2C Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2C Gene

Disorders for POLR2C Gene

Additional Disease Information for POLR2C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for POLR2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLR2C Gene

Publications for POLR2C Gene

  1. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S … Benhamou S (Carcinogenesis 2009) 3 44 58
  2. RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product. (PMID: 16141233) Corbi N … Passananti C (Journal of cell science 2005) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin. (PMID: 12207009) Corbi N … Passananti C (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002) 3 22 58
  5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 3 4 58

Products for POLR2C Gene

Sources for POLR2C Gene

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