Aliases for POLR2C Gene
External Ids for POLR2C Gene
Previous GeneCards Identifiers for POLR2C Gene
This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]
GeneCards Summary for POLR2C Gene
POLR2C (RNA Polymerase II Subunit C) is a Protein Coding gene. Diseases associated with POLR2C include Nemaline Myopathy 7. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include protein dimerization activity and RNA polymerase II activity. An important paralog of this gene is POLR1C.
UniProtKB/Swiss-Prot Summary for POLR2C Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).