This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 2... See more...

Aliases for POLR2C Gene

Aliases for POLR2C Gene

  • RNA Polymerase II Subunit C 2 3 5
  • RNA Polymerase II Subunit 3 2 3 4
  • DNA-Directed RNA Polymerase II 33 KDa Polypeptide 3 4
  • DNA-Directed RNA Polymerase II Subunit RPB3 3 4
  • DNA-Directed RNA Polymerase II Subunit C 3 4
  • RNA Polymerase II Subunit B3 3 4
  • RPB31 3 4
  • RPB33 3 4
  • RPB3 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide C (33kD) 2
  • Polymerase (RNA) II (DNA Directed) Polypeptide C, 33kDa 3
  • Polymerase (RNA) II Subunit C 3
  • HRPB33 3
  • HsRPB3 3
  • POLR2C 5

External Ids for POLR2C Gene

Previous GeneCards Identifiers for POLR2C Gene

  • GC16P047891
  • GC16P057556
  • GC16P057230
  • GC16P057271
  • GC16P056054
  • GC16P057496
  • GC16P043364

Summaries for POLR2C Gene

Entrez Gene Summary for POLR2C Gene

  • This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2C Gene

POLR2C (RNA Polymerase II Subunit C) is a Protein Coding gene. Diseases associated with POLR2C include Nemaline Myopathy 7. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include protein dimerization activity and RNA polymerase II activity. An important paralog of this gene is POLR1C.

UniProtKB/Swiss-Prot Summary for POLR2C Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).

Gene Wiki entry for POLR2C Gene

Additional gene information for POLR2C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLR2C Gene

Genomics for POLR2C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POLR2C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR2C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLR2C

Top Transcription factor binding sites by QIAGEN in the POLR2C gene promoter:
  • aMEF-2
  • CREB
  • CUTL1
  • deltaCREB
  • MEF-2A
  • Meis-1
  • Meis-1a
  • MyoD
  • Zic3

Genomic Locations for POLR2C Gene

Genomic Locations for POLR2C Gene
chr16:57,462,660-57,472,009
(GRCh38/hg38)
Size:
9,350 bases
Orientation:
Plus strand
chr16:57,496,299-57,505,922
(GRCh37/hg19)
Size:
9,624 bases
Orientation:
Plus strand

Genomic View for POLR2C Gene

Genes around POLR2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2C Gene

Proteins for POLR2C Gene

  • Protein details for POLR2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19387-RPB3_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB3
    Protein Accession:
    P19387
    Secondary Accessions:
    • O15161

    Protein attributes for POLR2C Gene

    Size:
    275 amino acids
    Molecular mass:
    31441 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB11/POLR2J and RPB3/POLR2C subunits interact with each other.

    Three dimensional structures from OCA and Proteopedia for POLR2C Gene

neXtProt entry for POLR2C Gene

Post-translational modifications for POLR2C Gene

  • Ubiquitination at Lys20, Lys81, Lys175, Lys225, and Lys255
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLR2C Gene

Domains & Families for POLR2C Gene

Gene Families for POLR2C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for POLR2C Gene

InterPro:
Blocks:
  • DNA-directed RNA polymerase, 30-40 kDa subunit
ProtoNet:

Suggested Antigen Peptide Sequences for POLR2C Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76636, highly similar to Homo sapiens polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (POLR2C), transcript variant alpha, mRNA (Q6FGR6_HUMAN)
  • RPB31 (RPB3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P19387

UniProtKB/Swiss-Prot:

RPB3_HUMAN :
  • Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
Family:
  • Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR2C: view

Function for POLR2C Gene

Molecular function for POLR2C Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).
GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) small polypeptide C (33kDa)

Phenotypes From GWAS Catalog for POLR2C Gene

Gene Ontology (GO) - Molecular Function for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003899 contributes_to DNA-directed 5'-3' RNA polymerase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 12860379
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with POLR2C: view
genes like me logo Genes that share phenotypes with POLR2C: view

Animal Model Products

CRISPR Products

miRNA for POLR2C Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2C Gene

Localization for POLR2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2C gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubules (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 RNA polymerase II, core complex IDA 9852112
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with POLR2C: view

Pathways & Interactions for POLR2C Gene

PathCards logo

SuperPathways for POLR2C Gene

SuperPathway Contained pathways
1 HIV Transcription Elongation
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
.91
.91
.51
.39
.33
3 HIV Life Cycle
.45
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Signaling by FGFR2 in disease
genes like me logo Genes that share pathways with POLR2C: view

Pathways by source for POLR2C Gene

3 GeneGo (Thomson Reuters) pathways for POLR2C Gene
  • ATP/ITP metabolism
  • DNA damage_Role of Brca1 and Brca2 in DNA repair
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
17 Qiagen pathways for POLR2C Gene
  • AHR Pathway
  • Androgen Signaling
  • Assembly of RNA Polymerase-II Initiation Complex
  • CREB Pathway
  • Crosstalk Between CARM1 and ESRs

Gene Ontology (GO) - Biological Process for POLR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated IEA,TAS --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with POLR2C: view

No data available for SIGNOR curated interactions for POLR2C Gene

Drugs & Compounds for POLR2C Gene

(4) Drugs for POLR2C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for POLR2C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with POLR2C: view

Transcripts for POLR2C Gene

mRNA/cDNA for POLR2C Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2C

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2C Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for POLR2C Gene

GeneLoc Exon Structure for
POLR2C

Expression for POLR2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR2C Gene

Protein differential expression in normal tissues from HIPED for POLR2C Gene

This gene is overexpressed in Pancreas (13.3) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR2C Gene



Protein tissue co-expression partners for POLR2C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLR2C

SOURCE GeneReport for Unigene cluster for POLR2C Gene:

Hs.79402

Evidence on tissue expression from TISSUES for POLR2C Gene

  • Nervous system(4.8)
  • Muscle(4.5)
  • Kidney(4.4)
  • Liver(4.4)
  • Skin(3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with POLR2C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2C Gene

Orthologs for POLR2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POLR2C 30 31
  • 99.03 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia POLR2C 31
  • 98 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia POLR2C 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia POLR2C 30 31
  • 92.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia POLR2C 30 31
  • 92.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Polr2c 30
  • 91.76 (n)
Mouse
(Mus musculus)
Mammalia Polr2c 30 17 31
  • 91.03 (n)
OneToOne
Chicken
(Gallus gallus)
Aves POLR2C 30 31
  • 84 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia POLR2C 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia polr2c 30
  • 79.64 (n)
MGC76329 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16883 30
Zebrafish
(Danio rerio)
Actinopterygii polr2c 30 31
  • 78.42 (n)
OneToOne
wufk48d01 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5536 30
Fruit Fly
(Drosophila melanogaster)
Insecta RpII33 30 31 32
  • 68.73 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010321 30
  • 64.46 (n)
Worm
(Caenorhabditis elegans)
Secernentea rpb-3 30 31
  • 57.74 (n)
OneToOne
C36B1.3 32
  • 56 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADL120C 30
  • 55 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16170g 30
  • 53.05 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB3 30 31 33
  • 51.92 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons NRPB3 30
  • 50.6 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1797 30
Soybean
(Glycine max)
eudicotyledons Gma.10273 30
Rice
(Oryza sativa)
Liliopsida Os09g0110400 30
  • 56.7 (n)
Os.5510 30
Barley
(Hordeum vulgare)
Liliopsida Hv.9186 30
Wheat
(Triticum aestivum)
Liliopsida Ta.10459 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4193 31
  • 68 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU01515 30
  • 56.08 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb3 30
  • 51.67 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5647 30
Species where no ortholog for POLR2C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2C Gene

ENSEMBL:
Gene Tree for POLR2C (if available)
TreeFam:
Gene Tree for POLR2C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR2C: view image

Paralogs for POLR2C Gene

Paralogs for POLR2C Gene

Pseudogenes.org Pseudogenes for POLR2C Gene

genes like me logo Genes that share paralogs with POLR2C: view

Variants for POLR2C Gene

Additional dbSNP identifiers (rs#s) for POLR2C Gene

Structural Variations from Database of Genomic Variants (DGV) for POLR2C Gene

Variant ID Type Subtype PubMed ID
esv2676266 CNV deletion 23128226
nsv833245 CNV loss 17160897

Variation tolerance for POLR2C Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLR2C Gene

Disorders for POLR2C Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLR2C Gene - From: DISEASES

Disorder Aliases PubMed IDs
nemaline myopathy 7
  • nem7
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for POLR2C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with POLR2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2C Gene

Publications for POLR2C Gene

  1. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S … Benhamou S (Carcinogenesis 2009) 3 41
  2. RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product. (PMID: 16141233) Corbi N … Passananti C (Journal of cell science 2005) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin. (PMID: 12207009) Corbi N … Passananti C (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002) 3 23
  5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 3 4

Products for POLR2C Gene

Sources for POLR2C Gene