POLR2B Gene (Protein Coding)

RNA Polymerase II Subunit B

GC04P056977
GIFtS:
42
This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptiona... See more...

Aliases for POLR2B Gene

Aliases for POLR2B Gene

  • RNA Polymerase II Subunit B 2 3 5
  • DNA-Directed RNA Polymerase II 140 KDa Polypeptide 3 4
  • DNA-Directed RNA Polymerase II Subunit RPB2 3 4
  • DNA-Directed RNA Polymerase II Subunit B 3 4
  • RNA Polymerase II Subunit B2 3 4
  • RNA Polymerase II Subunit 2 3 4
  • EC 2.7.7.6 4 51
  • RPB2 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide B (140kD) 2
  • Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa 3
  • RNA Polymerase II Second Largest Subunit 3
  • Polymerase (RNA) II Subunit B 3
  • EC 2.7.7 51
  • HRPB140 3
  • POL2RB 3
  • POLR2B 5

External Ids for POLR2B Gene

Previous GeneCards Identifiers for POLR2B Gene

  • GC04P057648
  • GC04P057841
  • GC04P057760
  • GC04P057685
  • GC04P057538
  • GC04P053798
  • GC04P057844

Summaries for POLR2B Gene

Entrez Gene Summary for POLR2B Gene

  • This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for POLR2B Gene

POLR2B (RNA Polymerase II Subunit B) is a Protein Coding gene. Diseases associated with POLR2B include Fusariosis and Eumycotic Mycetoma. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity. An important paralog of this gene is POLR3B.

UniProtKB/Swiss-Prot Summary for POLR2B Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Gene Wiki entry for POLR2B Gene

Additional gene information for POLR2B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLR2B Gene

Genomics for POLR2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for POLR2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLR2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLR2B

Top Transcription factor binding sites by QIAGEN in the POLR2B gene promoter:
  • C/EBPalpha
  • CUTL1
  • E47
  • FOXF2
  • HTF
  • ITF-2
  • NF-kappaB
  • NF-kappaB1
  • Tal-1beta
  • TBP

Genomic Locations for POLR2B Gene

Genomic Locations for POLR2B Gene
chr4:56,977,722-57,031,162
(GRCh38/hg38)
Size:
53,441 bases
Orientation:
Plus strand
chr4:57,843,888-57,897,334
(GRCh37/hg19)
Size:
53,447 bases
Orientation:
Plus strand

Genomic View for POLR2B Gene

Genes around POLR2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for POLR2B Gene

Proteins for POLR2B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for POLR2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30876-RPB2_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB2
    Protein Accession:
    P30876
    Secondary Accessions:
    • A8K1A8
    • Q8IZ61

    Protein attributes for POLR2B Gene

    Size:
    1174 amino acids
    Molecular mass:
    133897 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with WDR82. Interacts with MEN1.
    Miscellaneous:
    • The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity).

    Three dimensional structures from OCA and Proteopedia for POLR2B Gene

neXtProt entry for POLR2B Gene

Protein Expression for POLR2B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for POLR2B Gene

P30876:
  • AVGLVKNLALMAYISVGS
  • FGEMERD
  • GVSQVLNR
  • AMGKQAMG
  • HMVDDKIH
  • PQIGDKF
  • PILEFLEEW
  • EGRSRDGGLR
  • IFIGPTY
  • THCEIHP
  • GPTYYQRL
  • TDAGRICRPL
  • PSRMTIG
  • GDKFASR
  • TTRSMEYL
  • IGKIPIM
  • IPFPDHNQSPR
  • LNECPLDPGGYF
  • GKLAKPRQLHN
  • INGSEKVLIAQE
  • GGYFIING
  • PMMPNEARLRNLTY
  • KLRRQMDIIVSEVSM
  • LYYPQKPL
  • NPHAIPSRM
  • FCETKKAYF
  • KLLFQEL
  • ATKIFVNG
  • PLYVDITK
  • CPAETPEG
  • GEMERDC
  • HNQSPRNTYQ
  • GYNQEDS
  • DPEMMEMVKPSLDEAFV
  • SLDEAFV
  • ARLRNLTYSAPLYVD
  • STLSHLRR
  • LATGNWG
  • DGLIAPGVRVSG
  • KRLDLAGPLL
  • KGLVRQQLDSFD

Post-translational modifications for POLR2B Gene

  • Ubiquitination at Lys95, Lys130, Lys134, Lys146, Lys151, Lys199, Lys214, Lys264, Lys340, Lys421, Lys445, Lys457, Lys578, Lys730, Lys756, Lys821, Lys831, Lys847, Lys869, Lys917, Lys934, Lys942, Lys988, Lys993, Lys1010, Lys1036, Lys1143, and Lys1156
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for POLR2B
  • Boster Bio Antibodies for POLR2B

Domains & Families for POLR2B Gene

Gene Families for POLR2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for POLR2B Gene

InterPro:
Blocks:
  • RNA polymerase Rpb2, domain 6
  • RNA polymerase, beta subunit
  • RNA polymerase Rpb2, domain 5
  • RNA polymerase Rpb2, domain 4
ProtoNet:

Suggested Antigen Peptide Sequences for POLR2B Gene

GenScript: Design optimal peptide antigens:
  • RpB2 (B2WTN6_HUMAN)
  • DNA-directed RNA polymerase (C9J2Y9_HUMAN)
  • DNA-directed RNA polymerase (C9J4M6_HUMAN)
  • RNA polymerase II subunit B2 (RPB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30876

UniProtKB/Swiss-Prot:

RPB2_HUMAN :
  • Belongs to the RNA polymerase beta chain family.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR2B: view

Function for POLR2B Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for POLR2B Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA-COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:83400; EC=2.7.7.6;.
GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) large polypeptide B (140kDa)

Enzyme Numbers (IUBMB) for POLR2B Gene

Phenotypes From GWAS Catalog for POLR2B Gene

Gene Ontology (GO) - Molecular Function for POLR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IEA --
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0003899 contributes_to DNA-directed 5'-3' RNA polymerase activity IBA 21873635
GO:0005515 protein binding IPI 17998332
genes like me logo Genes that share ontologies with POLR2B: view
genes like me logo Genes that share phenotypes with POLR2B: view

Animal Model Products

CRISPR Products

miRNA for POLR2B Gene

miRTarBase miRNAs that target POLR2B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2B Gene

Localization for POLR2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2B Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2B gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POLR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IEA,IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 RNA polymerase II, core complex IDA 9852112
GO:0016020 membrane HDA --
genes like me logo Genes that share ontologies with POLR2B: view

Pathways & Interactions for POLR2B Gene

PathCards logo

SuperPathways for POLR2B Gene

SuperPathway Contained pathways
1 HIV Transcription Elongation
mRNA Capping
.93
RNA Pol II CTD phosphorylation and interaction with CE
.93
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
.93
RNA Polymerase II Pre-transcription Events
.83
Transcription of the HIV genome
.83
Formation of HIV elongation complex in the absence of HIV Tat
.80
Formation of RNA Pol II elongation complex
.80
RNA Polymerase II Transcription Elongation
.80
Formation of HIV-1 elongation complex containing HIV-1 Tat
.77
HIV elongation arrest and recovery
.77
HIV Transcription Elongation
.77
Pausing and recovery of HIV elongation
.77
Tat-mediated elongation of the HIV-1 transcript
.77
Pausing and recovery of Tat-mediated HIV elongation
.76
Tat-mediated HIV elongation arrest and recovery
.76
Formation of the Early Elongation Complex
.73
Formation of the HIV-1 Early Elongation Complex
.73
Abortive elongation of HIV-1 transcript in the absence of Tat
.71
TP53 Regulates Transcription of DNA Repair Genes
.70
RNA Polymerase II Transcription
.55
FGFR2 alternative splicing
.43
MicroRNA (miRNA) biogenesis
.32
RNA polymerase II transcribes snRNA genes
.30
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
Assembly of RNA Polymerase-II Initiation Complex
.91
Transcription of mRNA
.91
HIV Transcription Initiation
.71
RNA Polymerase II HIV Promoter Escape
.71
RNA Polymerase II Promoter Escape
.71
RNA Polymerase II Transcription Initiation
.71
RNA Polymerase II Transcription Initiation And Promoter Clearance
.71
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
.71
Eukaryotic Transcription Initiation
.53
Protein Acetylation and Deacetylation
.51
Crosstalk Between CARM1 and ESRs
.39
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.33
3 HIV Life Cycle
HIV Life Cycle
.91
Late Phase of HIV Life Cycle
.91
HIV Infection
.65
Infectious disease
.61
Disease
.45
Diseases of signal transduction
.43
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
.90
Gap-filling DNA repair synthesis and ligation in TC-NER
.90
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
.84
Nucleotide Excision Repair
.76
Formation of TC-NER Pre-Incision Complex
.68
5 Signaling by FGFR2 in disease
FGFR2 mutant receptor activation
.77
Signaling by FGFR2 in disease
.77
Signaling by FGFR in disease
.68
Signaling by FGFR2 IIIa TM
.01
genes like me logo Genes that share pathways with POLR2B: view

Pathways by source for POLR2B Gene

1 BioSystems pathway for POLR2B Gene
2 KEGG pathways for POLR2B Gene
3 GeneGo (Thomson Reuters) pathways for POLR2B Gene
  • ATP/ITP metabolism
  • DNA damage_Role of Brca1 and Brca2 in DNA repair
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
17 Qiagen pathways for POLR2B Gene
  • AHR Pathway
  • Androgen Signaling
  • Assembly of RNA Polymerase-II Initiation Complex
  • CREB Pathway
  • Crosstalk Between CARM1 and ESRs

Gene Ontology (GO) - Biological Process for POLR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with POLR2B: view

No data available for SIGNOR curated interactions for POLR2B Gene

Drugs & Compounds for POLR2B Gene

Products:

  1. Drug

(9) Drugs for POLR2B Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Thymidine 5'-triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0

(1) Additional Compounds for POLR2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
 14000-31-8

(3) ApexBio Compounds for POLR2B Gene

Compound Action Cas Number
Actinomycin D RNA polymerase inhibitor 50-76-0
PSI-6206 Inhibitor of HCV RNA polymerase,potent and selective 863329-66-2
PSI-7977 Antiviral agents for chronic HCV infection 1190307-88-0
genes like me logo Genes that share compounds with POLR2B: view

Drug Products

Transcripts for POLR2B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for POLR2B Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2B

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - -
SP14: - - -
SP15:

ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for POLR2B Gene

GeneLoc Exon Structure for
POLR2B

Expression for POLR2B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLR2B Gene

mRNA expression in normal human tissues for POLR2B Gene
mRNA expression by GTEx for POLR2B GenemRNA expression by BioGPS for POLR2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2B Gene

This gene is overexpressed in Lymph node (17.1) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR2B Gene



Protein tissue co-expression partners for POLR2B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLR2B

SOURCE GeneReport for Unigene cluster for POLR2B Gene:

Hs.602757

Evidence on tissue expression from TISSUES for POLR2B Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Liver(4.5)
  • Muscle(2.9)
  • Blood(2.8)
  • Eye(2.5)
  • Kidney(2.4)
  • Intestine(2.3)
  • Lung(2.3)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with POLR2B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2B Gene

Orthologs for POLR2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2B Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 100 (a)
 OneToMany
-- 31
  • 81 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia POLR2B 31
  • 100 (a)
 OneToOne
Chimpanzee
(Pan troglodytes)
 Mammalia POLR2B 30 31
  • 99.66 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia POLR2B 30 31
  • 94.92 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia POLR2B 30 31
  • 94.32 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Polr2b 30 17 31
  • 90.35 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Polr2b 30
  • 89.89 (n)
Chicken
(Gallus gallus)
 Aves POLR2B 30 31
  • 83.82 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia POLR2B 31
  • 99 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia polr2b 30
  • 82.61 (n)
Str.15006 30
African clawed frog
(Xenopus laevis)
 Amphibia MGC68569 30
Zebrafish
(Danio rerio)
 Actinopterygii polr2b 30 31
  • 77.98 (n)
 OneToOne
Dr.16327 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.13862 30
Fruit Fly
(Drosophila melanogaster)
 Insecta RpII140 30 31 32
  • 72.35 (n)
 OneToOne
RpIII128 32
  • 36 (a)
RpI135 32
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003648 30
  • 69.31 (n)
Worm
(Caenorhabditis elegans)
 Secernentea C26E6.4 32
  • 78 (a)
rpb-2 30 31
  • 70.2 (n)
 OneToOne
F09F7.3 32
  • 36 (a)
F14B4.3 32
  • 29 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes RPB2 30 31 33 33
  • 61.81 (n)
 OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0B05577g 30
  • 61.35 (n)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AFR404C 30
  • 60.06 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons NRPB2 30
  • 64.57 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.3309 30
Rice
(Oryza sativa)
 Liliopsida Os03g0646800 30
  • 64.35 (n)
Os.25542 30
Barley
(Hordeum vulgare)
 Liliopsida Hv.4411 30
Wheat
(Triticum aestivum)
 Liliopsida Ta.12287 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.1138 31
  • 82 (a)
 OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes rpb2 30
  • 62.59 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU05120 30
  • 59.4 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.11524 30
Species where no ortholog for POLR2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2B Gene

ENSEMBL:
Gene Tree for POLR2B (if available)
TreeFam:
Gene Tree for POLR2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR2B: view image

Paralogs for POLR2B Gene

Paralogs for POLR2B Gene

(3) SIMAP similar genes for POLR2B Gene using alignment to 5 proteins:

  • RPB2_HUMAN
  • C9J2Y9_HUMAN
  • C9J4M6_HUMAN
  • C9JMN3_HUMAN
  • C9JZW8_HUMAN
genes like me logo Genes that share paralogs with POLR2B: view

Variants for POLR2B Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLR2B Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
916568 Likely Pathogenic: Tracheoesophageal fistula 57,017,210(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for POLR2B Gene

Structural Variations from Database of Genomic Variants (DGV) for POLR2B Gene

Variant ID Type Subtype PubMed ID
dgv5214n100 CNV gain 25217958

Variation tolerance for POLR2B Gene

Residual Variation Intolerance Score: 3.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2B Gene

Disorders for POLR2B Gene

MalaCards: The human disease database

(21) MalaCards diseases for POLR2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
fusariosis
  • fusarium infection
eumycotic mycetoma
  • eumycetoma
dermatomycosis
  • dermatomycoses
tinea nigra
  • infection by cladosporium werneckii
basidiobolomycosis
  • infection by basidiobolus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for POLR2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with POLR2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2B Gene

Publications for POLR2B Gene

  1. Primary structure of the second largest subunit of human RNA polymerase II (or B). (PMID: 1518060) Acker J … Kédinger C (Journal of molecular biology 1992) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S … Benhamou S (Carcinogenesis 2009) 3 41
  4. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PMID: 17998332) Lee JH … Skalnik DG (Molecular and cellular biology 2008) 3 4
  5. Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. (PMID: 17494052) Michiels S … Benhamou S (Carcinogenesis 2007) 3 41

ExternalLinks

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