Aliases for POLR2B Gene
Aliases for POLR2B Gene
- RNA Polymerase II Subunit B 2 3 5
- DNA-Directed RNA Polymerase II 140 KDa Polypeptide 3 4
- DNA-Directed RNA Polymerase II Subunit B 3 4
- RNA Polymerase II Subunit B2 3 4
- RNA Polymerase II Subunit 2 3 4
- Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa 3
- Polymerase (RNA) II (DNA Directed) Polypeptide B (140kD) 2
- DNA-Directed RNA Polymerase II Subunit RPB2 3
External Ids for POLR2B Gene
- HGNC: 9188
- Entrez Gene: 5431
- Ensembl: ENSG00000047315
- OMIM: 180661
- UniProtKB: P30876
Previous GeneCards Identifiers for POLR2B Gene
- GC04P057648
- GC04P057841
- GC04P057760
- GC04P057685
- GC04P057538
- GC04P053798
- GC04P057844
Summaries for POLR2B Gene
-
This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for POLR2B Gene
POLR2B (RNA Polymerase II Subunit B) is a Protein Coding gene. Diseases associated with POLR2B include Eumycotic Mycetoma and Pulmonic Stenosis. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA-directed 5-3 RNA polymerase activity. An important paralog of this gene is POLR3B.
UniProtKB/Swiss-Prot for POLR2B Gene
-
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
Additional gene information for POLR2B Gene
- Monarch Initiative
- Search for POLR2B at DataMed
- Search for POLR2B at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2B Gene
Genomics for POLR2B Gene
GeneHancer (GH) Regulatory Elements for POLR2B Gene
Promoters and enhancers for POLR2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around POLR2B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the POLR2B gene promoter:
-
- TBP
- CUTL1
- FOXF2
- C/EBPalpha
- Tal-1beta
- ITF-2
- E47
- NF-kappaB
- NF-kappaB1
- HTF
Regulatory Element Products
Genomic Locations for POLR2B Gene
Genomic Locations for POLR2B Gene
- chr4:56,977,722-57,031,168
- (GRCh38/hg38)
- Size:
- 53,447 bases
- Orientation:
- Plus strand
- chr4:57,843,888-57,897,334
- (GRCh37/hg19)
- Size:
- 53,447 bases
- Orientation:
- Plus strand
Genomic View for POLR2B Gene
Genes around POLR2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q12 by Entrez Gene
- 4q12 by HGNC
- 4q12 by Ensembl
POLR2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POLR2B Gene
Proteins for POLR2B Gene
-
Protein details for POLR2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30876-RPB2_HUMAN
- Recommended name:
- DNA-directed RNA polymerase II subunit RPB2
- Protein Accession:
- P30876
- A8K1A8
- Q8IZ61
Protein attributes for POLR2B Gene
- Size:
- 1174 amino acids
- Molecular mass:
- 133897 Da
- Quaternary structure:
-
- Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with WDR82. Interacts with MEN1.
- Miscellaneous:
-
- The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity).
Protein Expression for POLR2B Gene
Post-translational modifications for POLR2B Gene
- Ubiquitination at posLast=11561156, posLast=11431143, posLast=10361036, Lys1010, posLast=993993, posLast=988988, posLast=942942, Lys934, posLast=917917, posLast=869869, Lys847, posLast=831831, posLast=821821, Lys756, Lys730, posLast=578578, Lys457, posLast=445445, posLast=421421, posLast=340340, posLast=264264, Lys214, posLast=199199, Lys151, Lys146, Lys134, Lys130, and Lys95
- Modification sites at PhosphoSitePlus
Other Protein References for POLR2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for POLR2B
- Novus Biologicals Antibodies for POLR2B
-
Abcam antibodies for POLR2B
- Invitrogen Antibodies for POLR2B
- GeneTex POLR2B Antibody for POLR2B
-
Boster Bio Antibodies for POLR2B
-
Santa Cruz Biotechnology (SCBT) Antibodies for POLR2B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for POLR2B
- Origene Custom Protein Services for POLR2B
- Novus Biologicals proteins for POLR2B
- Search GeneTex for Proteins for POLR2B
Assay Products
No data available for DME Specific Peptides for POLR2B Gene
Domains & Families for POLR2B Gene
Gene Families for POLR2B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for POLR2B Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for POLR2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P30876- Family:
-
- Belongs to the RNA polymerase beta chain family.
Function for POLR2B Gene
Molecular function for POLR2B Gene
- UniProtKB/Swiss-Prot Function:
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
- GENATLAS Biochemistry:
- polymerase II,RNA (DNA directed) large polypeptide B (140kDa)
Enzyme Numbers (IUBMB) for POLR2B Gene
Phenotypes From GWAS Catalog for POLR2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001055 | contributes_to RNA polymerase II activity | IBA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003899 | CONTRIBUTES_TO DNA-directed 5-3 RNA polymerase activity | IEA,IBA | -- |
Phenotypes for POLR2B Gene
- GenomeRNAi human phenotypes for POLR2B:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Reduced mammosphere formation
- Decreased ionizing radiation sensitivity
- Increased circadian period length
- Decreased shRNA abundance
- Decreased viability
- no effect
- Decreased cell number
- Increased vaccinia virus (VACV) infection
- Downregulation of NFkappaB pathway
- Decreased hepcidin::fluc mRNA expression
- Decreased NF-kappaB reporter expression
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for POLR2B
-
CRISPR Products
-
OriGene CRISPR knockouts for POLR2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POLR2B
- genomics-online: gRNA clones - Search results for available POLR2B gene related products
- Applied Biological Materials CRISPR for POLR2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for POLR2B
- GenScript: Design CRISPR guide RNA sequences for POLR2B
miRNA for POLR2B Gene
- miRTarBase miRNAs that target POLR2B
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for POLR2B
- Browse OriGene Inhibitory RNA Products For POLR2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2B
- genomics-online: shRNA clones - Search results for available POLR2B gene related products
Clone Products
- Sino Biological Human cDNA Clone for POLR2B
- VectorBuilder custom plasmid, inducible vectors for POLR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POLR2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POLR2B
- genomics-online: cdna clones - Search results for available POLR2B gene related products
- orf clones - Search results for available POLR2B gene related products
- Applied Biological Materials Clones for POLR2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2B Gene
Localization for POLR2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for POLR2B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IDA | 24270157 |
| GO:0005634 | nucleus | IEA,IDA | 9852112 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005665 | DNA-directed RNA polymerase II, core complex | IDA | 9852112 |
| GO:0016020 | membrane | HDA | 19946888 |
Pathways & Interactions for POLR2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
.93
|
|
| 2 | RNA Polymerase II Transcription Initiation And Promoter Clearance | ||
| 3 | HIV Life Cycle |
.91
.64
|
.45
|
| 4 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 5 | Signaling by FGFR2 in disease | ||
Pathways by source for POLR2B Gene
1 BioSystems pathway for POLR2B Gene
66 Reactome pathways for POLR2B Gene
6 KEGG pathways for POLR2B Gene
3 GeneGo (Thomson Reuters) pathways for POLR2B Gene
17 Qiagen pathways for POLR2B Gene
Interacting Proteins for POLR2B Gene
Selected Interacting proteins:
ENSP00000312735
P30876-RPB2_HUMAN
for POLR2B Gene via
STRING
MINT
IID
GPS-Prot Interaction Network for POLR2B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
| GO:0006351 | transcription, DNA-templated | TAS,IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
No data available for SIGNOR curated interactions for POLR2B Gene
Drugs & Compounds for POLR2B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Magnesium | Approved | Nutra | 0 | |||
| Cytidine triphosphate | Experimental | Pharma | 0 | |||
| Guanosine triphosphate | Experimental | Pharma | 0 | |||
| Uridine triphosphate | Experimental, Investigational | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
|||
| Thymidine 5'-triphosphate |
|
365-08-2 |
|
(3) ApexBio Compounds for POLR2B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Actinomycin D | RNA polymerase inhibitor | 50-76-0 |
| PSI-6206 | Inhibitor of HCV RNA polymerase,potent and selective | 863329-66-2 |
| PSI-7977 | Antiviral agents for chronic HCV infection | 1190307-88-0 |
Transcripts for POLR2B Gene
mRNA/cDNA for POLR2B Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (414) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000450656 608 bps (uc062wwa.1)
- ENST00000381227 4108 bps (uc062wwb.1)
- ENST00000495311 541 bps (uc062wwc.1)
- ENST00000431623 3666 bps (uc011caf.2)
- ENST00000441246 3839 bps (uc011cae.2)
Unigene Clusters for POLR2B Gene
- Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for POLR2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POLR2B
- genomics-online: gRNA clones - Search results for available POLR2B gene related products
- Applied Biological Materials CRISPR for POLR2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for POLR2B
- GenScript: Design CRISPR guide RNA sequences for POLR2B
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for POLR2B
- Browse OriGene Inhibitory RNA Products For POLR2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2B
- genomics-online: shRNA clones - Search results for available POLR2B gene related products
Clone Products
- Sino Biological Human cDNA Clone for POLR2B
- VectorBuilder custom plasmid, inducible vectors for POLR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POLR2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POLR2B
- genomics-online: cdna clones - Search results for available POLR2B gene related products
- orf clones - Search results for available POLR2B gene related products
- Applied Biological Materials Clones for POLR2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP13: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||||||
| SP15: |
Expression for POLR2B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Primary Oocyte Primary Follicle
-
Gonad
- Primary Oocyte Primary Follicle
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Lymph node (17.1) and Peripheral blood mononuclear cells (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR2B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of POLR2B Gene:
POLR2BSOURCE GeneReport for Unigene cluster for POLR2B Gene:
Hs.602757Evidence on tissue expression from TISSUES for POLR2B Gene
- Nervous system(4.9)
- Liver(4.4)
- Skin(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for POLR2B
-
OriGene qPCR primer pairs for POLR2B
- genomics-online: primer clones - Search results for available POLR2B gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2B Gene
Orthologs for POLR2B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | POLR2B 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | POLR2B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | POLR2B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | POLR2B 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Polr2b 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Polr2b 33 |
|
||
| chicken (Gallus gallus) |
Aves | POLR2B 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | POLR2B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | polr2b 33 |
|
||
| Str.15006 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68569 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | polr2b 34 33 |
|
OneToOne | |
| Dr.16327 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13862 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RpII140 34 35 33 |
|
OneToOne | |
| RpIII128 35 |
|
|
|||
| RpI135 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003648 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C26E6.4 35 |
|
|
|
| rpb-2 34 33 |
|
OneToOne | |||
| F09F7.3 35 |
|
|
|||
| F14B4.3 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPB2 36 34 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B05577g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR404C 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | NRPB2 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3309 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0646800 33 |
|
||
| Os.25542 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.4411 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.12287 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1138 34 |
|
OneToOne | |
| Cin.11524 33 |
|
||||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rpb2 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU05120 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.11524 33 |
|
- Species where no ortholog for POLR2B was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for POLR2B Gene
- ENSEMBL:
- Gene Tree for POLR2B (if available)
- TreeFam:
- Gene Tree for POLR2B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for POLR2B: view image
Paralogs for POLR2B Gene
Variants for POLR2B Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs866994863 | pathogenic, Retinal arterial macroaneurysm with supravascular pulmonic stenosis | 57,031,337(+) | C/T | downstream_transcript_variant | |
| rs1000009816 | -- | 57,020,284(+) | G/A | intron_variant | |
| rs10000395 | -- | 57,008,288(+) | T/C | intron_variant | |
| rs1000148356 | -- | 56,978,691(+) | A/G | 5_prime_UTR_variant | |
| rs10002090 | -- | 56,993,426(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5214n100 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
3.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.89;
18.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for POLR2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- POLR2B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2B Gene
Disorders for POLR2B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| eumycotic mycetoma |
|
|
| pulmonic stenosis |
|
|
| cutaneous mycosis |
|
|
Search POLR2B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for POLR2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2B Gene
Publications for POLR2B Gene
- Primary structure of the second largest subunit of human RNA polymerase II (or B). (PMID: 1518060) Acker J … Kédinger C (Journal of molecular biology 1992) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S … Benhamou S (Carcinogenesis 2009) 3 44 58
- Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PMID: 17998332) Lee JH … Skalnik DG (Molecular and cellular biology 2008) 3 4 58
- Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. (PMID: 17494052) Michiels S … Benhamou S (Carcinogenesis 2007) 3 44 58
Products for POLR2B Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 51 available POLR2B Antibodies ranked by validation data
- Compare Top POLR2B Antibodies
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- GeneTex POLR2B Antibody for POLR2B
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- Santa Cruz Biotechnology (SCBT) Antibodies for POLR2B
- Search Santa Cruz Biotechnology (SCBT) for POLR2B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for POLR2B
- genomics-online: cdna clones - Search results for available POLR2B gene related products
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- Boster Bio Antibodies for POLR2B
- Browse Boster Bio ELISA Kits
Sources for POLR2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (28) ASD
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- (30) GeneAnnot
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- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
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- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
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- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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- (60) TGDB
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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- (92) COMPARTMENTS
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