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Aliases for POLR2B Gene

Aliases for POLR2B Gene

  • RNA Polymerase II Subunit B 2 3 5
  • DNA-Directed RNA Polymerase II 140 KDa Polypeptide 3 4
  • DNA-Directed RNA Polymerase II Subunit B 3 4
  • RNA Polymerase II Subunit B2 3 4
  • RNA Polymerase II Subunit 2 3 4
  • Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide B (140kD) 2
  • DNA-Directed RNA Polymerase II Subunit RPB2 3
  • RNA Polymerase II Second Largest Subunit 3
  • Polymerase (RNA) II Subunit B 3
  • EC 2.7.7.6 4
  • HRPB140 3
  • POL2RB 3
  • RPB2 3

External Ids for POLR2B Gene

Previous GeneCards Identifiers for POLR2B Gene

  • GC04P057648
  • GC04P057841
  • GC04P057760
  • GC04P057685
  • GC04P057538
  • GC04P053798
  • GC04P057844

Summaries for POLR2B Gene

Entrez Gene Summary for POLR2B Gene

  • This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for POLR2B Gene

POLR2B (RNA Polymerase II Subunit B) is a Protein Coding gene. Diseases associated with POLR2B include Eumycotic Mycetoma and Pulmonic Stenosis. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA-directed 5-3 RNA polymerase activity. An important paralog of this gene is POLR3B.

UniProtKB/Swiss-Prot for POLR2B Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).

Gene Wiki entry for POLR2B Gene

Additional gene information for POLR2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2B Gene

Genomics for POLR2B Gene

GeneHancer (GH) Regulatory Elements for POLR2B Gene

Promoters and enhancers for POLR2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J056975 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 650.7 +1.8 1821 7.5 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NOA1 POLR2B ENSG00000269949 RNU6-998P REST AASDH
GH04J056433 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.7 -541.9 -541860 4.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC04P056436 PAICS PPAT GC04P056437 SRP72 CEP135 AASDH POLR2B RN7SKP30 ENSG00000269921
GH04J056906 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23.6 -68.7 -68746 4.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS MXD4 REST AASDH CEP135 NOA1 POLR2B SRP72 ENSG00000269949 SPINK2 ENSG00000251799 RNU6-998P
GH04J056652 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.6 -322.9 -322930 5.3 CTCF MXI1 SUZ12 SIN3A FEZF1 ZIC2 YY1 ZNF335 GLIS2 ZNF366 HOPX AASDH SRP72 CEP135 POLR2B SPINK2 ENSG00000251799 GC04P056642 ENSG00000280285
GH04J057101 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.9 +125.8 125769 4.7 FOXA2 ARID4B THRB RARA ZNF335 HMG20B RXRA REST KAT8 NR2F2 POLR2B NOA1 IGFBP7-AS1 IGFBP7 UBE2CP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around POLR2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLR2B gene promoter:

Genomic Locations for POLR2B Gene

Genomic Locations for POLR2B Gene
chr4:56,977,722-57,031,168
(GRCh38/hg38)
Size:
53,447 bases
Orientation:
Plus strand
chr4:57,843,888-57,897,334
(GRCh37/hg19)

Genomic View for POLR2B Gene

Genes around POLR2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2B Gene

Proteins for POLR2B Gene

  • Protein details for POLR2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30876-RPB2_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB2
    Protein Accession:
    P30876
    Secondary Accessions:
    • A8K1A8
    • Q8IZ61

    Protein attributes for POLR2B Gene

    Size:
    1174 amino acids
    Molecular mass:
    133897 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with WDR82. Interacts with MEN1.
    Miscellaneous:
    • The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity).

    Three dimensional structures from OCA and Proteopedia for POLR2B Gene

neXtProt entry for POLR2B Gene

Post-translational modifications for POLR2B Gene

  • Ubiquitination at posLast=11561156, posLast=11431143, posLast=10361036, Lys1010, posLast=993993, posLast=988988, posLast=942942, Lys934, posLast=917917, posLast=869869, Lys847, posLast=831831, posLast=821821, Lys756, Lys730, posLast=578578, Lys457, posLast=445445, posLast=421421, posLast=340340, posLast=264264, Lys214, posLast=199199, Lys151, Lys146, Lys134, Lys130, and Lys95
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for POLR2B Gene

Domains & Families for POLR2B Gene

Gene Families for POLR2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for POLR2B Gene

Graphical View of Domain Structure for InterPro Entry

P30876

UniProtKB/Swiss-Prot:

RPB2_HUMAN :
  • Belongs to the RNA polymerase beta chain family.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR2B: view

Function for POLR2B Gene

Molecular function for POLR2B Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) large polypeptide B (140kDa)

Enzyme Numbers (IUBMB) for POLR2B Gene

Phenotypes From GWAS Catalog for POLR2B Gene

Gene Ontology (GO) - Molecular Function for POLR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0003899 CONTRIBUTES_TO DNA-directed 5-3 RNA polymerase activity IEA,IBA --
genes like me logo Genes that share ontologies with POLR2B: view
genes like me logo Genes that share phenotypes with POLR2B: view

Animal Model Products

CRISPR Products

miRNA for POLR2B Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2B

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLR2B Gene

Localization for POLR2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2B gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IEA,IDA 9852112
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with POLR2B: view

Pathways & Interactions for POLR2B Gene

SuperPathways for POLR2B Gene

SuperPathway Contained pathways
1 Formation of HIV-1 elongation complex containing HIV-1 Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 HIV Life Cycle
.45
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Signaling by FGFR2 in disease
genes like me logo Genes that share pathways with POLR2B: view

Gene Ontology (GO) - Biological Process for POLR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS,IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with POLR2B: view

No data available for SIGNOR curated interactions for POLR2B Gene

Drugs & Compounds for POLR2B Gene

(8) Drugs for POLR2B Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(2) Additional Compounds for POLR2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • Deoxy-TTP
  • Deoxythymidine 5'-triphosphate
  • Deoxythymidine triphosphate
365-08-2

(3) ApexBio Compounds for POLR2B Gene

Compound Action Cas Number
Actinomycin D RNA polymerase inhibitor 50-76-0
PSI-6206 Inhibitor of HCV RNA polymerase,potent and selective 863329-66-2
PSI-7977 Antiviral agents for chronic HCV infection 1190307-88-0
genes like me logo Genes that share compounds with POLR2B: view

Drug Products

Transcripts for POLR2B Gene

mRNA/cDNA for POLR2B Gene

Unigene Clusters for POLR2B Gene

Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLR2B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - -
SP14: - - -
SP15:

ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for POLR2B Gene

GeneLoc Exon Structure for
POLR2B
ECgene alternative splicing isoforms for
POLR2B

Expression for POLR2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLR2B Gene

This gene is overexpressed in Lymph node (17.1) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR2B Gene



Protein tissue co-expression partners for POLR2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2B Gene:

POLR2B

SOURCE GeneReport for Unigene cluster for POLR2B Gene:

Hs.602757

Evidence on tissue expression from TISSUES for POLR2B Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with POLR2B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2B Gene

Orthologs for POLR2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2B Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 100 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia POLR2B 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2B 34 33
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia POLR2B 34 33
  • 94.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia POLR2B 34 33
  • 94.32 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Polr2b 16 34 33
  • 90.35 (n)
rat
(Rattus norvegicus)
Mammalia Polr2b 33
  • 89.89 (n)
chicken
(Gallus gallus)
Aves POLR2B 34 33
  • 83.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLR2B 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2b 33
  • 82.61 (n)
Str.15006 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68569 33
zebrafish
(Danio rerio)
Actinopterygii polr2b 34 33
  • 77.98 (n)
OneToOne
Dr.16327 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13862 33
fruit fly
(Drosophila melanogaster)
Insecta RpII140 34 35 33
  • 72.35 (n)
OneToOne
RpIII128 35
  • 36 (a)
RpI135 35
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003648 33
  • 69.31 (n)
worm
(Caenorhabditis elegans)
Secernentea C26E6.4 35
  • 78 (a)
rpb-2 34 33
  • 70.2 (n)
OneToOne
F09F7.3 35
  • 36 (a)
F14B4.3 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPB2 36 34 33
  • 61.81 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05577g 33
  • 61.35 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR404C 33
  • 60.06 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NRPB2 33
  • 64.57 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3309 33
rice
(Oryza sativa)
Liliopsida Os03g0646800 33
  • 64.35 (n)
Os.25542 33
barley
(Hordeum vulgare)
Liliopsida Hv.4411 33
wheat
(Triticum aestivum)
Liliopsida Ta.12287 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1138 34
  • 82 (a)
OneToOne
Cin.11524 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpb2 33
  • 62.59 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05120 33
  • 59.4 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11524 33
Species where no ortholog for POLR2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for POLR2B Gene

ENSEMBL:
Gene Tree for POLR2B (if available)
TreeFam:
Gene Tree for POLR2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLR2B: view image

Paralogs for POLR2B Gene

Paralogs for POLR2B Gene

(3) SIMAP similar genes for POLR2B Gene using alignment to 5 proteins:

  • RPB2_HUMAN
  • C9J2Y9_HUMAN
  • C9J4M6_HUMAN
  • C9JMN3_HUMAN
  • C9JZW8_HUMAN
genes like me logo Genes that share paralogs with POLR2B: view

Variants for POLR2B Gene

Sequence variations from dbSNP and Humsavar for POLR2B Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs866994863 pathogenic, Retinal arterial macroaneurysm with supravascular pulmonic stenosis 57,031,337(+) C/T downstream_transcript_variant
rs1000009816 -- 57,020,284(+) G/A intron_variant
rs10000395 -- 57,008,288(+) T/C intron_variant
rs1000148356 -- 56,978,691(+) A/G 5_prime_UTR_variant
rs10002090 -- 56,993,426(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for POLR2B Gene

Variant ID Type Subtype PubMed ID
dgv5214n100 CNV gain 25217958

Variation tolerance for POLR2B Gene

Residual Variation Intolerance Score: 3.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLR2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLR2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR2B Gene

Disorders for POLR2B Gene

MalaCards: The human disease database

(3) MalaCards diseases for POLR2B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
eumycotic mycetoma
  • eumycetoma
pulmonic stenosis
  • valvular pulmonic stenosis
cutaneous mycosis
  • dermatomycoses
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for POLR2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with POLR2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLR2B Gene

Publications for POLR2B Gene

  1. Primary structure of the second largest subunit of human RNA polymerase II (or B). (PMID: 1518060) Acker J … Kédinger C (Journal of molecular biology 1992) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S … Benhamou S (Carcinogenesis 2009) 3 44 58
  4. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PMID: 17998332) Lee JH … Skalnik DG (Molecular and cellular biology 2008) 3 4 58
  5. Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. (PMID: 17494052) Michiels S … Benhamou S (Carcinogenesis 2007) 3 44 58

Products for POLR2B Gene

Sources for POLR2B Gene

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