Aliases for POLR2B Gene
External Ids for POLR2B Gene
Previous GeneCards Identifiers for POLR2B Gene
This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for POLR2B Gene
POLR2B (RNA Polymerase II Subunit B) is a Protein Coding gene. Diseases associated with POLR2B include Fusariosis and Eumycotic Mycetoma. Among its related pathways are DREAM Repression and Dynorphin Expression and Tat-mediated elongation of the HIV-1 transcript. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity. An important paralog of this gene is POLR3B.
UniProtKB/Swiss-Prot Summary for POLR2B Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).