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Aliases for POLR2A Gene

Aliases for POLR2A Gene

  • RNA Polymerase II Subunit A 2 3 5
  • RNA Polymerase II Subunit B1 2 3 4
  • DNA-Directed RNA Polymerase II Largest Subunit, RNA Polymerase II 220 Kd Subunit 2 3
  • Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa 2 3
  • DNA-Directed RNA Polymerase III Largest Subunit 3 4
  • RNA-Directed RNA Polymerase II Subunit RPB1 3 4
  • DNA-Directed RNA Polymerase II Subunit A 3 4
  • EC 2.7.7.6 4 56
  • POLR2 3 4
  • DNA-Directed RNA Polymerase II Subunit RPB1 3
  • Polymerase (RNA) II Subunit A 3
  • EC 2.7.7.48 4
  • HRPB220 3
  • RpIILS 3
  • HsRPB1 3
  • POLRA 3
  • RPBh1 3
  • RPOL2 3
  • RPB1 3
  • RPO2 3

External Ids for POLR2A Gene

Previous HGNC Symbols for POLR2A Gene

  • POLR2

Previous GeneCards Identifiers for POLR2A Gene

  • GC17M007800
  • GC17P008117
  • GC17P007330
  • GC17P007588
  • GC17P007329
  • GC17P007387
  • GC17P007491
  • GC17P007493
  • GC17P007499
  • GC17P007515
  • GC17P007626
  • GC17P007643
  • GC17P007668

Summaries for POLR2A Gene

Entrez Gene Summary for POLR2A Gene

  • This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for POLR2A Gene

POLR2A (RNA Polymerase II Subunit A) is a Protein Coding gene. Diseases associated with POLR2A include Cockayne Syndrome B and La Crosse Encephalitis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include DNA-directed 5-3 RNA polymerase activity.

UniProtKB/Swiss-Prot for POLR2A Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (By similarity). Initiation or early elongation steps of transcription of growth-factors-induced immediate early genes are regulated by the acetylation status of the CTD (PubMed:24207025). Methylation and dimethylation have a repressive effect on target genes expression (By similarity).

  • (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.

Gene Wiki entry for POLR2A Gene

Additional gene information for POLR2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR2A Gene

Genomics for POLR2A Gene

GeneHancer (GH) Regulatory Elements for POLR2A Gene

Promoters and enhancers for POLR2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 631 -3.8 -3777 12.5 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC POLR2A ZBTB4 SLC35G6 DVL2 PFAS SNORD10 CTC1 WRAP53 SNORA48 CNTROB
GH17I008172 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 94.4 +690.6 690601 5.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF416 LOC105371520 GC17M008511 SNORD118 TMEM107 DVL2 CTC1 CNTROB POLR2A WRAP53 SNORD10
GH17I007833 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 71.6 +355.4 355363 12.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 KDM6B DVL2 PFAS CTC1 WRAP53 CNTROB POLR2A SNORD10 SNORA48 PER1
GH17I008185 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 54 +704.0 703968 5.9 CLOCK MLX ZFP64 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC BORCS6 ENSG00000279152 GC17M008515 GC17M008516 PIR38375 PIR38980 PIR40201 MIR4521 TRI-AAT5-5 TRS-GCT4-3
GH17I007010 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49.3 -466.7 -466652 13.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MIR497HG RNASEK BCL6B C17orf49 ENSG00000267047 MIR195 MIR497 DVL2 SNORD10 CNTROB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around POLR2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLR2A gene promoter:

Genomic Locations for POLR2A Gene

Genomic Locations for POLR2A Gene
chr17:7,484,366-7,514,618
(GRCh38/hg38)
Size:
30,253 bases
Orientation:
Plus strand
chr17:7,387,685-7,417,935
(GRCh37/hg19)

Genomic View for POLR2A Gene

Genes around POLR2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLR2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR2A Gene

Proteins for POLR2A Gene

  • Protein details for POLR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24928-RPB1_HUMAN
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB1
    Protein Accession:
    P24928
    Secondary Accessions:
    • A6NN93
    • B9EH88
    • Q6NX41

    Protein attributes for POLR2A Gene

    Size:
    1970 amino acids
    Molecular mass:
    217176 Da
    Quaternary structure:
    • Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active). Interacts (via the C-terminal domain (CTD)) with U2AF2; recruits PRPF19 and the Prp19 complex to the pre-mRNA and may couple transcription to pre-mRNA splicing. Interacts (via the C-terminal domain (CTD)) with SMN1/SMN2; recruits SMN1/SMN2 to RNA Pol II elongation complexes. Interacts via the phosphorylated C-terminal domain with WDR82 and with SETD1A and SETD1B only in the presence of WDR82. When phosphorylated at Ser-5, interacts with MEN1; the unphosphorylated form, or phosphorylated at Ser-2 does not interact. When phosphorylated at Ser-2, interacts with SUPT6H (via SH2 domain). Interacts with RECQL5 and TCEA1; binding of RECQL5 prevents TCEA1 binding. The phosphorylated C-terminal domain interacts with FNBP3 and SYNCRIP. Interacts with ATF7IP. Interacts with DDX5. Interacts with WWP2. Interacts with SETX. Interacts (phosphorylated) with PIH1D1. Interacts (via the C-terminal domain (CTD)) with TDRD3. Interacts with PRMT5. Interacts with XRN2. Interacts with SAFB/SAFB1. Interacts with CCNL1. Interacts with CCNL2, MYO1C, PAF1 and SFRS19. Interacts (via C-terminus) with CMTR1, CTDSP1 and SCAF8. Interacts (via the C-terminal domain (CTD)) with CCNT2 (PubMed:15563843).
    • (Microbial infection) Interacts with herpes simplex virus 1 protein ICP22; this interaction causes loss of CTD Ser-2 phosphorylation from pol II engaged in transcription (PubMed:23029222).
    Miscellaneous:
    • The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.

    Three dimensional structures from OCA and Proteopedia for POLR2A Gene

    Alternative splice isoforms for POLR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR2A Gene

Selected DME Specific Peptides for POLR2A Gene

P24928:
  • TFHYAGV
  • RGNLMGKRVD
  • GREGLIDTA
  • ETGYIQRRL
  • TQMTLNTFH
  • GKRVDFS
  • GYKVERH
  • EFFFHAM
  • CPGHFGH
  • SPSYSPSSP
  • LAKPVFH
  • FSARTVI
  • RLKGKEGR
  • GFVENSYL
  • CSFEETV
  • LQFHVAT
  • DFDGDEMN
  • KNVTLGVPRL
  • TSPKYSPTSP
  • NADFDGD
  • YSPTSPNY
  • GSYVNYRH
  • VGALAAQS

Post-translational modifications for POLR2A Gene

  • Among tandem heptapeptide repeats of the C-terminal domain (CTD) some do not match the Y-S-P-T-S-P-S consensus, the seventh serine residue Ser-7 being replaced by a lysine. Lys-7 in these non-consensus heptapeptide repeats can be alternatively acetylated, methylated and dimethylated. EP300 is one of the enzyme able to acetylate Lys-7. Acetylation at Lys-7 of non-consensus heptapeptide repeats is associated with Ser-2 phosphorylation and active transcription. Regulates initiation or early elongation steps of transcription specially for inducible genes.
  • Methylated at Arg-1810 prior to transcription initiation when the CTD is hypophosphorylated, phosphorylation at Ser-1805 and Ser-1808 preventing this methylation. Symmetrically or asymmetrically dimethylated at Arg-1810 by PRMT5 and CARM1 respectively. Symmetric or asymmetric dimethylation modulates interactions with CTD-binding proteins like SMN1/SMN2 and TDRD3. SMN1/SMN2 interacts preferentially with the symmetrically dimethylated form while TDRD3 interacts with the asymmetric form. Through the recruitment of SMN1/SMN2, symmetric dimethylation is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. CTD dimethylation may also facilitate the expression of select RNAs. Among tandem heptapeptide repeats of the C-terminal domain (CTD) some do not match the Y-S-P-T-S-P-S consensus, the seventh serine residue Ser-7 being replaced by a lysine. Lys-7 in these non-consensus heptapeptide repeats can be alternatively acetylated, methylated, dimethylated and trimethylated. Methylation occurs in the earliest transcription stages and precedes or is concomitant to Ser-5 and Ser-7 phosphorylation. Dimethylation and trimehtylation at Lys-7 of non-consensus heptapeptide repeats are exclusively associated with phosphorylated CTD.
  • The tandem heptapeptide repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues Ser-2 and Ser-5 of the heptapeptide repeat and is mediated, at least, by CDK7 and CDK9. CDK7 phosphorylation of POLR2A associated with DNA promotes transcription initiation by triggering dissociation from DNA. Phosphorylation also takes place at Ser-7 of the heptapeptide repeat, which is required for efficient transcription of snRNA genes and processing of the transcripts. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatases, and a CTD code that specifies the position of Pol II within the transcription cycle has been proposed. Dephosphorylated by the protein phosphatase CTDSP1.
  • Ubiquitinated by WWP2 leading to proteasomal degradation (By similarity). Following UV treatment, the elongating form of RNA polymerase II (RNA pol IIo) is ubiquitinated on UV damage sites without leading to degradation: ubiquitination is facilitated by KIAA1530/UVSSA and promotes RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery.
  • Ubiquitination at isoforms=242, Lys163, isoforms=2213, isoforms=2279, Lys285, isoforms=619, Lys707, isoforms=710, Lys758, isoforms=767, isoforms=796, Lys803, isoforms=812, Lys853, isoforms=866, Lys910, isoforms=940, isoforms=976, isoforms=992, isoforms=1008, Lys1019, isoforms=1125, Lys1225, isoforms=1268, isoforms=1319, and Lys1350
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for POLR2A Gene

Gene Families for POLR2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for POLR2A Gene

Graphical View of Domain Structure for InterPro Entry

P24928

UniProtKB/Swiss-Prot:

RPB1_HUMAN :
  • The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
  • Belongs to the RNA polymerase beta chain family.
Domain:
  • The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
Family:
  • Belongs to the RNA polymerase beta chain family.
genes like me logo Genes that share domains with POLR2A: view

Function for POLR2A Gene

Molecular function for POLR2A Gene

GENATLAS Biochemistry:
polymerase II,RNA (DNA directed) large polypeptide A (220kDa)
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (By similarity). Initiation or early elongation steps of transcription of growth-factors-induced immediate early genes are regulated by the acetylation status of the CTD (PubMed:24207025). Methylation and dimethylation have a repressive effect on target genes expression (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.

Enzyme Numbers (IUBMB) for POLR2A Gene

Phenotypes From GWAS Catalog for POLR2A Gene

Gene Ontology (GO) - Molecular Function for POLR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001055 contributes_to RNA polymerase II activity IBA --
GO:0003677 DNA binding NAS,TAS 7622068
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003899 DNA-directed 5-3 RNA polymerase activity NAS,TAS 7622068
GO:0003968 RNA-directed 5-3 RNA polymerase activity IEA --
genes like me logo Genes that share ontologies with POLR2A: view
genes like me logo Genes that share phenotypes with POLR2A: view

Animal Models for POLR2A Gene

MGI Knock Outs for POLR2A:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLR2A Gene

Localization for POLR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR2A Gene

Nucleus. Cytoplasm. Note=Hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear. {ECO:0000269 PubMed:26566685}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLR2A gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 colocalizes_with Prp19 complex IDA 21536736
GO:0005634 nucleus NAS 7622068
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9852112
GO:0005730 NOT nucleolus IDA 16109376
genes like me logo Genes that share ontologies with POLR2A: view

Pathways & Interactions for POLR2A Gene

SuperPathways for POLR2A Gene

SuperPathway Contained pathways
1 Formation of HIV elongation complex in the absence of HIV Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 mRNA Capping
4 HIV Life Cycle
.45
5 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
genes like me logo Genes that share pathways with POLR2A: view

SIGNOR curated interactions for POLR2A Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for POLR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001172 transcription, RNA-templated IEA --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated TAS --
GO:0006353 DNA-templated transcription, termination IMP 26700805
genes like me logo Genes that share ontologies with POLR2A: view

Drugs & Compounds for POLR2A Gene

(10) Drugs for POLR2A Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma 1166
Phosphoric acid Approved Pharma 0
Magnesium Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for POLR2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2

(4) ApexBio Compounds for POLR2A Gene

Compound Action Cas Number
Actinomycin D RNA polymerase inhibitor 50-76-0
Cytarabine 147-94-4
PSI-6206 Inhibitor of HCV RNA polymerase,potent and selective 863329-66-2
PSI-7977 Antiviral agents for chronic HCV infection 1190307-88-0
genes like me logo Genes that share compounds with POLR2A: view

Drug Products

Transcripts for POLR2A Gene

Unigene Clusters for POLR2A Gene

Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR2A Gene

No ASD Table

Relevant External Links for POLR2A Gene

GeneLoc Exon Structure for
POLR2A
ECgene alternative splicing isoforms for
POLR2A

Expression for POLR2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLR2A Gene

Protein differential expression in normal tissues from HIPED for POLR2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9), Lymph node (11.9), and Nasal epithelium (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLR2A Gene



Protein tissue co-expression partners for POLR2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of POLR2A Gene:

POLR2A

SOURCE GeneReport for Unigene cluster for POLR2A Gene:

Hs.270017

Evidence on tissue expression from TISSUES for POLR2A Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Pancreas(4.3)
  • Lung(3.8)
  • Intestine(3.6)
  • Skin(2.9)
  • Blood(2.7)
  • Eye(2.6)
  • Heart(2.5)
  • Kidney(2.5)
  • Muscle(2.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with POLR2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLR2A Gene

Orthologs for POLR2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLR2A Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia POLR2A 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR2A 34
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLR2A 33 34
  • 97.22 (n)
cow
(Bos Taurus)
Mammalia POLR2A 33 34
  • 91.54 (n)
dog
(Canis familiaris)
Mammalia POLR2A 33 34
  • 90.58 (n)
mouse
(Mus musculus)
Mammalia Polr2a 33 16 34
  • 90.17 (n)
rat
(Rattus norvegicus)
Mammalia Polr2a 33
  • 89.61 (n)
lizard
(Anolis carolinensis)
Reptilia POLR2A 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia polr2a 33