Aliases for POLR1C Gene
External Ids for POLR1C Gene
Previous GeneCards Identifiers for POLR1C Gene
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for POLR1C Gene
POLR1C (RNA Polymerase I And III Subunit C) is a Protein Coding gene. Diseases associated with POLR1C include Treacher Collins Syndrome 3 and Leukodystrophy, Hypomyelinating, 11. Among its related pathways are RNA Polymerase III Transcription Initiation and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and RNA polymerase III activity. An important paralog of this gene is POLR2C.
UniProtKB/Swiss-Prot Summary for POLR1C Gene
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).