This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010... See more...

Aliases for POLL Gene

Aliases for POLL Gene

  • DNA Polymerase Lambda 2 3 4 5
  • Polymerase (DNA Directed), Lambda 2 3
  • Polymerase (DNA) Lambda 2 3
  • DNA Polymerase Beta-2 3 4
  • DNA Polymerase Kappa 3 4
  • DNA Polymerase Beta-N 3
  • EC 4.2.99.- 4
  • Pol Lambda 4
  • EC 2.7.7.7 4
  • Pol Beta2 4
  • POLKAPPA 3
  • BETAN 3
  • POLL 5

External Ids for POLL Gene

Previous GeneCards Identifiers for POLL Gene

  • GC10M102231
  • GC10M102572
  • GC10M103469
  • GC10M103003
  • GC10M103328
  • GC10M096969

Summaries for POLL Gene

Entrez Gene Summary for POLL Gene

  • This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]

GeneCards Summary for POLL Gene

POLL (DNA Polymerase Lambda) is a Protein Coding gene. Diseases associated with POLL include Xeroderma Pigmentosum, Variant Type and Split-Hand/Foot Malformation 3. Among its related pathways are DNA Double-Strand Break Repair and DNA Double Strand Break Response. Gene Ontology (GO) annotations related to this gene include lyase activity and DNA polymerase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot Summary for POLL Gene

  • DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195).

Gene Wiki entry for POLL Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLL Gene

Genomics for POLL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POLL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLL

Top Transcription factor binding sites by QIAGEN in the POLL gene promoter:
  • c-Ets-1
  • c-Myc
  • FOXO4
  • IRF-1
  • Max1
  • PPAR-gamma1
  • PPAR-gamma2
  • RREB-1
  • RSRFC4
  • Sp1

Genomic Locations for POLL Gene

Latest Assembly
chr10:101,578,882-101,588,319
(GRCh38/hg38)
Size:
9,438 bases
Orientation:
Minus strand

Previous Assembly
chr10:103,338,639-103,348,027
(GRCh37/hg19 by Entrez Gene)
Size:
9,389 bases
Orientation:
Minus strand

chr10:103,338,639-103,348,027
(GRCh37/hg19 by Ensembl)
Size:
9,389 bases
Orientation:
Minus strand

Genomic View for POLL Gene

Genes around POLL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLL Gene

Proteins for POLL Gene

  • Protein details for POLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGP5-DPOLL_HUMAN
    Recommended name:
    DNA polymerase lambda
    Protein Accession:
    Q9UGP5
    Secondary Accessions:
    • D3DR76
    • Q5JQP5
    • Q6NUM2
    • Q9BTN8
    • Q9HA10
    • Q9HB35

    Protein attributes for POLL Gene

    Size:
    575 amino acids
    Molecular mass:
    63482 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Binds PCNA.
    SequenceCaution:
    • Sequence=BAB14050.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for POLL Gene

    Alternative splice isoforms for POLL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLL Gene

Post-translational modifications for POLL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for POLL Gene

Domains & Families for POLL Gene

Gene Families for POLL Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for POLL Gene

InterPro:
Blocks:
  • Helix-hairpin-helix DNA-binding, class 1
  • DNA polymerase family X
  • DNA-polymerase family X pol beta-like signature

Suggested Antigen Peptide Sequences for POLL Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55191, highly similar to DNA polymerase lambda (EC 2.7.7.7) (B4DEF5_HUMAN)
  • cDNA FLJ54109, weakly similar to DNA polymerase lambda (EC 2.7.7.7) (B7Z1M4_HUMAN)
  • DNA polymerase kappa (DPOLL_HUMAN)
  • DNA polymerase lambda (Q5ZEY5_HUMAN)
  • DNA polymerase lambda (Q5ZEY6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UGP5

UniProtKB/Swiss-Prot:

DPOLL_HUMAN :
  • Belongs to the DNA polymerase type-X family.
Family:
  • Belongs to the DNA polymerase type-X family.
genes like me logo Genes that share domains with POLL: view

Function for POLL Gene

Molecular function for POLL Gene

UniProtKB/Swiss-Prot Function:
DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7; Evidence={ECO:0000269|PubMed:10887191, ECO:0000269|PubMed:10982892, ECO:0000269|PubMed:12809503, ECO:0000269|PubMed:14627824, ECO:0000269|PubMed:15537631, ECO:0000269|PubMed:19806195};.
GENATLAS Biochemistry:
polymerase (DNA-directed), lambda

Enzyme Numbers (IUBMB) for POLL Gene

Phenotypes From GWAS Catalog for POLL Gene

Gene Ontology (GO) - Molecular Function for POLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10982892
GO:0003887 DNA-directed DNA polymerase activity TAS --
GO:0005515 protein binding IPI --
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with POLL: view
genes like me logo Genes that share phenotypes with POLL: view

Animal Models for POLL Gene

MGI Knock Outs for POLL:
  • Poll Poll<tm1Crey>

Animal Models for research

  • Taconic Biosciences Mouse Models for POLL

miRNA for POLL Gene

miRTarBase miRNAs that target POLL

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLL

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLL Gene

Localization for POLL Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLL gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,NAS 10982892
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with POLL: view

Pathways & Interactions for POLL Gene

genes like me logo Genes that share pathways with POLL: view

Pathways by source for POLL Gene

Gene Ontology (GO) - Biological Process for POLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 20693240
GO:0006260 DNA replication NAS 10982892
GO:0006281 DNA repair IEA --
GO:0006287 base-excision repair, gap-filling IDA 19806195
GO:0006289 nucleotide-excision repair IDA 10982892
genes like me logo Genes that share ontologies with POLL: view

No data available for SIGNOR curated interactions for POLL Gene

Drugs & Compounds for POLL Gene

(8) Drugs for POLL Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clofarabine Approved, Investigational Pharma Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 168
Manganese Approved Nutra 65
dATP Experimental Pharma 0
dctp Experimental Pharma 0
dgtp Experimental Pharma 0

(3) Additional Compounds for POLL Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8

(1) ApexBio Compounds for POLL Gene

Compound Action Cas Number
Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 123318-82-1
genes like me logo Genes that share compounds with POLL: view

Drug products for research

Transcripts for POLL Gene

mRNA/cDNA for POLL Gene

4 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLL

Alternative Splicing Database (ASD) splice patterns (SP) for POLL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: -
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - -
SP22: - - -
SP23: - - - -
SP24: - - - - - - - - - - - - - - - -
SP25: - - - - - - - - - - - -
SP26: - - - - - -
SP27: - - - - - - - - - - - -
SP28: - - - - - - - - - - - - -
SP29: - - - - - - -
SP30: - - -
SP31: - - - - -
SP32: - - - - - - - - - - - - -
SP33: - - - -
SP34:
SP35:
SP36:
SP37: - - - - - - - - - -

ExUns: 7e · 7f ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - - -
SP11: -
SP12: - - - - - - - -
SP13: - - - -
SP14:
SP15:
SP16:
SP17: - - - - - - - - -
SP18:
SP19: -
SP20: - - - - - - - - - -
SP21: -
SP22:
SP23: - - - - - - - - -
SP24: - -
SP25:
SP26:
SP27: - - - - - - - - -
SP28: - - - - - - - - -
SP29:
SP30:
SP31:
SP32: - -
SP33: - -
SP34: - - - -
SP35: - - -
SP36:
SP37: - - - - - - - - - - - - -

Relevant External Links for POLL Gene

GeneLoc Exon Structure for
POLL

Expression for POLL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLL Gene

Protein differential expression in normal tissues from HIPED for POLL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.8) and Ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLL Gene



Protein tissue co-expression partners for POLL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLL

SOURCE GeneReport for Unigene cluster for POLL Gene:

Hs.523230

mRNA Expression by UniProt/SwissProt for POLL Gene:

Q9UGP5-DPOLL_HUMAN
Tissue specificity: Expressed in a number of tissues. Abundant in testis.

Evidence on tissue expression from TISSUES for POLL Gene

  • Lung(4.4)
  • Nervous system(4.4)
  • Lymph node(4.3)
  • Intestine(2.7)
  • Kidney(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with POLL: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLL Gene

Orthologs for POLL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POLL 29 30
  • 99.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia POLL 29 30
  • 86.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia POLL 29 30
  • 86.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Poll 29
  • 84.7 (n)
Mouse
(Mus musculus)
Mammalia Poll 29 16 30
  • 84.12 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia POLL 30
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia POLL 30
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves POLL 29 30
  • 68.58 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia POLL 30
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia poll 29
  • 62.11 (n)
Str.3820 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.6067 29
Zebrafish
(Danio rerio)
Actinopterygii poll 29
  • 58.41 (n)
ved 30
  • 3 (a)
OneToOne
wufe49a04 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3101 29
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POL4 32 32
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G10520 29
  • 48.27 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0237200 29
  • 45.96 (n)
Species where no ortholog for POLL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for POLL Gene

ENSEMBL:
Gene Tree for POLL (if available)
TreeFam:
Gene Tree for POLL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLL: view image
Alliance of Genome Resources:
Additional Orthologs for POLL

Paralogs for POLL Gene

Paralogs for POLL Gene

(2) SIMAP similar genes for POLL Gene using alignment to 15 proteins:

  • DPOLL_HUMAN
  • B4DEF5_HUMAN
  • B7Z1M4_HUMAN
  • Q5JQN9_HUMAN
  • Q5JQP0_HUMAN
  • Q5JQP1_HUMAN
  • Q5JQP2_HUMAN
  • Q5JQP3_HUMAN
  • Q5JQP4_HUMAN
  • Q5JQP7_HUMAN
  • Q5JQP8_HUMAN
  • Q5ZEY5_HUMAN
  • Q5ZEY6_HUMAN
  • Q9BTN8_HUMAN
  • Q9HBN3_HUMAN
genes like me logo Genes that share paralogs with POLL: view

Variants for POLL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLL Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs3730463 -- p.Thr221Pro
rs3730477 -- p.Arg438Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for POLL Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for POLL Gene

Variant ID Type Subtype PubMed ID
dgv964n100 CNV gain 25217958
esv2750847 CNV gain 17911159
esv2760144 CNV gain 21179565
esv3624382 CNV gain 21293372
nsv1053934 CNV gain 25217958
nsv526529 CNV loss 19592680
nsv527185 CNV loss 19592680
nsv552056 CNV gain 21841781

Variation tolerance for POLL Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLL Gene

Human Gene Mutation Database (HGMD)
POLL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLL
Leiden Open Variation Database (LOVD)
POLL

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLL Gene

Disorders for POLL Gene

MalaCards: The human disease database

(5) MalaCards diseases for POLL Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search POLL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for POLL

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with POLL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLL Gene

Publications for POLL Gene

  1. Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. (PMID: 19806195) Terrados G … Blanco L (PloS one 2009) 3 4 22
  2. Human DNA polymerase lambda is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine. (PMID: 17686665) Picher AJ … Blanco L (DNA repair 2007) 2 3 22
  3. DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. (PMID: 15537631) Maga G … Hübscher U (The Journal of biological chemistry 2005) 3 4 22
  4. A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. (PMID: 14992725) Garcia-Diaz M … Pedersen LC (Molecular cell 2004) 3 4 22
  5. The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. (PMID: 15358682) Maga G … Hübscher U (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004) 3 4 22

Products for POLL Gene

Sources for POLL Gene