Aliases for POLL Gene
External Ids for POLL Gene
Previous GeneCards Identifiers for POLL Gene
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]
GeneCards Summary for POLL Gene
POLL (DNA Polymerase Lambda) is a Protein Coding gene. Diseases associated with POLL include Xeroderma Pigmentosum, Variant Type and Split-Hand/Foot Malformation 3. Among its related pathways are DNA Double-Strand Break Repair and DNA Double Strand Break Response. Gene Ontology (GO) annotations related to this gene include lyase activity and DNA polymerase activity. An important paralog of this gene is POLB.
UniProtKB/Swiss-Prot Summary for POLL Gene
DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195).