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The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion. [provided by RefSeq... See more...
Aliases for POLI Gene
Aliases for POLI Gene
External Ids for POLI Gene
- HGNC: 9182
- Entrez Gene: 11201
- Ensembl: ENSG00000101751
- OMIM: 605252
- UniProtKB: Q9UNA4
Previous HGNC Symbols for POLI Gene
- RAD3OB
- RAD30B
Previous GeneCards Identifiers for POLI Gene
- GC18P051966
- GC18P051731
- GC18P050047
- GC18P050049
- GC18P048651
- GC18P051795
Summaries for POLI Gene
-
The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion. [provided by RefSeq, May 2017]
GeneCards Summary for POLI Gene
POLI (DNA Polymerase Iota) is a Protein Coding gene. Diseases associated with POLI include Tracheitis and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include damaged DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is REV1.
UniProtKB/Swiss-Prot Summary for POLI Gene
-
Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunogobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940).
Additional gene information for POLI Gene
- HGNC(9182)
- Entrez Gene(11201)
- Ensembl(ENSG00000101751)
- OMIM(605252)
- UniProtKB(Q9UNA4)
- Open Targets Platform(ENSG00000101751)
- Monarch Initiative
- Search for POLI at DataMed
- Search for POLI at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLI Gene
Genomics for POLI Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for POLI Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around POLI on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLI
- Top Transcription factor binding sites by QIAGEN in the POLI gene promoter:
-
- Brachyury
- CUTL1
- E47
- Hand1
- NF-AT
- NF-AT1
- NF-AT2
- Pax-4a
- RFX1
- TBP
Genomic Locations for POLI Gene
Genomic Locations for POLI Gene
- chr18:54,269,404-54,321,266
- (GRCh38/hg38)
- Size:
- 51,863 bases
- Orientation:
- Plus strand
- chr18:51,795,774-51,847,636
- (GRCh37/hg19)
- Size:
- 51,863 bases
- Orientation:
- Plus strand
Genomic View for POLI Gene
Genes around POLI on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.2 by HGNC
- 18q21.2 by Entrez Gene
- 18q21.2 by Ensembl
POLI Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POLI Gene
Proteins for POLI Gene
-
Protein details for POLI Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UNA4-POLI_HUMAN
- Recommended name:
- DNA polymerase iota
- Protein Accession:
- Q9UNA4
- Q8N590
- Q9H0S1
- Q9NYH6
Protein attributes for POLI Gene
- Size:
- 740 amino acids
- Molecular mass:
- 83006 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Interacts with POLH (PubMed:12606586). Interacts with REV1 (By similarity). Interacts with ubiquitin (By similarity).
- SequenceCaution:
-
- Sequence=AAD50381.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAF63383.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH32662.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAM11872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB66605.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for POLI Gene
Post-translational modifications for POLI Gene
- Monoubiquitinated. Protein monoubiquitination prevents POLI binding to ubiquitin via the ubiquitin-binding motif 1 and ubiquitin-binding motif 2.
-
Ubiquitination at Lys292, Lys296, Lys308, Lys345, Lys547, and Lys575
- NX_Q9UNA4 (NX_Q9UNA4-1)
- Modification sites at PhosphoSitePlus
Other Protein References for POLI Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences POLI Antibody
-
Custom Antibody ServicesOriGene Antibodies for POLI
- Novus Biologicals Antibodies for POLI
-
Abcam antibodies for POLI
- Invitrogen Antibodies for POLI (AFLGC-Poli)
-
Biorbyt antibodies for POLI
-
Santa Cruz Biotechnology (SCBT) Antibodies for POLI
Protein Products
-
OriGene Purified Proteins for POLI
- Search Origene for MassSpec and Protein Over-expression Lysates for POLI
- Origene Custom Protein Services for POLI
-
Abcam proteins for POLI
No data available for DME Specific Peptides for POLI Gene
Domains & Families for POLI Gene
Gene Families for POLI Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for POLI Gene
- InterPro:
- Blocks:
-
- UMUC-like DNA-repair protein
- ProtoNet:
Suggested Antigen Peptide Sequences for POLI Gene
- GenScript: Design optimal peptide antigens:
-
- RAD30 homolog B (POLI_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UNA4UniProtKB/Swiss-Prot:
POLI_HUMAN :- The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.
- Belongs to the DNA polymerase type-Y family.
- Domain:
-
- The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.
- Ubiquitin-binding motif 1 and ubiquitin-binding motif 2 regulate POLI protein monoubiquitination and localization to nuclear foci after UV-induced DNA damage.
- Family:
-
- Belongs to the DNA polymerase type-Y family.
Function for POLI Gene
Molecular function for POLI Gene
- UniProtKB/Swiss-Prot Function:
- Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunogobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7; Evidence={ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:27555320};.
Enzyme Numbers (IUBMB) for POLI Gene
Phenotypes From GWAS Catalog for POLI Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003684 | damaged DNA binding | IEA | -- |
| GO:0003887 | DNA-directed DNA polymerase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for POLI Gene
- MGI mutant phenotypes for POLI:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for POLI:
Animal Models for POLI Gene
- MGI Knock Outs for POLI:
-
- Poli Poli<tm1.1Lgh>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for POLI - Select products 50% OFF >
- * POLI CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for POLI
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POLI
-
Santa Cruz Biotechnology (SCBT) CRISPR for POLI
miRNA for POLI Gene
- miRTarBase miRNAs that target POLI
-
- hsa-miR-92a-3p (MIRT049053)
- hsa-miR-27b-5p (MIRT199031)
- hsa-miR-4255 (MIRT199032)
- hsa-miR-3591-5p (MIRT199033)
- hsa-miR-5197-3p (MIRT199034)
- hsa-miR-19a-3p (MIRT290693)
- hsa-miR-19b-3p (MIRT290694)
- hsa-miR-4760-5p (MIRT290697)
- hsa-miR-548aw (MIRT290698)
- hsa-miR-8061 (MIRT290699)
- hsa-miR-6864-3p (MIRT450741)
- hsa-miR-3672 (MIRT450742)
- hsa-miR-340-5p (MIRT450743)
- hsa-miR-1468-3p (MIRT450744)
- hsa-miR-548x-5p (MIRT450745)
- hsa-miR-548g-5p (MIRT450746)
- hsa-miR-548f-5p (MIRT450747)
- hsa-miR-548aj-5p (MIRT450748)
- hsa-miR-4786-5p (MIRT450749)
- hsa-miR-769-5p (MIRT450750)
- hsa-miR-889-3p (MIRT450751)
- hsa-miR-1277-5p (MIRT450752)
- hsa-miR-142-3p (MIRT450753)
- hsa-miR-376a-5p (MIRT497085)
- hsa-miR-455-5p (MIRT497086)
- hsa-miR-203a-3p (MIRT763695)
- hsa-miR-3190-5p (MIRT765380)
- hsa-miR-3926 (MIRT767724)
- hsa-miR-513b-3p (MIRT773391)
- hsa-miR-548s (MIRT774517)
- hsa-miR-5583-3p (MIRT774727)
- hsa-miR-6849-3p (MIRT780321)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for POLI
- Browse OriGene Inhibitory RNA Products For POLI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLI
Clone Products
- Applied Biological Materials (abm): Clones for POLI - Select products 50% OFF >
- * POLI as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209951
- MG216260
- MR209951
- MR209951L3
- MR209951L4
- MR216260
- MR216260L3
- MR216260L4
- MR230470
- MR230792
- RC207550
- RC207550L1
- RC207550L2
- RC207550L3
- RC207550L4
- RG207550
- RR204969
- RR204969L3
- RR204969L4
- MR209951L3V
- MR209951L4V
- MR216260L3V
- MR216260L4V
- RC207550L1V
- RC207550L2V
- RC207550L3V
- RC207550L4V
- RR204969L3V
- RR204969L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for POLI
- Addgene plasmids for POLI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POLI
Cell Line Products
-
Horizon Cell Lines for POLI
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLI Gene
Localization for POLI Gene
Subcellular locations from UniProtKB/Swiss-Prot for POLI Gene
- Nucleus. Note=Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage. {ECO:0000250 UniProtKB:Q6R3M4}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| peroxisome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nuclear speckles (3)
- Cytoplasmic bodies (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IDA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016607 | nuclear speck | IDA | -- |
| GO:0036464 | cytoplasmic ribonucleoprotein granule | IDA | -- |
Pathways & Interactions for POLI Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | ||
| 2 | Fanconi anemia pathway | ||
| 3 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for POLI Gene
1 KEGG pathway for POLI Gene
Interacting Proteins for POLI Gene
Selected Interacting proteins:
Q9UNA4-POLI_HUMAN
ENSP00000462664
for POLI Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for POLI
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006260 | DNA replication | IEA | -- |
| GO:0006281 | DNA repair | IEA,TAS | 10458907 |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
| GO:0019985 | translesion synthesis | IBA,TAS | -- |
| GO:0042276 | error-prone translesion synthesis | TAS | -- |
No data available for SIGNOR curated interactions for POLI Gene
Drugs & Compounds for POLI Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for POLI Gene
mRNA/cDNA for POLI Gene
- 14 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000217800 2289 nts (view in UCSC)
- ENST00000406285 2030 nts (view in UCSC)
- ENST00000577361 786 nts (view in UCSC)
- ENST00000577612 585 nts (view in UCSC)
- ENST00000577727 801 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for POLI - Select products 50% OFF >
- * POLI CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for POLI
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POLI
-
Santa Cruz Biotechnology (SCBT) CRISPR for POLI
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for POLI
- Browse OriGene Inhibitory RNA Products For POLI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLI
Clone Products
- Applied Biological Materials (abm): Clones for POLI - Select products 50% OFF >
- * POLI as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209951
- MG216260
- MR209951
- MR209951L3
- MR209951L4
- MR216260
- MR216260L3
- MR216260L4
- MR230470
- MR230792
- RC207550
- RC207550L1
- RC207550L2
- RC207550L3
- RC207550L4
- RG207550
- RR204969
- RR204969L3
- RR204969L4
- MR209951L3V
- MR209951L4V
- MR216260L3V
- MR216260L4V
- RC207550L1V
- RC207550L2V
- RC207550L3V
- RC207550L4V
- RR204969L3V
- RR204969L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for POLI
- Addgene plasmids for POLI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POLI
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 14b | · | 14c |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: |
Relevant External Links for POLI Gene
- GeneLoc Exon Structure for
- POLI
Expression for POLI Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Testis (41.1), Pancreas (10.3), and Peripheral blood mononuclear cells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POLI Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLI
SOURCE GeneReport for Unigene cluster for POLI Gene:
Hs.438533mRNA Expression by UniProt/SwissProt for POLI Gene:
Q9UNA4-POLI_HUMAN
Tissue specificity:
Ubiquitous. Highly expressed in testis.
Evidence on tissue expression from TISSUES for POLI Gene
- Nervous system(4.6)
- Heart(4.5)
- Skin(3.3)
- Kidney(3.1)
- Spleen(2.8)
- Intestine(2.8)
- Lung(2.8)
- Muscle(2.7)
- Blood(2.7)
- Lymph node(2.6)
- Thyroid gland(2.5)
- Liver(2.5)
- Stomach(2.3)
- Pancreas(2.2)
- Eye(2.2)
- Adrenal gland(2.1)
- Bone marrow(2.1)
- Bone(2.1)
Primer Products
-
OriGene qPCR primer pairs for POLI
-
OriGene qPCR primer pairs and template standards for POLI
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLI Gene
Orthologs for POLI Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | POLI 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | POLI 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | POLI 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Poli 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Poli 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | POLI 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | POLI 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | POLI 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | poli 30 |
|
||
| Str.14738 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | poli 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | DNApol-&igr; 32 |
|
|
|
| DNApol-iota 31 |
|
OneToOne | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | REV1 31 |
|
OneToMany |
- Species where no ortholog for POLI was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for POLI Gene
- ENSEMBL:
- Gene Tree for POLI (if available)
- TreeFam:
- Gene Tree for POLI (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for POLI: view image
Paralogs for POLI Gene
Variants for POLI Gene
Residual Variation Intolerance Score:
96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.69;
57.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for POLI Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLI Gene
Disorders for POLI Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tracheitis |
|
|
| xeroderma pigmentosum, variant type |
|
|
| tracheal disease |
|
|
| mouth disease |
|
|
| ross river fever |
|
|
Search POLI in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for POLI
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for POLI Gene
Publications for POLI Gene
- Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese. (PMID: 17609217) Frank EG … Woodgate R (The Journal of biological chemistry 2007) 2 3 23
- Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. (PMID: 15254543) Nair DT … Aggarwal AK (Nature 2004) 3 4 23
- Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. (PMID: 15199127) Washington MT … Prakash L (Molecular and cellular biology 2004) 3 4 23
- Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. (PMID: 12606586) Kannouche P … Lehmann AR (The EMBO journal 2003) 3 4 23
- Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. (PMID: 12410315) Faili A … Weill JC (Nature 2002) 3 4 23
ExternalLinks
Products for POLI Gene
- Custom Antibody ServicesOriGene Antibodies for POLI
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for POLI
- Search Origene for MassSpec and Protein Over-expression Lysates for POLI
- Origene Custom Protein Services for POLI
- Origene shrna, sirna, and RNAi products in human, mouse, rat for POLI
- Browse OriGene Inhibitory RNA Products For POLI
- OriGene qPCR primer pairs for POLI
- OriGene qPCR primer pairs and template standards for POLI
- OriGene CRISPR knockouts for POLI
- MG209951
- MG216260
- MR209951
- MR209951L3
- MR209951L4
- MR216260
- MR216260L3
- MR216260L4
- MR230470
- MR230792
- RC207550
- RC207550L1
- RC207550L2
- RC207550L3
- RC207550L4
- RG207550
- RR204969
- RR204969L3
- RR204969L4
- MR209951L3V
- MR209951L4V
- MR216260L3V
- MR216260L4V
- RC207550L1V
- RC207550L2V
- RC207550L3V
- RC207550L4V
- RR204969L3V
- RR204969L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For POLI
- Sino Biological Human cDNA Clone for POLI
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
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- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for POLI
- Novus Biologicals proteins and lysates for POLI
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for POLI
- Abcam proteins for POLI
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for POLI (AFLGC-Poli)
- VectorBuilder Custom and pre-made DNA vectors for POLI (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for POLI (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for POLI (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for POLI CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for POLI
- Addgene plasmids for POLI
- antibodies-online: Show 30 available POLI Antibodies ranked by validation data
- Compare Top POLI Antibodies
- antibodies-online: Search results for available POLI related products ranked by validation data
- antibodies-online: Show 5 available POLI Proteins ranked by validation data
- Compare Top POLI Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for POLI
- Search Santa Cruz Biotechnology (SCBT) for POLI siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for POLI
- Horizon Cell Lines for POLI
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for POLI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for POLI
- Search GeneCopoeia for miRNA 3'UTR Target clone products for POLI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLI
- Biorbyt antibodies for POLI
Sources for POLI Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB