Aliases for POLE4 Gene
External Ids for POLE4 Gene
Previous GeneCards Identifiers for POLE4 Gene
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
GeneCards Summary for POLE4 Gene
POLE4 (DNA Polymerase Epsilon 4, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is NFYC.
UniProtKB/Swiss-Prot Summary for POLE4 Gene
Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity).