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Aliases for POLE3 Gene

Aliases for POLE3 Gene

  • DNA Polymerase Epsilon 3, Accessory Subunit 2 3 5
  • Polymerase (DNA Directed), Epsilon 3 (P17 Subunit) 2 3
  • Chromatin Accessibility Complex 17 KDa Protein 3 4
  • Polymerase (DNA) Epsilon 3, Accessory Subunit 2 3
  • DNA Polymerase Epsilon P17 Subunit 2 3
  • DNA Polymerase Epsilon Subunit P17 3 4
  • Arsenic Transactivated Protein 2 3
  • Histone Fold Protein CHRAC17 2 3
  • DNA Polymerase II Subunit 3 3 4
  • HuCHRAC17 3 4
  • CHRAC-17 3 4
  • CHRAC17 3 4
  • AsTP 3 4
  • Polymerase (DNA Directed), Epsilon 3, Accessory Subunit 3
  • Chromatin Accessibility Complex 17 2
  • DNA Polymerase Epsilon Subunit 3 3
  • Arsenic-Transactivated Protein 4
  • EC 2.7.7.7 4
  • CHARAC17 3
  • YBL1 3
  • P17 3

External Ids for POLE3 Gene

Previous GeneCards Identifiers for POLE3 Gene

  • GC09M106967
  • GC09M107901
  • GC09M109623
  • GC09M111545
  • GC09M113249
  • GC09M115209
  • GC09M116169
  • GC09M085777

Summaries for POLE3 Gene

Entrez Gene Summary for POLE3 Gene

  • POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

GeneCards Summary for POLE3 Gene

POLE3 (DNA Polymerase Epsilon 3, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity. An important paralog of this gene is NFYB.

UniProtKB/Swiss-Prot for POLE3 Gene

  • Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.

Gene Wiki entry for POLE3 Gene

Additional gene information for POLE3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLE3 Gene

Genomics for POLE3 Gene

GeneHancer (GH) Regulatory Elements for POLE3 Gene

Promoters and enhancers for POLE3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J113409 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.1 128 2.7 CLOCK DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 C9orf43 POLE3 PRPF4 RGS3 FKBP15 CDC26
GH09J113372 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.4 +32.7 32749 11.9 HDGF PKNOX1 CLOCK FOXA2 ARNT MLX ARID4B SIN3A DMAP1 YBX1 HDHD3 RGS3 PRPF4 C9orf43 POLE3 RNF183 ALAD CDC26 BSPRY
GH09J113577 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -169.5 -169474 6.3 HDGF PKNOX1 SIN3A IRF4 YY1 ZNF207 ZNF143 ATF7 FOS RUNX3 RGS3 C9orf43 POLE3 ALAD RNF183 LOC105376221 GC09P114256
GH09J113563 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 10 -154.8 -154757 3.1 HDAC1 PKNOX1 ARNT NFXL1 ZBTB40 POLR2B ATF7 IKZF2 RUNX3 EGR2 RGS3 C9orf43 PRPF4 RNF183 POLE3 CDC26 ALAD GC09P114256 GC09P114257
GH09J113339 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 +70.6 70591 1.7 MLX DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC ZC3H11A ZNF610 WDR31 PRPF4 RPL32P22 CDC26 BSPRY RNF183 ALAD C9orf43 POLE3 HDHD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLE3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLE3 gene promoter:
  • AP-1
  • GR
  • GR-alpha

Genomic Locations for POLE3 Gene

Genomic Locations for POLE3 Gene
chr9:113,407,235-113,410,749
(GRCh38/hg38)
Size:
3,515 bases
Orientation:
Minus strand
chr9:116,169,515-116,173,029
(GRCh37/hg19)
Size:
3,515 bases
Orientation:
Minus strand

Genomic View for POLE3 Gene

Genes around POLE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLE3 Gene

Proteins for POLE3 Gene

  • Protein details for POLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRF9-DPOE3_HUMAN
    Recommended name:
    DNA polymerase epsilon subunit 3
    Protein Accession:
    Q9NRF9
    Secondary Accessions:
    • Q5W0U1
    • Q8N758
    • Q8NCE5
    • Q9NR32

    Protein attributes for POLE3 Gene

    Size:
    147 amino acids
    Molecular mass:
    16860 Da
    Quaternary structure:
    • Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Interacts with CHRAC1. Together with CHRAC1, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.

neXtProt entry for POLE3 Gene

Post-translational modifications for POLE3 Gene

  • Ubiquitination at posLast=8686, Lys62, and Lys31
  • Modification sites at PhosphoSitePlus

Other Protein References for POLE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POLE3 Gene

Domains & Families for POLE3 Gene

Gene Families for POLE3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for POLE3 Gene

Suggested Antigen Peptide Sequences for POLE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with POLE3: view

No data available for UniProtKB/Swiss-Prot for POLE3 Gene

Function for POLE3 Gene

Molecular function for POLE3 Gene

UniProtKB/Swiss-Prot Function:
Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.
UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Enzyme Numbers (IUBMB) for POLE3 Gene

Phenotypes From GWAS Catalog for POLE3 Gene

Gene Ontology (GO) - Molecular Function for POLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity TAS,IEA --
GO:0005515 protein binding IPI 10801849
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with POLE3: view
genes like me logo Genes that share phenotypes with POLE3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLE3

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLE3 Gene

Localization for POLE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLE3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLE3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for POLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10801849
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0008622 epsilon DNA polymerase complex IDA 10801849
genes like me logo Genes that share ontologies with POLE3: view

Pathways & Interactions for POLE3 Gene

SuperPathways for POLE3 Gene

SuperPathway Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
2 CDK-mediated phosphorylation and removal of Cdc6
.78
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 DNA Double-Strand Break Repair
5 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
genes like me logo Genes that share pathways with POLE3: view

Gene Ontology (GO) - Biological Process for POLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS 10801849
GO:0006270 DNA replication initiation TAS --
GO:0032201 telomere maintenance via semi-conservative replication TAS --
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with POLE3: view

No data available for SIGNOR curated interactions for POLE3 Gene

Drugs & Compounds for POLE3 Gene

(6) Drugs for POLE3 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Target, inhibitor Apoptosis inducer in CLL cells 81
Clofarabine Approved, Investigational Pharma Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 161
Phosphoric acid Approved Pharma 0
dATP Experimental Pharma Full agonist, Agonist 0
dctp Experimental Pharma 0

(2) Additional Compounds for POLE3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • Deoxy-TTP
  • Deoxythymidine 5'-triphosphate
  • Deoxythymidine triphosphate
365-08-2

(1) ApexBio Compounds for POLE3 Gene

Compound Action Cas Number
Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 123318-82-1
genes like me logo Genes that share compounds with POLE3: view

Drug Products

Transcripts for POLE3 Gene

mRNA/cDNA for POLE3 Gene

Unigene Clusters for POLE3 Gene

Polymerase (DNA directed), epsilon 3, accessory subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLE3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLE3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: -
SP2: - -
SP3:
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for POLE3 Gene

GeneLoc Exon Structure for
POLE3
ECgene alternative splicing isoforms for
POLE3

Expression for POLE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLE3 Gene

This gene is overexpressed in Bone (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLE3 Gene



Protein tissue co-expression partners for POLE3 Gene

NURSA nuclear receptor signaling pathways regulating expression of POLE3 Gene:

POLE3

SOURCE GeneReport for Unigene cluster for POLE3 Gene:

Hs.108112

mRNA Expression by UniProt/SwissProt for POLE3 Gene:

Q9NRF9-DPOE3_HUMAN
Tissue specificity: Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for POLE3 Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Eye(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with POLE3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLE3 Gene

Orthologs for POLE3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLE3 34 33
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia POLE3 34 33
  • 93.88 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLE3 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pole3 16 34 33
  • 91.53 (n)
Gm21827 34
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia POLE3 34 33
  • 91.38 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pole3 33
  • 90.98 (n)
chicken
(Gallus gallus)
Aves POLE3 34 33
  • 77.87 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pole3 33
  • 77.51 (n)
Str.10053 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.32726 33
zebrafish
(Danio rerio)
Actinopterygii pole3 34 33
  • 74.25 (n)
OneToOne
zgc73351 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9305 33
fruit fly
(Drosophila melanogaster)
Insecta Chrac-14 34 33
  • 58.5 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP3 34
  • 20 (a)
OneToMany
Species where no ortholog for POLE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLE3 Gene

ENSEMBL:
Gene Tree for POLE3 (if available)
TreeFam:
Gene Tree for POLE3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLE3: view image

Paralogs for POLE3 Gene

Paralogs for POLE3 Gene

(1) SIMAP similar genes for POLE3 Gene using alignment to 1 proteins:

  • DPOE3_HUMAN
genes like me logo Genes that share paralogs with POLE3: view

Variants for POLE3 Gene

Sequence variations from dbSNP and Humsavar for POLE3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000276581 -- 113,411,362(-) G/C upstream_transcript_variant
rs1000857194 -- 113,407,345(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1001562761 -- 113,407,093(-) T/A downstream_transcript_variant
rs1001844529 -- 113,410,736(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1002178653 -- 113,412,499(-) AAA/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for POLE3 Gene

Variant ID Type Subtype PubMed ID
esv3621540 CNV gain 21293372

Variation tolerance for POLE3 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLE3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLE3 Gene

Disorders for POLE3 Gene

Additional Disease Information for POLE3

No disorders were found for POLE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLE3 Gene

Publications for POLE3 Gene

  1. Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. (PMID: 10801849) Li Y … Linn S (The Journal of biological chemistry 2000) 2 3 4 58
  2. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. (PMID: 10880450) Poot RA … Varga-Weisz PD (The EMBO journal 2000) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. (PMID: 14759371) Kukimoto I … Varga-Weisz PD (Molecular cell 2004) 3 22 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58

Products for POLE3 Gene

Sources for POLE3 Gene

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