Aliases for POLDIP3 Gene
External Ids for POLDIP3 Gene
Previous GeneCards Identifiers for POLDIP3 Gene
This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for POLDIP3 Gene
POLDIP3 (DNA Polymerase Delta Interacting Protein 3) is a Protein Coding gene. Diseases associated with POLDIP3 include Methylmalonic Aciduria, Cblb Type. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ALYREF.
UniProtKB/Swiss-Prot Summary for POLDIP3 Gene
Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex.