This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of... See more...

Aliases for POLD2 Gene

Aliases for POLD2 Gene

  • DNA Polymerase Delta 2, Accessory Subunit 2 3 5
  • DNA Polymerase Delta Subunit P50 2 3 4
  • Polymerase (DNA Directed), Delta 2, Regulatory Subunit 50kDa 2 3
  • Polymerase (DNA) Delta 2, Accessory Subunit 2 3
  • DNA Polymerase Delta Subunit 2 3 4
  • Pol Delta B Subunit (P50) 2 3
  • Polymerase (DNA Directed), Delta 2, Regulatory Subunit (50kD) 2
  • Polymerase (DNA Directed), Delta 2, Accessory Subunit 3
  • DAN Polymerase Delta 2, Accessory Subunit 3
  • EC 2.7.7.7 51
  • POLD2 5

External Ids for POLD2 Gene

Previous GeneCards Identifiers for POLD2 Gene

  • GC07M043800
  • GC07M043861
  • GC07M043895
  • GC07M043927
  • GC07M044120
  • GC07M044039

Summaries for POLD2 Gene

Entrez Gene Summary for POLD2 Gene

  • This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

GeneCards Summary for POLD2 Gene

POLD2 (DNA Polymerase Delta 2, Accessory Subunit) is a Protein Coding gene. Diseases associated with POLD2 include Xeroderma Pigmentosum, Variant Type. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot Summary for POLD2 Gene

  • Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:22801543, PubMed:17317665, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).

Gene Wiki entry for POLD2 Gene

Additional gene information for POLD2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for POLD2 Gene

Genomics for POLD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for POLD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J044121 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.3 1296 3.5 SP1 CREB1 PRDM10 ZNF629 RFX1 IKZF1 POLR2A ZNF692 TARDBP LARP7 POLD2 lnc-MYL7-1 DDX56 POLM TMED4 SNORA5B SNHG15 ENSG00000228434 SNORA5C SPDYE1
GH07J044146 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -22.5 -22544 2.8 LEF1 IKZF1 JUND PHF21A PKNOX1 REST ZNF740 EZH2 DPF2 HDAC1 GCK LOC105375258 MYL7 POLD2
GH07J044086 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 11.7 +36.2 36166 3.2 HNRNPL KDM1A TAF1 JUND ZNF580 FOS ZNF205 BCOR SAP130 GABPB1 POLM RASA4CP ENSG00000241057 ENSG00000239775 PGAM2 POLD2 AEBP1 YKT6 RF00017-6148
GH07J044157 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 12.2 -34.0 -34043 2.4 IKZF1 FOXA1 SP1 UBTF EGR1 CTCF NR2C2 NCOR1 TBP NR2F1 GCK POLD2 RNA5SP230 AEBP1 POLM ENSG00000239775 PGAM2 LOC105375257 LOC105375258 MYL7
GH07J044196 Enhancer 0.9 Ensembl ENCODE 12.3 -72.1 -72142 1 CTCF PRDM1 ZNF143 PKNOX1 REST RAD21 TRIM22 IRF3 SMC3 RFX5 GCK lnc-GCK-1 MYL7 POLD2 RNA5SP230 POLM AEBP1 YKT6 lnc-YKT6-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for POLD2

Top Transcription factor binding sites by QIAGEN in the POLD2 gene promoter:
  • AP-4
  • c-Myc
  • Egr-4
  • ER-alpha
  • Max
  • Pax-2
  • Pax-2a
  • Pax-2b

Genomic Locations for POLD2 Gene

Genomic Locations for POLD2 Gene
chr7:44,114,680-44,124,358
(GRCh38/hg38)
Size:
9,679 bases
Orientation:
Minus strand
chr7:44,154,286-44,163,957
(GRCh37/hg19)
Size:
9,672 bases
Orientation:
Minus strand

Genomic View for POLD2 Gene

Genes around POLD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLD2 Gene

Proteins for POLD2 Gene

  • Protein details for POLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49005-DPOD2_HUMAN
    Recommended name:
    DNA polymerase delta subunit 2
    Protein Accession:
    P49005
    Secondary Accessions:
    • A4D2J4
    • B2R5S4

    Protein attributes for POLD2 Gene

    Size:
    469 amino acids
    Molecular mass:
    51289 Da
    Quaternary structure:
    • Component of both the DNA polymerase delta and DNA polymerase zeta complexes (PubMed:22801543, PubMed:17317665, PubMed:24449906). Component of the tetrameric DNA polymerase delta complex (Pol-delta4), which consists of POLD1/p125, POLD2/p50, POLD3/p66/p68 and POLD4/p12, with POLD1 bearing DNA polymerase and 3' to 5' proofreading exonuclease activities (PubMed:22801543, PubMed:17317665). Within Pol-delta4, directly interacts with POLD1, POLD3 and POLD4 (PubMed:11328591, PubMed:16510448). Following stress caused by DNA damaging agents or by replication stress, POLD4 is degraded and Pol-delta4 is converted into a trimeric form of the complex (Pol-delta3), which consists of POLD1, POLD2 and POLD3. Pol-delta3 is the major form occurring at S phase replication sites, as well as DNA damage sites (PubMed:22801543, PubMed:17317665). Also observed as a dimeric complex with POLD2 (Pol-delta2 complex). Pol-delta2 is relatively insensitive to the PCNA stimulation (2-5-fold) compared to Pol-delta4 that is stimulated by over 50-fold (PubMed:12403614). Contrary to the other components of Pol-delta4, does not directly interact with PCNA (PubMed:12403614, PubMed:16510448). As POLD1 and POLD4, directly interacts with WRNIP1; this interaction stimulates DNA polymerase delta-mediated DNA synthesis, independently of the presence of PCNA. This stimulation may be due predominantly to an increase of initiation frequency and also to increased processivity (PubMed:15670210). Directly interacts with POLDIP2 and POLDIP3 (PubMed:12522211). Directly interacts with KCTD13/PDIP1; in the presence of PCNA, this interaction may stimulate DNA polymerase activity (PubMed:11593007). Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3, with REV3L bearing DNA polymerase catalytic activity (PubMed:24449906). Interacts with KCTD10 (By similarity).

    Three dimensional structures from OCA and Proteopedia for POLD2 Gene

neXtProt entry for POLD2 Gene

Selected DME Specific Peptides for POLD2 Gene

P49005:
  • PTAPDTLGCYPFYK
  • RQYAHIYATRL
  • ECPHVYFCGNTPSFGSK
  • KKTQAASVEAVKMLDEILLQ
  • VKKLCELQP
  • SRVILAGNLLS

Post-translational modifications for POLD2 Gene

  • Ubiquitination at Lys81, Lys90, Lys99, Lys125, Lys267, Lys389, and Lys413
  • Modification sites at PhosphoSitePlus

Domains & Families for POLD2 Gene

Gene Families for POLD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for POLD2 Gene

Suggested Antigen Peptide Sequences for POLD2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ78293, highly similar to Homo sapiens polymerase (DNA directed), delta 2, regulatory subunit 50kDa (POLD2), mRNA (A4D2J4_HUMAN)
  • DNA polymerase delta subunit p50 (DPOD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49005

UniProtKB/Swiss-Prot:

DPOD2_HUMAN :
  • Belongs to the DNA polymerase delta/II small subunit family.
Family:
  • Belongs to the DNA polymerase delta/II small subunit family.
genes like me logo Genes that share domains with POLD2: view

Function for POLD2 Gene

Molecular function for POLD2 Gene

UniProtKB/Swiss-Prot Function:
Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:22801543, PubMed:17317665, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).
GENATLAS Biochemistry:
polymerase (DNA directed) delta 2,small catalytic subunit 48kDa,involved in DNA replication of nuclear genome

Enzyme Numbers (IUBMB) for POLD2 Gene

Phenotypes From GWAS Catalog for POLD2 Gene

Gene Ontology (GO) - Molecular Function for POLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0005515 protein binding IPI 12403614
genes like me logo Genes that share ontologies with POLD2: view
genes like me logo Genes that share phenotypes with POLD2: view

Animal Models for POLD2 Gene

MGI Knock Outs for POLD2:
  • Pold2 Pold2<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for POLD2 Gene

miRTarBase miRNAs that target POLD2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLD2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLD2 Gene

Localization for POLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLD2 Gene

Nucleus. Note=Recruited to DNA damage sites within 2 hours following UV irradiation. {ECO:0000269 PubMed:22801543}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLD2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8530069
GO:0005654 nucleoplasm IDA,TAS --
GO:0016035 zeta DNA polymerase complex IDA 22465957
GO:0042575 DNA polymerase complex IBA 21873635
GO:0043625 delta DNA polymerase complex IEA,IDA 11595739
genes like me logo Genes that share ontologies with POLD2: view

Pathways & Interactions for POLD2 Gene

PathCards logo

SuperPathways for POLD2 Gene

SuperPathway Contained pathways
1 Telomere C-strand (Lagging Strand) Synthesis
.48
2 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
3 Mismatch repair
4 DNA Double-Strand Break Repair
5 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
genes like me logo Genes that share pathways with POLD2: view

Pathways by source for POLD2 Gene

1 GeneGo (Thomson Reuters) pathway for POLD2 Gene
  • Cell cycle Transition and termination of DNA replication
2 Qiagen pathways for POLD2 Gene
  • Cell Cycle Control of Chromosomal Replication
  • DNA Repair Mechanisms

Gene Ontology (GO) - Biological Process for POLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance TAS --
GO:0006260 DNA replication IEA,TAS 8530069
GO:0006261 DNA-dependent DNA replication IEA --
GO:0006271 DNA strand elongation involved in DNA replication IBA 21873635
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with POLD2: view

No data available for SIGNOR curated interactions for POLD2 Gene

Drugs & Compounds for POLD2 Gene

(4) Drugs for POLD2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dATP Experimental Pharma Agonist, Full agonist 0
dctp Experimental Pharma 0
dgtp Experimental Pharma 0
Thymidine 5'-triphosphate Experimental Pharma 0

(1) Additional Compounds for POLD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with POLD2: view

Transcripts for POLD2 Gene

mRNA/cDNA for POLD2 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for POLD2

Alternative Splicing Database (ASD) splice patterns (SP) for POLD2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - - - -
SP8: - - -
SP9:
SP10:
SP11: - - -
SP12: - - - -
SP13: - - - -
SP14: - - - - - - - - - -
SP15:
SP16:
SP17: -

ExUns: 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c
SP1: -
SP2:
SP3:
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:

Relevant External Links for POLD2 Gene

GeneLoc Exon Structure for
POLD2

Expression for POLD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for POLD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLD2 Gene

This gene is overexpressed in Breast (30.6) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLD2 Gene



Protein tissue co-expression partners for POLD2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for POLD2

SOURCE GeneReport for Unigene cluster for POLD2 Gene:

Hs.306791

Evidence on tissue expression from TISSUES for POLD2 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Skin(3.5)
  • Intestine(3.1)
  • Kidney(2.8)
  • Blood(2.5)
  • Liver(2.2)
  • Muscle(2.2)
  • Heart(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with POLD2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLD2 Gene

Orthologs for POLD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLD2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia POLD2 30 31
  • 99.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia POLD2 30 31
  • 89.55 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Pold2 30 17 31
  • 88.14 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia POLD2 31
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pold2 30
  • 87.41 (n)
Dog
(Canis familiaris)
Mammalia POLD2 30 31
  • 85.53 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia POLD2 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves POLD2 30 31
  • 73.64 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia POLD2 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pold2 30
  • 68.7 (n)
Str.12411 30
African clawed frog
(Xenopus laevis)
Amphibia pold2-prov 30
Zebrafish
(Danio rerio)
Actinopterygii pold2 30 31
  • 66.59 (n)
OneToOne
Dr.18066 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008910 30
  • 51.73 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG12018 30 31
  • 51.28 (n)
OneToOne
BcDNA:HL03874 32
  • 43 (a)
Worm
(Caenorhabditis elegans)
Secernentea F12F6.7 31 32
  • 27 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POL31 31 33
  • 30 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons POLD2 30
  • 48.64 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0128500 30
  • 49.92 (n)
Species where no ortholog for POLD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for POLD2 Gene

ENSEMBL:
Gene Tree for POLD2 (if available)
TreeFam:
Gene Tree for POLD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLD2: view image

Paralogs for POLD2 Gene

Pseudogenes.org Pseudogenes for POLD2 Gene

genes like me logo Genes that share paralogs with POLD2: view

No data available for Paralogs for POLD2 Gene

Variants for POLD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for POLD2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs3087366 - p.Asn303Ser

Additional dbSNP identifiers (rs#s) for POLD2 Gene

Structural Variations from Database of Genomic Variants (DGV) for POLD2 Gene

Variant ID Type Subtype PubMed ID
dgv11297n54 CNV loss 21841781
esv998294 CNV deletion 20482838
nsv428165 CNV gain 18775914
nsv470210 CNV loss 18288195
nsv8082 CNV gain 18304495
nsv830983 CNV loss 17160897

Variation tolerance for POLD2 Gene

Residual Variation Intolerance Score: 7.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for POLD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POLD2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLD2 Gene

Disorders for POLD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for POLD2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
xeroderma pigmentosum, variant type
  • xpv
- elite association - COSMIC cancer census association via MalaCards
Search POLD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for POLD2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Open Targets Platform
genes like me logo Genes that share disorders with POLD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POLD2 Gene

Publications for POLD2 Gene

  1. Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2). (PMID: 8530069) Zhang J … So AG (Genomics 1995) 2 3 4
  2. Polymorphisms in the base excision repair pathway and graft-versus-host disease. (PMID: 20574454) Arora M … Thyagarajan B (Leukemia 2010) 3 41
  3. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. (PMID: 20226869) Thyagarajan B … Arora M (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010) 3 41
  4. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PMID: 19237606) Michiels S … Benhamou S (Carcinogenesis 2009) 3 41
  5. X-ray structure of the complex of regulatory subunits of human DNA polymerase delta. (PMID: 18818516) Baranovskiy AG … Tahirov TH (Cell cycle (Georgetown, Tex.) 2008) 3 4

Products for POLD2 Gene

Sources for POLD2 Gene