Aliases for POLB Gene
External Ids for POLB Gene
Previous GeneCards Identifiers for POLB Gene
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
GeneCards Summary for POLB Gene
POLB (DNA Polymerase Beta) is a Protein Coding gene. Diseases associated with POLB include Werner Syndrome and Chlorhexidine Allergy. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include enzyme binding and damaged DNA binding. An important paralog of this gene is POLL.
UniProtKB/Swiss-Prot Summary for POLB Gene
Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.