Aliases for POLA2 Gene
- DNA Polymerase Alpha 2, Accessory Subunit 2 3 5
- DNA Polymerase Alpha 70 KDa Subunit 2 3 4
- DNA Polymerase Alpha Subunit B 2 3 4
- Polymerase (DNA Directed), Alpha 2 (70kD Subunit) 2 3
- Polymerase (DNA) Alpha 2, Accessory Subunit 2 3
- Polymerase (DNA Directed), Alpha 2, Accessory Subunit 3
- Polymerase (DNA-Directed), Alpha (70kD) 3
- FLJ21662 2
- POLA2 5
External Ids for POLA2 Gene
Previous GeneCards Identifiers for POLA2 Gene
GeneCards Summary for POLA2 Gene
POLA2 (DNA Polymerase Alpha 2, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Mitotic G1-G1/S phases. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and DNA-directed DNA polymerase activity. An important paralog of this gene is ENSG00000285816.
UniProtKB/Swiss-Prot Summary for POLA2 Gene
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).