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Aliases for POLA2 Gene

Aliases for POLA2 Gene

  • DNA Polymerase Alpha 2, Accessory Subunit 2 3 5
  • DNA Polymerase Alpha 70 KDa Subunit 2 3 4
  • Polymerase (DNA Directed), Alpha 2 (70kD Subunit) 2 3
  • Polymerase (DNA) Alpha 2, Accessory Subunit 2 3
  • DNA Polymerase Alpha Subunit B 2 3
  • Polymerase (DNA Directed), Alpha 2, Accessory Subunit 3
  • Polymerase (DNA-Directed), Alpha (70kD) 3

External Ids for POLA2 Gene

Previous GeneCards Identifiers for POLA2 Gene

  • GC11P067545
  • GC11P066711
  • GC11P064804
  • GC11P064786
  • GC11P065029
  • GC11P061356

Summaries for POLA2 Gene

GeneCards Summary for POLA2 Gene

POLA2 (DNA Polymerase Alpha 2, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLA2 Gene

  • May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.

Gene Wiki entry for POLA2 Gene

Additional gene information for POLA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLA2 Gene

Genomics for POLA2 Gene

GeneHancer (GH) Regulatory Elements for POLA2 Gene

Promoters and enhancers for POLA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065260 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 702.5 +0.3 313 2.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 POLA2 SF1 PCNX3 SART1 ZFPL1 EIF1AD SF3B2 ENSG00000255320 KAT5 MUS81
GH11J065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 188.4 +228.3 228322 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 POLA2 PCNX3 ZFPL1 EIF1AD SART1 LOC105369352 MUS81 KAT5
GH11J065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 111.1 +162.4 162419 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 ENSG00000278050 ENSG00000278144 GC11P065538 SF1 LOC105369352 ZFPL1 POLA2 EIF1AD
GH11J065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 100.9 +595.7 595722 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD ENSG00000258297 POLA2 RBM14 SART1 PCNX3 RBM4 ZFPL1
GH11J065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 73.6 +633.7 633696 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP DRAP1 RBM14 ENSG00000258297 KAT5 MUS81 SART1 SF3B2 RBM4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around POLA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the POLA2 gene promoter:
  • NF-1/L
  • NF-1
  • AML1a
  • MyoD
  • SEF-1 (1)
  • E47
  • c-Myc
  • Max1
  • Meis-1b
  • Meis-1a

Genomic Locations for POLA2 Gene

Genomic Locations for POLA2 Gene
chr11:65,261,762-65,305,598
(GRCh38/hg38)
Size:
43,837 bases
Orientation:
Plus strand
chr11:65,029,233-65,073,060
(GRCh37/hg19)
Size:
43,828 bases
Orientation:
Plus strand

Genomic View for POLA2 Gene

Genes around POLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLA2 Gene

Proteins for POLA2 Gene

  • Protein details for POLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14181-DPOA2_HUMAN
    Recommended name:
    DNA polymerase alpha subunit B
    Protein Accession:
    Q14181
    Secondary Accessions:
    • B4DNB4
    • Q9BPV3

    Protein attributes for POLA2 Gene

    Size:
    598 amino acids
    Molecular mass:
    65948 Da
    Quaternary structure:
    • DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Subunit B binds to subunit A.

    Three dimensional structures from OCA and Proteopedia for POLA2 Gene

    Alternative splice isoforms for POLA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLA2 Gene

Post-translational modifications for POLA2 Gene

  • Phosphorylated in a cell cycle-dependent manner, in G2/M phase.
  • Ubiquitination at Lys564, posLast=500500, Lys292, posLast=212212, Lys207, posLast=194194, Lys160, and Lys72
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for POLA2 Gene

Domains & Families for POLA2 Gene

Gene Families for POLA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for POLA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14181

UniProtKB/Swiss-Prot:

DPOA2_HUMAN :
  • The N-terminal 240 amino acids are sufficient to mediate complex formation.
  • Belongs to the DNA polymerase alpha subunit B family.
Domain:
  • The N-terminal 240 amino acids are sufficient to mediate complex formation.
Family:
  • Belongs to the DNA polymerase alpha subunit B family.
genes like me logo Genes that share domains with POLA2: view

Function for POLA2 Gene

Molecular function for POLA2 Gene

UniProtKB/Swiss-Prot Function:
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.

Phenotypes From GWAS Catalog for POLA2 Gene

Gene Ontology (GO) - Molecular Function for POLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0046982 protein heterodimerization activity IBA,IEA --
genes like me logo Genes that share ontologies with POLA2: view
genes like me logo Genes that share phenotypes with POLA2: view

Animal Models for POLA2 Gene

MGI Knock Outs for POLA2:
  • Pola2 Pola2<tm1b(KOMP)Mbp>

Animal Model Products

miRNA for POLA2 Gene

miRTarBase miRNAs that target POLA2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for POLA2 Gene

Localization for POLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for POLA2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for POLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005658 alpha DNA polymerase:primase complex IBA,IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with POLA2: view

Pathways & Interactions for POLA2 Gene

genes like me logo Genes that share pathways with POLA2: view

Gene Ontology (GO) - Biological Process for POLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IEA --
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication NAS,IEA 8223465
GO:0006270 DNA replication initiation TAS --
GO:0032201 telomere maintenance via semi-conservative replication TAS --
genes like me logo Genes that share ontologies with POLA2: view

No data available for SIGNOR curated interactions for POLA2 Gene

Drugs & Compounds for POLA2 Gene

(2) Drugs for POLA2 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dacarbazine Approved, Investigational Pharma Target, other/unknown 719
Fludarabine Phosphate (Fludara) Pharma Inhibits STAT1 activation and DNA synthesis 0
genes like me logo Genes that share compounds with POLA2: view

Transcripts for POLA2 Gene

Unigene Clusters for POLA2 Gene

Polymerase (DNA directed), alpha 2, accessory subunit:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a ·
SP1: - - - -
SP2:
SP3: - - -
SP4:
SP5:
SP6: - -
SP7: -

ExUns: 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for POLA2 Gene

GeneLoc Exon Structure for
POLA2
ECgene alternative splicing isoforms for
POLA2

Expression for POLA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for POLA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLA2 Gene

This gene is overexpressed in Pancreas (30.5), Heart (18.9), and Fetal ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for POLA2 Gene



Protein tissue co-expression partners for POLA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of POLA2 Gene:

POLA2

SOURCE GeneReport for Unigene cluster for POLA2 Gene:

Hs.201897

Evidence on tissue expression from TISSUES for POLA2 Gene

  • Lung(4.5)
  • Heart(4.1)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with POLA2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for POLA2 Gene

Orthologs for POLA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLA2 34 33
  • 99.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia POLA2 34 33
  • 86.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia POLA2 34 33
  • 85.84 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pola2 33
  • 82.83 (n)
mouse
(Mus musculus)
Mammalia Pola2 16 34 33
  • 81.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
-- 34
  • 74 (a)
OneToMany
-- 34
  • 47 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia POLA2 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859759 33
  • 59.87 (n)
POLA2 34
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLA2 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pola2 33
  • 64.59 (n)
Str.6808 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4593 33
zebrafish
(Danio rerio)
Actinopterygii pola2 34 33
  • 62.21 (n)
OneToOne
wufb48f05 33
fruit fly
(Drosophila melanogaster)
Insecta DNApol-alpha73 34 33
  • 47.62 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004392 33
  • 45.82 (n)
worm
(Caenorhabditis elegans)
Secernentea div-1 34
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POL12 36 34
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons POLA2 33
  • 50.25 (n)
rice
(Oryza sativa)
Liliopsida Os12g0242900 33
  • 48.98 (n)
Species where no ortholog for POLA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLA2 Gene

ENSEMBL:
Gene Tree for POLA2 (if available)
TreeFam:
Gene Tree for POLA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for POLA2: view image

Paralogs for POLA2 Gene

No data available for Paralogs for POLA2 Gene

Variants for POLA2 Gene

Sequence variations from dbSNP and Humsavar for POLA2 Gene