This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in... See more...

Aliases for PODXL Gene

Aliases for PODXL Gene

  • Podocalyxin Like 2 3 5
  • Podocalyxin-Like Protein 1 3 4
  • GCTM-2 Antigen 3 4
  • Podocalyxin 3 4
  • PCLP-1 3 4
  • Gp200 3 4
  • PCLP 3 4
  • PC 3 4
  • Podocalyxin-Like 2
  • PCLP1 4

External Ids for PODXL Gene

Previous GeneCards Identifiers for PODXL Gene

  • GC07M129527
  • GC07M130587
  • GC07M130601
  • GC07M130642
  • GC07M130835
  • GC07M131185
  • GC07M125500

Summaries for PODXL Gene

Entrez Gene Summary for PODXL Gene

  • This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]

GeneCards Summary for PODXL Gene

PODXL (Podocalyxin Like) is a Protein Coding gene. Diseases associated with PODXL include Atypical Juvenile Parkinsonism and Parkinson Disease 2, Autosomal Recessive Juvenile. Among its related pathways are Ectoderm Differentiation and Hepatitis C and Hepatocellular Carcinoma.

UniProtKB/Swiss-Prot Summary for PODXL Gene

  • Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Gene Wiki entry for PODXL Gene

Additional gene information for PODXL Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PODXL Gene

Genomics for PODXL Gene

GeneHancer (GH) Regulatory Elements for PODXL Gene

Promoters and enhancers for PODXL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J131553 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +2.3 2266 5.9 HNRNPK NRF1 USF1 ZNF639 ZNF10 ZIC2 ZBTB10 ZBTB26 SAP30 CHD1 PODXL lnc-PODXL-2 piR-48820-091 RF00017-6639
GH07J131602 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 14.1 -47.3 -47314 6.3 USF1 JUND FOS TEAD4 REST GABPA MYC EP300 NFYB CTBP1 PODXL piR-61882 EEF1B2P6 RF00017-6639
GH07J131585 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12 -28.5 -28476 1.8 NRF1 USF1 PHB2 HES1 TSC22D4 MYC CTBP1 EP300 MEF2A NCOR1 PODXL piR-61882 EEF1B2P6 RF00017-6639
GH07J131580 Enhancer 0.8 Ensembl ENCODE dbSUPER 12.1 -23.7 -23675 2.6 USF1 NR2F2 MAX CTCF STAT1 PODXL piR-61882 EEF1B2P6 RF00017-6639
GH07J131521 Enhancer 0.8 ENCODE dbSUPER 11.9 +36.1 36115 2.1 TEAD4 POLR2A IRF1 IRF2 GTF2F1 MCM7 MAZ TCF7L2 PRDM6 GTF3C2 ENSG00000224545 RPL31P36 lnc-MKLN1-3 PODXL MKLN1-AS piR-48820-091 lnc-PODXL-2 RF00017-6639
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PODXL on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PODXL

Top Transcription factor binding sites by QIAGEN in the PODXL gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • p53
  • Sp1
  • USF-1
  • USF1

Genomic Locations for PODXL Gene

Genomic Locations for PODXL Gene
chr7:131,500,262-131,558,217
(GRCh38/hg38)
Size:
57,956 bases
Orientation:
Minus strand
chr7:131,185,021-131,242,976
(GRCh37/hg19)
Size:
57,956 bases
Orientation:
Minus strand

Genomic View for PODXL Gene

Genes around PODXL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PODXL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PODXL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PODXL Gene

Proteins for PODXL Gene

  • Protein details for PODXL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00592-PODXL_HUMAN
    Recommended name:
    Podocalyxin
    Protein Accession:
    O00592
    Secondary Accessions:
    • A6NHX8
    • Q52LZ7
    • Q53ER6

    Protein attributes for PODXL Gene

    Size:
    558 amino acids
    Molecular mass:
    58635 Da
    Quaternary structure:
    • Monomer; when associated with the membrane raft. Oligomer; when integrated in the apical membrane. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R1 (via the PDZ domains); the interaction is not detected in glomerular epithelium cells, take place early in the secretory pathway and is necessary for its apical membrane sorting. Found in a complex with EZR, PODXL and SLC9A3R2. Associates with the actin cytoskeleton through complex formation with EZR and SLC9A3R2. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R2 (via the PDZ 1 domain); interaction is detected in glomerular epithelium cells (By similarity). Interacts with EZR.

    Alternative splice isoforms for PODXL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PODXL Gene

Post-translational modifications for PODXL Gene

  • N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
  • Glycosylation at Asn33, Asn43, Asn104, Thr117, Thr118, Thr119, Ser125, Thr126, Asn144, Ser162, Ser163, Thr167, Thr168, Thr171, Ser172, Thr173, Thr179, Thr180, Thr184, Ser185, Ser188, Thr193, Ser194, Thr195, Thr200, Thr202, Ser203, Ser204, Thr307, Thr309, Ser315, Ser316, Ser317, Thr319, Ser322, Thr323, Thr324, Thr330, Ser332, Thr334, Ser339, Asn360, Thr387, Ser401, Ser405, Thr407, Thr414, and Thr417
  • Ubiquitination at Lys526
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PODXL_HUMAN (1617)

Other Protein References for PODXL Gene

Antibody Products

No data available for DME Specific Peptides for PODXL Gene

Domains & Families for PODXL Gene

Gene Families for PODXL Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for PODXL Gene

Blocks:
  • CD34/Podocalyxin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PODXL Gene

GenScript: Design optimal peptide antigens:
  • PODXL protein (B7ZKQ8_HUMAN)
  • Podocalyxin-like protein 1 (PODXL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00592

UniProtKB/Swiss-Prot:

PODXL_HUMAN :
  • Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes.
  • Belongs to the podocalyxin family.
Domain:
  • Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes.
Family:
  • Belongs to the podocalyxin family.
genes like me logo Genes that share domains with PODXL: view

Function for PODXL Gene

Molecular function for PODXL Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
GENATLAS Biochemistry:
podocalyxin-like protein,integral component of the glomerular epithelial cell glycocalyx

Phenotypes From GWAS Catalog for PODXL Gene

Gene Ontology (GO) - Molecular Function for PODXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22662192
genes like me logo Genes that share ontologies with PODXL: view
genes like me logo Genes that share phenotypes with PODXL: view

Human Phenotype Ontology for PODXL Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for PODXL Gene

miRTarBase miRNAs that target PODXL

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PODXL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PODXL Gene

Localization for PODXL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PODXL Gene

Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Membrane raft. Membrane; Single-pass type I membrane protein. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PODXL gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 3
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Centriolar satellite (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PODXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 18456258
GO:0005615 extracellular space HDA 16502470
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 18456258
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with PODXL: view

Pathways & Interactions for PODXL Gene

genes like me logo Genes that share pathways with PODXL: view

SIGNOR curated interactions for PODXL Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PODXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion ISS --
GO:0016477 cell migration ISS --
GO:0022407 regulation of cell-cell adhesion IEA --
GO:0022408 negative regulation of cell-cell adhesion ISS --
genes like me logo Genes that share ontologies with PODXL: view

Drugs & Compounds for PODXL Gene

No Compound Related Data Available

Transcripts for PODXL Gene

mRNA/cDNA for PODXL Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PODXL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PODXL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for PODXL Gene

GeneLoc Exon Structure for
PODXL

Expression for PODXL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PODXL Gene

mRNA differential expression in normal tissues according to GTEx for PODXL Gene

This gene is overexpressed in Kidney - Cortex (x5.5).

Protein differential expression in normal tissues from HIPED for PODXL Gene

This gene is overexpressed in Nasal epithelium (28.2), Breast (11.3), and Urine (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PODXL Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PODXL

SOURCE GeneReport for Unigene cluster for PODXL Gene:

Hs.744213

mRNA Expression by UniProt/SwissProt for PODXL Gene:

O00592-PODXL_HUMAN
Tissue specificity: Glomerular epithelium cell (podocyte).

Evidence on tissue expression from TISSUES for PODXL Gene

  • Heart(4.5)
  • Liver(4.1)
  • Kidney(3.6)
  • Nervous system(3)
  • Lung(2.9)
  • Intestine(2.1)
  • Muscle(2.1)
  • Urine(2.1)
genes like me logo Genes that share expression patterns with PODXL: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PODXL Gene

Orthologs for PODXL Gene

This gene was present in the common ancestor of chordates.

Orthologs for PODXL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PODXL 31 30
  • 98.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Podxl 31
  • 44 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PODXL 31
  • 41 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PODXL 31
  • 38 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PODXL 31
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves PODXL 31
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PODXL 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9085 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18470 30
zebrafish
(Danio rerio)
Actinopterygii podxl 31
  • 22 (a)
OneToOne
Species where no ortholog for PODXL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PODXL Gene

ENSEMBL:
Gene Tree for PODXL (if available)
TreeFam:
Gene Tree for PODXL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PODXL: view image

Paralogs for PODXL Gene

(7) SIMAP similar genes for PODXL Gene using alignment to 5 proteins:

  • PODXL_HUMAN
  • B7ZKQ8_HUMAN
  • F5GWY5_HUMAN
  • F5H7A2_HUMAN
  • G3V0E6_HUMAN
genes like me logo Genes that share paralogs with PODXL: view

No data available for Paralogs for PODXL Gene

Variants for PODXL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PODXL Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1554391082 Likely Pathogenic: Parkinson disease 2; not provided 131,556,270(-) G/GGGGGCGAC FRAMESHIFT_VARIANT
rs55698400 Uncertain Significance: not provided. - 131,511,158(-) T/Gp.Thr126Pro MISSENSE_VARIANT
rs786204840 Uncertain Significance: not provided 131,505,926(-) A/C MISSENSE_VARIANT
rs869312170 Uncertain Significance: Parkinson disease, late-onset 131,505,966(-) G/T MISSENSE_VARIANT
rs869312171 Uncertain Significance: Parkinson disease, late-onset 131,506,614(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for PODXL Gene

Structural Variations from Database of Genomic Variants (DGV) for PODXL Gene

Variant ID Type Subtype PubMed ID
dgv6617n100 CNV gain 25217958
esv2735154 CNV deletion 23290073
esv2735155 CNV deletion 23290073
esv2735156 CNV deletion 23290073
esv7269 CNV gain 19470904
nsv1126809 CNV deletion 24896259
nsv473637 CNV novel sequence insertion 20440878
nsv608424 CNV loss 21841781
nsv831134 CNV gain 17160897
nsv981580 CNV duplication 23825009

Variation tolerance for PODXL Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PODXL Gene

Human Gene Mutation Database (HGMD)
PODXL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PODXL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PODXL Gene

Disorders for PODXL Gene

MalaCards: The human disease database

(11) MalaCards diseases for PODXL Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
atypical juvenile parkinsonism
parkinson disease 2, autosomal recessive juvenile
  • park2
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
focal segmental glomerulosclerosis
  • fgs
familial nephrotic syndrome
  • congenital nephrotic syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PODXL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PODXL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PODXL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PODXL Gene

Publications for PODXL Gene

  1. Expression of podocalyxin enhances the adherence, migration, and intercellular communication of cells. (PMID: 18456258) Larrucea S … Parrilla R (Experimental cell research 2008) 3 4 23 54
  2. Podocalyxin variants and risk of prostate cancer and tumor aggressiveness. (PMID: 16434482) Casey G … Witte JS (Human molecular genetics 2006) 3 23 41 54
  3. Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin. (PMID: 12504081) Schopperle WM … DeWolf WC (Biochemical and biophysical research communications 2003) 3 4 23 54
  4. Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin. (PMID: 9188463) Kershaw DB … Wiggins RC (The Journal of biological chemistry 1997) 3 4 23 54
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 41 54

Products for PODXL Gene

Sources for PODXL Gene