This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learni... See more...

Aliases for PNOC Gene

Aliases for PNOC Gene

  • Prepronociceptin 2 3 4 5
  • Orphanin FQ 2 3
  • Nocistatin 2 3
  • OFQ 3 4
  • Pre-Pro-N/OFQ 3
  • Pronociceptin 3
  • Nociceptin 3
  • PpN/OFQ 3
  • N/OFQ 3
  • PPNOC 3
  • NOP 3

External Ids for PNOC Gene

Previous GeneCards Identifiers for PNOC Gene

  • GC08P027957
  • GC08P028679
  • GC08P028196
  • GC08P028230
  • GC08P028174
  • GC08P026719

Summaries for PNOC Gene

Entrez Gene Summary for PNOC Gene

  • This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]

GeneCards Summary for PNOC Gene

PNOC (Prepronociceptin) is a Protein Coding gene. Diseases associated with PNOC include Postpartum Depression and Drug Dependence. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include neuropeptide hormone activity and opioid peptide activity. An important paralog of this gene is PENK.

UniProtKB/Swiss-Prot Summary for PNOC Gene

  • Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
  • Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
  • Orphanin FQ2: Has potent analgesic activity.

Tocris Summary for PNOC Gene

  • The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and mu receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).

Additional gene information for PNOC Gene

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PNOC Gene

Genomics for PNOC Gene

GeneHancer (GH) Regulatory Elements for PNOC Gene

Promoters and enhancers for PNOC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PNOC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PNOC gene promoter:
  • AREB6
  • C/EBPalpha
  • HEN1
  • IRF-7A
  • p300
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)
  • ZID

Genomic Locations for PNOC Gene

Genomic Locations for PNOC Gene
chr8:28,316,986-28,343,355
(GRCh38/hg38)
Size:
26,370 bases
Orientation:
Plus strand
chr8:28,174,503-28,200,872
(GRCh37/hg19)
Size:
26,370 bases
Orientation:
Plus strand

Genomic View for PNOC Gene

Genes around PNOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNOC Gene

Proteins for PNOC Gene

  • Protein details for PNOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13519-PNOC_HUMAN
    Recommended name:
    Prepronociceptin
    Protein Accession:
    Q13519
    Secondary Accessions:
    • B7Z749
    • Q6FH16

    Protein attributes for PNOC Gene

    Size:
    176 amino acids
    Molecular mass:
    20295 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PNOC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNOC Gene

Post-translational modifications for PNOC Gene

  • Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
  • The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PNOC Gene

Antibody Products

No data available for DME Specific Peptides for PNOC Gene

Domains & Families for PNOC Gene

Gene Families for PNOC Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PNOC Gene

Suggested Antigen Peptide Sequences for PNOC Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50894, highly similar to Nociceptin (B7Z749_HUMAN)
  • Prepronociceptin (PNOC_HUMAN)
  • Prepronociceptin, isoform CRA_a (Q6FH16_HUMAN)
  • Prepronociceptin (Q9BYY3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13519

UniProtKB/Swiss-Prot:

PNOC_HUMAN :
  • Belongs to the opioid neuropeptide precursor family.
Family:
  • Belongs to the opioid neuropeptide precursor family.
genes like me logo Genes that share domains with PNOC: view

Function for PNOC Gene

Molecular function for PNOC Gene

UniProtKB/Swiss-Prot Function:
Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
UniProtKB/Swiss-Prot Function:
Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
UniProtKB/Swiss-Prot Function:
Orphanin FQ2: Has potent analgesic activity.
GENATLAS Biochemistry:
prepronociceptin,precursor of the natural agonist of opioid receptor-like receptor,expressed in the central nervous system and (weakly) ovary

Phenotypes From GWAS Catalog for PNOC Gene

Gene Ontology (GO) - Molecular Function for PNOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001515 opioid peptide activity IEA --
GO:0005184 neuropeptide hormone activity TAS 10419552
GO:0031628 opioid receptor binding IBA 21873635
genes like me logo Genes that share ontologies with PNOC: view
genes like me logo Genes that share phenotypes with PNOC: view

Animal Models for PNOC Gene

MGI Knock Outs for PNOC:

Animal Model Products

CRISPR Products

miRNA for PNOC Gene

miRTarBase miRNAs that target PNOC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNOC

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PNOC Gene

Localization for PNOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNOC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNOC gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PNOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane IBA 21873635
GO:0030425 dendrite IBA 21873635
GO:0043025 neuronal cell body IBA 21873635
GO:0043679 axon terminus IBA 21873635
genes like me logo Genes that share ontologies with PNOC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PNOC Gene

Pathways & Interactions for PNOC Gene

genes like me logo Genes that share pathways with PNOC: view

Gene Ontology (GO) - Biological Process for PNOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9521323
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with PNOC: view

No data available for SIGNOR curated interactions for PNOC Gene

Drugs & Compounds for PNOC Gene

(42) Drugs for PNOC Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nocistatin (bovine) Pharma 0
[(pF)Phe4]Nociceptin(1-13)NH2 Pharma Potent, selective nociceptin receptor agonist 0
Ac-RYYRWK-NH2 Pharma Potent, selective NOP partial agonist peptide 0
Nociceptin Pharma Endogenous NOP agonist 8
Nociceptin (1-13)NH2 Pharma Potent ORL1 agonist 0

(22) Additional Compounds for PNOC Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Phe1psi(CH2-NH)Gly2]Nociceptin(1-13)NH2
213130-17-7

(5) Tocris Compounds for PNOC Gene

Compound Action Cas Number
[(pF)Phe4]Nociceptin(1-13)NH2 Potent, selective nociceptin receptor agonist 380620-88-2
[Phe1psi(CH2-NH)Gly2]Nociceptin(1-13)NH2 Selective nociceptin receptor agonist 213130-17-7
Ac-RYYRWK-NH2 Potent, selective NOP partial agonist peptide 200959-47-3
Nociceptin Endogenous NOP agonist 170713-75-4
Nociceptin (1-13)NH2 Potent ORL1 agonist 178064-02-3

(1) ApexBio Compounds for PNOC Gene

Compound Action Cas Number
Nocistatin (bovine) 208253-85-4
genes like me logo Genes that share compounds with PNOC: view

Transcripts for PNOC Gene

mRNA/cDNA for PNOC Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNOC

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNOC Gene

No ASD Table

Relevant External Links for PNOC Gene

GeneLoc Exon Structure for
PNOC
ECgene alternative splicing isoforms for
PNOC

Expression for PNOC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNOC Gene

mRNA differential expression in normal tissues according to GTEx for PNOC Gene

This gene is overexpressed in Spleen (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of PNOC Gene:

PNOC

SOURCE GeneReport for Unigene cluster for PNOC Gene:

Hs.88218

mRNA Expression by UniProt/SwissProt for PNOC Gene:

Q13519-PNOC_HUMAN
Tissue specificity: Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.

Evidence on tissue expression from TISSUES for PNOC Gene

  • Nervous system(4.6)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with PNOC: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNOC Gene

Orthologs for PNOC Gene

This gene was present in the common ancestor of chordates.

Orthologs for PNOC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNOC 33 32
  • 99.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PNOC 33 32
  • 86.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PNOC 33 32
  • 85.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pnoc 17 33 32
  • 85.31 (n)
rat
(Rattus norvegicus)
Mammalia Pnoc 32
  • 83.88 (n)
oppossum
(Monodelphis domestica)
Mammalia PNOC 33
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PNOC 33
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNOC 33
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PNOC 33
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pnoc 32
  • 58.28 (n)
zebrafish
(Danio rerio)
Actinopterygii pnoca 33 32
  • 50 (n)
OneToMany
pnocb 33
  • 28 (a)
OneToMany
Species where no ortholog for PNOC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PNOC Gene

ENSEMBL:
Gene Tree for PNOC (if available)
TreeFam:
Gene Tree for PNOC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PNOC: view image

Paralogs for PNOC Gene

Paralogs for PNOC Gene

(1) SIMAP similar genes for PNOC Gene using alignment to 4 proteins:

  • PNOC_HUMAN
  • B7Z749_HUMAN
  • E7EVP0_HUMAN
  • Q9BYY3_HUMAN
genes like me logo Genes that share paralogs with PNOC: view

Variants for PNOC Gene

Sequence variations from dbSNP and Humsavar for PNOC Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000018752 -- 28,341,623(+) T/C intron_variant
rs1000067654 -- 28,320,373(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000091992 -- 28,341,362(+) T/C intron_variant
rs1000171890 -- 28,318,287(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000204714 -- 28,318,545(+) G/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PNOC Gene

Variant ID Type Subtype PubMed ID
dgv456n21 CNV gain 19592680
nsv6134 CNV insertion 18451855
nsv819240 CNV gain 19587683

Variation tolerance for PNOC Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PNOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNOC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNOC Gene

Disorders for PNOC Gene

MalaCards: The human disease database

(8) MalaCards diseases for PNOC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
postpartum depression
  • maternity blues
drug dependence
pain agnosia
  • analgesia
agnosia
  • alexia
alcohol dependence
  • alcoholism
- elite association - COSMIC cancer census association via MalaCards
Search PNOC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PNOC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PNOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNOC Gene

Publications for PNOC Gene

  1. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. (PMID: 8710928) Mollereau C … Parmentier M (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 23 56
  2. Human neutrophils as a source of nociceptin: a novel link between pain and inflammation. (PMID: 12950177) Fiset ME … Pouliot M (Biochemistry 2003) 3 4 23 56
  3. Genetic association studies of schizophrenia using the 8p21-22 genes: prepronociceptin (PNOC), neuronal nicotinic cholinergic receptor alpha polypeptide 2 (CHRNA2) and arylamine N-acetyltransferase 1 (NAT1). (PMID: 11436130) Blaveri E … Gurling HM (European journal of human genetics : EJHG 2001) 3 23 43 56
  4. Primary structure and tissue distribution of the orphanin FQ precursor. (PMID: 8710930) Nothacker HP … Civelli O (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 23 56
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56

Products for PNOC Gene

Sources for PNOC Gene