Aliases for PNOC Gene
External Ids for PNOC Gene
Previous GeneCards Identifiers for PNOC Gene
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]
GeneCards Summary for PNOC Gene
PNOC (Prepronociceptin) is a Protein Coding gene. Diseases associated with PNOC include Postpartum Depression and Drug Dependence. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include neuropeptide hormone activity and opioid peptide activity. An important paralog of this gene is PENK.
UniProtKB/Swiss-Prot Summary for PNOC Gene
Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.
Orphanin FQ2: Has potent analgesic activity.
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and mu receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).