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Aliases for PNO1 Gene

Aliases for PNO1 Gene

  • Partner Of NOB1 Homolog 2 3 5
  • KH-Type RNA-Binding Protein 1 2 3
  • RNA Binding Protein 2 3
  • Partner Of NOB1 Homolog (S. Cerevisiae) 2
  • KH-Type RNA Binding Protein 1 2
  • RNA-Binding Protein PNO1 3
  • KHRBP1 3
  • RRP20 3

External Ids for PNO1 Gene

Previous HGNC Symbols for PNO1 Gene

  • KHRBP1

Previous GeneCards Identifiers for PNO1 Gene

  • GC02P068238
  • GC02P068384
  • GC02P068122

Summaries for PNO1 Gene

GeneCards Summary for PNO1 Gene

PNO1 (Partner Of NOB1 Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for PNO1 Gene

  • Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3-end of 18S rRNA (PubMed:25851604).

Gene Wiki entry for PNO1 Gene

Additional gene information for PNO1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNO1 Gene

Genomics for PNO1 Gene

GeneHancer (GH) Regulatory Elements for PNO1 Gene

Promoters and enhancers for PNO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I068156 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 165 3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 YY1 PNO1 WDR92 PPP3R1 PIR60274 ENSG00000273398 GC02P067636
GH02I068248 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 +93.8 93761 5.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PPP3R1 WDR92 ETAA1 PNO1 LOC102724389 ENSG00000273398 GC02P067636
GH02I068192 Enhancer 1.5 VISTA Ensembl ENCODE dbSUPER 11.9 +36.0 35997 2.2 JUN TAL1 CEBPG CHAMP1 FOSL1 TCF12 ZNF316 NCOR1 EGR1 CBFA2T2 WDR92 PPP3R1 PNO1 ENSG00000273275 LOC102724389 ENSG00000273398 GC02P067636
GH02I068120 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.9 -36.7 -36712 1.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT FEZF1 IRF4 YY1 ZNF766 E2F8 WDR92 PNO1 CNRIP1 C1D PPIAP64 LOC105374789 GC02P067636
GH02I068190 Enhancer 1.1 Ensembl ENCODE dbSUPER 12 +33.5 33518 1.7 MEIS2 FOXA2 JUN CEBPG FOSL1 PRDM10 FOSL2 FOS ZNF362 CEBPB PPP3R1 WDR92 PNO1 ENSG00000273275 LOC102724389 ENSG00000273398 GC02P067636
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PNO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PNO1 gene promoter:

Genomic Locations for PNO1 Gene

Genomic Locations for PNO1 Gene
chr2:68,157,844-68,176,238
(GRCh38/hg38)
Size:
18,395 bases
Orientation:
Plus strand
chr2:68,384,976-68,403,370
(GRCh37/hg19)

Genomic View for PNO1 Gene

Genes around PNO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNO1 Gene

Proteins for PNO1 Gene

  • Protein details for PNO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX1-PNO1_HUMAN
    Recommended name:
    RNA-binding protein PNO1
    Protein Accession:
    Q9NRX1
    Secondary Accessions:
    • A8K6Q0
    • Q53G13
    • Q8WVB8

    Protein attributes for PNO1 Gene

    Size:
    252 amino acids
    Molecular mass:
    27924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PNO1 Gene

Post-translational modifications for PNO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PNO1 Gene

No data available for DME Specific Peptides for PNO1 Gene

Domains & Families for PNO1 Gene

Gene Families for PNO1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PNO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PNO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX1

UniProtKB/Swiss-Prot:

PNO1_HUMAN :
  • Belongs to the PNO1 family.
Family:
  • Belongs to the PNO1 family.
genes like me logo Genes that share domains with PNO1: view

Function for PNO1 Gene

Molecular function for PNO1 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3-end of 18S rRNA (PubMed:25851604).

Phenotypes From GWAS Catalog for PNO1 Gene

Gene Ontology (GO) - Molecular Function for PNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22681889
genes like me logo Genes that share ontologies with PNO1: view
genes like me logo Genes that share phenotypes with PNO1: view

Animal Models for PNO1 Gene

MGI Knock Outs for PNO1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PNO1 Gene

Localization for PNO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNO1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNO1 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 15497447
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PNO1: view

Pathways & Interactions for PNO1 Gene

genes like me logo Genes that share pathways with PNO1: view

Gene Ontology (GO) - Biological Process for PNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with PNO1: view

No data available for SIGNOR curated interactions for PNO1 Gene

Drugs & Compounds for PNO1 Gene

No Compound Related Data Available

Transcripts for PNO1 Gene

Unigene Clusters for PNO1 Gene

Partner of NOB1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - -
SP3:

Relevant External Links for PNO1 Gene

GeneLoc Exon Structure for
PNO1
ECgene alternative splicing isoforms for
PNO1

Expression for PNO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PNO1 Gene

This gene is overexpressed in Breast (45.2) and Lung (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PNO1 Gene



Protein tissue co-expression partners for PNO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PNO1 Gene:

PNO1

SOURCE GeneReport for Unigene cluster for PNO1 Gene:

Hs.262858

mRNA Expression by UniProt/SwissProt for PNO1 Gene:

Q9NRX1-PNO1_HUMAN
Tissue specificity: Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weakly or not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for PNO1 Gene

  • Adrenal gland(4.2)
  • Eye(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with PNO1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNO1 Gene

Orthologs for PNO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PNO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNO1 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia PNO1 33 34
  • 87.92 (n)
cow
(Bos Taurus)
Mammalia PNO1 33 34
  • 87.57 (n)
mouse
(Mus musculus)
Mammalia Pno1 33 16 34
  • 87.37 (n)
rat
(Rattus norvegicus)
Mammalia Pno1 33
  • 85.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PNO1 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PNO1 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PNO1 33 34
  • 71.09 (n)
lizard
(Anolis carolinensis)
Reptilia PNO1 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pno1 33
  • 73.05 (n)
Str.8210 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53417 33
zebrafish
(Danio rerio)
Actinopterygii pno1 33 34
  • 66.52 (n)
zgc65782 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8532 33
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0004 33 34
  • 59.89 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004145 33
  • 59.18 (n)
worm
(Caenorhabditis elegans)
Secernentea Y53C12B.2 33 34
  • 60.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PNO1 33 34 36
  • 61.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06446g 33
  • 60.37 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR390C 33
  • 57.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G13230 33
  • 57.94 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10303 33
rice
(Oryza sativa)
Liliopsida Os03g0115200 33
  • 56.22 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.699 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 69 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rbp28 33
  • 57.64 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07956 33
  • 53.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11273 33
Species where no ortholog for PNO1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PNO1 Gene

ENSEMBL:
Gene Tree for PNO1 (if available)
TreeFam:
Gene Tree for PNO1 (if available)

Paralogs for PNO1 Gene

Pseudogenes.org Pseudogenes for PNO1 Gene

genes like me logo Genes that share paralogs with PNO1: view

No data available for Paralogs for PNO1 Gene

Variants for PNO1 Gene

Sequence variations from dbSNP and Humsavar for PNO1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000084481 -- 68,165,228(+) G/A intron_variant
rs1000115082 -- 68,163,040(+) C/A intron_variant
rs1000372833 -- 68,157,296(+) C/T upstream_transcript_variant
rs1001070748 -- 68,170,679(+) C/T intron_variant
rs1001127133 -- 68,164,295(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PNO1 Gene

Variant ID Type Subtype PubMed ID
nsv834251 CNV loss 17160897

Variation tolerance for PNO1 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PNO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNO1 Gene

Disorders for PNO1 Gene

Additional Disease Information for PNO1

No disorders were found for PNO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNO1 Gene

Publications for PNO1 Gene

  1. Cloning and characterization of a novel human RNA binding protein gene PNO1. (PMID: 15497447) Zhou GJ … Yu L (DNA sequence : the journal of DNA sequencing and mapping 2004) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PNO1 Gene

Sources for PNO1 Gene

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