Aliases for PNMT Gene
External Ids for PNMT Gene
Previous HGNC Symbols for PNMT Gene
Previous GeneCards Identifiers for PNMT Gene
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for PNMT Gene
PNMT (Phenylethanolamine N-Methyltransferase) is a Protein Coding gene. Diseases associated with PNMT include Extra-Adrenal Pheochromocytoma and Von Hippel-Lindau Syndrome. Among its related pathways are noradrenaline and adrenaline degradation and Biogenic Amine Synthesis. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and phenylethanolamine N-methyltransferase activity. An important paralog of this gene is NNMT.
UniProtKB/Swiss-Prot Summary for PNMT Gene
Converts noradrenaline to adrenaline.