Aliases for PNMA8B Gene

Aliases for PNMA8B Gene

  • PNMA Family Member 8B 2 3 5
  • Paraneoplastic Ma Antigen Family Member 8B 2 3
  • Paraneoplastic Ma Antigen Family Like 2 2 3
  • Paraneoplastic Antigen-Like Protein 8B 3 4
  • PNMA-Like Protein 2 3 4
  • PNMA-Like 2 2 3
  • PNMAL2 3 4
  • KIAA1183 4

External Ids for PNMA8B Gene

Previous HGNC Symbols for PNMA8B Gene

  • PNMAL2

Summaries for PNMA8B Gene

GeneCards Summary for PNMA8B Gene

PNMA8B (PNMA Family Member 8B) is a Protein Coding gene. An important paralog of this gene is PNMA8A.

Additional gene information for PNMA8B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PNMA8B Gene

Genomics for PNMA8B Gene

GeneHancer (GH) Regulatory Elements for PNMA8B Gene

Promoters and enhancers for PNMA8B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PNMA8B on UCSC Golden Path with GeneCards custom track

Genomic Locations for PNMA8B Gene

Genomic Locations for PNMA8B Gene
chr19:46,486,906-46,496,498
(GRCh38/hg38)
Size:
9,593 bases
Orientation:
Minus strand
chr19:46,990,163-46,999,755
(GRCh37/hg19)
Size:
9,593 bases
Orientation:
Minus strand

Genomic View for PNMA8B Gene

Genes around PNMA8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNMA8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNMA8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNMA8B Gene

Proteins for PNMA8B Gene

  • Protein details for PNMA8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULN7-PNM8B_HUMAN
    Recommended name:
    Paraneoplastic antigen-like protein 8B
    Protein Accession:
    Q9ULN7
    Secondary Accessions:
    • C9JGD5
    • M0R374
    • Q08E79
    • Q0D2F9
    • Q6ZVD1

    Protein attributes for PNMA8B Gene

    Size:
    635 amino acids
    Molecular mass:
    68615 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PNMA8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNMA8B Gene

Post-translational modifications for PNMA8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PNMA8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PNMA8B Gene

Domains & Families for PNMA8B Gene

Gene Families for PNMA8B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PNMA8B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PNMA8B Gene

GenScript: Design optimal peptide antigens:
  • PNMA-like protein 2 (PNML2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULN7

UniProtKB/Swiss-Prot:

PNM8B_HUMAN :
  • Belongs to the PNMA family.
Family:
  • Belongs to the PNMA family.
genes like me logo Genes that share domains with PNMA8B: view

Function for PNMA8B Gene

Phenotypes From GWAS Catalog for PNMA8B Gene

Phenotypes for PNMA8B Gene

genes like me logo Genes that share phenotypes with PNMA8B: view

Animal Model Products

CRISPR Products

miRNA for PNMA8B Gene

miRTarBase miRNAs that target PNMA8B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNMA8B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PNMA8B Gene

Localization for PNMA8B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNMA8B gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PNMA8B Gene

Pathways & Interactions for PNMA8B Gene

PathCards logo

SuperPathways for PNMA8B Gene

No Data Available

Gene Ontology (GO) - Biological Process for PNMA8B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PNMA8B Gene

Drugs & Compounds for PNMA8B Gene

No Compound Related Data Available

Transcripts for PNMA8B Gene

mRNA/cDNA for PNMA8B Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNMA8B

Alternative Splicing Database (ASD) splice patterns (SP) for PNMA8B Gene

No ASD Table

Relevant External Links for PNMA8B Gene

GeneLoc Exon Structure for
PNMA8B
ECgene alternative splicing isoforms for
PNMA8B

Expression for PNMA8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PNMA8B Gene:

PNMA8B
genes like me logo Genes that share expression patterns with PNMA8B: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNMA8B Gene

Orthologs for PNMA8B Gene

This gene was present in the common ancestor of mammals.

Orthologs for PNMA8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PNMAL2 33 32
  • 99.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PNMAL2 33 32
  • 73.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PNMAL2 32
  • 72.96 (n)
-- 33
  • 27 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pnmal2 17 33 32
  • 71 (n)
rat
(Rattus norvegicus)
Mammalia Pnmal2 32
  • 70.88 (n)
Species where no ortholog for PNMA8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNMA8B Gene

ENSEMBL:
Gene Tree for PNMA8B (if available)
TreeFam:
Gene Tree for PNMA8B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PNMA8B: view image

Paralogs for PNMA8B Gene

genes like me logo Genes that share paralogs with PNMA8B: view

Variants for PNMA8B Gene

Sequence variations from dbSNP and Humsavar for PNMA8B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000265498 -- 46,493,401(-) G/A 3_prime_UTR_variant
rs1000269308 -- 46,494,078(-) A/C coding_sequence_variant, missense_variant
rs1000465880 -- 46,494,900(-) G/A coding_sequence_variant, missense_variant
rs1000861251 -- 46,490,694(-) C/T downstream_transcript_variant
rs1000975204 -- 46,490,934(-) C/T downstream_transcript_variant

Variation tolerance for PNMA8B Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.62; 91.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PNMA8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNMA8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PNMA8B Gene

Disorders for PNMA8B Gene

Additional Disease Information for PNMA8B

No disorders were found for PNMA8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNMA8B Gene

Publications for PNMA8B Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 56
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 56
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 56

Products for PNMA8B Gene

Sources for PNMA8B Gene