Aliases for PNMA8A Gene

Aliases for PNMA8A Gene

  • PNMA Family Member 8A 2 3 5
  • Paraneoplastic Ma Antigen Family Member 8A 2 3
  • Paraneoplastic Ma Antigen Family Like 1 2 3
  • Paraneoplastic Antigen-Like Protein 8A 3 4
  • PNMA-Like Protein 1 3 4
  • PNMAL1 3 4
  • PNMA-Like 1 2
  • KIAA1183L 2
  • FLJ10781 2
  • PNMA8A 5

External Ids for PNMA8A Gene

Previous HGNC Symbols for PNMA8A Gene

  • PNMAL1

Summaries for PNMA8A Gene

GeneCards Summary for PNMA8A Gene

PNMA8A (PNMA Family Member 8A) is a Protein Coding gene. Diseases associated with PNMA8A include Oligodendroglioma. An important paralog of this gene is PNMA8B.

Gene Wiki entry for PNMA8A Gene

Additional gene information for PNMA8A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PNMA8A Gene

Genomics for PNMA8A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PNMA8A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046470 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 671.4 +0.2 201 2.5 RFX1 RFX5 POLR2A MTA1 HDAC1 EP300 NRF1 MGA RAD21 NKRF PNMA8A piR-59450 piR-35418 PNMA8C
GH19J046472 Enhancer 0.5 ENCODE dbSUPER 600.7 -1.3 -1297 0.3 RFX1 SP7 PNMA8A piR-59450 RF00017-3022 PNMA8B
GH19J047225 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 24.6 -757.8 -757771 8.3 ZNF221 BRCA1 RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 BBC3 lnc-ZC3H4-1 ZC3H4 BICRA ENSG00000268810 NOP53-AS1 CCDC9 NOP53 SNORD23 PPP5D1
GH19J046465 Enhancer 0.9 Ensembl ENCODE dbSUPER 54 +4.7 4676 2.3 JUND RUNX3 TCF12 FOS FOSL2 JUNB IRF4 BATF EBF1 CREM piR-35418 piR-59222 PNMA8A HSALNG0126684 PNMA8C
GH19J046425 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 25.2 +44.0 44049 3.7 CREB1 ATF7 RFX1 RFX5 JUND POLR2A EZH2 HDAC1 YY1 NRF1 PNMA8C PNMA8A CCDC8 lnc-PNMA8C-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PNMA8A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PNMA8A

Genomic Locations for PNMA8A Gene

Genomic Locations for PNMA8A Gene
chr19:46,466,491-46,471,577
(GRCh38/hg38)
Size:
5,087 bases
Orientation:
Minus strand
chr19:46,969,748-46,974,820
(GRCh37/hg19)
Size:
5,073 bases
Orientation:
Minus strand

Genomic View for PNMA8A Gene

Genes around PNMA8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNMA8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNMA8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNMA8A Gene

Proteins for PNMA8A Gene

  • Protein details for PNMA8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V59-PNM8A_HUMAN
    Recommended name:
    Paraneoplastic antigen-like protein 8A
    Protein Accession:
    Q86V59
    Secondary Accessions:
    • A8K2F3
    • Q5U638
    • Q8N3H4
    • Q9NVE8

    Protein attributes for PNMA8A Gene

    Size:
    439 amino acids
    Molecular mass:
    48161 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91804.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAF82907.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAF82907.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=EAW57420.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for PNMA8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNMA8A Gene

Post-translational modifications for PNMA8A Gene

  • Ubiquitination at Lys3, Lys58, Lys108, and Lys229
  • Modification sites at PhosphoSitePlus

Other Protein References for PNMA8A Gene

No data available for DME Specific Peptides for PNMA8A Gene

Domains & Families for PNMA8A Gene

Gene Families for PNMA8A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PNMA8A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PNMA8A Gene

GenScript: Design optimal peptide antigens:
  • PNMA-like protein 1 (PNML1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86V59

UniProtKB/Swiss-Prot:

PNM8A_HUMAN :
  • Belongs to the PNMA family.
Family:
  • Belongs to the PNMA family.
genes like me logo Genes that share domains with PNMA8A: view

Function for PNMA8A Gene

Phenotypes From GWAS Catalog for PNMA8A Gene

genes like me logo Genes that share phenotypes with PNMA8A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNMA8A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PNMA8A Gene

Localization for PNMA8A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNMA8A gene
Compartment Confidence
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PNMA8A Gene

Pathways & Interactions for PNMA8A Gene

PathCards logo

SuperPathways for PNMA8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for PNMA8A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PNMA8A Gene

Drugs & Compounds for PNMA8A Gene

No Compound Related Data Available

Transcripts for PNMA8A Gene

mRNA/cDNA for PNMA8A Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNMA8A

Alternative Splicing Database (ASD) splice patterns (SP) for PNMA8A Gene

No ASD Table

Relevant External Links for PNMA8A Gene

GeneLoc Exon Structure for
PNMA8A

Expression for PNMA8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PNMA8A

Evidence on tissue expression from TISSUES for PNMA8A Gene

  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with PNMA8A: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNMA8A Gene

Orthologs for PNMA8A Gene

This gene was present in the common ancestor of mammals.

Orthologs for PNMA8A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PNMAL1 30 31
  • 99.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC102151906 30
  • 81.25 (n)
PNMAL1 31
  • 65 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PNMAL1 30 31
  • 77.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pnmal1 30
  • 73.36 (n)
Mouse
(Mus musculus)
Mammalia Pnmal1 30 17 31
  • 72.37 (n)
OneToOne
Species where no ortholog for PNMA8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PNMA8A Gene

ENSEMBL:
Gene Tree for PNMA8A (if available)
TreeFam:
Gene Tree for PNMA8A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PNMA8A: view image

Paralogs for PNMA8A Gene

genes like me logo Genes that share paralogs with PNMA8A: view

Variants for PNMA8A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PNMA8A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12610254 - p.Ser80Thr
rs7248888 - p.Cys97Tyr

Additional dbSNP identifiers (rs#s) for PNMA8A Gene

Variation tolerance for PNMA8A Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.07; 68.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PNMA8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNMA8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PNMA8A Gene

Disorders for PNMA8A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PNMA8A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oligodendroglioma
  • oligodendroglial neoplasm
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PNMA8A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNMA8A Gene

Publications for PNMA8A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for PNMA8A Gene

Sources for PNMA8A Gene