Aliases for PNLIPRP3 Gene

Aliases for PNLIPRP3 Gene

  • Pancreatic Lipase Related Protein 3 2 3 5
  • Pancreatic Lipase-Related Protein 3 3 4
  • EC 3.1.1.3 4 50
  • PL-RP3 3 4
  • PNLIPRP3 5
  • EC 3.1.1 50

External Ids for PNLIPRP3 Gene

Previous GeneCards Identifiers for PNLIPRP3 Gene

  • GC10P117817
  • GC10P118177
  • GC10P111814

Summaries for PNLIPRP3 Gene

GeneCards Summary for PNLIPRP3 Gene

PNLIPRP3 (Pancreatic Lipase Related Protein 3) is a Protein Coding gene. Diseases associated with PNLIPRP3 include Cervical Incompetence. Among its related pathways are Metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include carboxylic ester hydrolase activity and triglyceride lipase activity. An important paralog of this gene is PNLIPRP1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PNLIPRP3 Gene

Genomics for PNLIPRP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PNLIPRP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J116426 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 250.7 +1.4 1442 4.6 ATF3 YY1 FOXA2 RXRA ZBTB33 JUND HNF4A FOXA1 MAX SP1 PNLIPRP3 SLC18A2 HMGB3P8 PNLIP
GH10J116417 Promoter/Enhancer 0.7 EPDnew ENCODE dbSUPER 250.4 -9.2 -9183 3 PNLIPRP3 PNLIP SLC18A2 SNRPGP6 HSALNG0080852 CCDC172
GH10J116398 Enhancer 0.6 Ensembl ENCODE 0.3 -29.4 -29446 0.8 ZNF217 ELF1 CTBP1 SMARCE1 DPF2 ESRRA CCDC172 piR-33422-045 lnc-PNLIPRP3-1 PNLIPRP3 HSALNG0080852
GH10J116421 Enhancer 0.4 ENCODE dbSUPER 0.4 -5.8 -5805 1.2 ATF2 SLC18A2 HSALNG0080852 PNLIPRP3 SNRPGP6 CCDC172
GH10J116465 Enhancer 0.6 Ensembl ENCODE 0.3 +37.9 37854 1.4 NFE2 MAFG L3MBTL2 ZNF680 PRDM10 EMSY piR-41245-044 HMGB3P8 PNLIPRP3 PNLIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PNLIPRP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PNLIPRP3

Top Transcription factor binding sites by QIAGEN in the PNLIPRP3 gene promoter:
  • GATA-2
  • GR
  • GR-alpha
  • GR-beta
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for PNLIPRP3 Gene

Latest Assembly
chr10:116,427,847-116,477,961
(GRCh38/hg38)
Size:
50,115 bases
Orientation:
Plus strand

Previous Assembly
chr10:118,187,359-118,237,469
(GRCh37/hg19 by Entrez Gene)
Size:
50,111 bases
Orientation:
Plus strand

chr10:118,187,379-118,237,469
(GRCh37/hg19 by Ensembl)
Size:
50,091 bases
Orientation:
Plus strand

Genomic View for PNLIPRP3 Gene

Genes around PNLIPRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIPRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIPRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP3 Gene

Proteins for PNLIPRP3 Gene

  • Protein details for PNLIPRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RR3-LIPR3_HUMAN
    Recommended name:
    Pancreatic lipase-related protein 3
    Protein Accession:
    Q17RR3

    Protein attributes for PNLIPRP3 Gene

    Size:
    467 amino acids
    Molecular mass:
    52254 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PNLIPRP3 Gene

Selected DME Specific Peptides for PNLIPRP3 Gene

Q17RR3:
  • LIGHSLGAH
  • RLDPSDA
  • EVCYERLGCF
  • GRITGLD
  • DFYPNGG
  • GLDPAGP

Post-translational modifications for PNLIPRP3 Gene

  • Glycosylation at Asn74 and Asn125
  • Modification sites at PhosphoSitePlus

Other Protein References for PNLIPRP3 Gene

Domains & Families for PNLIPRP3 Gene

Gene Families for PNLIPRP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for PNLIPRP3 Gene

InterPro:
Blocks:
  • Lipase, active site
  • Lipase
  • Pancreatic lipase signature

Suggested Antigen Peptide Sequences for PNLIPRP3 Gene

GenScript: Design optimal peptide antigens:
  • Pancreatic lipase-related protein 3 (LIPR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q17RR3

UniProtKB/Swiss-Prot:

LIPR3_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP3: view

Function for PNLIPRP3 Gene

Molecular function for PNLIPRP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;.

Enzyme Numbers (IUBMB) for PNLIPRP3 Gene

Phenotypes From GWAS Catalog for PNLIPRP3 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity IBA 21873635
GO:0005515 protein binding IEA --
GO:0016298 lipase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PNLIPRP3: view
genes like me logo Genes that share phenotypes with PNLIPRP3: view

Animal Models for research

miRNA for PNLIPRP3 Gene

miRTarBase miRNAs that target PNLIPRP3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNLIPRP3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PNLIPRP3 Gene

Localization for PNLIPRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNLIPRP3 gene
Compartment Confidence
extracellular 4
peroxisome 0
cytosol 0
lysosome 0

Gene Ontology (GO) - Cellular Components for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with PNLIPRP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PNLIPRP3 Gene

Pathways & Interactions for PNLIPRP3 Gene

genes like me logo Genes that share pathways with PNLIPRP3: view

Pathways by source for PNLIPRP3 Gene

Interacting Proteins for PNLIPRP3 Gene

Gene Ontology (GO) - Biological Process for PNLIPRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IBA 21873635
genes like me logo Genes that share ontologies with PNLIPRP3: view

No data available for SIGNOR curated interactions for PNLIPRP3 Gene

Drugs & Compounds for PNLIPRP3 Gene

(8) Drugs for PNLIPRP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved Pharma 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
arachidonic acid Experimental Pharma 41
Myristic acid Experimental Pharma 0

(12) Additional Compounds for PNLIPRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2
genes like me logo Genes that share compounds with PNLIPRP3: view

Transcripts for PNLIPRP3 Gene

mRNA/cDNA for PNLIPRP3 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNLIPRP3

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP3 Gene

No ASD Table

Relevant External Links for PNLIPRP3 Gene

GeneLoc Exon Structure for
PNLIPRP3

Expression for PNLIPRP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PNLIPRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x19.9) and Skin - Not Sun Exposed (Suprapubic) (x17.0).

Protein differential expression in normal tissues from HIPED for PNLIPRP3 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PNLIPRP3 Gene



Protein tissue co-expression partners for PNLIPRP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PNLIPRP3

SOURCE GeneReport for Unigene cluster for PNLIPRP3 Gene:

Hs.276724

mRNA Expression by UniProt/SwissProt for PNLIPRP3 Gene:

Q17RR3-LIPR3_HUMAN
Tissue specificity: Overexpressed in hepatocellular carcinoma.

Evidence on tissue expression from TISSUES for PNLIPRP3 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with PNLIPRP3: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PNLIPRP3 Gene

Orthologs for PNLIPRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PNLIPRP3 29 30
  • 99.36 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PNLIPRP3 29
  • 86.22 (n)
Cow
(Bos Taurus)
Mammalia PNLIPRP3 29 30
  • 85.8 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PNLIPRP3 30
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PNLIPRP3 29
  • 58.92 (n)
Lizard
(Anolis carolinensis)
Reptilia PNLIPRP3 30
  • 45 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CABZ01090041.1 30
  • 23 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG6847 29
  • 45.08 (n)
CG5966 30
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4080 30
  • 34 (a)
OneToMany
Species where no ortholog for PNLIPRP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PNLIPRP3 Gene

ENSEMBL:
Gene Tree for PNLIPRP3 (if available)
TreeFam:
Gene Tree for PNLIPRP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PNLIPRP3: view image
Alliance of Genome Resources:
Additional Orthologs for PNLIPRP3

Paralogs for PNLIPRP3 Gene

Paralogs for PNLIPRP3 Gene

(6) SIMAP similar genes for PNLIPRP3 Gene using alignment to 1 proteins:

  • LIPR3_HUMAN
genes like me logo Genes that share paralogs with PNLIPRP3: view

Variants for PNLIPRP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PNLIPRP3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs10736251 -- p.Val381Ile
rs10885929 -- p.Leu2Phe
rs1897519 -- p.Arg382Gly
rs2116286 -- p.Phe450Tyr
rs7077408 -- p.Phe332Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PNLIPRP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP3 Gene

Variant ID Type Subtype PubMed ID
esv3624658 CNV loss 21293372
nsv7211 OTHER inversion 18451855
nsv819162 CNV gain 19587683
nsv832001 CNV loss 17160897
nsv948195 CNV duplication 23825009

Variation tolerance for PNLIPRP3 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.83; 86.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PNLIPRP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNLIPRP3
Leiden Open Variation Database (LOVD)
PNLIPRP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNLIPRP3 Gene

Disorders for PNLIPRP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PNLIPRP3 Gene - From: COP

Disorder Aliases PubMed IDs
cervical incompetence
  • uterine cervical incompetence
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PNLIPRP3

genes like me logo Genes that share disorders with PNLIPRP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNLIPRP3 Gene

Publications for PNLIPRP3 Gene

  1. Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of DNA loss on chromosome 10q25.3 in hepatocellular carcinoma. (PMID: 19640199) Saelee P … Karalak A (Asian Pacific journal of cancer prevention : APJCP 2009) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4

Products for PNLIPRP3 Gene

Sources for PNLIPRP3 Gene