This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015] See more...

Aliases for PNLIPRP2 Gene

Aliases for PNLIPRP2 Gene

  • Pancreatic Lipase Related Protein 2 (Gene/Pseudogene) 2 3 5
  • PLRP2 2 3 4
  • Pancreatic Lipase-Related Protein 2 3 4
  • Cytotoxic T Lymphocyte Lipase 3 4
  • Triacylglycerol Lipase 3 4
  • Galactolipase 3 4
  • EC 3.1.1.3 4 50
  • PL-RP2 3 4
  • Pancreatic Lipase Related Protein 2 2
  • EC 3.1.1.26 4
  • PNLIPRP2 5
  • EC 3.1.1 50

External Ids for PNLIPRP2 Gene

Previous GeneCards Identifiers for PNLIPRP2 Gene

  • GC10P117299
  • GC10P117624
  • GC10P118511
  • GC10P118045
  • GC10P118370
  • GC10P112007

Summaries for PNLIPRP2 Gene

Entrez Gene Summary for PNLIPRP2 Gene

  • This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]

GeneCards Summary for PNLIPRP2 Gene

PNLIPRP2 (Pancreatic Lipase Related Protein 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Salivary secretion and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PNLIP.

UniProtKB/Swiss-Prot Summary for PNLIPRP2 Gene

  • Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:15287741, PubMed:17401110, PubMed:19451396, PubMed:21865348, PubMed:20083229, PubMed:26494624, PubMed:18702514). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:23732775, PubMed:19824014, PubMed:21652702). Hydrolyzes short- medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:15287741, PubMed:17401110, PubMed:21865348, PubMed:21652702, PubMed:18702514). Can completely deacylates triacylglycerols (PubMed:21865348). When liver matures and bile salt synthesis increases, it likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in plant-based diet releasing long-chain polyunsaturated fatty acids (PubMed:15287741, PubMed:17401110, PubMed:20083229, PubMed:26494624, PubMed:18702514). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (PubMed:20083229, PubMed:18702514). May act together with LIPF to hydrolyze partially digested triglycerides (PubMed:23732775). Hydrolyzes long-chain monoglycerides with high efficiency (PubMed:17401110, PubMed:21652702, PubMed:23732775). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Has also low phospholipase activity, but its physiological relevance is not clear (PubMed:17401110, PubMed:18702514).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PNLIPRP2 Gene

Genomics for PNLIPRP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PNLIPRP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J116618 Promoter/Enhancer 1 Ensembl ENCODE 272.7 -0.6 -560 3.2 CEBPA ZIC2 FEZF1 CEBPG EGR2 TCF7 ZFHX2 PNLIPRP2 HSALNG0080865 RF00017-730 PNLIPRP1
GH10J116614 Enhancer 0.4 FANTOM5 79 -6.7 -6673 0.4 ZNF548 PKNOX1 RF00017-730 PNLIP PNLIPRP2 PNLIPRP1
GH10J116634 Enhancer 0.4 Ensembl 41.7 +13.8 13848 0.8 JUND ZNF202 PRDM1 PNLIPRP2 HSPA12A HSALNG0080866 HSALNG0080865 C10orf82
GH10J116608 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 11.4 -10.6 -10614 3.4 ZNF600 ZNF580 ZIC2 ZEB1 KLF9 ZNF610 SP2 DDX20 ZNF189 ZBTB1 HSALNG0080863 PNLIPRP2 LOC105378499 RF00017-730 PNLIPRP1
GH10J116589 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 11.4 -30.4 -30434 2.3 FEZF1 FOXA2 RXRA ZNF843 HNF4A FOXA1 SCRT1 HHEX NFIB ZNF18 HSALNG0080860 PNLIPRP1 PNLIPRP2 PNLIP RNU6-1090P lnc-PNLIP-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PNLIPRP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PNLIPRP2

Top Transcription factor binding sites by QIAGEN in the PNLIPRP2 gene promoter:
  • AML1a
  • ATF6
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GATA-1
  • LUN-1
  • NF-E2
  • NF-E2 p45
  • p53

Genomic Locations for PNLIPRP2 Gene

Latest Assembly
chr10:116,620,953-116,645,143
(GRCh38/hg38)
Size:
24,191 bases
Orientation:
Plus strand

Previous Assembly
chr10:118,380,465-118,404,654
(GRCh37/hg19 by Entrez Gene)
Size:
24,190 bases
Orientation:
Plus strand

Genomic View for PNLIPRP2 Gene

Genes around PNLIPRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIPRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIPRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP2 Gene

Proteins for PNLIPRP2 Gene

  • Protein details for PNLIPRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54317-LIPR2_HUMAN
    Recommended name:
    Pancreatic lipase-related protein 2
    Protein Accession:
    P54317
    Secondary Accessions:
    • A0A075B781
    • A8K627
    • Q6IB55

    Protein attributes for PNLIPRP2 Gene

    Size:
    469 amino acids
    Molecular mass:
    51961 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIPRP2 Gene

neXtProt entry for PNLIPRP2 Gene

Selected DME Specific Peptides for PNLIPRP2 Gene

P54317:
  • RLDPSDA
  • GCFSDEKPW
  • GCPKMGH
  • DFFPNGG
  • WRYKVSVTLSG
  • TIEASNFQ
  • VNCICVDW
  • GRITGLD
  • FLLYTNENPNN
  • GLDPAGP
  • FVDVIHTD

Post-translational modifications for PNLIPRP2 Gene

  • Glycosylation at Asn353 and Asn428
  • Modification sites at PhosphoSitePlus

Other Protein References for PNLIPRP2 Gene

Domains & Families for PNLIPRP2 Gene

Gene Families for PNLIPRP2 Gene

HGNC:

Protein Domains for PNLIPRP2 Gene

InterPro:
Blocks:
  • Lipase, active site
  • Lipoxygenase, LH2 domain
  • Lipase
  • Pancreatic lipase signature

Suggested Antigen Peptide Sequences for PNLIPRP2 Gene

GenScript: Design optimal peptide antigens:
  • Galactolipase (LIPR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P54317

UniProtKB/Swiss-Prot:

LIPR2_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP2: view

Function for PNLIPRP2 Gene

Molecular function for PNLIPRP2 Gene

UniProtKB/Swiss-Prot Function:
Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:15287741, PubMed:17401110, PubMed:19451396, PubMed:21865348, PubMed:20083229, PubMed:26494624, PubMed:18702514). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:23732775, PubMed:19824014, PubMed:21652702). Hydrolyzes short- medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:15287741, PubMed:17401110, PubMed:21865348, PubMed:21652702, PubMed:18702514). Can completely deacylates triacylglycerols (PubMed:21865348). When liver matures and bile salt synthesis increases, it likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in plant-based diet releasing long-chain polyunsaturated fatty acids (PubMed:15287741, PubMed:17401110, PubMed:20083229, PubMed:26494624, PubMed:18702514). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (PubMed:20083229, PubMed:18702514). May act together with LIPF to hydrolyze partially digested triglycerides (PubMed:23732775). Hydrolyzes long-chain monoglycerides with high efficiency (PubMed:17401110, PubMed:21652702, PubMed:23732775). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Has also low phospholipase activity, but its physiological relevance is not clear (PubMed:17401110, PubMed:18702514).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000269|PubMed:15287741, ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:18702514, ECO:0000269|PubMed:19451396, ECO:0000269|PubMed:21652702, ECO:0000269|PubMed:21865348, ECO:0000269|PubMed:26494624};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+); Xref=Rhea:RHEA:13189, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15754, ChEBI:CHEBI:17615, ChEBI:CHEBI:28868; EC=3.1.1.26; Evidence={ECO:0000269|PubMed:15287741, ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:18702514, ECO:0000269|PubMed:20083229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence={ECO:0000269|PubMed:18702514, ECO:0000269|PubMed:19451396, ECO:0000269|PubMed:21652702, ECO:0000269|PubMed:21865348, ECO:0000269|PubMed:26494624};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:47868, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75937, ChEBI:CHEBI:75945; Evidence={ECO:0000269|PubMed:21865348};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:39955, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75937; Evidence={ECO:0000269|PubMed:18702514, ECO:0000269|PubMed:21865348};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence={ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:18702514};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + H(+) + propanoate; Xref=Rhea:RHEA:48024, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17272, ChEBI:CHEBI:88153, ChEBI:CHEBI:88155; Evidence={ECO:0000269|PubMed:18702514};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+); Xref=Rhea:RHEA:40475, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:35020, ChEBI:CHEBI:76478; Evidence={ECO:0000269|PubMed:15287741, ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:18702514, ECO:0000269|PubMed:21652702, ECO:0000269|PubMed:26494624};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate; Xref=Rhea:RHEA:47864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:76978, ChEBI:CHEBI:88066; Evidence={ECO:0000269|PubMed:15287741, ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:18702514, ECO:0000269|PubMed:21652702, ECO:0000269|PubMed:26494624};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+); Xref=Rhea:RHEA:48596, ChEBI:CHEBI:11152, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:90605; Evidence={ECO:0000269|PubMed:15287741};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol; Xref=Rhea:RHEA:48700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:90477, ChEBI:CHEBI:90770; Evidence={ECO:0000305|PubMed:18702514};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol; Xref=Rhea:RHEA:48696, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:90453, ChEBI:CHEBI:90769; Evidence={ECO:0000269|PubMed:20083229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+); Xref=Rhea:RHEA:48540, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:90340, ChEBI:CHEBI:90515; Evidence={ECO:0000269|PubMed:15287741, ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:18702514};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+); Xref=Rhea:RHEA:48536, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:90342, ChEBI:CHEBI:90514; Evidence={ECO:0000269|PubMed:17401110};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+); Xref=Rhea:RHEA:48372, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28396, ChEBI:CHEBI:28868, ChEBI:CHEBI:90310; Evidence={ECO:0000269|PubMed:26494624};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol; Xref=Rhea:RHEA:48708, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:90463, ChEBI:CHEBI:90774; Evidence={ECO:0000269|PubMed:20083229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol; Xref=Rhea:RHEA:48692, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:90457, ChEBI:CHEBI:90768; Evidence={ECO:0000269|PubMed:20083229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+); Xref=Rhea:RHEA:48516, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:90337, ChEBI:CHEBI:90359; Evidence={ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:18702514};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:44664, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:84465; Evidence={ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:18702514};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.8 for triacylglycerol lipase activity, 8.5 for phospholipase activity and 8 for galactolipase activity. The enzyme activities decrease in the pH 5-7 range corresponding to the physiological conditions occurring in the small intestine. {ECO:0000269|PubMed:17401110};
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by CLPS and bile salts levels ranging 1-5 mM in neonates and 2-30 mM in healthy adults. CLPS stimulates milk fat digestion in the presence of 4 mM bile salts (PubMed:23732775). Triacylglycerol lipase activity toward short- and medium-chain triglycerides is inhibited by increasing concentrations of bile salts and weakly reactivated by CLPS (PubMed:15287741, PubMed:17401110, PubMed:21652702, PubMed:26494624). Optimal triacylglycerol lipase activity is reached at bile salts concentrations ranging from 0.1 to 0.5 mM and then decreases at concentrations higher than 1 mM (PubMed:21652702, PubMed:15287741, PubMed:17401110). Lipase activity toward long-chain glycerolipids is stimulated by CLPS in the presence of 4 mM bile salts (PubMed:21652702). Galactolipase activity is inhibited at high concentrations of bile salts (PubMed:20083229). Triacylglycerol lipase activity is inhibited by anti-obesity drug tetrahydrolipstatin (PubMed:17401110).

Enzyme Numbers (IUBMB) for PNLIPRP2 Gene

Phenotypes From GWAS Catalog for PNLIPRP2 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IDA 17401110
GO:0004806 triglyceride lipase activity TAS,ISS --
GO:0005509 calcium ion binding IDA 18702514
GO:0005515 protein binding IEA --
GO:0016298 lipase activity IBA 21873635
genes like me logo Genes that share ontologies with PNLIPRP2: view
genes like me logo Genes that share phenotypes with PNLIPRP2: view

Animal Models for PNLIPRP2 Gene

MGI Knock Outs for PNLIPRP2:

miRNA for PNLIPRP2 Gene

miRTarBase miRNAs that target PNLIPRP2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNLIPRP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PNLIPRP2 Gene

Localization for PNLIPRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP2 Gene

Secreted. Membrane. Peripheral membrane protein. Note=Associated with zymogen granule membranes. {ECO:0000250 UniProtKB:P54318}.

Gene Ontology (GO) - Cellular Components for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,IDA 18702514
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PNLIPRP2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PNLIPRP2 Gene

Pathways & Interactions for PNLIPRP2 Gene

genes like me logo Genes that share pathways with PNLIPRP2: view

Pathways by source for PNLIPRP2 Gene

UniProtKB/Swiss-Prot P54317-LIPR2_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol degradation.
  • Pathway: Glycolipid metabolism.

Interacting Proteins for PNLIPRP2 Gene

Selected Interacting proteins: P54317-LIPR2_HUMAN for PNLIPRP2 Gene via IID

Gene Ontology (GO) - Biological Process for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006641 triglyceride metabolic process TAS 1379598
GO:0006968 cellular defense response IEA --
GO:0009395 phospholipid catabolic process IBA,IDA 18702514
GO:0009617 response to bacterium IEA --
genes like me logo Genes that share ontologies with PNLIPRP2: view

No data available for SIGNOR curated interactions for PNLIPRP2 Gene

Drugs & Compounds for PNLIPRP2 Gene

(10) Drugs for PNLIPRP2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved Pharma 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
Capric dimethyl amine oxide Experimental Pharma Target 0
arachidonic acid Experimental Pharma 41

(16) Additional Compounds for PNLIPRP2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2
genes like me logo Genes that share compounds with PNLIPRP2: view

Transcripts for PNLIPRP2 Gene

mRNA/cDNA for PNLIPRP2 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNLIPRP2

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP2 Gene

No ASD Table

Relevant External Links for PNLIPRP2 Gene

GeneLoc Exon Structure for
PNLIPRP2

Expression for PNLIPRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PNLIPRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP2 Gene

This gene is overexpressed in Pancreas (x52.6).

Protein differential expression in normal tissues from HIPED for PNLIPRP2 Gene

This gene is overexpressed in Pancreatic juice (56.5) and Pancreas (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PNLIPRP2 Gene



Protein tissue co-expression partners for PNLIPRP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PNLIPRP2

SOURCE GeneReport for Unigene cluster for PNLIPRP2 Gene:

Hs.423598

mRNA Expression by UniProt/SwissProt for PNLIPRP2 Gene:

P54317-LIPR2_HUMAN
Tissue specificity: Pancreas.
genes like me logo Genes that share expression patterns with PNLIPRP2: view

Primer products for research

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNLIPRP2 Gene

Orthologs for PNLIPRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PNLIPRP2 29
  • 98.94 (n)
Dog
(Canis familiaris)
Mammalia PNLIPRP2 29
  • 83.08 (n)
Cow
(Bos Taurus)
Mammalia PNLIPRP2 29
  • 82.66 (n)
Rat
(Rattus norvegicus)
Mammalia Pnliprp2 29
  • 79.84 (n)
Mouse
(Mus musculus)
Mammalia Pnliprp2 29 16
  • 79.63 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG6472 31
  • 36 (a)
CG6847 31
  • 35 (a)
CG5966 31
  • 35 (a)
CG6271 31
  • 34 (a)
CG7367 31
  • 34 (a)
CG6277 31
  • 33 (a)
CG17192 31
  • 32 (a)
CG6283 31
  • 32 (a)
Species where no ortholog for PNLIPRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PNLIPRP2 Gene

ENSEMBL:
Gene Tree for PNLIPRP2 (if available)
TreeFam:
Gene Tree for PNLIPRP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PNLIPRP2: view image
Alliance of Genome Resources:
Additional Orthologs for PNLIPRP2

Paralogs for PNLIPRP2 Gene

Paralogs for PNLIPRP2 Gene

(10) SIMAP similar genes for PNLIPRP2 Gene using alignment to 2 proteins:

  • LIPR2_HUMAN
  • F5H1V6_HUMAN

Pseudogenes.org Pseudogenes for PNLIPRP2 Gene

genes like me logo Genes that share paralogs with PNLIPRP2: view

Variants for PNLIPRP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PNLIPRP2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs4751996 -- p.Ile361Val

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP2 Gene

Variant ID Type Subtype PubMed ID
esv1523619 CNV insertion 17803354
esv3624661 CNV loss 21293372

Additional Variant Information for PNLIPRP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNLIPRP2
Leiden Open Variation Database (LOVD)
PNLIPRP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for PNLIPRP2 Gene

Disorders for PNLIPRP2 Gene

Additional Disease Information for PNLIPRP2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for PNLIPRP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNLIPRP2 Gene

Publications for PNLIPRP2 Gene

  1. Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2. (PMID: 20083229) Amara S … Carrière F (Biochimica et biophysica acta 2010) 3 4 22
  2. Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation. (PMID: 18702514) Eydoux C … Carrière F (Biochemistry 2008) 3 4 22
  3. Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells. (PMID: 17401110) Eydoux C … De Caro A (Journal of lipid research 2007) 3 4 22
  4. Human pancreatic lipase-related protein 2 is a galactolipase. (PMID: 15287741) Sias B … Carrière F (Biochemistry 2004) 3 4 22
  5. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. (PMID: 1379598) Giller T … Hunziker W (The Journal of biological chemistry 1992) 2 3 4

Products for PNLIPRP2 Gene

Sources for PNLIPRP2 Gene