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Aliases for PNLIPRP2 Gene

Aliases for PNLIPRP2 Gene

  • Pancreatic Lipase Related Protein 2 (Gene/Pseudogene) 2 3 5
  • Galactolipase 3 4
  • PL-RP2 3 4
  • PLRP2 3 4
  • Pancreatic Lipase-Related Protein 2 3
  • Pancreatic Lipase Related Protein 2 2
  • EC 4
  • EC 4

External Ids for PNLIPRP2 Gene

Previous GeneCards Identifiers for PNLIPRP2 Gene

  • GC10P117299
  • GC10P117624
  • GC10P118511
  • GC10P118045
  • GC10P118370
  • GC10P112007

Summaries for PNLIPRP2 Gene

Entrez Gene Summary for PNLIPRP2 Gene

  • This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]

GeneCards Summary for PNLIPRP2 Gene

PNLIPRP2 (Pancreatic Lipase Related Protein 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Glycerolipid metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PNLIP.

UniProtKB/Swiss-Prot for PNLIPRP2 Gene

  • Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.

Additional gene information for PNLIPRP2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PNLIPRP2 Gene

Genomics for PNLIPRP2 Gene

GeneHancer (GH) Regulatory Elements for PNLIPRP2 Gene

Promoters and enhancers for PNLIPRP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J116618 Enhancer 0.5 ENCODE 672.7 -0.6 -560 3.2 ZFHX2 CEBPA TCF7 CEBPG FEZF1 ZIC2 EGR2 PNLIPRP2 PNLIPRP1
GH10J116614 Enhancer 0.4 FANTOM5 79 -6.7 -6673 0.4 PKNOX1 ZNF548 PNLIP PNLIPRP2 PNLIPRP1
GH10J116589 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 11.4 -30.4 -30434 2.3 SCRT1 FOXA2 NFIA RXRA NFIB FEZF1 ZNF843 FOXA1 SP1 GATA3 PNLIPRP1 PNLIPRP2 PNLIP RNU6-1090P
GH10J116608 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.4 -10.6 -10614 3.4 HDGF PKNOX1 INSM2 ZEB1 ZNF335 GLIS2 ZNF548 ZNF202 SP3 ZBTB11 PNLIPRP2 LOC105378499 PNLIPRP1
GH10J116627 Enhancer 0.5 Ensembl 14.7 +6.6 6640 0.8 CTCF ZNF143 BACH1 KLF9 RAD21 PNLIPRP2 PNLIPRP1 C10orf82 LOC105378499
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PNLIPRP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PNLIPRP2 gene promoter:
  • FOXO3b
  • FOXO3a
  • FOXO3
  • LUN-1
  • AML1a
  • GATA-1
  • p53
  • ATF6
  • NF-E2 p45
  • NF-E2

Genomic Locations for PNLIPRP2 Gene

Genomic Locations for PNLIPRP2 Gene
24,191 bases
Plus strand
24,190 bases
Plus strand

Genomic View for PNLIPRP2 Gene

Genes around PNLIPRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIPRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIPRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP2 Gene

Proteins for PNLIPRP2 Gene

  • Protein details for PNLIPRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pancreatic lipase-related protein 2
    Protein Accession:
    Secondary Accessions:
    • A0A075B781
    • A8K627
    • Q6IB55

    Protein attributes for PNLIPRP2 Gene

    469 amino acids
    Molecular mass:
    51961 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIPRP2 Gene

neXtProt entry for PNLIPRP2 Gene

Post-translational modifications for PNLIPRP2 Gene

  • Glycosylation at Asn428 and Asn353
  • Modification sites at PhosphoSitePlus

Other Protein References for PNLIPRP2 Gene

No data available for DME Specific Peptides for PNLIPRP2 Gene

Domains & Families for PNLIPRP2 Gene

Gene Families for PNLIPRP2 Gene

Suggested Antigen Peptide Sequences for PNLIPRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP2: view

Function for PNLIPRP2 Gene

Molecular function for PNLIPRP2 Gene

UniProtKB/Swiss-Prot Function:
Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H(2)O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.
UniProtKB/Swiss-Prot EnzymeRegulation:
CLPS stimulates triacylglycerol lipase activity. Triacylglycerol lipase activity is not inhibited by increasing bile salt concentration.

Enzyme Numbers (IUBMB) for PNLIPRP2 Gene

Phenotypes From GWAS Catalog for PNLIPRP2 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IDA 18702514
GO:0004806 triglyceride lipase activity ISS --
GO:0005509 calcium ion binding IDA 18702514
GO:0005515 protein binding IEA --
GO:0047372 acylglycerol lipase activity TAS --
genes like me logo Genes that share ontologies with PNLIPRP2: view
genes like me logo Genes that share phenotypes with PNLIPRP2: view

Animal Models for PNLIPRP2 Gene

MGI Knock Outs for PNLIPRP2:

Animal Model Products

CRISPR Products

miRNA for PNLIPRP2 Gene

miRTarBase miRNAs that target PNLIPRP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNLIPRP2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PNLIPRP2 Gene

Localization for PNLIPRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP2 Gene


Gene Ontology (GO) - Cellular Components for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IDA 18702514
genes like me logo Genes that share ontologies with PNLIPRP2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PNLIPRP2 Gene

Pathways & Interactions for PNLIPRP2 Gene

genes like me logo Genes that share pathways with PNLIPRP2: view

Pathways by source for PNLIPRP2 Gene

Interacting Proteins for PNLIPRP2 Gene

Selected Interacting proteins: P54317-LIPR2_HUMAN for PNLIPRP2 Gene via IID

Gene Ontology (GO) - Biological Process for PNLIPRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006641 triglyceride metabolic process TAS 1379598
GO:0009395 phospholipid catabolic process IDA 18702514
GO:0016042 lipid catabolic process IEA --
GO:0019376 galactolipid catabolic process IDA 18702514
genes like me logo Genes that share ontologies with PNLIPRP2: view

No data available for SIGNOR curated interactions for PNLIPRP2 Gene

Drugs & Compounds for PNLIPRP2 Gene

(9) Drugs for PNLIPRP2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
Decylamine-N,N-Dimethyl-N-Oxide Experimental Pharma Target 0
Myristic acid Experimental Pharma 0

(14) Additional Compounds for PNLIPRP2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
  • Eicosanoic acid
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group C
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z,14Z)-icosa-11,14-dienoic acid
  • DAG(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2)
  • DAG(15:0/0:0/20:2n6)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with PNLIPRP2: view

Transcripts for PNLIPRP2 Gene


Unigene Clusters for PNLIPRP2 Gene

Pancreatic lipase-related protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNLIPRP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP2 Gene

No ASD Table

Relevant External Links for PNLIPRP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PNLIPRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PNLIPRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP2 Gene

This gene is overexpressed in Pancreas (x52.6).

Protein differential expression in normal tissues from HIPED for PNLIPRP2 Gene

This gene is overexpressed in Pancreatic juice (56.5) and Pancreas (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PNLIPRP2 Gene

Protein tissue co-expression partners for PNLIPRP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PNLIPRP2 Gene:


SOURCE GeneReport for Unigene cluster for PNLIPRP2 Gene:


mRNA Expression by UniProt/SwissProt for PNLIPRP2 Gene:

Tissue specificity: Pancreas.
genes like me logo Genes that share expression patterns with PNLIPRP2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNLIPRP2 Gene

Orthologs for PNLIPRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PNLIPRP2 33
  • 98.94 (n)
(Canis familiaris)
Mammalia PNLIPRP2 33
  • 83.08 (n)
(Bos Taurus)
Mammalia PNLIPRP2 33
  • 82.66 (n)
(Rattus norvegicus)
Mammalia Pnliprp2 33
  • 79.84 (n)
(Mus musculus)
Mammalia Pnliprp2 16 33
  • 79.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6472 35
  • 36 (a)
CG5966 35
  • 35 (a)
CG6847 35
  • 35 (a)
CG6271 35
  • 34 (a)
CG7367 35
  • 34 (a)
CG6277 35
  • 33 (a)
CG17192 35
  • 32 (a)
CG6283 35
  • 32 (a)
Species where no ortholog for PNLIPRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PNLIPRP2 Gene

Gene Tree for PNLIPRP2 (if available)
Gene Tree for PNLIPRP2 (if available)
Evolutionary constrained regions (ECRs) for PNLIPRP2: view image

Paralogs for PNLIPRP2 Gene

Paralogs for PNLIPRP2 Gene

(10) SIMAP similar genes for PNLIPRP2 Gene using alignment to 2 proteins:

  • F5H1V6_HUMAN Pseudogenes for PNLIPRP2 Gene

genes like me logo Genes that share paralogs with PNLIPRP2: view

Variants for PNLIPRP2 Gene

Sequence variations from dbSNP and Humsavar for PNLIPRP2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000288981 -- 116,637,116(+) T/C intron_variant
rs1000364041 -- 116,645,638(+) G/A downstream_transcript_variant
rs1000798722 -- 116,645,256(+) C/T downstream_transcript_variant
rs1000997797 -- 116,626,534(+) G/A intron_variant
rs1001051059 -- 116,632,570(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP2 Gene

Variant ID Type Subtype PubMed ID
esv1523619 CNV insertion 17803354
esv3624661 CNV loss 21293372

Additional Variant Information for PNLIPRP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PNLIPRP2 Gene

Disorders for PNLIPRP2 Gene

Additional Disease Information for PNLIPRP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PNLIPRP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PNLIPRP2 Gene

Publications for PNLIPRP2 Gene

  1. Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation. (PMID: 18702514) Eydoux C … Carrière F (Biochemistry 2008) 3 4 22 58
  2. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. (PMID: 1379598) Giller T … Hunziker W (The Journal of biological chemistry 1992) 2 3 4 58
  3. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A … EUROSPAN consortium (PLoS genetics 2012) 3 44 58
  4. Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2. (PMID: 20083229) Amara S … Carrière F (Biochimica et biophysica acta 2010) 4 22 58
  5. Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). (PMID: 19548271) Alves BN … Hudig D (Cell biochemistry and function 2009) 3 22 58

Products for PNLIPRP2 Gene

Sources for PNLIPRP2 Gene

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