Aliases for PNLIPRP1 Gene

Aliases for PNLIPRP1 Gene

  • Pancreatic Lipase Related Protein 1 2 3 5
  • PLRP1 2 3 4
  • Inactive Pancreatic Lipase-Related Protein 1 3 4
  • EC 3.1.1.3 50
  • PNLIPRP1 5
  • EC 3.1.1 50
  • PL-RP1 4

External Ids for PNLIPRP1 Gene

Previous GeneCards Identifiers for PNLIPRP1 Gene

  • GC10P117269
  • GC10P117550
  • GC10P118437
  • GC10P118001
  • GC10P118015
  • GC10P118340
  • GC10P111977

Summaries for PNLIPRP1 Gene

GeneCards Summary for PNLIPRP1 Gene

PNLIPRP1 (Pancreatic Lipase Related Protein 1) is a Protein Coding gene. Diseases associated with PNLIPRP1 include Macular Degeneration, Age-Related, 10. Among its related pathways are Salivary secretion and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and triglyceride lipase activity. An important paralog of this gene is PNLIP.

UniProtKB/Swiss-Prot Summary for PNLIPRP1 Gene

  • May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PNLIPRP1 Gene

Genomics for PNLIPRP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PNLIPRP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J116589 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 250.7 +0.1 134 2.3 FEZF1 FOXA2 RXRA ZNF843 HNF4A FOXA1 SCRT1 HHEX NFIB ZNF18 HSALNG0080860 PNLIPRP1 PNLIPRP2 PNLIP RNU6-1090P lnc-PNLIP-1
GH10J116614 Enhancer 0.4 FANTOM5 72 +23.9 23895 0.4 ZNF548 PKNOX1 RF00017-730 PNLIP PNLIPRP2 PNLIPRP1
GH10J116627 Promoter 0.7 CraniofacialAtlas 11.1 +37.1 37105 0.4 CTCF KLF9 GABPB1 RAD21 ZNF143 SMC3 BACH1 PNLIPRP2 PNLIPRP1 C10orf82 LOC105378499 HSALNG0080865 HSALNG0080866
GH10J116556 Enhancer 0.5 Ensembl 10.4 -34.4 -34384 0.4 ATF2 SP7 CREB1 ZNF366 ZNF629 PNLIPRP1 RF00017-728 HSALNG0080858 PNLIP
GH10J116237 Enhancer 0.6 Ensembl CraniofacialAtlas 5.7 -352.2 -352240 0.9 HNF4A SP1 RXRA POLR2A GFRA1 PNLIPRP1 lnc-C10orf82-2 SNORD158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PNLIPRP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PNLIPRP1

Top Transcription factor binding sites by QIAGEN in the PNLIPRP1 gene promoter:
  • AREB6
  • c-Ets-1
  • C/EBPalpha
  • CHOP-10
  • E47
  • Elk-1
  • FOXL1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • Tal-1beta

Genomic Locations for PNLIPRP1 Gene

Latest Assembly
chr10:116,590,385-116,609,175
(GRCh38/hg38)
Size:
18,791 bases
Orientation:
Plus strand

Previous Assembly
chr10:118,350,471-118,368,687
(GRCh37/hg19 by Entrez Gene)
Size:
18,217 bases
Orientation:
Plus strand

chr10:118,349,897-118,368,687
(GRCh37/hg19 by Ensembl)
Size:
18,791 bases
Orientation:
Plus strand

Genomic View for PNLIPRP1 Gene

Genes around PNLIPRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNLIPRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNLIPRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNLIPRP1 Gene

Proteins for PNLIPRP1 Gene

  • Protein details for PNLIPRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54315-LIPR1_HUMAN
    Recommended name:
    Inactive pancreatic lipase-related protein 1
    Protein Accession:
    P54315
    Secondary Accessions:
    • Q68D83
    • Q68DR6
    • Q8TAU2
    • Q9BS82

    Protein attributes for PNLIPRP1 Gene

    Size:
    467 amino acids
    Molecular mass:
    51848 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PNLIPRP1 Gene

    Alternative splice isoforms for PNLIPRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNLIPRP1 Gene

Selected DME Specific Peptides for PNLIPRP1 Gene

P54315:
  • HLRSYKYY
  • LIGHSLGAH
  • NVRVVGA
  • RLDPSDA
  • CPQMGHYAD
  • DFFPNGG
  • TIEASNFQ
  • VNCICVDW
  • SILNPDGF
  • NFARWRY
  • EFDAKLDVGTIEKVKFLWNN
  • FLLYTNENPNN
  • HVAGEAG
  • FVDVIHTD
  • NNVINPTLP

Post-translational modifications for PNLIPRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

Domains & Families for PNLIPRP1 Gene

Gene Families for PNLIPRP1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PNLIPRP1 Gene

InterPro:
Blocks:
  • Lipase, active site
  • Lipoxygenase, LH2 domain
  • Lipase
  • Pancreatic lipase signature

Suggested Antigen Peptide Sequences for PNLIPRP1 Gene

GenScript: Design optimal peptide antigens:
  • Pancreatic lipase-related protein 1 (LIPR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P54315

UniProtKB/Swiss-Prot:

LIPR1_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PNLIPRP1: view

Function for PNLIPRP1 Gene

Molecular function for PNLIPRP1 Gene

UniProtKB/Swiss-Prot Function:
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for PNLIPRP1 Gene

Phenotypes From GWAS Catalog for PNLIPRP1 Gene

Gene Ontology (GO) - Molecular Function for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity IEA,TAS 1379598
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IEA,IPI 32296183
GO:0016298 NOT lipase activity IDA 19824014
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PNLIPRP1: view
genes like me logo Genes that share phenotypes with PNLIPRP1: view

Animal Models for PNLIPRP1 Gene

MGI Knock Outs for PNLIPRP1:

Animal Models for research

  • Taconic Biosciences Mouse Models for PNLIPRP1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNLIPRP1

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PNLIPRP1 Gene

Localization for PNLIPRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNLIPRP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNLIPRP1 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS 1379598
GO:0005615 NOT extracellular space IDA 19824014
genes like me logo Genes that share ontologies with PNLIPRP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PNLIPRP1 Gene

Pathways & Interactions for PNLIPRP1 Gene

genes like me logo Genes that share pathways with PNLIPRP1: view

Gene Ontology (GO) - Biological Process for PNLIPRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PNLIPRP1: view

No data available for SIGNOR curated interactions for PNLIPRP1 Gene

Drugs & Compounds for PNLIPRP1 Gene

(9) Drugs for PNLIPRP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved Pharma 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
arachidonic acid Experimental Pharma 41
Myristic acid Experimental Pharma 0

(15) Additional Compounds for PNLIPRP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2
genes like me logo Genes that share compounds with PNLIPRP1: view

Transcripts for PNLIPRP1 Gene

mRNA/cDNA for PNLIPRP1 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNLIPRP1

Alternative Splicing Database (ASD) splice patterns (SP) for PNLIPRP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - -
SP12: - - -
SP13: - - -
SP14: - - - - -
SP15:

ExUns: 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PNLIPRP1 Gene

GeneLoc Exon Structure for
PNLIPRP1

Expression for PNLIPRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PNLIPRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNLIPRP1 Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for PNLIPRP1 Gene

This gene is overexpressed in Pancreatic juice (59.9) and Pancreas (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PNLIPRP1 Gene



Protein tissue co-expression partners for PNLIPRP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PNLIPRP1

SOURCE GeneReport for Unigene cluster for PNLIPRP1 Gene:

Hs.73923

mRNA Expression by UniProt/SwissProt for PNLIPRP1 Gene:

P54315-LIPR1_HUMAN
Tissue specificity: Pancreas.

Evidence on tissue expression from TISSUES for PNLIPRP1 Gene

  • Pancreas(4.9)
  • Liver(4.5)
genes like me logo Genes that share expression patterns with PNLIPRP1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PNLIPRP1 Gene

Orthologs for PNLIPRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PNLIPRP1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia PNLIPRP1 29 30
  • 87.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PNLIPRP1 29
  • 84.55 (n)
Rat
(Rattus norvegicus)
Mammalia Pnliprp1 29
  • 83.8 (n)
Mouse
(Mus musculus)
Mammalia Pnliprp1 29 16 30
  • 83.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PNLIPRP1 30
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PNLIPRP1 30
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PNLIP 29 30
  • 63.3 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 63 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100486161 29
  • 64.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007672 29
  • 49.47 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7367 31
  • 38 (a)
CG6472 31
  • 37 (a)
CG6847 31
  • 36 (a)
CG6277 31
  • 33 (a)
CG6271 31
  • 32 (a)
CG5966 30 31
  • 27 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4080 30
  • 40 (a)
OneToMany
Species where no ortholog for PNLIPRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PNLIPRP1 Gene

ENSEMBL:
Gene Tree for PNLIPRP1 (if available)
TreeFam:
Gene Tree for PNLIPRP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PNLIPRP1: view image
Alliance of Genome Resources:
Additional Orthologs for PNLIPRP1

Paralogs for PNLIPRP1 Gene

Paralogs for PNLIPRP1 Gene

(10) SIMAP similar genes for PNLIPRP1 Gene using alignment to 8 proteins:

  • LIPR1_HUMAN
  • E7EX42_HUMAN
  • E9PJC9_HUMAN
  • E9PMA6_HUMAN
  • E9PMX6_HUMAN
  • E9PR20_HUMAN
  • E9PRT6_HUMAN
  • H0YDY1_HUMAN
genes like me logo Genes that share paralogs with PNLIPRP1: view

Variants for PNLIPRP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PNLIPRP1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
VAR_036379 A breast cancer sample p.Ser129Cys
rs1049125 -- p.Leu461Pro
rs11197744 -- p.Asn61Asp
rs2305204 -- p.Glu414Asp
rs2305205 -- p.Ala271Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PNLIPRP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PNLIPRP1 Gene

Variant ID Type Subtype PubMed ID
esv3624660 CNV gain 21293372
nsv7211 OTHER inversion 18451855

Variation tolerance for PNLIPRP1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.28; 88.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PNLIPRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNLIPRP1
Leiden Open Variation Database (LOVD)
PNLIPRP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNLIPRP1 Gene

Disorders for PNLIPRP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PNLIPRP1 Gene - From: COP

Disorder Aliases PubMed IDs
macular degeneration, age-related, 10
  • armd10
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PNLIPRP1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PNLIPRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNLIPRP1 Gene

Publications for PNLIPRP1 Gene

  1. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. (PMID: 19824014) Berton A … Crenon I (Molecular nutrition & food research 2009) 3 4 22
  2. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. (PMID: 1379598) Giller T … Hunziker W (The Journal of biological chemistry 1992) 2 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for PNLIPRP1 Gene

Sources for PNLIPRP1 Gene