PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008] See more...

Aliases for PNCK Gene

Aliases for PNCK Gene

  • Pregnancy Up-Regulated Nonubiquitous CaM Kinase 2 3 5
  • Pregnancy Up-Regulated Non-Ubiquitously-Expressed CaM Kinase 3 4
  • Pregnancy Upregulated Non-Ubiquitously Expressed CaM Kinase 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type 1B 3 4
  • CaM Kinase I Beta 3 4
  • CaM Kinase IB 3 4
  • EC 2.7.11.17 4 51
  • CaM-KI Beta 3 4
  • CaMKI-Beta 3 4
  • CaMK1b 2 3
  • Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase 2
  • EC 2.7.11 51
  • MGC45419 2
  • BSTK3 3
  • PNCK 5

External Ids for PNCK Gene

Previous GeneCards Identifiers for PNCK Gene

  • GC0XM151404
  • GC0XM152456
  • GC0XM152590
  • GC0XM152935
  • GC0XM141592

Summaries for PNCK Gene

Entrez Gene Summary for PNCK Gene

  • PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PNCK Gene

PNCK (Pregnancy Up-Regulated Nonubiquitous CaM Kinase) is a Protein Coding gene. Diseases associated with PNCK include Megalencephalic Leukoencephalopathy With Subcortical Cysts 1. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and VEGF Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK1.

UniProtKB/Swiss-Prot Summary for PNCK Gene

  • Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PNCK Gene

Genomics for PNCK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PNCK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PNCK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PNCK

Top Transcription factor binding sites by QIAGEN in the PNCK gene promoter:
  • Egr-4
  • HSF2
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for PNCK Gene

Genomic Locations for PNCK Gene
chrX:153,669,723-153,689,010
(GRCh38/hg38)
Size:
19,288 bases
Orientation:
Minus strand
chrX:152,935,185-152,954,465
(GRCh37/hg19)
Size:
19,281 bases
Orientation:
Minus strand

Genomic View for PNCK Gene

Genes around PNCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PNCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PNCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PNCK Gene

Proteins for PNCK Gene

  • Protein details for PNCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2M8-KCC1B_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type 1B
    Protein Accession:
    Q6P2M8
    Secondary Accessions:
    • B4DJR8
    • B4E1A6
    • B7WPG0
    • D3DWU7
    • Q8N4R0

    Protein attributes for PNCK Gene

    Size:
    343 amino acids
    Molecular mass:
    38500 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PNCK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PNCK Gene

Selected DME Specific Peptides for PNCK Gene

Q6P2M8:
  • KCIPKKAL
  • YVAPELL
  • VTGGELF
  • GGELFDR
  • ENEIAVL
  • LKPENLL
  • RDLKPEN
  • VHRDLKP
  • IVHRDLK

Post-translational modifications for PNCK Gene

Domains & Families for PNCK Gene

Gene Families for PNCK Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PNCK Gene

GenScript: Design optimal peptide antigens:
  • Pregnancy up-regulated non-ubiquitously-expressed CaM kinase (KCC1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P2M8

UniProtKB/Swiss-Prot:

KCC1B_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with PNCK: view

Function for PNCK Gene

Molecular function for PNCK Gene

UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin.

Enzyme Numbers (IUBMB) for PNCK Gene

Phenotypes From GWAS Catalog for PNCK Gene

Gene Ontology (GO) - Molecular Function for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IBA 21873635
GO:0004683 calmodulin-dependent protein kinase activity IBA 21873635
GO:0005516 calmodulin binding IBA 21873635
genes like me logo Genes that share ontologies with PNCK: view
genes like me logo Genes that share phenotypes with PNCK: view

Animal Models for PNCK Gene

MGI Knock Outs for PNCK:
  • Pnck Pnck<tm1b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for PNCK

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNCK

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PNCK Gene

Localization for PNCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for PNCK Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PNCK gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA 21873635
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PNCK: view

Pathways & Interactions for PNCK Gene

PathCards logo

SuperPathways for PNCK Gene

genes like me logo Genes that share pathways with PNCK: view

Pathways by source for PNCK Gene

2 Sino Biological pathways for PNCK Gene

SIGNOR curated interactions for PNCK Gene

Activates:

Gene Ontology (GO) - Biological Process for PNCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with PNCK: view

Drugs & Compounds for PNCK Gene

(1) Drugs for PNCK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with PNCK: view

Transcripts for PNCK Gene

mRNA/cDNA for PNCK Gene

9 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
32 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PNCK

Alternative Splicing Database (ASD) splice patterns (SP) for PNCK Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - - -
SP6: -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: -
SP14:

ExUns: 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PNCK Gene

GeneLoc Exon Structure for
PNCK

Expression for PNCK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PNCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PNCK Gene

This gene is overexpressed in Colon - Sigmoid (x4.8) and Brain - Nucleus accumbens (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for PNCK Gene

This gene is overexpressed in Plasma (57.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PNCK Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PNCK

SOURCE GeneReport for Unigene cluster for PNCK Gene:

Hs.436667

Evidence on tissue expression from TISSUES for PNCK Gene

  • Nervous system(4.8)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PNCK: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PNCK Gene

Orthologs for PNCK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PNCK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PNCK 30 31
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PNCK 30 31
  • 90.97 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Pnck 30
  • 89.21 (n)
Mouse
(Mus musculus)
Mammalia Pnck 30 17 31
  • 88.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PNCK 30 31
  • 88.3 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PNCK 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PNCK 31
  • 36 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PNCK 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pnck 30
  • 72.21 (n)
Zebrafish
(Danio rerio)
Actinopterygii pnck 30 31
  • 63.42 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7117 30
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEK1 33 33
Rice
(Oryza sativa)
Liliopsida Os03g0789000 30
  • 52.05 (n)
Os.12678 30
Barley
(Hordeum vulgare)
Liliopsida Hv.12128 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 56 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU02283 30
  • 54.6 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cmk1 30
  • 47.23 (n)
Species where no ortholog for PNCK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PNCK Gene

ENSEMBL:
Gene Tree for PNCK (if available)
TreeFam:
Gene Tree for PNCK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PNCK: view image

Paralogs for PNCK Gene

genes like me logo Genes that share paralogs with PNCK: view

Variants for PNCK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PNCK Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
782180 Benign: not provided 153,670,532(-) G/A SYNONYMOUS_VARIANT
rs782100269 Likely Benign: not provided 153,672,172(-) C/T MISSENSE_VARIANT
rs56060609 - p.Gln262His

Additional dbSNP identifiers (rs#s) for PNCK Gene

Structural Variations from Database of Genomic Variants (DGV) for PNCK Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
nsv1144323 CNV deletion 24896259

Variation tolerance for PNCK Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PNCK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PNCK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PNCK Gene

Disorders for PNCK Gene

MalaCards: The human disease database

(1) MalaCards diseases for PNCK Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search PNCK in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PNCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PNCK Gene

Publications for PNCK Gene

  1. The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer. (PMID: 11034105) Gardner HP … Chodosh LA (Cancer research 2000) 2 3 23
  2. Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma. (PMID: 23634203) Wu S … Wang R (PloS one 2013) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. (PMID: 27229929) Daakour S … Twizere JC (BMC cancer 2016) 3
  5. Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process. (PMID: 25773930) Deb TB … Johnson MD (Breast cancer research and treatment 2015) 3

Products for PNCK Gene

  • Boster Bio Antibodies for PNCK
  • Boster Bio ELISA Kits for PNCK

Sources for PNCK Gene