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This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015]
PMCH (Pro-Melanin Concentrating Hormone) is a Protein Coding gene. Diseases associated with PMCH include Byssinosis and Cardiomyopathy, Familial Hypertrophic, 20. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include melanin-concentrating hormone activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | hormone activity | IEA | -- |
GO:0030354 | melanin-concentrating hormone activity | IEA | -- |
GO:0031777 | type 1 melanin-concentrating hormone receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0045202 | synapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | RET signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007218 | neuropeptide signaling pathway | IEA | -- |
GO:0007268 | chemical synaptic transmission | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007283 | spermatogenesis | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Olanzapine | Approved, Investigational | Pharma | Antagonist, Agonist, Full agonist, Inverse agonist | 442 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PMCH 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PMCH 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PMCH 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pmch 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pmch 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | PMCH 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PMCH 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PMCH 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PMCH 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pmch 30 |
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710175 | Benign: not provided | 102,197,022(-) | C/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
byssinosis |
|
|
cardiomyopathy, familial hypertrophic, 20 |
|
|
frontometaphyseal dysplasia |
|
|
pontocerebellar hypoplasia |
|
|
respiratory allergy |
|
|