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PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) is a Protein Coding gene. Diseases associated with PMAIP1 include Adult T-Cell Leukemia and Mantle Cell Lymphoma. Among its related pathways are Apoptosis Modulation and Signaling and Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 15705586 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 12879012 |
GO:0005739 | mitochondrion | IBA,IDA | 14500711 |
GO:0005741 | mitochondrial outer membrane | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activation of BH3-only proteins | ||
2 | Apoptosis Modulation and Signaling |
.41
|
.31
|
3 | DNA Damage Response | ||
4 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
|
p53 Mediated Apoptosis
.84
|
5 | Apoptotic execution phase |
.31
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001836 | release of cytochrome c from mitochondria | IEA | -- |
GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | -- |
GO:0006915 | apoptotic process | IMP | 17599062 |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | -- |
GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | |||||||||||||
SP3: | - | - |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PMAIP1 30 |
|
||
Dog (Canis familiaris) |
Mammalia | PMAIP1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Pmaip1 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1055632 | CNV | loss | 25217958 |
nsv523228 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
adult t-cell leukemia |
|
|
mantle cell lymphoma |
|
|
alk-negative anaplastic large cell lymphoma |
|
|
colorectal cancer |
|
|
li-fraumeni syndrome |
|
|