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This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and... See more...
Aliases for PMAIP1 Gene
Aliases for PMAIP1 Gene
External Ids for PMAIP1 Gene
- HGNC: 9108
- NCBI Entrez Gene: 5366
- Ensembl: ENSG00000141682
- OMIM®: 604959
- UniProtKB/Swiss-Prot: Q13794
Previous GeneCards Identifiers for PMAIP1 Gene
- GC18P057399
- GC18P057540
- GC18P055716
- GC18P055718
- GC18P054277
- GC18P057568
Summaries for PMAIP1 Gene
-
This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020]
GeneCards Summary for PMAIP1 Gene
PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) is a Protein Coding gene. Diseases associated with PMAIP1 include Adult T-Cell Leukemia and Mantle Cell Lymphoma. Among its related pathways are DNA Damage Response (only ATM dependent) and TP53 Regulates Transcription of Cell Death Genes.
UniProtKB/Swiss-Prot Summary for PMAIP1 Gene
-
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Additional gene information for PMAIP1 Gene
- HGNC (9108)
- NCBI Entrez Gene (5366)
- Ensembl (ENSG00000141682)
- OMIM® (604959)
- UniProtKB/Swiss-Prot (Q13794)
- Open Targets Platform(ENSG00000141682)
- Search for PMAIP1 at DataMed
- Search for PMAIP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PMAIP1 Gene
Genomics for PMAIP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PMAIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PMAIP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PMAIP1
- Top Transcription factor binding sites by QIAGEN in the PMAIP1 gene promoter:
-
- c-Myc
- CUTL1
- FOXD3
- HSF2
- IRF-1
- Max1
- PPAR-gamma1
- STAT3
- STAT5A
Genomic Locations for PMAIP1 Gene
Latest Assembly
- chr18:59,899,996-59,904,305
- (GRCh38/hg38)
- Size:
- 4,310 bases
- Orientation:
- Plus strand
Previous Assembly
- chr18:57,567,228-57,571,537
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 4,310 bases
- Orientation:
- Plus strand
- chr18:57,567,180-57,571,538
- (GRCh37/hg19 by Ensembl)
- Size:
- 4,359 bases
- Orientation:
- Plus strand
Genomic View for PMAIP1 Gene
Genes around PMAIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.32 by HGNC
- 18q21.32 by Entrez Gene
- 18q21.32 by Ensembl
PMAIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PMAIP1 Gene
Proteins for PMAIP1 Gene
-
Protein details for PMAIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13794-APR_HUMAN
- Recommended name:
- Phorbol-12-myristate-13-acetate-induced protein 1
- Protein Accession:
- Q13794
- B2R4T7
- Q8N589
Protein attributes for PMAIP1 Gene
- Size:
- 54 amino acids
- Molecular mass:
- 6030 Da
- Quaternary structure:
-
- Interacts with MCL1, BCL2A1 and BAX.
Post-translational modifications for PMAIP1 Gene
Other Protein References for PMAIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PMAIP1 / NOXA Antibody (LS-B121) and PMAIP1 / NOXA Antibody (LS-B184)
-
Custom Antibody ServicesOriGene Antibodies for PMAIP1
- Novus Biologicals Antibodies for PMAIP1
-
Abcam antibodies for PMAIP1
- Invitrogen Antibodies for PMAIP1 (AFLGC-PMAIP1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PMAIP1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for PMAIP1
- Origene Custom Protein Services for PMAIP1
-
Abcam proteins for PMAIP1
Assay products for research
No data available for DME Specific Peptides for PMAIP1 Gene
Domains & Families for PMAIP1 Gene
Gene Families for PMAIP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for PMAIP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein Noxa (APR_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13794UniProtKB/Swiss-Prot:
APR_HUMAN :- The BH3 motif is essential for pro-apoptotic activity.
- Belongs to the PMAIP1 family.
- Domain:
-
- The BH3 motif is essential for pro-apoptotic activity.
- Family:
-
- Belongs to the PMAIP1 family.
Function for PMAIP1 Gene
Molecular function for PMAIP1 Gene
- UniProtKB/Swiss-Prot Function:
- Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses.
Phenotypes From GWAS Catalog for PMAIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15705586 |
Phenotypes for PMAIP1 Gene
- GenomeRNAi human phenotypes for PMAIP1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased viability
- Strongly decreased CFP-tsO45G cell surface transport
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PMAIP1 - Starting at $85 >
- * PMAIP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PMAIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PMAIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PMAIP1
miRNA for PMAIP1 Gene
- miRTarBase miRNAs that target PMAIP1
-
- mmu-miR-155-5p (MIRT006206)
- hsa-miR-200c-3p (MIRT007018)
- mmu-miR-30e-5p (MIRT013296)
- hsa-miR-186-5p (MIRT021168)
- hsa-miR-98-5p (MIRT027675)
- hsa-miR-26b-5p (MIRT029656)
- hsa-let-7f-2-3p (MIRT038989)
- hsa-miR-18a-3p (MIRT040967)
- hsa-miR-193b-3p (MIRT041571)
- hsa-miR-331-3p (MIRT043467)
- hsa-miR-125b-5p (MIRT045943)
- hsa-miR-15b-3p (MIRT080498)
- hsa-miR-568 (MIRT080501)
- hsa-miR-570-5p (MIRT080502)
- hsa-miR-624-3p (MIRT080503)
- hsa-miR-3924 (MIRT080504)
- hsa-miR-548ag (MIRT080505)
- hsa-miR-548ai (MIRT080506)
- hsa-miR-4517 (MIRT080507)
- hsa-miR-4528 (MIRT080508)
- hsa-miR-5583-3p (MIRT080509)
- hsa-miR-548ba (MIRT080510)
- hsa-miR-3646 (MIRT080516)
- hsa-miR-29a-5p (MIRT080530)
- hsa-miR-193a-3p (MIRT080531)
- hsa-miR-934 (MIRT080533)
- hsa-miR-4699-3p (MIRT080536)
- hsa-miR-22-5p (MIRT080542)
- hsa-miR-2116-5p (MIRT080547)
- hsa-miR-4677-5p (MIRT080553)
- hsa-miR-4716-5p (MIRT080554)
- hsa-miR-448 (MIRT080559)
- hsa-miR-519c-5p (MIRT080560)
- hsa-miR-519b-5p (MIRT080561)
- hsa-miR-523-5p (MIRT080562)
- hsa-miR-518f-5p (MIRT080563)
- hsa-miR-526a (MIRT080564)
- hsa-miR-520c-5p (MIRT080565)
- hsa-miR-518e-5p (MIRT080566)
- hsa-miR-518d-5p (MIRT080567)
- hsa-miR-522-5p (MIRT080568)
- hsa-miR-519a-5p (MIRT080569)
- hsa-miR-1298-5p (MIRT080570)
- hsa-miR-4777-5p (MIRT080571)
- hsa-miR-5700 (MIRT080572)
- hsa-miR-8076 (MIRT080573)
- hsa-miR-511-3p (MIRT080574)
- hsa-miR-1185-2-3p (MIRT080575)
- hsa-miR-1185-1-3p (MIRT080576)
- hsa-miR-5591-3p (MIRT080578)
- hsa-miR-488-5p (MIRT080581)
- hsa-miR-3169 (MIRT080586)
- hsa-miR-3651 (MIRT080588)
- hsa-miR-26a-5p (MIRT080605)
- hsa-miR-499a-5p (MIRT080609)
- hsa-miR-548c-3p (MIRT080612)
- hsa-miR-888-5p (MIRT080613)
- hsa-miR-1297 (MIRT080615)
- hsa-miR-1244 (MIRT080616)
- hsa-miR-4432 (MIRT080617)
- hsa-miR-4465 (MIRT080618)
- hsa-miR-5697 (MIRT080621)
- hsa-miR-576-3p (MIRT080622)
- hsa-miR-1294 (MIRT080623)
- hsa-miR-4316 (MIRT080624)
- hsa-miR-4775 (MIRT080629)
- hsa-miR-200b-3p (MIRT080631)
- hsa-miR-429 (MIRT080632)
- hsa-miR-577 (MIRT117450)
- hsa-miR-3662 (MIRT117451)
- hsa-miR-27a-3p (MIRT148810)
- hsa-miR-27b-3p (MIRT148813)
- hsa-miR-1284 (MIRT252245)
- hsa-miR-181a-5p (MIRT252248)
- hsa-miR-181b-5p (MIRT252249)
- hsa-miR-181c-5p (MIRT252250)
- hsa-miR-181d-5p (MIRT252254)
- hsa-miR-4738-3p (MIRT252259)
- hsa-miR-6083 (MIRT290895)
- hsa-miR-190a-3p (MIRT290929)
- hsa-miR-5011-5p (MIRT290930)
- hsa-miR-6074 (MIRT290931)
- hsa-miR-8084 (MIRT290940)
- hsa-miR-570-3p (MIRT290941)
- hsa-miR-5683 (MIRT290942)
- hsa-miR-379-3p (MIRT346610)
- hsa-miR-552-5p (MIRT346611)
- hsa-miR-411-3p (MIRT346612)
- hsa-miR-146a-5p (MIRT387607)
- hsa-miR-146b-5p (MIRT387608)
- hsa-miR-589-5p (MIRT387609)
- hsa-miR-7153-5p (MIRT387611)
- hsa-miR-197-3p (MIRT438410)
- mmu-miR-23a-3p (MIRT438523)
- mmu-miR-27a-3p (MIRT438524)
- hsa-miR-587 (MIRT492620)
- hsa-miR-202-3p (MIRT492621)
- hsa-miR-590-3p (MIRT492622)
- hsa-let-7a-5p (MIRT492623)
- hsa-let-7b-5p (MIRT492624)
- hsa-let-7d-5p (MIRT492625)
- hsa-let-7e-5p (MIRT492626)
- hsa-let-7g-5p (MIRT492627)
- hsa-let-7i-5p (MIRT492628)
- hsa-miR-4458 (MIRT492629)
- hsa-let-7f-5p (MIRT492630)
- hsa-let-7c-5p (MIRT492631)
- hsa-miR-4500 (MIRT492632)
- hsa-miR-297 (MIRT506122)
- hsa-miR-4307 (MIRT506123)
- hsa-miR-101-5p (MIRT506124)
- hsa-miR-8087 (MIRT506125)
- hsa-miR-5583-5p (MIRT506126)
- hsa-miR-3129-3p (MIRT506127)
- hsa-miR-3684 (MIRT510956)
- hsa-miR-6502-3p (MIRT510957)
- hsa-miR-643 (MIRT510958)
- hsa-miR-6750-3p (MIRT510959)
- hsa-miR-223-5p (MIRT510960)
- hsa-miR-380-3p (MIRT510961)
- hsa-miR-4495 (MIRT510962)
- hsa-miR-3688-3p (MIRT510963)
- hsa-miR-660-5p (MIRT510964)
- hsa-miR-5580-3p (MIRT510965)
- hsa-miR-3185 (MIRT547072)
- hsa-miR-1255b-2-3p (MIRT547073)
- hsa-miR-5692a (MIRT547074)
- hsa-miR-335-3p (MIRT547075)
- hsa-miR-1537-3p (MIRT547076)
- hsa-miR-4795-3p (MIRT574525)
- hsa-miR-622 (MIRT574526)
- hsa-miR-892b (MIRT574527)
- mmu-miR-5135 (MIRT601848)
- mmu-miR-3082-5p (MIRT601849)
- mmu-miR-139-5p (MIRT601850)
- mmu-miR-665-3p (MIRT601851)
- hsa-miR-106a-5p (MIRT761125)
- hsa-miR-106b-5p (MIRT761133)
- hsa-miR-17-5p (MIRT762955)
- hsa-miR-208a-3p (MIRT763738)
- hsa-miR-208b-3p (MIRT763745)
- hsa-miR-20a-5p (MIRT763762)
- hsa-miR-20b-5p (MIRT763774)
- hsa-miR-323a-3p (MIRT765551)
- hsa-miR-3609 (MIRT765871)
- hsa-miR-3617-5p (MIRT766099)
- hsa-miR-4509 (MIRT769834)
- hsa-miR-4714-3p (MIRT771407)
- hsa-miR-4744 (MIRT771899)
- hsa-miR-4796-3p (MIRT772500)
- hsa-miR-519d-3p (MIRT773723)
- hsa-miR-526b-3p (MIRT773919)
- hsa-miR-548ah-5p (MIRT774108)
- hsa-miR-641 (MIRT776157)
- hsa-miR-93-5p (MIRT782763)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PMAIP1
- Browse OriGene Inhibitory RNA Products For PMAIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PMAIP1
Clone products for research
- Applied Biological Materials (abm): Clones for PMAIP1 - Starting at $45 >
- * PMAIP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PMAIP1
- Addgene plasmids for PMAIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PMAIP1
Cell Lines for research
-
Horizon Cell Lines for PMAIP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PMAIP1 Gene
Localization for PMAIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PMAIP1 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 12879012 |
| GO:0005739 | mitochondrion | IBA,IDA | 14500711 |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PMAIP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of BH3-only proteins | ||
| 2 | Apoptosis Modulation and Signaling |
.41
|
.31
|
| 3 | DNA Damage Response | ||
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
|
p53 Mediated Apoptosis
.84
|
| 5 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
Pathways by source for PMAIP1 Gene
9 BioSystems pathways for PMAIP1 Gene
11 Reactome pathways for PMAIP1 Gene
7 KEGG pathways for PMAIP1 Gene
1 GeneGo (Thomson Reuters) pathway for PMAIP1 Gene
- Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
4 Qiagen pathways for PMAIP1 Gene
- Cellular Apoptosis Pathway
- Mitochondrial Apoptosis
- Molecular Mechanisms of Cancer
- p53 Mediated Apoptosis
1 Cell Signaling Technology pathway for PMAIP1 Gene
1 GeneTex pathway for PMAIP1 Gene
Interacting Proteins for PMAIP1 Gene
Selected Interacting proteins:
Q13794-APR_HUMAN
ENSP00000326119
for PMAIP1 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for PMAIP1
SIGNOR curated interactions for PMAIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001836 | release of cytochrome c from mitochondria | IEA | -- |
| GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | -- |
| GO:0006915 | apoptotic process | IMP | 17599062 |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
Transcripts for PMAIP1 Gene
mRNA/cDNA for PMAIP1 Gene
- 6 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000269518 1262 nts (view in UCSC)
- ENST00000316660 1899 nts (view in UCSC)
- ENST00000590596 804 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PMAIP1 - Starting at $85 >
- * PMAIP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PMAIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PMAIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PMAIP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PMAIP1
- Browse OriGene Inhibitory RNA Products For PMAIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PMAIP1
Clone products for research
- Applied Biological Materials (abm): Clones for PMAIP1 - Starting at $45 >
- * PMAIP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PMAIP1
- Addgene plasmids for PMAIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PMAIP1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | |||||||||||||
| SP3: | - | - |
Relevant External Links for PMAIP1 Gene
- GeneLoc Exon Structure for
- PMAIP1
Expression for PMAIP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells (Uncategorized)
- Inner Cell Mass (Early Embryonic Tissues)
- Brain (Nervous System)
- Placenta (Extraembryonic Tissues)
- Umbilical Cord (Extraembryonic Tissues)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PMAIP1
SOURCE GeneReport for Unigene cluster for PMAIP1 Gene:
Hs.96mRNA Expression by UniProt/SwissProt for PMAIP1 Gene:
Q13794-APR_HUMAN
Tissue specificity:
Highly expressed in adult T-cell leukemia cell line.
Evidence on tissue expression from TISSUES for PMAIP1 Gene
- Bone marrow(2.9)
- Nervous system(2.7)
- Intestine(2.6)
- Kidney(2.6)
- Lymph node(2.5)
- Heart(2.5)
- Skin(2.5)
- Spleen(2.5)
- Blood(2.4)
- Muscle(2.4)
- Liver(2.3)
- Stomach(2.3)
- Lung(2.2)
- Thyroid gland(2.1)
- Pancreas(2.1)
Primer products for research
-
OriGene qPCR primer pairs for PMAIP1
-
OriGene qPCR primer pairs and template standards for PMAIP1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PMAIP1 Gene
Orthologs for PMAIP1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PMAIP1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | PMAIP1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pmaip1 31 |
|
OneToOne |
- Species where no ortholog for PMAIP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for PMAIP1 Gene
- ENSEMBL:
- Gene Tree for PMAIP1 (if available)
- TreeFam:
- Gene Tree for PMAIP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PMAIP1: view image
Paralogs for PMAIP1 Gene
No data available for Paralogs for PMAIP1 Gene
Variants for PMAIP1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1055632 | CNV | loss | 25217958 |
| nsv523228 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.31;
62.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PMAIP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PMAIP1 Gene
Disorders for PMAIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adult t-cell leukemia |
|
|
| mantle cell lymphoma |
|
|
| alk-negative anaplastic large cell lymphoma |
|
|
| colorectal cancer |
|
|
| pyriform sinus cancer |
|
|
Search PMAIP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PMAIP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PMAIP1 Gene
Publications for PMAIP1 Gene
- Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line. (PMID: 2398525) Hijikata M … Shimotohno K (Journal of virology 1990) 2 3 4
- The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer. (PMID: 18231856) Ishida M … Horii A (Digestive diseases and sciences 2008) 3 23
- The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. (PMID: 18408751) Hassan M … Hengge UR (Oncogene 2008) 3 23
- Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection. (PMID: 15705586) Sun Y … Leaman DW (The Journal of biological chemistry 2005) 3 4
- Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. (PMID: 15694340) Chen L … Huang DC (Molecular cell 2005) 3 4
ExternalLinks
Products for PMAIP1 Gene
- Custom Antibody ServicesOriGene Antibodies for PMAIP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PMAIP1
- Origene Custom Protein Services for PMAIP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PMAIP1
- Browse OriGene Inhibitory RNA Products For PMAIP1
- OriGene qPCR primer pairs for PMAIP1
- OriGene qPCR primer pairs and template standards for PMAIP1
- OriGene CRISPR knockouts for PMAIP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PMAIP1
- Sino Biological Human cDNA Clone for PMAIP1
- Browse Sino Biological Recombinant Proteins
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for PMAIP1
- Novus Biologicals proteins and lysates for PMAIP1
- Browse Antibodies
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- Browse Primary Antibodies
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- Invitrogen Antibodies for PMAIP1 (AFLGC-PMAIP1)
- VectorBuilder Custom and pre-made DNA vectors for PMAIP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PMAIP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PMAIP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PMAIP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PMAIP1
- Addgene plasmids for PMAIP1
- antibodies-online: Show 16 available NOXA Antibodies ranked by validation data
- Compare Top NOXA Antibodies
- antibodies-online: Show 12 available NOXA Elisa Kits ranked by validation data
- Compare Top NOXA Elisa Kits
- antibodies-online: Show 6 available NOXA Proteins ranked by validation data
- Compare Top NOXA Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PMAIP1
- Search Santa Cruz Biotechnology (SCBT) for PMAIP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PMAIP1
- Custom Antibody ServicesProSci Antibodies for PMAIP1
- Search for PMAIP1 Proteins at ProSci
- Horizon Cell Lines for PMAIP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PMAIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PMAIP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PMAIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PMAIP1
Sources for PMAIP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB