Aliases for PMAIP1 Gene
Aliases for PMAIP1 Gene
External Ids for PMAIP1 Gene
- HGNC: 9108
- Entrez Gene: 5366
- Ensembl: ENSG00000141682
- OMIM: 604959
- UniProtKB: Q13794
Previous GeneCards Identifiers for PMAIP1 Gene
- GC18P057399
- GC18P057540
- GC18P055716
- GC18P055718
- GC18P054277
- GC18P057568
Summaries for PMAIP1 Gene
GeneCards Summary for PMAIP1 Gene
PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) is a Protein Coding gene. Diseases associated with PMAIP1 include Adult T-Cell Leukemia and Ischemic Neuropathy. Among its related pathways are Gene Expression and Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins.
UniProtKB/Swiss-Prot for PMAIP1 Gene
-
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Additional gene information for PMAIP1 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PMAIP1 Gene
Genomics for PMAIP1 Gene
GeneHancer (GH) Regulatory Elements for PMAIP1 Gene
Promoters and enhancers for PMAIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PMAIP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PMAIP1 gene promoter:
Regulatory Element Products
Genomic Locations for PMAIP1 Gene
Genomic Locations for PMAIP1 Gene
- chr18:59,899,948-59,904,306
- (GRCh38/hg38)
- Size:
- 4,359 bases
- Orientation:
- Plus strand
- chr18:57,567,180-57,571,538
- (GRCh37/hg19)
Genomic View for PMAIP1 Gene
Genes around PMAIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.32 by Entrez Gene
- 18q21.32 by HGNC
- 18q21.32 by Ensembl
PMAIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PMAIP1 Gene
Proteins for PMAIP1 Gene
-
Protein details for PMAIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13794-APR_HUMAN
- Recommended name:
- Phorbol-12-myristate-13-acetate-induced protein 1
- Protein Accession:
- Q13794
- B2R4T7
- Q8N589
Protein attributes for PMAIP1 Gene
- Size:
- 54 amino acids
- Molecular mass:
- 6030 Da
- Quaternary structure:
-
- Interacts with MCL1, BCL2A1 and BAX.
Post-translational modifications for PMAIP1 Gene
Other Protein References for PMAIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PMAIP1
- Novus Biologicals Antibodies for PMAIP1
- Invitrogen Antibodies for PMAIP1
- GeneTex PMAIP1 Antibody for PMAIP1
-
Boster Bio Antibodies for PMAIP1
-
Custom Antibody ServicesProSci Antibodies for PMAIP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PMAIP1
Protein Products
-
OriGene Purified Proteins for PMAIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for PMAIP1
- Origene Custom Protein Services for PMAIP1
- Search GeneTex for Proteins for PMAIP1
Assay Products
No data available for DME Specific Peptides for PMAIP1 Gene
Domains & Families for PMAIP1 Gene
Gene Families for PMAIP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for PMAIP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13794UniProtKB/Swiss-Prot:
APR_HUMAN :- The BH3 motif is essential for pro-apoptotic activity.
- Belongs to the PMAIP1 family.
- Domain:
-
- The BH3 motif is essential for pro-apoptotic activity.
- Family:
-
- Belongs to the PMAIP1 family.
Function for PMAIP1 Gene
Molecular function for PMAIP1 Gene
- UniProtKB/Swiss-Prot Function:
- Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses.
Phenotypes From GWAS Catalog for PMAIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15694340 |
Phenotypes for PMAIP1 Gene
- GenomeRNAi human phenotypes for PMAIP1:
-
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased hepcidin::fluc mRNA expression
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PMAIP1
-
CRISPR Products
-
OriGene CRISPR knockouts for PMAIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PMAIP1
- genomics-online: gRNA clones - Search results for 101 available NOXA gene related products
- Overview of 101 available NOXA gene related products
- Applied Biological Materials CRISPR for PMAIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PMAIP1
- GenScript: Design CRISPR guide RNA sequences for PMAIP1
miRNA for PMAIP1 Gene
- miRTarBase miRNAs that target PMAIP1
-
- hsa-mir-200c-3p (MIRT007018)
- hsa-mir-186-5p (MIRT021168)
- hsa-mir-98-5p (MIRT027675)
- hsa-mir-26b-5p (MIRT029656)
- hsa-let-7f-2-3p (MIRT038989)
- hsa-mir-18a-3p (MIRT040967)
- hsa-mir-193b-3p (MIRT041571)
- hsa-mir-331-3p (MIRT043467)
- hsa-mir-125b-5p (MIRT045943)
- hsa-mir-15b-3p (MIRT080498)
- hsa-mir-568 (MIRT080501)
- hsa-mir-570-5p (MIRT080502)
- hsa-mir-624-3p (MIRT080503)
- hsa-mir-3924 (MIRT080504)
- hsa-mir-548ag (MIRT080505)
- hsa-mir-548ai (MIRT080506)
- hsa-mir-4517 (MIRT080507)
- hsa-mir-4528 (MIRT080508)
- hsa-mir-5583-3p (MIRT080509)
- hsa-mir-548ba (MIRT080510)
- hsa-mir-3646 (MIRT080516)
- hsa-mir-29a-5p (MIRT080530)
- hsa-mir-193a-3p (MIRT080531)
- hsa-mir-934 (MIRT080533)
- hsa-mir-4699-3p (MIRT080536)
- hsa-mir-22-5p (MIRT080542)
- hsa-mir-2116-5p (MIRT080547)
- hsa-mir-4677-5p (MIRT080553)
- hsa-mir-4716-5p (MIRT080554)
- hsa-mir-448 (MIRT080559)
- hsa-mir-519c-5p (MIRT080560)
- hsa-mir-519b-5p (MIRT080561)
- hsa-mir-523-5p (MIRT080562)
- hsa-mir-518f-5p (MIRT080563)
- hsa-mir-526a (MIRT080564)
- hsa-mir-520c-5p (MIRT080565)
- hsa-mir-518e-5p (MIRT080566)
- hsa-mir-518d-5p (MIRT080567)
- hsa-mir-522-5p (MIRT080568)
- hsa-mir-519a-5p (MIRT080569)
- hsa-mir-1298-5p (MIRT080570)
- hsa-mir-4777-5p (MIRT080571)
- hsa-mir-5700 (MIRT080572)
- hsa-mir-8076 (MIRT080573)
- hsa-mir-511-3p (MIRT080574)
- hsa-mir-1185-2-3p (MIRT080575)
- hsa-mir-1185-1-3p (MIRT080576)
- hsa-mir-5591-3p (MIRT080578)
- hsa-mir-488-5p (MIRT080581)
- hsa-mir-3169 (MIRT080586)
- hsa-mir-3651 (MIRT080588)
- hsa-mir-26a-5p (MIRT080605)
- hsa-mir-499a-5p (MIRT080609)
- hsa-mir-548c-3p (MIRT080612)
- hsa-mir-888-5p (MIRT080613)
- hsa-mir-1297 (MIRT080615)
- hsa-mir-1244 (MIRT080616)
- hsa-mir-4432 (MIRT080617)
- hsa-mir-4465 (MIRT080618)
- hsa-mir-5697 (MIRT080621)
- hsa-mir-576-3p (MIRT080622)
- hsa-mir-1294 (MIRT080623)
- hsa-mir-4316 (MIRT080624)
- hsa-mir-4775 (MIRT080629)
- hsa-mir-200b-3p (MIRT080631)
- hsa-mir-429 (MIRT080632)
- hsa-mir-577 (MIRT117450)
- hsa-mir-3662 (MIRT117451)
- hsa-mir-27a-3p (MIRT148810)
- hsa-mir-27b-3p (MIRT148813)
- hsa-mir-1284 (MIRT252245)
- hsa-mir-181a-5p (MIRT252248)
- hsa-mir-181b-5p (MIRT252249)
- hsa-mir-181c-5p (MIRT252250)
- hsa-mir-181d-5p (MIRT252254)
- hsa-mir-4738-3p (MIRT252259)
- hsa-mir-6083 (MIRT290895)
- hsa-mir-190a-3p (MIRT290929)
- hsa-mir-5011-5p (MIRT290930)
- hsa-mir-6074 (MIRT290931)
- hsa-mir-8084 (MIRT290940)
- hsa-mir-570-3p (MIRT290941)
- hsa-mir-5683 (MIRT290942)
- hsa-mir-379-3p (MIRT346610)
- hsa-mir-552-5p (MIRT346611)
- hsa-mir-411-3p (MIRT346612)
- hsa-mir-146a-5p (MIRT387607)
- hsa-mir-146b-5p (MIRT387608)
- hsa-mir-589-5p (MIRT387609)
- hsa-mir-7153-5p (MIRT387611)
- hsa-mir-197-3p (MIRT438410)
- hsa-mir-587 (MIRT492620)
- hsa-mir-202-3p (MIRT492621)
- hsa-mir-590-3p (MIRT492622)
- hsa-let-7a-5p (MIRT492623)
- hsa-let-7b-5p (MIRT492624)
- hsa-let-7d-5p (MIRT492625)
- hsa-let-7e-5p (MIRT492626)
- hsa-let-7g-5p (MIRT492627)
- hsa-let-7i-5p (MIRT492628)
- hsa-mir-4458 (MIRT492629)
- hsa-let-7f-5p (MIRT492630)
- hsa-let-7c-5p (MIRT492631)
- hsa-mir-4500 (MIRT492632)
- hsa-mir-297 (MIRT506122)
- hsa-mir-4307 (MIRT506123)
- hsa-mir-101-5p (MIRT506124)
- hsa-mir-8087 (MIRT506125)
- hsa-mir-5583-5p (MIRT506126)
- hsa-mir-3129-3p (MIRT506127)
- hsa-mir-3684 (MIRT510956)
- hsa-mir-6502-3p (MIRT510957)
- hsa-mir-643 (MIRT510958)
- hsa-mir-6750-3p (MIRT510959)
- hsa-mir-223-5p (MIRT510960)
- hsa-mir-380-3p (MIRT510961)
- hsa-mir-4495 (MIRT510962)
- hsa-mir-3688-3p (MIRT510963)
- hsa-mir-660-5p (MIRT510964)
- hsa-mir-5580-3p (MIRT510965)
- hsa-mir-3185 (MIRT547072)
- hsa-mir-1255b-2-3p (MIRT547073)
- hsa-mir-5692a (MIRT547074)
- hsa-mir-335-3p (MIRT547075)
- hsa-mir-1537-3p (MIRT547076)
- hsa-mir-4795-3p (MIRT574525)
- hsa-mir-622 (MIRT574526)
- hsa-mir-892b (MIRT574527)
- hsa-mir-106a-5p (MIRT761125)
- hsa-mir-106b-5p (MIRT761133)
- hsa-mir-17-5p (MIRT762955)
- hsa-mir-208a-3p (MIRT763738)
- hsa-mir-208b-3p (MIRT763745)
- hsa-mir-20a-5p (MIRT763762)
- hsa-mir-20b-5p (MIRT763774)
- hsa-mir-323a-3p (MIRT765551)
- hsa-mir-3609 (MIRT765871)
- hsa-mir-3617-5p (MIRT766099)
- hsa-mir-4509 (MIRT769834)
- hsa-mir-4714-3p (MIRT771407)
- hsa-mir-4744 (MIRT771899)
- hsa-mir-4796-3p (MIRT772500)
- hsa-mir-519d-3p (MIRT773723)
- hsa-mir-526b-3p (MIRT773919)
- hsa-mir-548ah-5p (MIRT774108)
- hsa-mir-641 (MIRT776157)
- hsa-mir-93-5p (MIRT782763)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PMAIP1
- Browse OriGene Inhibitory RNA Products For PMAIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PMAIP1
- genomics-online: shRNA clones - Search results for 101 available NOXA gene related products
- Overview of 101 available NOXA gene related products
Clone Products
- Sino Biological Human cDNA Clone for PMAIP1
- VectorBuilder custom plasmid, inducible vectors for PMAIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PMAIP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PMAIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PMAIP1
- Applied Biological Materials Clones for PMAIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PMAIP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PMAIP1 Gene
Localization for PMAIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PMAIP1 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 12879012 |
| GO:0005739 | mitochondrion | IDA,IEA | 14500711 |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PMAIP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of BH3-only proteins | ||
| 2 | Apoptosis Modulation and Signaling |
.41
|
.31
|
| 3 | DNA Damage Response | ||
| 4 | Apoptotic Pathways in Synovial Fibroblasts | ||
| 5 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
Pathways by source for PMAIP1 Gene
1 GeneTex pathway for PMAIP1 Gene
9 BioSystems pathways for PMAIP1 Gene
11 Reactome pathways for PMAIP1 Gene
7 KEGG pathways for PMAIP1 Gene
1 GeneGo (Thomson Reuters) pathway for PMAIP1 Gene
4 Qiagen pathways for PMAIP1 Gene
1 Cell Signaling Technology pathway for PMAIP1 Gene
Interacting Proteins for PMAIP1 Gene
Selected Interacting proteins:
Q13794-APR_HUMAN
ENSP00000326119
for PMAIP1 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for PMAIP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001836 | release of cytochrome c from mitochondria | IEA | -- |
| GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | -- |
| GO:0006915 | apoptotic process | IMP | 17599062 |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
Transcripts for PMAIP1 Gene
mRNA/cDNA for PMAIP1 Gene
- (117) Selected AceView cDNA sequences:
- (4) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000269518 1262 bps (uc002lid.3)
- ENST00000316660 1948 bps (uc002lic.3)
- ENST00000590596 804 bps (uc060pru.1)
Unigene Clusters for PMAIP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PMAIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PMAIP1
- genomics-online: gRNA clones - Search results for 101 available NOXA gene related products
- Overview of 101 available NOXA gene related products
- Applied Biological Materials CRISPR for PMAIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PMAIP1
- GenScript: Design CRISPR guide RNA sequences for PMAIP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PMAIP1
- Browse OriGene Inhibitory RNA Products For PMAIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PMAIP1
- genomics-online: shRNA clones - Search results for 101 available NOXA gene related products
- Overview of 101 available NOXA gene related products
Clone Products
- Sino Biological Human cDNA Clone for PMAIP1
- VectorBuilder custom plasmid, inducible vectors for PMAIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PMAIP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PMAIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PMAIP1
- Applied Biological Materials Clones for PMAIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | |||||||||||||
| SP3: | - | - |
Expression for PMAIP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells (Uncategorized)
- Inner Cell Mass (Early Embryonic Tissues)
- Umbilical Cord (Extraembryonic Tissues)
- Placenta (Extraembryonic Tissues)
- Brain (Nervous System)
- Bone (Muscoskeletal System)
- Intestine (Gastrointestinal Tract)
- Thyroid (Endocrine System)
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
NURSA nuclear receptor signaling pathways regulating expression of PMAIP1 Gene:
PMAIP1SOURCE GeneReport for Unigene cluster for PMAIP1 Gene:
Hs.96mRNA Expression by UniProt/SwissProt for PMAIP1 Gene:
Q13794-APR_HUMAN
Tissue specificity:
Highly expressed in adult T-cell leukemia cell line.
Evidence on tissue expression from TISSUES for PMAIP1 Gene
- Bone marrow(2.3)
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for PMAIP1
-
OriGene qPCR primer pairs for PMAIP1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PMAIP1 Gene
Orthologs for PMAIP1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PMAIP1 33 |
|
||
| dog (Canis familiaris) |
Mammalia | PMAIP1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Pmaip1 34 |
|
OneToOne |
- Species where no ortholog for PMAIP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for PMAIP1 Gene
- ENSEMBL:
- Gene Tree for PMAIP1 (if available)
- TreeFam:
- Gene Tree for PMAIP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PMAIP1: view image
Paralogs for PMAIP1 Gene
No data available for Paralogs for PMAIP1 Gene
Variants for PMAIP1 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000374717 | -- | 59,900,674(+) | G/A | intron_variant | |
| rs1001089796 | -- | 59,899,834(+) | T/G | upstream_transcript_variant | |
| rs1001376120 | -- | 59,902,085(+) | G/A | intron_variant | |
| rs1002191572 | -- | 59,904,464(+) | A/G | downstream_transcript_variant | |
| rs1002371860 | -- | 59,898,612(+) | C/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1055632 | CNV | loss | 25217958 |
| nsv523228 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.31;
62.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PMAIP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PMAIP1 Gene
Disorders for PMAIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adult t-cell leukemia |
|
|
| ischemic neuropathy |
|
|
| t-cell leukemia |
|
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| alk-negative anaplastic large cell lymphoma |
|
|
| superior mesenteric artery syndrome |
|
|
Search PMAIP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PMAIP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PMAIP1 Gene
Publications for PMAIP1 Gene
- Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line. (PMID: 2398525) Hijikata M … Shimotohno K (Journal of virology 1990) 2 3 4 58
- The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer. (PMID: 18231856) Ishida M … Horii A (Digestive diseases and sciences 2008) 3 22 58
- The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. (PMID: 18408751) Hassan M … Hengge UR (Oncogene 2008) 3 22 58
- Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. (PMID: 15694340) Chen L … Huang DC (Molecular cell 2005) 3 4 58
- Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection. (PMID: 15705586) Sun Y … Leaman DW (The Journal of biological chemistry 2005) 3 4 58
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Sources for PMAIP1 Gene
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