Aliases for PMAIP1 Gene
External Ids for PMAIP1 Gene
Previous GeneCards Identifiers for PMAIP1 Gene
GeneCards Summary for PMAIP1 Gene
PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) is a Protein Coding gene. Diseases associated with PMAIP1 include Adult T-Cell Leukemia and T-Cell Leukemia. Among its related pathways are Direct p53 effectors and CDK-mediated phosphorylation and removal of Cdc6.
UniProtKB/Swiss-Prot Summary for PMAIP1 Gene
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.