Aliases for PLXNC1 Gene
External Ids for PLXNC1 Gene
Previous GeneCards Identifiers for PLXNC1 Gene
This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for PLXNC1 Gene
PLXNC1 (Plexin C1) is a Protein Coding gene. Diseases associated with PLXNC1 include Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is PLXND1.
UniProtKB/Swiss-Prot Summary for PLXNC1 Gene
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).