Aliases for PLXNB3 Gene
External Ids for PLXNB3 Gene
Previous HGNC Symbols for PLXNB3 Gene
Previous GeneCards Identifiers for PLXNB3 Gene
The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for PLXNB3 Gene
PLXNB3 (Plexin B3) is a Protein Coding gene. Diseases associated with PLXNB3 include Glioma. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include semaphorin receptor activity. An important paralog of this gene is PLXNB1.
UniProtKB/Swiss-Prot for PLXNB3 Gene
Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.