Aliases for PLXNA4 Gene
External Ids for PLXNA4 Gene
Previous HGNC Symbols for PLXNA4 Gene
Previous GeneCards Identifiers for PLXNA4 Gene
GeneCards Summary for PLXNA4 Gene
PLXNA4 (Plexin A4) is a Protein Coding gene. Diseases associated with PLXNA4 include Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease. Among its related pathways are Semaphorin interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include semaphorin receptor activity. An important paralog of this gene is PLXNA2.
UniProtKB/Swiss-Prot Summary for PLXNA4 Gene
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).