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Aliases for PLXNA3 Gene

Aliases for PLXNA3 Gene

  • Plexin A3 2 3 5
  • Semaphorin Receptor SEX 3 4
  • Plexin-4 3 4
  • PLXN4 3 4
  • Sex Chromosome X Transmembrane Protein Of HGF Receptor Family 3 3
  • HSSEXGENE 3
  • Plexin-A3 3
  • PLXN3 3
  • XAP-6 3
  • 6.3 3
  • SEX 4

External Ids for PLXNA3 Gene

Previous HGNC Symbols for PLXNA3 Gene

  • PLXN4

Previous GeneCards Identifiers for PLXNA3 Gene

  • GC0XU990185
  • GC0XM150067
  • GC0XP151274
  • GC0XP152154
  • GC0XP152118
  • GC0XP153250
  • GC0XP153339
  • GC0XP153686
  • GC0XP142263

Summaries for PLXNA3 Gene

Entrez Gene Summary for PLXNA3 Gene

  • This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

GeneCards Summary for PLXNA3 Gene

PLXNA3 (Plexin A3) is a Protein Coding gene. Diseases associated with PLXNA3 include Childhood-Onset Schizophrenia. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include semaphorin receptor activity. An important paralog of this gene is PLXNA1.

UniProtKB/Swiss-Prot for PLXNA3 Gene

  • Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Gene Wiki entry for PLXNA3 Gene

Additional gene information for PLXNA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNA3 Gene

Genomics for PLXNA3 Gene

GeneHancer (GH) Regulatory Elements for PLXNA3 Gene

Promoters and enhancers for PLXNA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ154457 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 693.8 +0.7 724 3.2 SIN3A ZNF766 GLIS2 FOS ATF7 SP3 ZNF585B SMARCA4 GLIS1 NBN PLXNA3 FAM3A FAM50A HCFC1 LAGE3
GH0XJ154396 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 59 -58.8 -58801 6.2 HNRNPUL1 PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 SNORA70 ENSG00000280195 GC0XP154401 GC0XP154402 RPL10 HCFC1 PLXNA3 DKC1 SNORA56 EMD
GH0XJ154364 Promoter/Enhancer 2.5 VISTA EPDnew Ensembl ENCODE dbSUPER 51.1 -88.1 -88091 10.7 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 EMD FLNA PLXNA3 FAM50A SLC10A3 DKC1 CH17-340M24.3 ENSG00000285018 GC0XM154351 GC0XM154352
GH0XJ154376 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 29.8 -79.1 -79136 5.7 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 POLR2B ZNF213 E2F8 ZNF207 EMD PLXNA3 DKC1 HCFC1 SNORA70 SLC10A3 SNORA56 TMEM187 RPL10 CH17-340M24.3
GH0XJ154346 Enhancer 1.1 Ensembl ENCODE dbSUPER 52 -108.8 -108795 6.6 GTF2F1 BCOR KLF1 ESRRA NFIB EBF1 HIC1 POLR2B POLR2A RBM22 GC0XM154351 GC0XM154352 PLXNA3 FAM50A FAM3A LOC105373386 FLNA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLXNA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLXNA3 gene promoter:
  • deltaCREB
  • CREB
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for PLXNA3 Gene

Genomic Locations for PLXNA3 Gene
chrX:154,458,281-154,477,779
(GRCh38/hg38)
Size:
19,499 bases
Orientation:
Plus strand
chrX:153,686,621-153,701,989
(GRCh37/hg19)
Size:
15,369 bases
Orientation:
Plus strand

Genomic View for PLXNA3 Gene

Genes around PLXNA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNA3 Gene

Proteins for PLXNA3 Gene

  • Protein details for PLXNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51805-PLXA3_HUMAN
    Recommended name:
    Plexin-A3
    Protein Accession:
    P51805
    Secondary Accessions:
    • Q5HY36

    Protein attributes for PLXNA3 Gene

    Size:
    1871 amino acids
    Molecular mass:
    207703 Da
    Quaternary structure:
    • Interacts with CBFA2T3/MTG16.

neXtProt entry for PLXNA3 Gene

Post-translational modifications for PLXNA3 Gene

  • Glycosylation at isoforms=1162, Asn1115, isoforms=1073, Asn1036, isoforms=1009, isoforms=746, Asn738, Asn637, isoforms=548, and isoforms=59
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNA3 Gene

No data available for DME Specific Peptides for PLXNA3 Gene

Domains & Families for PLXNA3 Gene

Gene Families for PLXNA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PLXNA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51805

UniProtKB/Swiss-Prot:

PLXA3_HUMAN :
  • Belongs to the plexin family.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNA3: view

Function for PLXNA3 Gene

Molecular function for PLXNA3 Gene

UniProtKB/Swiss-Prot Function:
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
GENATLAS Biochemistry:
plexin A3,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth factor receptor family, expressed in fetal brain,putatively involved in signal transduction

Phenotypes From GWAS Catalog for PLXNA3 Gene

Gene Ontology (GO) - Molecular Function for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 8570614
GO:0005515 protein binding IPI 20138877
GO:0017154 semaphorin receptor activity IEA --
genes like me logo Genes that share ontologies with PLXNA3: view
genes like me logo Genes that share phenotypes with PLXNA3: view

Animal Models for PLXNA3 Gene

MGI Knock Outs for PLXNA3:

Animal Model Products

CRISPR Products

miRNA for PLXNA3 Gene

miRTarBase miRNAs that target PLXNA3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLXNA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNA3 Gene

Localization for PLXNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNA3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLXNA3 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex TAS 19909241
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane TAS 8570614
genes like me logo Genes that share ontologies with PLXNA3: view

Pathways & Interactions for PLXNA3 Gene

genes like me logo Genes that share pathways with PLXNA3: view

Pathways by source for PLXNA3 Gene

1 Cell Signaling Technology pathway for PLXNA3 Gene

Gene Ontology (GO) - Biological Process for PLXNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion IBA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development TAS 8570614
GO:0007411 axon guidance IEA --
GO:0008360 regulation of cell shape IBA --
genes like me logo Genes that share ontologies with PLXNA3: view

No data available for SIGNOR curated interactions for PLXNA3 Gene

Drugs & Compounds for PLXNA3 Gene

No Compound Related Data Available

Transcripts for PLXNA3 Gene

mRNA/cDNA for PLXNA3 Gene

Unigene Clusters for PLXNA3 Gene

Plexin A3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLXNA3

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNA3 Gene

No ASD Table

Relevant External Links for PLXNA3 Gene

GeneLoc Exon Structure for
PLXNA3
ECgene alternative splicing isoforms for
PLXNA3

Expression for PLXNA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLXNA3 Gene

Protein differential expression in normal tissues from HIPED for PLXNA3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLXNA3 Gene



Protein tissue co-expression partners for PLXNA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLXNA3 Gene:

PLXNA3

SOURCE GeneReport for Unigene cluster for PLXNA3 Gene:

Hs.632839

Evidence on tissue expression from TISSUES for PLXNA3 Gene

  • Nervous system(4.6)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with PLXNA3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLXNA3 Gene

Orthologs for PLXNA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLXNA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLXNA3 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GDI1 34
  • 95 (a)
OneToOne
PLXNA3 33
  • 90.22 (n)
cow
(Bos Taurus)
Mammalia PLXNA3 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plxna3 16 34 33
  • 86.55 (n)
rat
(Rattus norvegicus)
Mammalia Plxna3 33
  • 86.44 (n)
oppossum
(Monodelphis domestica)
Mammalia PLXNA3 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLXNA3 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNA3 34
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397805 33
zebrafish
(Danio rerio)
Actinopterygii plxna3 34 33
  • 70.71 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea Cin.2624 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2624 33
Species where no ortholog for PLXNA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLXNA3 Gene

ENSEMBL:
Gene Tree for PLXNA3 (if available)
TreeFam:
Gene Tree for PLXNA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLXNA3: view image

Paralogs for PLXNA3 Gene

Paralogs for PLXNA3 Gene

(10) SIMAP similar genes for PLXNA3 Gene using alignment to 2 proteins:

  • PLXA3_HUMAN
  • L8ECH0_HUMAN
genes like me logo Genes that share paralogs with PLXNA3: view

Variants for PLXNA3 Gene

Sequence variations from dbSNP and Humsavar for PLXNA3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs149367480 uncertain-significance, Autism, Microtia 154,460,397(+) G/A coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant
rs200042650 benign, Childhood-Onset Schizophrenia 154,464,420(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs374246725 uncertain-significance, not provided 154,466,520(+) G/A intron_variant
rs1000612271 -- 154,470,910(+) C/T genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000735586 -- 154,464,302(+) C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNA3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv519042 CNV gain 19592680

Variation tolerance for PLXNA3 Gene

Residual Variation Intolerance Score: 1.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.37; 85.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLXNA3 Gene

Human Gene Mutation Database (HGMD)
PLXNA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLXNA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNA3 Gene

Disorders for PLXNA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLXNA3 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
childhood-onset schizophrenia
  • childhood schizophrenia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLXNA3

genes like me logo Genes that share disorders with PLXNA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLXNA3 Gene

Publications for PLXNA3 Gene

  1. A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. (PMID: 8570614) Maestrini E … Comoglio PM (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 22 58
  2. Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner. (PMID: 20138877) Fiedler SE … Carr DW (FEBS letters 2010) 3 4 58
  3. Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages. (PMID: 19480842) Ji JD … Ivashkiv LB (Human immunology 2009) 3 22 58
  4. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen EY … D'Urso M (Human molecular genetics 1996) 2 3 58
  5. Transcriptional organization of a 450-kb region of the human X chromosome in Xq28. (PMID: 8248200) Bione S … Toniolo D (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 58

Products for PLXNA3 Gene

Sources for PLXNA3 Gene

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