Aliases for PLXNA3 Gene
External Ids for PLXNA3 Gene
Previous HGNC Symbols for PLXNA3 Gene
Previous GeneCards Identifiers for PLXNA3 Gene
This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]
GeneCards Summary for PLXNA3 Gene
PLXNA3 (Plexin A3) is a Protein Coding gene. Diseases associated with PLXNA3 include Childhood-Onset Schizophrenia. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include semaphorin receptor activity. An important paralog of this gene is PLXNA1.
UniProtKB/Swiss-Prot for PLXNA3 Gene
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.