Aliases for PLXNA2 Gene
External Ids for PLXNA2 Gene
Previous HGNC Symbols for PLXNA2 Gene
Previous GeneCards Identifiers for PLXNA2 Gene
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLXNA2 Gene
PLXNA2 (Plexin A2) is a Protein Coding gene. Diseases associated with PLXNA2 include Subacute Leukemia and Generalized Anxiety Disorder. Among its related pathways are Ectoderm Differentiation and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include semaphorin receptor activity. An important paralog of this gene is PLXNA4.
UniProtKB/Swiss-Prot Summary for PLXNA2 Gene
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).