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Aliases for PLXNA2 Gene

Aliases for PLXNA2 Gene

  • Plexin A2 2 3 5
  • Semaphorin Receptor OCT 2 3 4
  • Transmembrane Protein OCT 2 3
  • Plexin-A2 2 3
  • Plexin 2 2 3
  • PLXN2 3 4
  • OCT 3 4
  • KIAA0463 4

External Ids for PLXNA2 Gene

Previous HGNC Symbols for PLXNA2 Gene

  • PLXN2

Previous GeneCards Identifiers for PLXNA2 Gene

  • GC01M206840
  • GC01M203909
  • GC01M204842
  • GC01M205283
  • GC01M204588
  • GC01M206262
  • GC01M208195
  • GC01M178869

Summaries for PLXNA2 Gene

Entrez Gene Summary for PLXNA2 Gene

  • This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLXNA2 Gene

PLXNA2 (Plexin A2) is a Protein Coding gene. Diseases associated with PLXNA2 include Disuse Amblyopia and Hidradenoma. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include semaphorin receptor activity. An important paralog of this gene is PLXNA4.

UniProtKB/Swiss-Prot for PLXNA2 Gene

  • Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Gene Wiki entry for PLXNA2 Gene

Additional gene information for PLXNA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLXNA2 Gene

Genomics for PLXNA2 Gene

GeneHancer (GH) Regulatory Elements for PLXNA2 Gene

Promoters and enhancers for PLXNA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J208230 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 656.2 +5.9 5949 15.1 HDGF FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF213 ZNF143 FOS PLXNA2 GC01P208237 CD55 LOC105372884
GH01J208199 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +39.0 38988 11.1 PKNOX1 FOXA2 ZNF133 ARID4B SIN3A FEZF1 ZNF48 ZNF121 ATF7 FOS LOC105372884 PLXNA2 CD55 GC01P208155
GH01J208176 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +63.0 62969 10.4 PKNOX1 FOXA2 ARNT ZFP64 SIN3A FEZF1 ZNF2 ZNF213 FOS DEK PLXNA2 GC01P208155 LOC105372884
GH01J208217 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.1 +23.8 23818 6.6 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 E2F8 FOS ATF7 RXRA PLXNA2 CDCA4P4 CD46 LOC105372884 GC01P208237
GH01J208158 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +84.1 84070 4.6 FOXA2 ARID4B ZNF48 YY1 TCF12 NFKBIZ RXRA MCM5 MXD4 MIER2 PLXNA2 GC01P208155 LOC105372884
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLXNA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLXNA2 gene promoter:
  • c-Myb
  • HNF-4alpha2
  • HNF-4alpha1
  • COUP-TF1
  • COUP-TF
  • COUP
  • p53
  • FOXO1a
  • FOXO1
  • POU2F1a

Genomic Locations for PLXNA2 Gene

Genomic Locations for PLXNA2 Gene
chr1:208,022,242-208,244,384
(GRCh38/hg38)
Size:
222,143 bases
Orientation:
Minus strand
chr1:208,195,587-208,417,665
(GRCh37/hg19)
Size:
222,079 bases
Orientation:
Minus strand

Genomic View for PLXNA2 Gene

Genes around PLXNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLXNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLXNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLXNA2 Gene

Proteins for PLXNA2 Gene

  • Protein details for PLXNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75051-PLXA2_HUMAN
    Recommended name:
    Plexin-A2
    Protein Accession:
    O75051
    Secondary Accessions:
    • A2RTX9
    • B2RMX7
    • Q6UX61
    • Q96GN9
    • Q9BRL1
    • Q9UIW1

    Protein attributes for PLXNA2 Gene

    Size:
    1894 amino acids
    Molecular mass:
    211104 Da
    Quaternary structure:
    • Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1.
    SequenceCaution:
    • Sequence=BAA32308.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLXNA2 Gene

    Alternative splice isoforms for PLXNA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLXNA2 Gene

Post-translational modifications for PLXNA2 Gene

  • Glycosylation at isoforms=1205, isoforms=756, isoforms=696, Asn598, isoforms=2327, Asn91, and Asn76
  • Modification sites at PhosphoSitePlus

Other Protein References for PLXNA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for PLXNA2

No data available for DME Specific Peptides for PLXNA2 Gene

Domains & Families for PLXNA2 Gene

Gene Families for PLXNA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PLXNA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75051

UniProtKB/Swiss-Prot:

PLXA2_HUMAN :
  • Belongs to the plexin family.
Family:
  • Belongs to the plexin family.
genes like me logo Genes that share domains with PLXNA2: view

Function for PLXNA2 Gene

Molecular function for PLXNA2 Gene

UniProtKB/Swiss-Prot Function:
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
GENATLAS Biochemistry:
plexin A2,calcium-dependent cell adhesion molecule at the neuronal cell surface,homologous to the hepatocyte growth factor receptor family,expressed in fetal brain,putatively involved in signal transduction

Phenotypes From GWAS Catalog for PLXNA2 Gene

Gene Ontology (GO) - Molecular Function for PLXNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12372285
GO:0017154 semaphorin receptor activity ISS --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with PLXNA2: view
genes like me logo Genes that share phenotypes with PLXNA2: view

Animal Models for PLXNA2 Gene

MGI Knock Outs for PLXNA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLXNA2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLXNA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLXNA2 Gene

Localization for PLXNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLXNA2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLXNA2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PLXNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex TAS 19909241
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLXNA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLXNA2 Gene

Pathways & Interactions for PLXNA2 Gene

genes like me logo Genes that share pathways with PLXNA2: view

Pathways by source for PLXNA2 Gene

1 GeneGo (Thomson Reuters) pathway for PLXNA2 Gene
1 Cell Signaling Technology pathway for PLXNA2 Gene

SIGNOR curated interactions for PLXNA2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLXNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0007162 negative regulation of cell adhesion IBA --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0008360 regulation of cell shape IBA --
genes like me logo Genes that share ontologies with PLXNA2: view

Drugs & Compounds for PLXNA2 Gene

No Compound Related Data Available

Transcripts for PLXNA2 Gene

mRNA/cDNA for PLXNA2 Gene

Unigene Clusters for PLXNA2 Gene

Plexin A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLXNA2

Alternative Splicing Database (ASD) splice patterns (SP) for PLXNA2 Gene

No ASD Table

Relevant External Links for PLXNA2 Gene

GeneLoc Exon Structure for
PLXNA2
ECgene alternative splicing isoforms for
PLXNA2

Expression for PLXNA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLXNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLXNA2 Gene

This gene is overexpressed in Pancreas (x4.5).

Protein differential expression in normal tissues from HIPED for PLXNA2 Gene

This gene is overexpressed in Fetal Brain (41.8), Pancreas (11.0), and Frontal cortex (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLXNA2 Gene



Protein tissue co-expression partners for PLXNA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLXNA2 Gene:

PLXNA2

SOURCE GeneReport for Unigene cluster for PLXNA2 Gene:

Hs.497626

mRNA Expression by UniProt/SwissProt for PLXNA2 Gene:

O75051-PLXA2_HUMAN
Tissue specificity: Detected in fetal brain.

Evidence on tissue expression from TISSUES for PLXNA2 Gene

  • Nervous system(4.8)
  • Muscle(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PLXNA2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLXNA2 Gene

Orthologs for PLXNA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLXNA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLXNA2 34 33
  • 99.56 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 90 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PLXNA2 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLXNA2 34 33
  • 92.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLXNA2 34 33
  • 90.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Plxna2 16 34 33
  • 88.53 (n)
rat
(Rattus norvegicus)
Mammalia Plxna2 33
  • 88.37 (n)
chicken
(Gallus gallus)
Aves PLXNA2 34 33
  • 81.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLXNA2 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plxna2 33
  • 75.99 (n)
Str.10779 33
zebrafish
(Danio rerio)
Actinopterygii plxna1 34
  • 79 (a)
ManyToMany
si:dkey-164k14.1 34 33
  • 75.83 (n)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000064 33
  • 54.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta plexA 33
  • 48.14 (n)
worm
(Caenorhabditis elegans)
Secernentea plx-1 33
  • 46.27 (n)
Species where no ortholog for PLXNA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLXNA2 Gene

ENSEMBL:
Gene Tree for PLXNA2 (if available)
TreeFam:
Gene Tree for PLXNA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLXNA2: view image

Paralogs for PLXNA2 Gene

Paralogs for PLXNA2 Gene

(10) SIMAP similar genes for PLXNA2 Gene using alignment to 1 proteins:

  • PLXA2_HUMAN
genes like me logo Genes that share paralogs with PLXNA2: view

Variants for PLXNA2 Gene

Sequence variations from dbSNP and Humsavar for PLXNA2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000003404 -- 208,233,328(-) G/A intron_variant
rs1000034035 -- 208,048,308(-) G/C intron_variant
rs1000035462 -- 208,082,761(-) C/T intron_variant
rs1000042537 -- 208,025,784(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000059364 -- 208,032,629(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLXNA2 Gene

Variant ID Type Subtype PubMed ID
esv28439 CNV loss 19812545
esv3447338 CNV insertion 20981092
nsv1145398 CNV deletion 24896259
nsv4276 CNV insertion 18451855
nsv4287 CNV insertion 18451855
nsv470778 CNV loss 18288195
nsv477883 CNV novel sequence insertion 20440878
nsv479347 CNV novel sequence insertion 20440878
nsv832437 CNV gain+loss 17160897

Variation tolerance for PLXNA2 Gene

Residual Variation Intolerance Score: 4.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.21; 96.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLXNA2 Gene

Human Gene Mutation Database (HGMD)
PLXNA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLXNA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLXNA2 Gene

Disorders for PLXNA2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PLXNA2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
disuse amblyopia
  • deprivation amblyopia
hidradenoma
  • hidradenoma of skin
tetralogy of fallot
  • tof
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLXNA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLXNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLXNA2 Gene

Publications for PLXNA2 Gene

  1. Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder. (PMID: 20455246) Coric V … Stock EG (Depression and anxiety 2010) 3 22 44 58
  2. Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia. (PMID: 18065206) Takeshita M … Yoshikawa T (Schizophrenia research 2008) 3 22 44 58
  3. Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population. (PMID: 17346868) Fujii T … Kunugi H (Progress in neuro-psychopharmacology & biological psychiatry 2007) 3 22 44 58
  4. Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia. (PMID: 16402134) Mah S … Braun A (Molecular psychiatry 2006) 3 22 44 58
  5. Association of PLXNA2 polymorphisms with vertebral fracture risk and bone mineral density in postmenopausal Korean population. (PMID: 16932874) Hwang JY … Kim SY (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2006) 3 22 44 58

Products for PLXNA2 Gene

Sources for PLXNA2 Gene

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