Aliases for PLXNA1 Gene
External Ids for PLXNA1 Gene
Previous HGNC Symbols for PLXNA1 Gene
Previous GeneCards Identifiers for PLXNA1 Gene
GeneCards Summary for PLXNA1 Gene
PLXNA1 (Plexin A1) is a Protein Coding gene. Diseases associated with PLXNA1 include Hereditary Congenital Facial Paresis and Dubowitz Syndrome. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include semaphorin receptor activity. An important paralog of this gene is PLXNA3.
UniProtKB/Swiss-Prot for PLXNA1 Gene
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).