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Aliases for PLVAP Gene

Aliases for PLVAP Gene

  • Plasmalemma Vesicle Associated Protein 2 3 5
  • Fenestrated-Endothelial Linked Structure Protein; PV-1 Protein 2 3
  • Fenestrated Endothelial-Linked Structure Protein 3 4
  • Plasmalemma Vesicle Protein 1 3 4
  • FELS 3 4
  • PV-1 3 4
  • PV1 3 4
  • Plasmalemma Vesicle-Associated Protein 3
  • Gp68 3

External Ids for PLVAP Gene

Previous GeneCards Identifiers for PLVAP Gene

  • GC19M017956
  • GC19M017855
  • GC19M017307
  • GC19M017323
  • GC19M017462
  • GC19M017028

Summaries for PLVAP Gene

GeneCards Summary for PLVAP Gene

PLVAP (Plasmalemma Vesicle Associated Protein) is a Protein Coding gene. Diseases associated with PLVAP include Breast Benign Neoplasm and Thoracic Benign Neoplasm. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for PLVAP Gene

  • Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability.

Gene Wiki entry for PLVAP Gene

Additional gene information for PLVAP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLVAP Gene

Genomics for PLVAP Gene

GeneHancer (GH) Regulatory Elements for PLVAP Gene

Promoters and enhancers for PLVAP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I017377 Promoter/Enhancer 1.4 EPDnew Ensembl dbSUPER 550.8 +0.0 49 0.6 TEAD4 TAL1 TCF12 NCOR1 EGR1 VEZF1 CBFA2T2 SMARCE1 BHLHE40 CBFA2T3 PLVAP BISPR GC19P020268
GH19I017336 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.6 +40.0 39994 2.5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 GTPBP3 CHERP ENSG00000269578 ENSG00000268743 IQCN COLGALT1 C19orf44 SIN3B HAUS8 MVB12A
GH19I018150 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 -775.4 -775442 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ENSG00000269145 ENSG00000268173 PIK3R2 PDE4C ENSG00000268030 UPF1 ENSG00000268938 COLGALT1 ENSG00000269191 GTPBP3
GH19I017552 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.1 -177.5 -177508 4.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 COLGALT1 ENSG00000269578 ENSG00000267904 ENSG00000268087 MVB12A ENSG00000268938 ENSG00000268743 GTPBP3 IQCN ENSG00000269191
GH19I018097 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.6 -721.4 -721417 2.9 HDGF PKNOX1 ARNT ZNF2 IRF4 ZNF213 ZNF207 ZNF143 ATF7 FOS IL12RB1 MAST3 PLVAP PDE4C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLVAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLVAP gene promoter:

Genomic Locations for PLVAP Gene

Genomic Locations for PLVAP Gene
25,903 bases
Minus strand

Genomic View for PLVAP Gene

Genes around PLVAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLVAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLVAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLVAP Gene

Proteins for PLVAP Gene

  • Protein details for PLVAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Plasmalemma vesicle-associated protein
    Protein Accession:
    Secondary Accessions:
    • Q86VP0
    • Q8N8Y0
    • Q8ND68
    • Q8TER8
    • Q9BZD5

    Protein attributes for PLVAP Gene

    442 amino acids
    Molecular mass:
    50594 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for PLVAP Gene

Post-translational modifications for PLVAP Gene

  • Glycosylation at Asn83, isoforms=89, isoforms=113, and Asn151
  • Modification sites at PhosphoSitePlus

Other Protein References for PLVAP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PLVAP
  • Santa Cruz Biotechnology (SCBT) Antibodies for PLVAP

No data available for DME Specific Peptides for PLVAP Gene

Domains & Families for PLVAP Gene

Gene Families for PLVAP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PLVAP Gene


Suggested Antigen Peptide Sequences for PLVAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLVAP: view

No data available for UniProtKB/Swiss-Prot for PLVAP Gene

Function for PLVAP Gene

Molecular function for PLVAP Gene

UniProtKB/Swiss-Prot Function:
Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability.
UniProtKB/Swiss-Prot Induction:
By phorbol myristate acetate (PMA) or VEGF in endothelial cell culture.

Phenotypes From GWAS Catalog for PLVAP Gene

Gene Ontology (GO) - Molecular Function for PLVAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19420356
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with PLVAP: view
genes like me logo Genes that share phenotypes with PLVAP: view

Animal Models for PLVAP Gene

MGI Knock Outs for PLVAP:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLVAP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLVAP Gene

Localization for PLVAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLVAP Gene

Cell membrane; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Cytoplasm, perinuclear region. Note=Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region. {ECO:0000250 UniProtKB:Q9WV78}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLVAP gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PLVAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0005901 colocalizes_with caveola IEA,IDA 19420356
GO:0009986 cell surface IDA 15155804
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLVAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLVAP Gene

Pathways & Interactions for PLVAP Gene

SuperPathways for PLVAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLVAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IDA 15155804
GO:0002693 positive regulation of cellular extravasation IMP 19420356
GO:0033209 tumor necrosis factor-mediated signaling pathway IDA 19420356
GO:0070528 NOT protein kinase C signaling IDA 15155804
genes like me logo Genes that share ontologies with PLVAP: view

No data available for Pathways by source and SIGNOR curated interactions for PLVAP Gene

Drugs & Compounds for PLVAP Gene

No Compound Related Data Available

Transcripts for PLVAP Gene

mRNA/cDNA for PLVAP Gene

Unigene Clusters for PLVAP Gene

Plasmalemma vesicle associated protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLVAP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP3: -

Relevant External Links for PLVAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLVAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLVAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLVAP Gene

This gene is overexpressed in Thyroid (x5.4).

Protein differential expression in normal tissues from HIPED for PLVAP Gene

This gene is overexpressed in Pancreas (11.6), Stomach (6.7), Gallbladder (6.2), and Placenta (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLVAP Gene

NURSA nuclear receptor signaling pathways regulating expression of PLVAP Gene:


SOURCE GeneReport for Unigene cluster for PLVAP Gene:


mRNA Expression by UniProt/SwissProt for PLVAP Gene:

Tissue specificity: Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium.

Evidence on tissue expression from TISSUES for PLVAP Gene

  • Kidney(4.5)
  • Spleen(4.5)
  • Lymph node(4.4)
  • Nervous system(4.2)
  • Heart(2.4)
  • Blood(2.1)
  • Muscle(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with PLVAP: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLVAP Gene

Orthologs for PLVAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLVAP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLVAP 33 34
  • 99.47 (n)
(Canis familiaris)
Mammalia PLVAP 33 34
  • 84.58 (n)
(Bos Taurus)
Mammalia PLVAP 33 34
  • 80.24 (n)
(Rattus norvegicus)
Mammalia Plvap 33
  • 71 (n)
(Mus musculus)
Mammalia Plvap 33 16 34
  • 69.94 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
-- 34
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia PLVAP 34
  • 43 (a)
(Gallus gallus)
Aves PLVAP 34
  • 24 (a)
Species where no ortholog for PLVAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLVAP Gene

Gene Tree for PLVAP (if available)
Gene Tree for PLVAP (if available)

Paralogs for PLVAP Gene

No data available for Paralogs for PLVAP Gene

Variants for PLVAP Gene

Sequence variations from dbSNP and Humsavar for PLVAP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000053724 -- 17,378,309(-) A/G upstream_transcript_variant
rs1000245140 -- 17,376,849(-) A/T intron_variant
rs1000264796 -- 17,361,564(-) C/A intron_variant
rs1000406358 -- 17,361,628(-) C/A intron_variant
rs1000554537 -- 17,370,660(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLVAP Gene

Variant ID Type Subtype PubMed ID
nsv1109170 CNV deletion 24896259
nsv833768 CNV loss 17160897

Variation tolerance for PLVAP Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLVAP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLVAP Gene

Disorders for PLVAP Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLVAP Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
breast benign neoplasm
thoracic benign neoplasm
  • benign neoplasm of thorax
norrie disease
  • nd
- elite association - COSMIC cancer census association via MalaCards
Search PLVAP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLVAP

genes like me logo Genes that share disorders with PLVAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLVAP Gene

Publications for PLVAP Gene

  1. cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes. (PMID: 11401446) Stan RV … Palade GE (Genomics 2001) 2 3 4 22 58
  2. Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF). (PMID: 15971170) Strickland LA … Koeppen H (The Journal of pathology 2005) 3 4 22 58
  3. PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms. (PMID: 15155804) Stan RV … Niesman IR (Molecular biology of the cell 2004) 3 4 22 58
  4. The prototype endothelial marker PAL-E is a leukocyte trafficking molecule. (PMID: 19420356) Keuschnigg J … Jalkanen S (Blood 2009) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for PLVAP Gene

Sources for PLVAP Gene

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