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Aliases for PLSCR5 Gene

Aliases for PLSCR5 Gene

  • Phospholipid Scramblase Family Member 5 2 3 3 5
  • Phospholipid Scramblase Family, Member 5 2

External Ids for PLSCR5 Gene

Previous GeneCards Identifiers for PLSCR5 Gene

  • GC00U916995
  • GC03M147777
  • GC03M146294
  • GC03M143680

Summaries for PLSCR5 Gene

GeneCards Summary for PLSCR5 Gene

PLSCR5 (Phospholipid Scramblase Family Member 5) is a Protein Coding gene. An important paralog of this gene is PLSCR1.

Gene Wiki entry for PLSCR5 Gene

Additional gene information for PLSCR5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLSCR5 Gene

Genomics for PLSCR5 Gene

GeneHancer (GH) Regulatory Elements for PLSCR5 Gene

Promoters and enhancers for PLSCR5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J146605 Promoter 0.5 EPDnew 650.7 +0.9 879 0.1 PLSCR5 PLSCR5-AS1
GH03J146611 Promoter 0.5 EPDnew 650.4 -5.1 -5066 0.1 PLSCR5 LINC02010
GH03J146189 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 9.9 +416.5 416507 0.2 CTCF ZNF654 ZBTB6 NRF1 TRIM22 CEBPB REST RAD21 RFX5 SMC3 PLOD2 LOC105374145 ENSG00000243415 LNCSRLR PLSCR5 GC03M146166
GH03J146580 Enhancer 1.1 Ensembl ENCODE 11.4 +24.4 24398 2.6 ELF3 FOXA2 MLX THRB RFX5 RARA ETS1 CREM MIXL1 ZNF680 PLSCR5 PLSCR1 ENSG00000243415 PLOD2 LNCSRLR GC03M146579 PLSCR5-AS1
GH03J146125 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.1 +480.1 480133 1.4 FOXA2 JUN CEBPG RFX5 FOSL2 FOS GATAD2A RXRA CEBPB REST PLOD2 LNCSRLR ENSG00000243415 PLSCR5 ENSG00000261051 GC03P146077
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLSCR5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLSCR5 gene promoter:
  • GATA-2
  • STAT1alpha
  • STAT1
  • STAT1beta
  • IRF-7A
  • Lhx3a
  • LHX3b
  • p53
  • POU3F1
  • Evi-1

Genomic Locations for PLSCR5 Gene

Genomic Locations for PLSCR5 Gene
29,662 bases
Minus strand
29,662 bases
Minus strand

Genomic View for PLSCR5 Gene

Genes around PLSCR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLSCR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLSCR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR5 Gene

Proteins for PLSCR5 Gene

  • Protein details for PLSCR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipid scramblase family member 5
    Protein Accession:
    Secondary Accessions:
    • B2RXK5

    Protein attributes for PLSCR5 Gene

    271 amino acids
    Molecular mass:
    30027 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLSCR5 Gene


neXtProt entry for PLSCR5 Gene

Post-translational modifications for PLSCR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLSCR5 Gene

No data available for DME Specific Peptides for PLSCR5 Gene

Domains & Families for PLSCR5 Gene

Gene Families for PLSCR5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PLSCR5 Gene


Suggested Antigen Peptide Sequences for PLSCR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with PLSCR5: view

Function for PLSCR5 Gene

Phenotypes From GWAS Catalog for PLSCR5 Gene

Gene Ontology (GO) - Molecular Function for PLSCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017128 phospholipid scramblase activity IBA --
genes like me logo Genes that share ontologies with PLSCR5: view

Phenotypes for PLSCR5 Gene

genes like me logo Genes that share phenotypes with PLSCR5: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLSCR5 Gene

Localization for PLSCR5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLSCR5 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PLSCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with PLSCR5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PLSCR5 Gene

Pathways & Interactions for PLSCR5 Gene

SuperPathways for PLSCR5 Gene

No Data Available

Interacting Proteins for PLSCR5 Gene

Gene Ontology (GO) - Biological Process for PLSCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017121 phospholipid scrambling IEA --
genes like me logo Genes that share ontologies with PLSCR5: view

No data available for Pathways by source and SIGNOR curated interactions for PLSCR5 Gene

Drugs & Compounds for PLSCR5 Gene

(511) Additional Compounds for PLSCR5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
  • 1-(Hexadec-1-enyl)-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • PE(P-16:0/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1W7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
Phosphatidylcholines Group B
  • 1-Hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
  • 2-(9Z,12Z-Octadecadienoyl)-1-hexadecyl-sn-glycero-3-phosphocholine
  • PC Ae C34:2
  • PC(16:0E/18:2(9Z,12Z))
  • PC(O-34:2)
genes like me logo Genes that share compounds with PLSCR5: view

Transcripts for PLSCR5 Gene

mRNA/cDNA for PLSCR5 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLSCR5 Gene

Phospholipid scramblase family, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR5 Gene

No ASD Table

Relevant External Links for PLSCR5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLSCR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLSCR5 Gene

mRNA differential expression in normal tissues according to GTEx for PLSCR5 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x8.0), Brain - Putamen (basal ganglia) (x5.4), and Colon - Sigmoid (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of PLSCR5 Gene:


SOURCE GeneReport for Unigene cluster for PLSCR5 Gene:

genes like me logo Genes that share expression patterns with PLSCR5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLSCR5 Gene

Orthologs for PLSCR5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLSCR5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLSCR5 34 33
  • 98.28 (n)
(Canis familiaris)
Mammalia PLSCR5 34 33
  • 92.58 (n)
(Bos Taurus)
Mammalia PLSCR5 34 33
  • 90.94 (n)
(Rattus norvegicus)
Mammalia Plscr5 33
  • 87.45 (n)
(Mus musculus)
Mammalia Plscr5 16 34 33
  • 87.08 (n)
(Monodelphis domestica)
Mammalia PLSCR5 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia PLSCR5 34
  • 80 (a)
(Gallus gallus)
Aves PLSCR5 34 33
  • 74.69 (n)
(Anolis carolinensis)
Reptilia PLSCR5 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plscr5 33
  • 66.67 (n)
(Danio rerio)
Actinopterygii si:ch73-206p6.1 34 33
  • 62.06 (n)
si:ch211-71m22.5 34
  • 50 (a)
si:ch211-71m22.1 34
  • 48 (a)
FP245465.1 34
  • 33 (a)
si:ch211-71m22.3 34
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta scramb2 34
  • 35 (a)
scramb1 34
  • 27 (a)
CG9084 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea scrm-1 34
  • 32 (a)
scrm-4 34
  • 25 (a)
scrm-6 34
  • 22 (a)
scrm-5 34
  • 20 (a)
scrm-7 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2436 34
  • 50 (a)
Species where no ortholog for PLSCR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLSCR5 Gene

Gene Tree for PLSCR5 (if available)
Gene Tree for PLSCR5 (if available)
Evolutionary constrained regions (ECRs) for PLSCR5: view image

Paralogs for PLSCR5 Gene

Paralogs for PLSCR5 Gene

(5) SIMAP similar genes for PLSCR5 Gene using alignment to 3 proteins:

  • L8EC74_HUMAN
genes like me logo Genes that share paralogs with PLSCR5: view

Variants for PLSCR5 Gene

Sequence variations from dbSNP and Humsavar for PLSCR5 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000242134 -- 146,596,561(-) T/C intron_variant
rs1000274654 -- 146,602,209(-) G/C/T intron_variant
rs1000361518 -- 146,584,620(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000416882 -- 146,602,683(-) C/G intron_variant
rs1000450304 -- 146,578,303(-) C/T genic_downstream_transcript_variant, intron_variant

Variation tolerance for PLSCR5 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLSCR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLSCR5 Gene

Disorders for PLSCR5 Gene

Additional Disease Information for PLSCR5

No disorders were found for PLSCR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLSCR5 Gene

Publications for PLSCR5 Gene

  1. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for PLSCR5 Gene

Sources for PLSCR5 Gene

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