Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLSCR4 Gene

Aliases for PLSCR4 Gene

  • Phospholipid Scramblase 4 2 3 5
  • Ca(2+)-Dependent Phospholipid Scramblase 4 3 4
  • PL Scramblase 4 3 4
  • TRA1 3 4
  • Cell Growth-Inhibiting Gene 43 Protein 4
  • Cell Growth Inhibiting Protein 43 3

External Ids for PLSCR4 Gene

Previous GeneCards Identifiers for PLSCR4 Gene

  • GC03M142702
  • GC03M146769
  • GC03M147191
  • GC03M147231
  • GC03M147392
  • GC03M145910
  • GC03M143286

Summaries for PLSCR4 Gene

GeneCards Summary for PLSCR4 Gene

PLSCR4 (Phospholipid Scramblase 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and SH3 domain binding. An important paralog of this gene is PLSCR1.

UniProtKB/Swiss-Prot for PLSCR4 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Gene Wiki entry for PLSCR4 Gene

Additional gene information for PLSCR4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLSCR4 Gene

Genomics for PLSCR4 Gene

GeneHancer (GH) Regulatory Elements for PLSCR4 Gene

Promoters and enhancers for PLSCR4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I146249 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 558.9 +0.3 332 2.9 KLF1 ATF1 SREBF2 MAX SIN3A CEBPG HIC1 ZNF335 E2F1 CTBP1 PLSCR4 PLSCR2 LOC105374145
GH03I146221 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 575.6 +28.7 28725 2.7 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 FOS PLSCR4 PLOD2 ENSG00000243415 LOC105374145
GH03I146151 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 +91.6 91581 15.9 FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 PLOD2 LNCSRLR PLSCR4 ENSG00000243415 ENSG00000261051 GC03M146166 LOC105374145 GC03P146077
GH03I146313 Enhancer 1.1 FANTOM5 Ensembl ENCODE 16.7 -63.0 -62997 2.2 JUN MAX CEBPB EP300 RFX5 ZKSCAN1 SP1 JUND POLR2A PRDM1 PLSCR4 PLSCR1 PLSCR2 LOC100419967
GH03I146307 Enhancer 0.9 Ensembl ENCODE 16.1 -57.5 -57514 2.8 JUN MAX RAD21 POLR2A RCOR1 NFE2L2 RXRA CEBPB EP300 GABPA PLSCR4 PLSCR1 LOC100419967
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLSCR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLSCR4 gene promoter:

Genomic Locations for PLSCR4 Gene

Genomic Locations for PLSCR4 Gene
58,845 bases
Minus strand

Genomic View for PLSCR4 Gene

Genes around PLSCR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLSCR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLSCR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR4 Gene

Proteins for PLSCR4 Gene

  • Protein details for PLSCR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipid scramblase 4
    Protein Accession:
    Secondary Accessions:
    • A8K2E9
    • Q2TTR3
    • Q658L3
    • Q6ZR73
    • Q7Z505

    Protein attributes for PLSCR4 Gene

    329 amino acids
    Molecular mass:
    37005 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PDCD6.
    • Sequence=AAP97186.1; Type=Frameshift; Positions=152, 155, 163, 325; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLSCR4 Gene

    Alternative splice isoforms for PLSCR4 Gene


neXtProt entry for PLSCR4 Gene

Post-translational modifications for PLSCR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLSCR4 Gene

Domains & Families for PLSCR4 Gene

Gene Families for PLSCR4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for PLSCR4 Gene


Graphical View of Domain Structure for InterPro Entry



  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with PLSCR4: view

Function for PLSCR4 Gene

Molecular function for PLSCR4 Gene

UniProtKB/Swiss-Prot Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Phenotypes From GWAS Catalog for PLSCR4 Gene

Gene Ontology (GO) - Molecular Function for PLSCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 10930526
GO:0005515 protein binding IPI 16189514
GO:0017124 SH3 domain binding IEA --
GO:0017128 phospholipid scramblase activity NAS 10930526
GO:0019899 enzyme binding IPI 19333378
genes like me logo Genes that share ontologies with PLSCR4: view
genes like me logo Genes that share phenotypes with PLSCR4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLSCR4 Gene

Localization for PLSCR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLSCR4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLSCR4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLSCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 19333378
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with PLSCR4: view

Pathways & Interactions for PLSCR4 Gene

SuperPathways for PLSCR4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLSCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017121 phospholipid scrambling NAS 10930526
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with PLSCR4: view

No data available for Pathways by source and SIGNOR curated interactions for PLSCR4 Gene

Drugs & Compounds for PLSCR4 Gene

(1) Drugs for PLSCR4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(511) Additional Compounds for PLSCR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-eicosenoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/20:1)
  • GPCho(16:0/20:1n9)
  • GPCho(16:0/20:1w9)
  • GPCho(36:1)
genes like me logo Genes that share compounds with PLSCR4: view

Transcripts for PLSCR4 Gene

Unigene Clusters for PLSCR4 Gene

Phospholipid scramblase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11
SP2: -
SP3: - - - - - - - -
SP4: -
SP5: -
SP6: - -
SP7: - - - -

Relevant External Links for PLSCR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLSCR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLSCR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLSCR4 Gene

This gene is overexpressed in Testis (8.8) and Spinal cord (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLSCR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLSCR4 Gene:


SOURCE GeneReport for Unigene cluster for PLSCR4 Gene:


mRNA Expression by UniProt/SwissProt for PLSCR4 Gene:

Tissue specificity: Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for PLSCR4 Gene

  • Nervous system(4.5)
  • Pancreas(4.2)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with PLSCR4: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLSCR4 Gene

Orthologs for PLSCR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLSCR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLSCR4 33 34
  • 99.19 (n)
(Canis familiaris)
Mammalia PLSCR4 34 33
  • 89.13 (n)
(Bos Taurus)
Mammalia PLSCR4 33 34
  • 85.67 (n)
(Mus musculus)
Mammalia Plscr4 33 16 34
  • 84.52 (n)
(Rattus norvegicus)
Mammalia Plscr4 33
  • 84.26 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
-- 34
  • 58 (a)
(Gallus gallus)
Aves -- 34
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
-- 34
  • 41 (a)
-- 34
  • 37 (a)
(Danio rerio)
Actinopterygii si:ch211-71m22.5 34
  • 44 (a)
si:ch211-71m22.1 34
  • 43 (a)
si:ch73-206p6.1 34
  • 42 (a)
si:ch211-71m22.3 34
  • 33 (a)
FP245465.1 34
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta scramb2 34
  • 39 (a)
scramb1 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea scrm-8 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2436 34
  • 43 (a)
Species where no ortholog for PLSCR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLSCR4 Gene

Gene Tree for PLSCR4 (if available)
Gene Tree for PLSCR4 (if available)

Paralogs for PLSCR4 Gene

Paralogs for PLSCR4 Gene

(4) SIMAP similar genes for PLSCR4 Gene using alignment to 8 proteins: Pseudogenes for PLSCR4 Gene

genes like me logo Genes that share paralogs with PLSCR4: view

Variants for PLSCR4 Gene

Sequence variations from dbSNP and Humsavar for PLSCR4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000068707 -- 146,245,294(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000088790 -- 146,244,981(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000157552 -- 146,198,778(-) AAAAAAAAA/AAAAAAAAAA intron_variant
rs1000210565 -- 146,223,259(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000266883 -- 146,239,091(-) AAAGAA/AA genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLSCR4 Gene

Variant ID Type Subtype PubMed ID
dgv2614n106 CNV deletion 24896259
esv1197123 CNV deletion 17803354
esv2265170 CNV deletion 18987734
esv2415943 CNV deletion 18987734
esv2442002 CNV deletion 19546169
esv2726021 CNV deletion 23290073
esv2726022 CNV deletion 23290073
esv3416330 CNV duplication 20981092
esv3562676 CNV deletion 23714750
esv3598087 CNV loss 21293372
esv3893781 CNV loss 25118596
esv4008 CNV loss 18987735
esv9695 CNV loss 19470904
nsv1011146 CNV loss 25217958
nsv1149841 CNV deletion 26484159
nsv955544 CNV deletion 24416366

Variation tolerance for PLSCR4 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLSCR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLSCR4 Gene

Disorders for PLSCR4 Gene

Additional Disease Information for PLSCR4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLSCR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLSCR4 Gene

Publications for PLSCR4 Gene

  1. Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PMID: 18256029) Shibata H … Maki M (The Journal of biological chemistry 2008) 3 4 22 58
  2. Identification of three new members of the phospholipid scramblase gene family. (PMID: 10930526) Wiedmer T … Sims PJ (Biochimica et biophysica acta 2000) 2 3 4 58
  3. Biochemical and functional characterization of human phospholipid scramblase 4 (hPLSCR4). (PMID: 23089641) Francis VG … Gummadi SN (Biological chemistry 2012) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane. (PMID: 19333378) Py B … Benichou S (PloS one 2009) 3 22 58

Products for PLSCR4 Gene

Sources for PLSCR4 Gene

Loading form....