Aliases for PLSCR2 Gene
External Ids for PLSCR2 Gene
Previous GeneCards Identifiers for PLSCR2 Gene
This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for PLSCR2 Gene
PLSCR2 (Phospholipid Scramblase 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phospholipid scramblase activity. An important paralog of this gene is PLSCR1.
UniProtKB/Swiss-Prot for PLSCR2 Gene
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.