Aliases for PLSCR1 Gene
External Ids for PLSCR1 Gene
Previous GeneCards Identifiers for PLSCR1 Gene
GeneCards Summary for PLSCR1 Gene
PLSCR1 (Phospholipid Scramblase 1) is a Protein Coding gene. Diseases associated with PLSCR1 include Miyoshi Muscular Dystrophy 3. Among its related pathways are EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is PLSCR2.
UniProtKB/Swiss-Prot Summary for PLSCR1 Gene
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.