Aliases for PLSCR1 Gene

Aliases for PLSCR1 Gene

  • Phospholipid Scramblase 1 2 3 4 5
  • Ca(2+)-Dependent Phospholipid Scramblase 1 3 4
  • Erythrocyte Phospholipid Scramblase 3 4
  • PL Scramblase 1 3 4
  • MMTRA1B 3
  • MmTRA1b 4

External Ids for PLSCR1 Gene

Previous GeneCards Identifiers for PLSCR1 Gene

  • GC03M143025
  • GC03M147108
  • GC03M147514
  • GC03M147553
  • GC03M147715
  • GC03M146232
  • GC03M143612

Summaries for PLSCR1 Gene

GeneCards Summary for PLSCR1 Gene

PLSCR1 (Phospholipid Scramblase 1) is a Protein Coding gene. Diseases associated with PLSCR1 include Miyoshi Muscular Dystrophy 3. Among its related pathways are EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is PLSCR2.

UniProtKB/Swiss-Prot Summary for PLSCR1 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
  • May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.

Gene Wiki entry for PLSCR1 Gene

Additional gene information for PLSCR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLSCR1 Gene

Genomics for PLSCR1 Gene

GeneHancer (GH) Regulatory Elements for PLSCR1 Gene

Promoters and enhancers for PLSCR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J146541 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 787.6 +1.9 1855 5.2 E2F8 SIN3A ZBTB40 ZBTB6 MLX RBPJ POLR2A HDAC2 CREB1 MIXL1 PLSCR1 lnc-PLSCR2-3 lnc-ZIC1-11 PLSCR2 PLSCR4 piR-59425-023
GH03J146502 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 20.6 +39.3 39288 5.8 CTCF SMARCE1 ETV6 ELF1 HLF POU5F1 TEAD4 ELF3 SP1 MAFK ENSG00000279320 lnc-PLSCR2-2 PLSCR1 RNU6-428P piR-39098-155
GH03J146510 Enhancer 0.9 Ensembl ENCODE dbSUPER 17.3 +33.3 33255 3.2 SP1 RXRA JUND YY1 ZBTB33 RAD21 HNF4A MAX EGR1 TAF1 PLSCR1 RNU6-428P ENSG00000279320 lnc-PLSCR2-2 piR-48049-057
GH03J146550 Enhancer 0.8 FANTOM5 ENCODE 17.9 -6.4 -6436 1.1 USF2 JUND HLF PKNOX1 RUNX3 FOS YY1 JUNB FOSL1 BATF PLSCR1 PLSCR4 PLSCR2 lnc-ZIC1-11 RF00026-742 RNU6-428P
GH03J146580 Enhancer 1 Ensembl ENCODE 11.2 -36.9 -36902 2.7 ATF1 NR2F6 CREB1 MIXL1 HLF RERE ELF3 CEBPG PPARG ZNF680 PLSCR5 PLSCR1 ENSG00000243415 PLOD2 LNCSRLR PLSCR5-AS1 RF00026-742 RNU6-428P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLSCR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLSCR1 gene promoter:
  • Evi-1
  • FOXD3
  • HNF-3beta
  • HSF1 (long)
  • HSF1short
  • HSF2
  • NCX
  • POU3F1
  • Sox9
  • STAT1

Genomic Locations for PLSCR1 Gene

Genomic Locations for PLSCR1 Gene
chr3:146,515,178-146,544,856
(GRCh38/hg38)
Size:
29,679 bases
Orientation:
Minus strand
chr3:146,232,967-146,262,651
(GRCh37/hg19)
Size:
29,685 bases
Orientation:
Minus strand

Genomic View for PLSCR1 Gene

Genes around PLSCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLSCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLSCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR1 Gene

Proteins for PLSCR1 Gene

  • Protein details for PLSCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15162-PLS1_HUMAN
    Recommended name:
    Phospholipid scramblase 1
    Protein Accession:
    O15162
    Secondary Accessions:
    • B2R8H8
    • B4DTE8

    Protein attributes for PLSCR1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35049 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with ABL (PubMed:11390389). Interacts with RELT, RELL1 and RELL2 (PubMed:22052202). Interacts with OXSR1 in the presence of RELT (PubMed:22052202).

    Three dimensional structures from OCA and Proteopedia for PLSCR1 Gene

    Alternative splice isoforms for PLSCR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLSCR1 Gene

Post-translational modifications for PLSCR1 Gene

  • Phosphorylated by OXSR1 in the presence of RELT.
  • Ubiquitination at Lys261
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PLSCR1 Gene

Domains & Families for PLSCR1 Gene

Gene Families for PLSCR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for PLSCR1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLSCR1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57588, highly similar to Phospholipid scramblase 1 (B4DTE8_HUMAN)
  • MmTRA1b (PLS1_HUMAN)
  • Phospholipid scramblase 1, isoform CRA_f (Q8WVK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15162

UniProtKB/Swiss-Prot:

PLS1_HUMAN :
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Family:
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with PLSCR1: view

Function for PLSCR1 Gene

Molecular function for PLSCR1 Gene

UniProtKB/Swiss-Prot Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
UniProtKB/Swiss-Prot Function:
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
UniProtKB/Swiss-Prot Induction:
By phosphorylation by PKC. Induced by IFNB1/IFN-beta in response to a viral infection.

Phenotypes From GWAS Catalog for PLSCR1 Gene

Gene Ontology (GO) - Molecular Function for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 16091359
GO:0003677 DNA binding IEA --
GO:0005154 epidermal growth factor receptor binding IPI 12009895
GO:0005509 calcium ion binding NAS 9218461
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PLSCR1: view
genes like me logo Genes that share phenotypes with PLSCR1: view

Animal Models for PLSCR1 Gene

MGI Knock Outs for PLSCR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLSCR1

CRISPR Products

miRNA for PLSCR1 Gene

miRTarBase miRNAs that target PLSCR1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLSCR1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLSCR1 Gene

Localization for PLSCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLSCR1 Gene

Cell membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the perinuclear region in the presence of RELT. {ECO:0000269 PubMed:22052202}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLSCR1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 5
mitochondrion 1
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Plasma membrane (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20870722
GO:0005730 nucleolus IDA 17567603
GO:0005737 cytoplasm IEA,IDA 22052202
GO:0005794 Golgi apparatus IDA 12586838
GO:0005829 cytosol IDA 17712045
genes like me logo Genes that share ontologies with PLSCR1: view

Pathways & Interactions for PLSCR1 Gene

PathCards logo

SuperPathways for PLSCR1 Gene

SuperPathway Contained pathways
1 EGF/EGFR Signaling Pathway
genes like me logo Genes that share pathways with PLSCR1: view

Pathways by source for PLSCR1 Gene

1 BioSystems pathway for PLSCR1 Gene

SIGNOR curated interactions for PLSCR1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006659 phosphatidylserine biosynthetic process ISS --
GO:0006915 apoptotic process IDA 10770950
GO:0006953 acute-phase response ISS --
GO:0010628 positive regulation of gene expression IMP 15308695
GO:0017121 phospholipid scrambling IEA,IDA 9218461
genes like me logo Genes that share ontologies with PLSCR1: view

Drugs & Compounds for PLSCR1 Gene

(3) Drugs for PLSCR1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773

(515) Additional Compounds for PLSCR1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PE(P-16:0e/16:0)
  • 1-(Hexadec-1-enyl)-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • PE(P-16:0/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
PEP-16:0/18:1(11Z))
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1W7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-Hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
  • 2-(9Z,12Z-Octadecadienoyl)-1-hexadecyl-sn-glycero-3-phosphocholine
  • PC Ae C34:2
  • PC(16:0E/18:2(9Z,12Z))
  • PC(O-34:2)
88542-95-4
genes like me logo Genes that share compounds with PLSCR1: view

Transcripts for PLSCR1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLSCR1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - -
SP13: - - - -
SP14: - - - - -
SP15:

Relevant External Links for PLSCR1 Gene

GeneLoc Exon Structure for
PLSCR1
ECgene alternative splicing isoforms for
PLSCR1

Expression for PLSCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLSCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLSCR1 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for PLSCR1 Gene

This gene is overexpressed in Urine (12.1) and Fetal gut (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLSCR1 Gene



Protein tissue co-expression partners for PLSCR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLSCR1 Gene:

PLSCR1

SOURCE GeneReport for Unigene cluster for PLSCR1 Gene:

Hs.130759

mRNA Expression by UniProt/SwissProt for PLSCR1 Gene:

O15162-PLS1_HUMAN
Tissue specificity: Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.

Evidence on tissue expression from TISSUES for PLSCR1 Gene

  • Blood(4.4)
  • Intestine(4.4)
  • Liver(4.4)
  • Kidney(4.3)
  • Stomach(2.4)
  • Bone marrow(2.3)
genes like me logo Genes that share expression patterns with PLSCR1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLSCR1 Gene

Orthologs for PLSCR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLSCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLSCR1 33 32
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC611500 32
  • 86 (n)
-- 33
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Plscr1 17 33 32
  • 80.72 (n)
1700057G04Rik 33
  • 68 (a)
ManyToMany
Plscr2 33
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Plscr1 32
  • 80.07 (n)
cow
(Bos Taurus)
Mammalia PLSCR2 33
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves PLSCR1 32
  • 70.1 (n)
-- 33
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 62 (a)
ManyToMany
-- 33
  • 59 (a)
ManyToMany
-- 33
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489273 32
  • 70.01 (n)
Str.951 32
zebrafish
(Danio rerio)
Actinopterygii si:ch73-206p6.1 33
  • 62 (a)
ManyToMany
si:ch211-71m22.5 33
  • 61 (a)
ManyToMany
si:ch211-71m22.1 33
  • 59 (a)
ManyToMany
plscr3b 32
  • 58.53 (n)
FP245465.1 33
  • 41 (a)
ManyToMany
si:ch211-71m22.3 33
  • 37 (a)
ManyToMany
Dr.16684 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005504 32
  • 57.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta scramb1 33 32
  • 54.67 (n)
ManyToMany
CG1893 34
  • 51 (a)
scramb2 33
  • 47 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea scrm-1 32
  • 50.6 (n)
ZK1053.5 34
  • 42 (a)
scrm-2 33
  • 39 (a)
ManyToMany
C04E12.7 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM25 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7036 33
  • 46 (a)
ManyToMany
Cin.10381 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10381 32
Species where no ortholog for PLSCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLSCR1 Gene

ENSEMBL:
Gene Tree for PLSCR1 (if available)
TreeFam:
Gene Tree for PLSCR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLSCR1: view image

Paralogs for PLSCR1 Gene

Paralogs for PLSCR1 Gene

(5) SIMAP similar genes for PLSCR1 Gene using alignment to 10 proteins:

  • PLS1_HUMAN
  • B4DTE8_HUMAN
  • C9J0H3_HUMAN
  • C9J7K9_HUMAN
  • C9J9P4_HUMAN
  • C9JE06_HUMAN
  • C9JSI9_HUMAN
  • F2Z3F2_HUMAN
  • H7C5I5_HUMAN
  • Q8WVK1_HUMAN

Pseudogenes.org Pseudogenes for PLSCR1 Gene

genes like me logo Genes that share paralogs with PLSCR1: view

Variants for PLSCR1 Gene

Sequence variations from dbSNP and Humsavar for PLSCR1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000196043 -- 146,543,990(-) T/C intron_variant
rs1000272049 -- 146,517,787(-) G/A intron_variant
rs1000359716 -- 146,514,784(-) CCC/CC downstream_transcript_variant
rs1000373474 -- 146,534,607(-) C/G/T intron_variant
rs1000544229 -- 146,540,477(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLSCR1 Gene

Variant ID Type Subtype PubMed ID
esv2496437 CNV deletion 19546169
esv2726024 CNV deletion 23290073
esv3569042 CNV loss 25503493
nsv1014493 CNV gain 25217958
nsv822282 CNV gain 20364138

Variation tolerance for PLSCR1 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLSCR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLSCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLSCR1 Gene

Disorders for PLSCR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLSCR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
miyoshi muscular dystrophy 3
  • mmd3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLSCR1

genes like me logo Genes that share disorders with PLSCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLSCR1 Gene

Publications for PLSCR1 Gene

  1. Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression. (PMID: 16091359) Zhou Q … Sims PJ (The Journal of biological chemistry 2005) 3 4 23 56
  2. Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha. (PMID: 15611084) Chen MH … Cingolani G (The Journal of biological chemistry 2005) 3 4 23 56
  3. Phospholipid scramblase 1 potentiates the antiviral activity of interferon. (PMID: 15308695) Dong B … Silverman RH (Journal of virology 2004) 3 4 23 56
  4. Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane. (PMID: 12564925) Wiedmer T … Sims PJ (Biochemistry 2003) 3 4 23 56
  5. Identification of three new members of the phospholipid scramblase gene family. (PMID: 10930526) Wiedmer T … Sims PJ (Biochimica et biophysica acta 2000) 3 4 23 56

Products for PLSCR1 Gene

Sources for PLSCR1 Gene