Aliases for PLSCR1 Gene

Aliases for PLSCR1 Gene

  • Phospholipid Scramblase 1 2 3 4 5
  • Ca(2+)-Dependent Phospholipid Scramblase 1 3 4
  • Erythrocyte Phospholipid Scramblase 3 4
  • Mg(2+)-Dependent Nuclease 3 4
  • PL Scramblase 1 3 4
  • MMTRA1B 2 3
  • EC 3.1.-.- 4
  • MmTRA1b 4
  • PLSCR1 5

External Ids for PLSCR1 Gene

Previous GeneCards Identifiers for PLSCR1 Gene

  • GC03M143025
  • GC03M147108
  • GC03M147514
  • GC03M147553
  • GC03M147715
  • GC03M146232
  • GC03M143612

Summaries for PLSCR1 Gene

GeneCards Summary for PLSCR1 Gene

PLSCR1 (Phospholipid Scramblase 1) is a Protein Coding gene. Diseases associated with PLSCR1 include Scott Syndrome. Among its related pathways are EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is PLSCR2.

UniProtKB/Swiss-Prot Summary for PLSCR1 Gene

  • Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:9218461, PubMed:8663431, PubMed:10770950, PubMed:9572851, PubMed:9485382, PubMed:18629440, PubMed:23590222, PubMed:24648509, PubMed:24343571, PubMed:32110987, PubMed:23659204, PubMed:29748552). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (PubMed:27206388, PubMed:17567603). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes (PubMed:15308695). Acts as an attachment receptor for HCV (PubMed:21806988).

Gene Wiki entry for PLSCR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLSCR1 Gene

Genomics for PLSCR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLSCR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLSCR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLSCR1

Top Transcription factor binding sites by QIAGEN in the PLSCR1 gene promoter:
  • Evi-1
  • FOXD3
  • HNF-3beta
  • HSF1 (long)
  • HSF1short
  • HSF2
  • NCX
  • POU3F1
  • Sox9
  • STAT1

Genomic Locations for PLSCR1 Gene

Latest Assembly
chr3:146,515,178-146,544,856
(GRCh38/hg38)
Size:
29,679 bases
Orientation:
Minus strand

Previous Assembly
chr3:146,232,967-146,262,394
(GRCh37/hg19 by Entrez Gene)
Size:
29,428 bases
Orientation:
Minus strand

chr3:146,232,967-146,262,651
(GRCh37/hg19 by Ensembl)
Size:
29,685 bases
Orientation:
Minus strand

Genomic View for PLSCR1 Gene

Genes around PLSCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLSCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLSCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLSCR1 Gene

Proteins for PLSCR1 Gene

  • Protein details for PLSCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15162-PLS1_HUMAN
    Recommended name:
    Phospholipid scramblase 1
    Protein Accession:
    O15162
    Secondary Accessions:
    • B2R8H8
    • B4DTE8

    Protein attributes for PLSCR1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35049 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Forms homooligomers in the presence of calcium (PubMed:24648509). Interacts with ABL (PubMed:11390389). Interacts with RELT, RELL1 and RELL2 (PubMed:22052202). Interacts with OXSR1 in the presence of RELT (PubMed:22052202). Interacts with TOP2A and TOP2B (PubMed:17567603). Interacts with OCLN (PubMed:21806988). Interacts with TRPC5 (PubMed:32110987). Interacts with TRPC1 and TRPC4 (By similarity).
    • (Microbial infection) Interacts with hepatitis C virus E1 and E2 glycoproteins.

    Three dimensional structures from OCA and Proteopedia for PLSCR1 Gene

    Alternative splice isoforms for PLSCR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLSCR1 Gene

Post-translational modifications for PLSCR1 Gene

  • Phosphorylation at Thr-161 by PKC/PKCD increases its phospholipid scramblase activity during both cell stimulation and apoptosis (PubMed:10770950). Phosphorylated by OXSR1 in the presence of RELT.
  • Palmitoylation is required for its phospholipid scramblase activity (PubMed:9572851). Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925).
  • Ubiquitination at Lys261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLSCR1 Gene

Domains & Families for PLSCR1 Gene

Gene Families for PLSCR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for PLSCR1 Gene

InterPro:
Blocks:
  • Scramblase

Suggested Antigen Peptide Sequences for PLSCR1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57588, highly similar to Phospholipid scramblase 1 (B4DTE8_HUMAN)
  • MmTRA1b (PLS1_HUMAN)
  • Phospholipid scramblase 1, isoform CRA_f (Q8WVK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15162

UniProtKB/Swiss-Prot:

PLS1_HUMAN :
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • The transmembrane domain is essential for membrane insertion, phospholipid scramblase activity and proper calcium-binding.
Family:
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with PLSCR1: view

Function for PLSCR1 Gene

Molecular function for PLSCR1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:9218461, PubMed:8663431, PubMed:10770950, PubMed:9572851, PubMed:9485382, PubMed:18629440, PubMed:23590222, PubMed:24648509, PubMed:24343571, PubMed:32110987, PubMed:23659204, PubMed:29748552). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (PubMed:27206388, PubMed:17567603). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes (PubMed:15308695). Acts as an attachment receptor for HCV (PubMed:21806988).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence={ECO:0000269|PubMed:10770950, ECO:0000269|PubMed:18629440, ECO:0000269|PubMed:23590222, ECO:0000269|PubMed:23659204, ECO:0000269|PubMed:24343571, ECO:0000269|PubMed:24648509, ECO:0000269|PubMed:8663431, ECO:0000269|PubMed:9218461, ECO:0000269|PubMed:9485382, ECO:0000269|PubMed:9572851};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out); Xref=Rhea:RHEA:38895, ChEBI:CHEBI:64612; Evidence={ECO:0000269|PubMed:18629440};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663, ChEBI:CHEBI:57262; Evidence={ECO:0000269|PubMed:23659204, ECO:0000269|PubMed:29748552, ECO:0000305|PubMed:32110987};.
UniProtKB/Swiss-Prot Induction:
(Microbial infection) Induced by IFNB1/IFN-beta in response to a viral infection.
UniProtKB/Swiss-Prot Induction:
Up-regulated during PMA-induced differentiation of the monocytic cell line THP-1.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.0-9.0 for nuclease activity. {ECO:0000269|PubMed:27206388}; Temperature dependence: Optimum temperature is 37 degrees Celsius for nuclease activity (PubMed:27206388). Activity reduced significantly beyond 45 degrees Celsius (PubMed:27206388). {ECO:0000269|PubMed:27206388};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Pb(2+) and Hg(2+) ions (PubMed:23659204, PubMed:29748552). Phosphorylation at Thr-161 by PKC/PKCD increases its phospholipid scramblase activity during both cell stimulation and apoptosis (PubMed:10770950).

Enzyme Numbers (IUBMB) for PLSCR1 Gene

Phenotypes From GWAS Catalog for PLSCR1 Gene

Gene Ontology (GO) - Molecular Function for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 27206388
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 16091359
GO:0001618 virus receptor activity IMP 21806988
GO:0003677 DNA binding IEA --
GO:0004518 nuclease activity IMP 27206388
genes like me logo Genes that share ontologies with PLSCR1: view
genes like me logo Genes that share phenotypes with PLSCR1: view

Animal Models for PLSCR1 Gene

MGI Knock Outs for PLSCR1:

Animal Models for research

  • Taconic Biosciences Mouse Models for PLSCR1

miRNA for PLSCR1 Gene

miRTarBase miRNAs that target PLSCR1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLSCR1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLSCR1 Gene

Localization for PLSCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLSCR1 Gene

Cell membrane. Single-pass type II membrane protein. Cell membrane. Lipid-anchor. Cytoplasmic side. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the perinuclear region in the presence of RELT (PubMed:22052202). Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925). {ECO:0000269 PubMed:12564925, ECO:0000269 PubMed:22052202}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLSCR1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 5
mitochondrion 2
endosome 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12564925
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 17567603
GO:0005737 cytoplasm IEA,IDA 22052202
GO:0005794 Golgi apparatus IDA 12586838
genes like me logo Genes that share ontologies with PLSCR1: view

Pathways & Interactions for PLSCR1 Gene

PathCards logo

SuperPathways for PLSCR1 Gene

SuperPathway Contained pathways
1 EGF/EGFR Signaling Pathway
genes like me logo Genes that share pathways with PLSCR1: view

Pathways by source for PLSCR1 Gene

1 BioSystems pathway for PLSCR1 Gene

SIGNOR curated interactions for PLSCR1 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PLSCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006659 phosphatidylserine biosynthetic process ISS --
GO:0006915 apoptotic process IDA 10770950
GO:0006953 acute-phase response ISS --
GO:0010288 response to lead ion IDA 29748552
GO:0010628 positive regulation of gene expression IMP 15308695
genes like me logo Genes that share ontologies with PLSCR1: view

Drugs & Compounds for PLSCR1 Gene

(5) Drugs for PLSCR1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Dilinoleoyllecithin Experimental Pharma 0
PE(16:0/16:0) Experimental Pharma 0
Calcium Nutra 6959

(522) Additional Compounds for PLSCR1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Beta-Cortolone
  • 1-Palmityl-2-palmitoleoyl-sn-glycero-3-phosphocholine
  • Gpcho(16:0/16:1)
  • Gpcho(16:0/16:1n7)
  • Gpcho(16:0/16:1W7)
  • Gpcho(32:1)
CE(22:0)
  • 1-Tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
  • GPCho(14:0/18:0)
  • Phosphatidylcholine(14:0/18:0)
  • 1-Myristoyl-2-stearoylphosphatidylcholine
  • 1m-2S-PC
61510-09-6
Hydroxyclomipramine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-icosatetraenoyl)-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-(1-Enyl-stearoyl)-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
  • 1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
  • 1-Alkenyl-2-acyl-glycerophosphoethanolamine
97859-69-3
LysoPE(P-16:0/0:0)
  • 1-(1Z-Hexadecenyl)-lysophosphatidylethanolamine
  • 1-(1Z-Hexadecenyl)-sn-glycero-3-phosphoethanolamine
  • LPE(16:1)
  • LPE(p-16:0)
  • LPE(p-16:0/0:0)
174062-72-7
PC(18:1(9Z)e/2:0)
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
genes like me logo Genes that share compounds with PLSCR1: view

Transcripts for PLSCR1 Gene

mRNA/cDNA for PLSCR1 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLSCR1

Alternative Splicing Database (ASD) splice patterns (SP) for PLSCR1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - -
SP13: - - - -
SP14: - - - - -
SP15:

Relevant External Links for PLSCR1 Gene

GeneLoc Exon Structure for
PLSCR1

Expression for PLSCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLSCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLSCR1 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for PLSCR1 Gene

This gene is overexpressed in Urine (12.1) and Fetal gut (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLSCR1 Gene



Protein tissue co-expression partners for PLSCR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLSCR1

SOURCE GeneReport for Unigene cluster for PLSCR1 Gene:

Hs.130759

mRNA Expression by UniProt/SwissProt for PLSCR1 Gene:

O15162-PLS1_HUMAN
Tissue specificity: Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.

Evidence on tissue expression from TISSUES for PLSCR1 Gene

  • Blood(4.5)
  • Intestine(4.5)
  • Kidney(4.5)
  • Liver(4.5)
  • Stomach(2.7)
  • Spleen(2.6)
  • Bone marrow(2.6)
  • Lymph node(2.4)
  • Lung(2.3)
  • Nervous system(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with PLSCR1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLSCR1 Gene

Orthologs for PLSCR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLSCR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLSCR1 29 30
  • 99.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC611500 29
  • 86 (n)
-- 30
  • 80 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Plscr1 29 16 30
  • 80.72 (n)
ManyToMany
1700057G04Rik 30
  • 68 (a)
ManyToMany
Plscr2 30
  • 68 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Plscr1 29
  • 80.07 (n)
Cow
(Bos Taurus)
Mammalia PLSCR2 30
  • 80 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 70 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 67 (a)
OneToMany
Chicken
(Gallus gallus)
Aves PLSCR1 29
  • 70.1 (n)
-- 30
  • 67 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 62 (a)
ManyToMany
-- 30
  • 59 (a)
ManyToMany
-- 30
  • 48 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100489273 29
  • 70.01 (n)
Str.951 29
Zebrafish
(Danio rerio)
Actinopterygii si:ch73-206p6.1 30
  • 62 (a)
ManyToMany
si:ch211-71m22.5 30
  • 61 (a)
ManyToMany
si:ch211-71m22.1 30
  • 59 (a)
ManyToMany
plscr3b 29
  • 58.53 (n)
FP245465.1 30
  • 41 (a)
ManyToMany
si:ch211-71m22.3 30
  • 37 (a)
ManyToMany
Dr.16684 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005504 29
  • 57.78 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta scramb1 29 30
  • 54.67 (n)
ManyToMany
CG1893 31
  • 51 (a)
scramb2 30
  • 47 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea scrm-1 29
  • 50.6 (n)
ZK1053.5 31
  • 42 (a)
scrm-2 30
  • 39 (a)
ManyToMany
C04E12.7 31
  • 35 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM25 32
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7036 30
  • 46 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.10381 29
Species where no ortholog for PLSCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PLSCR1 Gene

ENSEMBL:
Gene Tree for PLSCR1 (if available)
TreeFam:
Gene Tree for PLSCR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLSCR1: view image
Alliance of Genome Resources:
Additional Orthologs for PLSCR1

Paralogs for PLSCR1 Gene

Paralogs for PLSCR1 Gene

(5) SIMAP similar genes for PLSCR1 Gene using alignment to 10 proteins:

  • PLS1_HUMAN
  • B4DTE8_HUMAN
  • C9J0H3_HUMAN
  • C9J7K9_HUMAN
  • C9J9P4_HUMAN
  • C9JE06_HUMAN
  • C9JSI9_HUMAN
  • F2Z3F2_HUMAN
  • H7C5I5_HUMAN
  • Q8WVK1_HUMAN

Pseudogenes.org Pseudogenes for PLSCR1 Gene

genes like me logo Genes that share paralogs with PLSCR1: view

Variants for PLSCR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLSCR1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs343320 -- p.His262Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLSCR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLSCR1 Gene

Variant ID Type Subtype PubMed ID
esv2496437 CNV deletion 19546169
esv2726024 CNV deletion 23290073
esv3569042 CNV loss 25503493
nsv1014493 CNV gain 25217958
nsv822282 CNV gain 20364138

Variation tolerance for PLSCR1 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLSCR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLSCR1
Leiden Open Variation Database (LOVD)
PLSCR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLSCR1 Gene

Disorders for PLSCR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLSCR1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
scott syndrome
  • scts
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLSCR1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PLSCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLSCR1 Gene

Publications for PLSCR1 Gene

  1. Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies. (PMID: 18629440) Sahu SK … Gummadi SN (Biotechnology letters 2008) 3 4 22
  2. Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1. (PMID: 17567603) Wyles JP … Cole SP (Nucleic acids research 2007) 3 4 22
  3. Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha. (PMID: 15611084) Chen MH … Cingolani G (The Journal of biological chemistry 2005) 3 4 22
  4. Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression. (PMID: 16091359) Zhou Q … Sims PJ (The Journal of biological chemistry 2005) 3 4 22
  5. Phospholipid scramblase 1 potentiates the antiviral activity of interferon. (PMID: 15308695) Dong B … Silverman RH (Journal of virology 2004) 3 4 22

Products for PLSCR1 Gene

Sources for PLSCR1 Gene